Gene: ASIC2

40
ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1
acid sensing ion channel subunit 2
protein-coding
17q11.2-q12
Ensembl:ENSG00000108684 MIM:601784 Vega:OTTHUMG00000132885 UniprotKB:Q16515
NG_029763.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.096e-1 (AD)  5.113e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2036535chr17:33423995 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs7218135chr17:33166325 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR30.926
UBE2QL10.919
SYN20.918
TMEM1300.917
SYP0.917
ACTL6B0.916
THY10.916
SULT4A10.914
NPTX10.914
RAB3A0.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNN2-0.571
LATS2-0.567
AJUBA-0.559
RUNX3-0.559
REST-0.557
WWTR1-0.55
TFPI2-0.549
NEDD4-0.543
CLEC1A-0.543
RNF135-0.54

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00594AmilorideSmall Molecule2609-46-3ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ASIC2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASIC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASIC2 mRNA"27188386
D000143Acids[Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate19860742
D000255Adenosine Triphosphate[Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate19860742
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ASIC2 gene27153756
D000584AmilorideAmiloride binds to and results in decreased activity of ASIC2 protein19860742
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASIC2 mRNA16483693
D000661AmphetamineAmphetamine affects the localization of ASIC2 protein20566346
C015001arsenitearsenite results in increased methylation of ASIC2 promoter23974009
D001241AspirinAspirin results in decreased expression of ASIC2 mRNA11588175
C547126AZM551248AZM551248 results in increased expression of ASIC2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ASIC2 promoter]19654925
D004958EstradiolEstradiol affects the expression of ASIC2 mRNA23557687
D004958EstradiolEstradiol affects the expression of ASIC2 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of ASIC2 mRNA23557687
C006780bisphenol Abisphenol A results in increased methylation of ASIC2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ASIC2 mRNA16644059
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ASIC2 gene20938992
D003907DexamethasoneDexamethasone results in decreased expression of ASIC2 mRNA11588175
D003976DiazinonDiazinon affects the expression of ASIC2 mRNA22546817
D004008DiclofenacDiclofenac results in decreased expression of ASIC2 mRNA11588175
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA16931933
D004041Dietary FatsDietary Fats results in increased expression of ASIC2 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ASIC2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ASIC2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ASIC2 mRNA12075121
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ASIC2 gene20938992
D005682GadoliniumGadolinium binds to and results in decreased activity of ASIC2 protein19860742
D007052IbuprofenIbuprofen results in decreased expression of ASIC2 mRNA11588175
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA16931933
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ASIC2 gene20938992
C022838nickel chloridenickel chloride affects the expression of ASIC2 mRNA22546817
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASIC2 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASIC2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ASIC2 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of ASIC2 mRNA alternative form11162239
C043680ptaquilosideptaquiloside results in decreased expression of ASIC2 mRNA23274088
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA16931933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ASIC2 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in decreased expression of ASIC2 mRNA18175754
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ASIC2 mRNA17942748
D014212TretinoinTretinoin results in increased expression of ASIC2 mRNA21934132
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ASIC2 gene25560391
C025643vinclozolinvinclozolin affects the expression of ASIC2 mRNA19015723
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11802773  
GO:0015280ligand-gated sodium channel activity-TAS8626462  
GO:0044736acid-sensing ion channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003026regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback-IEA-  
GO:0007268chemical synaptic transmission-TAS8626462  
GO:0007417central nervous system development-TAS8626462  
GO:0007422peripheral nervous system development-TAS8626462  
GO:0007602phototransduction-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO:0010447response to acidic pH-IEA-  
GO:0015672monovalent inorganic cation transport-TAS8626462  
GO:0019229regulation of vasoconstriction-IEA-  
GO:0034220ion transmembrane transport-TAS-  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035418protein localization to synapse-IEA-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0050915sensory perception of sour taste-IMP19812697  
GO:0050974detection of mechanical stimulus involved in sensory perception-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal