Gene: LMNA

4000
CDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|MADA|PRO1
lamin A/C
protein-coding
1q22
Ensembl:ENSG00000160789 MIM:150330 Vega:OTTHUMG00000013961 UniprotKB:P02545
NG_008692.2
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.726e-3 (AD)  6.350e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22820188chr1:156086004LMNA1.900e-8Smoking27651444
cg19238380chr1:156093948LMNA2.240e-12Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RRBP10.904
MVP0.895
DNAJC10.868
STAT5A0.855
EFNA10.855
MAPKAPK20.853
SLC39A10.853
PLIN30.849
RELA0.849
SYNGR20.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.491
KIT-0.482
NDST3-0.452
MARCH4-0.449
IGF1-0.444
NEUROD6-0.439
FREM3-0.439
NXPH2-0.437
VWC2-0.436
LHX6-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of LMNA protein"27026707
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of LMNA mRNA"22101062
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LMNA mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of LMNA mRNA]"19414516
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LMNA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LMNA mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LMNA mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LMNA mRNA24525193
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LMNA protein24525193
C0114215-chloro-2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of LMNA protein29267982
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LMNA mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LMNA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LMNA mRNA]17585979
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LMNA mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LMNA mRNA19770486
C430898AGN 194204AGN 194204 results in decreased expression of LMNA mRNA16339527
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of LMNA mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of LMNA protein26072098|2659704
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LMNA protein26597043
D000616AminoglutethimideAminoglutethimide results in decreased expression of LMNA protein26102013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LMNA mRNA16483693
D001151ArsenicArsenic affects the methylation of LMNA gene25304211
D001241AspirinAspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein]17644113
D001280AtrazineAtrazine results in increased expression of LMNA mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LMNA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LMNA protein20097212
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of LMNA protein24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LMNA mRNA19770486|2222880
D004958EstradiolEstradiol affects the expression of LMNA mRNA23557687
D004958EstradiolEstradiol results in increased phosphorylation of LMNA protein27026707
C044887beta-methylcholinebeta-methylcholine affects the expression of LMNA mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LMNA mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LMNA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of LMNA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LMNA mRNA25181051
D001761BleomycinBleomycin results in increased expression of LMNA protein25933445
D000069286BortezomibBortezomib results in increased cleavage of LMNA protein20110775
C013418bromfenacoumbromfenacoum results in decreased expression of LMNA protein28903499
C515564bromovaninbromovanin results in increased expression of LMNA protein21419150
D019256Cadmium ChlorideCadmium Chloride results in increased cleavage of LMNA protein28229933
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LMNA mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of LMNA mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LMNA mRNA27339419
C016299chelerythrinechelerythrine results in increased cleavage of LMNA protein26124276
C084597chlorcyclizinechlorcyclizine results in increased expression of LMNA mRNA21058326
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LMNA mRNA28472532
C012843cinnamic aldehydecinnamic aldehyde results in increased metabolism of LMNA protein29267982
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LMNA mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of LMNA mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LMNA mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of LMNA mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of LMNA mRNA21163907|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of LMNA mRNA24834073
D003703DemecolcineDemecolcine results in increased expression of LMNA mRNA23649840
D003840Deoxycholic AcidAspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein]17644113
D003840Deoxycholic AcidDeoxycholic Acid results in increased cleavage of LMNA protein17644113
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of LMNA protein23811945
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of LMNA protein23352502
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LMNA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LMNA mRNA28628672
D003976DiazinonDiazinon results in increased methylation of LMNA gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LMNA mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LMNA mRNA21266533
D002945CisplatinCisplatin results in decreased expression of LMNA protein20540955
D002945CisplatinCisplatin affects the expression of LMNA mRNA21151649
D002945CisplatinCisplatin results in decreased expression of LMNA protein22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LMNA mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of LMNA protein"22248470
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased metabolism of LMNA protein29267982
D004298DopamineDopamine results in increased expression of LMNA protein24675778
D004317DoxorubicinDoxorubicin results in increased cleavage of LMNA protein18840609
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of LMNA protein22248470
C013525ENNGENNG results in increased expression of LMNA protein22248470
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LMNA protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LMNA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LMNA mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LMNA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LMNA mRNA16174780|2409603
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LMNA mRNA23649840
D018120FinasterideFinasteride results in increased expression of LMNA mRNA24136188
D005472FluorouracilFluorouracil results in increased cleavage of LMNA protein18497562
D005473FluoxetineFluoxetine results in decreased expression of LMNA mRNA21852994
D005485FlutamideFlutamide results in increased expression of LMNA mRNA24136188
D005485FlutamideFlutamide results in increased expression of LMNA protein17311803
C065180fluvastatinfluvastatin results in decreased farnesylation of LMNA protein16996129
D005557FormaldehydeFormaldehyde results in increased expression of LMNA mRNA23649840
C096856FTI 277FTI 277 results in increased expression of LMNA protein20884875
C096856FTI 277[FTI 277 co-treated with GGTI 2147] results in decreased farnesylation of LMNA protein18587406
C096856FTI 277[FTI 277 co-treated with GGTI 2147] results in decreased geranoylation of LMNA protein18587406
C056933fumonisin B1fumonisin B1 results in increased expression of LMNA mRNA16221962
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of LMNA protein]20884965
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of LMNA protein]20884965
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of LMNA protein]20884965
D019833GenisteinGenistein results in decreased expression of LMNA protein20884965
D019833GenisteinGenistein results in increased expression of LMNA protein20884965
D005839GentamicinsGentamicins results in increased expression of LMNA protein22061828
C466792GGTI 2147[FTI 277 co-treated with GGTI 2147] results in decreased farnesylation of LMNA protein18587406
C466792GGTI 2147[FTI 277 co-treated with GGTI 2147] results in decreased geranoylation of LMNA protein18587406
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA28433809
D017313FenretinideFenretinide results in decreased expression of LMNA mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LMNA protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in increased expression of LMNA protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased secretion of LMNA mRNA21179422
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LMNA protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of LMNA protein23178681
C031927hydroquinonehydroquinone affects the expression of LMNA protein17181942
C492448ICG 001ICG 001 results in decreased expression of LMNA mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LMNA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LMNA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LMNA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LMNA mRNA28628672
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of LMNA protein"22248470
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of LMNA protein22248470
C098607JP8 aviation fuelJP8 aviation fuel affects the metabolism of LMNA protein10892725
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of LMNA mRNA21889194
C510621KCC 009KCC 009 results in increased cleavage of LMNA protein16170020
C045463leflunomideleflunomide results in increased expression of LMNA mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LMNA mRNA25613284
D008094LithiumLithium results in increased expression of LMNA protein18296634
C115354lonafarniblonafarnib results in decreased farnesylation of LMNA protein16996129
D061466LopinavirLopinavir results in increased farnesylation of LMNA protein alternative form18230615
C558899lopinavir-ritonavir drug combinationlopinavir-ritonavir drug combination results in increased expression of LMNA protein20884875
C042720mercuric bromidemercuric bromide results in increased expression of LMNA mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
D008628MercuryMercury results in decreased expression of LMNA mRNA16823088
D008727MethotrexateMethotrexate results in increased expression of LMNA mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LMNA mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LMNA mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LMNA protein24675778
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LMNA protein26558463
D015741MetriboloneMetribolone results in decreased expression of LMNA protein17152098
C063855microcystin RRmicrocystin RR results in increased expression of LMNA protein19111056
D016685MitomycinLMNA protein affects the susceptibility to Mitomycin16217747
D009151Mustard GasFADD protein affects the reaction [Mustard Gas promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]12482751
D009151Mustard GasMustard Gas results in increased cleavage of LMNA protein12482751
D009151Mustard GasMustard Gas results in increased phosphorylation of LMNA protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LMNA protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LMNA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LMNA mRNA"25554681
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of LMNA protein19438287
C031721naphthalenenaphthalene results in decreased expression of LMNA protein19438287
C066471NCS 382NCS 382 results in increased expression of LMNA mRNA28119166
C051752nefazodonenefazodone results in increased expression of LMNA mRNA24136188
D009532NickelNickel results in increased expression of LMNA mRNA23195993|2476865
C028007nickel monoxidenickel monoxide results in increased expression of LMNA mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of LMNA protein19716841
C016340o,p'-DDT"o,p'-DDT results in increased expression of LMNA mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of LMNA mRNA"24096037
D052638Particulate MatterParticulate Matter results in increased expression of LMNA protein17922515
D052638Particulate Matter[LMNA gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of LMNA mRNA21222557|2122255
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LMNA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LMNA mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMNA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LMNA mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LMNA mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of LMNA mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of LMNA mRNA16221962
C006253pirinixic acidpirinixic acid results in increased expression of LMNA mRNA19162173
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA28433809
C545373ponatinibponatinib results in increased cleavage of LMNA protein22875613
D011192Potassium DichromatePotassium Dichromate results in increased expression of LMNA protein23718831
D017035PravastatinPravastatin results in increased expression of LMNA protein20884875
D011441PropylthiouracilPropylthiouracil results in decreased expression of LMNA mRNA24780913
D011794QuercetinQuercetin results in decreased expression of LMNA protein14750173|1522177
C037219quinolinequinoline analog results in decreased expression of LMNA protein18645022
C037219quinolinequinoline analog results in increased expression of LMNA protein18645022
C059514resveratrolBAX protein promotes the reaction [resveratrol promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]16518869
C059514resveratrolresveratrol promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]16518869
C059514resveratrolresveratrol promotes the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]23217256
C059514resveratrolresveratrol promotes the reaction [[LMNA protein binds to and results in increased activity of SIRT1 protein] which results in decreased acetylation of TP53 protein]23217256
C059514resveratrolresveratrol results in increased cleavage of LMNA protein16518869|1700701
C059514resveratrolTP53 protein promotes the reaction [resveratrol promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]16518869
C059514resveratrolresveratrol results in decreased expression of LMNA mRNA22610192
D019438RitonavirRitonavir results in increased expression of LMNA protein20884875
D019438RitonavirRitonavir results in increased farnesylation of LMNA protein alternative form18230615
C089730rosiglitazonerosiglitazone affects the expression of LMNA protein19556978
C541923sandostatinLARsandostatinLAR results in increased expression of LMNA mRNA17210224
D012643SeleniumSelenium results in increased expression of LMNA mRNA19244175
D020123SirolimusSirolimus results in decreased expression of LMNA protein16920414
C080703SK&F 83959SK&F 83959 results in decreased expression of LMNA protein25852303
C017947sodium arsenitesodium arsenite results in increased expression of LMNA protein28229933
C016104sodium bichromatesodium bichromate results in decreased expression of LMNA mRNA17685462
C016104sodium bichromatesodium bichromate results in increased expression of LMNA mRNA25993096
D012999SomanSoman results in increased expression of LMNA mRNA19281266
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of LMNA protein24464499
D053260SootSoot results in increased expression of LMNA protein24464499
D019311StaurosporineStaurosporine results in increased cleavage of LMNA protein26124276
D013498SuraminSuramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]23217256
D013629TamoxifenTamoxifen affects the expression of LMNA mRNA17555576
D013749TetrachlorodibenzodioxinLMNA protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]12761348
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LMNA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LMNA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LMNA mRNA16960034|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LMNA mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LMNA protein19201780
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LMNA mRNA16960034
C009495titanium dioxidetitanium dioxide results in increased expression of LMNA mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LMNA mRNA28111298
C012589trichostatin Atrichostatin A affects the expression of LMNA mRNA28542535
D014303TrinitrotolueneTrinitrotoluene affects the expression of LMNA mRNA21346803
C080163trovafloxacintrovafloxacin results in decreased expression of LMNA mRNA24136188
D014415TunicamycinTunicamycin results in increased expression of LMNA mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of LMNA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LMNA mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of LMNA mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of LMNA mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of LMNA mRNA19136453
D014640VancomycinVancomycin results in decreased expression of LMNA mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased expression of LMNA protein17922515
D001335Vehicle Emissions[LMNA gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of LMNA mRNA21222557|2122255
C025643vinclozolinvinclozolin results in decreased expression of LMNA mRNA23034163
D014750VincristineVincristine results in increased expression of LMNA mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of LMNA mRNA26682919
D014810Vitamin EVitamin E results in increased expression of LMNA mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of LMNA mRNA24714768
C088658zoledronic acidzoledronic acid results in decreased farnesylation of LMNA protein16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI10514485  10727209  11801724  15140953  15161933  15671068  
16247757  19323649  19933576  20000738  20580717  20618440  
21418524  21949239  21988832  22399800  22555292  23658700  
25416956  29568061  
GO ID GO Term Qualifier Evidence PubMed
GO:0006606protein import into nucleus-IEA-  
GO:0007084mitotic nuclear envelope reassembly-TAS-  
GO:0008285negative regulation of cell proliferation-IMP27534416  
GO:0010628positive regulation of gene expression-IEA-  
GO:0030334regulation of cell migration-ISS-  
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity-ISS-  
GO:0034504protein localization to nucleus-ISS-  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0055015ventricular cardiac muscle cell development-IEA-  
GO:0071456cellular response to hypoxia-IEP20810912  
GO:0072201negative regulation of mesenchymal cell proliferation-IEA-  
GO:0090201negative regulation of release of cytochrome c from mitochondria-IEA-  
GO:0090343positive regulation of cell aging-IDA20458013  
GO:1900180regulation of protein localization to nucleus-IEA-  
GO:1903243negative regulation of cardiac muscle hypertrophy in response to stress-ISS-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IDA18809582  20810912  
GO:0005635nuclear envelope-IDA18606848  27534416  
GO:0005635nuclear envelopecolocalizes_withIMP21610090  
GO:0005635nuclear envelope-TAS-  
GO:0005638lamin filament-IEA-  
GO:0005654nucleoplasm-IDA27534416  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IEA-  
GO:0031965nuclear membrane-HDA16791210  
KEGG ID KEGG Term
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseIEA
R-HSA-1643685DiseaseTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2993913Clearance of Nuclear Envelope Membranes from ChromatinTAS
R-HSA-2995383Initiation of Nuclear Envelope ReformationTAS
R-HSA-2995410Nuclear Envelope ReassemblyTAS
R-HSA-352238Breakdown of the nuclear laminaTAS
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4419969Depolymerisation of the Nuclear LaminaTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-75153Apoptotic execution phaseTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsIEA
R-HSA-8863678Neurodegenerative DiseasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19672032A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study). (2009 Aug)Akasaka HJ Atheroscler Thromb
24037902The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. (2013 Oct)Hirtle-Lewis MClin Cardiol