Gene: C15orf53

400359
-
chromosome 15 open reading frame 53
protein-coding
15q14
Ensembl:ENSG00000175779 Vega:OTTHUMG00000129841 UniprotKB:Q8NAA6
NC_000015.10
PubMed|SNP Mapped
13   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.224e-1 (AD)  5.106e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2132157chr15:38700346 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12916379chr15:38699319 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2172835chr15:38697970 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs35024396chr15:38697569 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs34281605chr15:38697473 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs34141940chr15:38697456 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs34356257chr15:38697404 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7165988chr15:38696614 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7171233chr15:38696559 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7163869chr15:38696190 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs35102843chr15:38695906 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12903120chr15:38695896 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12898460chr15:38694612 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4X10.908
OR5M100.904
OR2J30.897
OR10H40.886
OR2J10.88
OR4C460.871
KRTAP6-20.871
OR5T20.871
OR5M10.871
OR5I10.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.331
SFTPC-0.293
PLA2G6-0.283
SORCS2-0.272
CORO2B-0.269
CRB2-0.259
PCDH9-0.259
MYH7B-0.258
DBP-0.256
IGSF11-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of C15ORF53 gene27153756

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. (2013 Nov)Wang JCMol Psychiatry