Gene: EML6

400954
-
echinoderm microtubule associated protein like 6
protein-coding
2p16.1
Ensembl:ENSG00000214595 Vega:OTTHUMG00000152035 UniprotKB:Q6ZMW3
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.092e-1 (AD)  4.206e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2163618chr2:54884552 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13385982chr2:54876128 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UNC790.925
PHTF10.92
CACNA1B0.919
DLGAP20.918
DRP20.916
FAM153B0.915
FGFR1OP0.911
CAPRIN20.907
SUGP20.907
CSMD10.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.51
MDFI-0.487
YES1-0.483
RAB13-0.483
COPZ2-0.481
CNN2-0.473
MYL3-0.47
CCDC102A-0.467
RAI14-0.459
FAM89A-0.458

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EML6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EML6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EML6 mRNA29067470
C547126AZM551248AZM551248 results in increased expression of EML6 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of EML6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of EML6 mRNA25181051
C029892cupric chloridecupric chloride results in decreased expression of EML6 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of EML6 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EML6 mRNA]27941970
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of EML6 mRNA25270620
C118739entinostatentinostat results in increased expression of EML6 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EML6 mRNA26865667
D005557FormaldehydeFormaldehyde results in decreased expression of EML6 mRNA23649840
D019833GenisteinGenistein affects the expression of EML6 mRNA26865667
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of EML6 mRNA18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EML6 mRNA26752646
D007854LeadLead affects the expression of EML6 mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EML6 mRNA23649840
D009532NickelNickel results in decreased expression of EML6 mRNA24768652|2558310
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EML6 mRNA24680724
C012589trichostatin Atrichostatin A affects the expression of EML6 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EML6 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of EML6 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EML6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EML6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of EML6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EML6 mRNA23179753|2438349
D014750VincristineVincristine results in decreased expression of EML6 mRNA23649840
C111237vorinostatvorinostat results in increased expression of EML6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008017microtubule binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005874microtubule-IEA-  
GO:0015630microtubule cytoskeleton-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal