Gene: PHOX2A

401
ARIX|CFEOM2|FEOM2|NCAM2|PMX2A
paired like homeobox 2a
protein-coding
11q13.4
Ensembl:ENSG00000165462 MIM:602753 Vega:OTTHUMG00000167899 UniprotKB:O14813
NG_008169.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.591e-1 (AD)  4.823e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAT10.535
FBXO470.512
SERPINE10.504
TNFAIP30.484
F2RL30.482
FOSL10.482
FRMD10.474
TMEM950.471
HPD0.469
C2CD4B0.459

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC6A5-0.383
VSTM5-0.362
CASC1-0.358
SAMD12-0.356
GPR150-0.354
SLITRK1-0.35
EIF4E1B-0.346
LSM11-0.345
KHDC1-0.341
SRRM4-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PHOX2A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PHOX2A mRNA24449571
D001280AtrazineAtrazine results in decreased expression of PHOX2A mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of PHOX2A mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of PHOX2A promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of PHOX2A promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PHOX2A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PHOX2A gene28505145
D002211CapsaicinCapsaicin results in increased expression of PHOX2A mRNA16278290
C000541cyclopaminecyclopamine results in decreased expression of PHOX2A mRNA22265815
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHOX2A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHOX2A mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of PHOX2A mRNA18035473
D004397FonofosFonofos results in increased methylation of PHOX2A promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of PHOX2A mRNA19167457
C039281furanfuran results in increased methylation of PHOX2A gene22079235
C028577monobutyl phthalatemonobutyl phthalate affects the expression of PHOX2A mRNA19162170
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PHOX2A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PHOX2A mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of PHOX2A mRNA19167457
D010278ParathionParathion results in increased methylation of PHOX2A promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHOX2A mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of PHOX2A mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of PHOX2A mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of PHOX2A mRNA24780913
C428725pyridabenpyridaben results in decreased expression of PHOX2A mRNA22563483
D053260SootSoot results in increased expression of PHOX2A mRNA26551751
C012568terbufosterbufos results in increased methylation of PHOX2A promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHOX2A mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHOX2A mRNA17942748

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA16280598  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-NAS8661014  
GO ID GO Term Qualifier Evidence PubMed
GO:0003357noradrenergic neuron differentiation-IC19573018  
GO:0003357noradrenergic neuron differentiation-NAS16280598  
GO:0006351transcription, DNA-templated-IEA-  
GO:0021523somatic motor neuron differentiation-IEA-  
GO:0021623oculomotor nerve formation-IEA-  
GO:0021642trochlear nerve formation-IEA-  
GO:0021703locus ceruleus development-IEA-  
GO:0030901midbrain development-IEA-  
GO:0043576regulation of respiratory gaseous exchange-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16280598  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP19573018  
GO:0048485sympathetic nervous system development-IEA-  
GO:0071542dopaminergic neuron differentiation-IC19573018  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA16280598  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett
25555412Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. (2015 Sep)Weng JTComput Biol Med