Gene: LRRD1

401387
-
leucine rich repeats and death domain containing 1
protein-coding
7q21.2
Ensembl:ENSG00000240720 Vega:OTTHUMG00000155861 UniprotKB:A4D1F6
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.109e-2 (AD)  3.430e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6465353chr7:92150657 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN7A0.477
CALML40.475
TRIM130.475
GCFC20.473
RUNDC3B0.461
UBE3D0.457
TRAPPC20.454
ASPM0.454
RSBN10.453
C8orf590.453

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM25A-0.287
OR4F16-0.269
TBX5-0.256
PLA2G5-0.236
PI3-0.219
REG3A-0.211
ADAMTSL5-0.209
GNAT1-0.208
PRM2-0.205
MTRNR2L10-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of LRRD1 mRNA25181051

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0045199maintenance of epithelial cell apical/basal polarity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0016323basolateral plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal