Gene: LOR

4014
-
loricrin
protein-coding
1q21.3
Ensembl:ENSG00000203782 MIM:152445 Vega:OTTHUMG00000013938 UniprotKB:P23490
NG_011818.1
PubMed
0   ANCO-SNPs
CD|ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.173e-1 (AD)  4.050e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALML50.607
KRT10.591
KRT140.579
KRT20.572
KRT50.562
KRTDAP0.543
FLG20.527
CASP140.512
TNS40.491
SERPINA120.48

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGB8-0.285
SLC52A3-0.284
TRPC5OS-0.281
CDC14A-0.281
IKZF2-0.279
SLC16A1-0.276
FGD4-0.276
ZFHX3-0.274
NEDD1-0.273
CDH23-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LOR mRNA"22698814
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of LOR mRNA]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of LOR protein]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of LOR mRNA]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of LOR protein]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of LOR mRNA21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of LOR protein21524694
D000082AcetaminophenAcetaminophen affects the expression of LOR mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of LOR mRNA11264010
D001149ArsenatesArsenates results in decreased expression of LOR mRNA9219563
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LOR mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of LOR mRNA16985168
C075388beta-damascenonebeta-damascenone results in increased expression of LOR mRNA22982537
D004958EstradiolEstradiol results in decreased expression of LOR mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of LOR mRNA25181051
D002118Calcium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of LOR mRNA]21524694
D002118Calcium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of LOR protein]21524694
D002118CalciumCalcium results in increased expression of LOR mRNA21524694|2465850
D002118CalciumCalcium results in increased expression of LOR protein21524694|2465850
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of LOR mRNA]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of LOR protein]24658506
D002118CalciumCTNNB1 mutant form inhibits the reaction [Calcium results in increased expression of LOR mRNA]24658506
D002118CalciumCTNNB1 mutant form inhibits the reaction [Calcium results in increased expression of LOR protein]24658506
D002118CalciumSB 203580 inhibits the reaction [Calcium results in increased expression of LOR mRNA]21524694
D002118CalciumSB 203580 inhibits the reaction [Calcium results in increased expression of LOR protein]21524694
D002118CalciumWNT5A protein promotes the reaction [Calcium results in increased expression of LOR mRNA]24658506
D002118CalciumWNT5A protein promotes the reaction [Calcium results in increased expression of LOR protein]24658506
D002840ChromatesChromates results in decreased expression of LOR mRNA9219563
C031180chrysenechrysene results in increased expression of LOR mRNA26377693
D002922CiguatoxinsCiguatoxins affects the expression of LOR mRNA18353800
D002994ClofibrateClofibrate results in increased expression of LOR mRNA10951269
D002994ClofibrateClofibrate results in increased expression of LOR protein10951269
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of LOR mRNA24690739
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LOR mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LOR mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LOR mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of LOR mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LOR mRNA15171707
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of LOR mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of LOR mRNA24690739
D007840LatexLatex analog results in decreased expression of LOR mRNA24768652
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of LOR mRNA22563483
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of LOR mRNA29162477
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LOR mRNA26924002
D009151Mustard Gas2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of LOR mRNA]21524694
D009151Mustard Gas2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of LOR protein]21524694
D009151Mustard GasMustard Gas results in increased expression of LOR mRNA21524694
D009151Mustard GasMustard Gas results in increased expression of LOR protein21524694
D009151Mustard GasSB 203580 inhibits the reaction [Mustard Gas results in increased expression of LOR mRNA]21524694
D009151Mustard GasSB 203580 inhibits the reaction [Mustard Gas results in increased expression of LOR protein]21524694
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LOR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LOR mRNA"25620056
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of LOR mRNA22563483
D010269ParaquatParaquat results in decreased expression of LOR mRNA22563483
C006253pirinixic acidpirinixic acid results in increased expression of LOR mRNA10951269
C006253pirinixic acidpirinixic acid results in increased expression of LOR protein10951269
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of LOR mRNA27029645
C093642SB 203580SB 203580 inhibits the reaction [Calcium results in increased expression of LOR mRNA]21524694
C093642SB 203580SB 203580 inhibits the reaction [Calcium results in increased expression of LOR protein]21524694
C093642SB 203580SB 203580 inhibits the reaction [Mustard Gas results in increased expression of LOR mRNA]21524694
C093642SB 203580SB 203580 inhibits the reaction [Mustard Gas results in increased expression of LOR protein]21524694
C093642SB 203580SB 203580 results in decreased expression of LOR protein21524694
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LOR mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of LOR gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of LOR mRNA19524636
C017947sodium arsenitesodium arsenite results in increased expression of LOR protein18572023|1952463
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LOR mRNA17035482
C009495titanium dioxidetitanium dioxide results in increased expression of LOR mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LOR mRNA27480279
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LOR protein27480279
D014212TretinoinTretinoin results in decreased expression of LOR mRNA16985168
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LOR mRNA19042947
D014638VanadatesVanadates results in decreased expression of LOR mRNA9219563
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LOR gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IBA21873635  
GO:0005198structural molecule activity-IDA10908733  
GO:0005200structural constituent of cytoskeleton-TAS2007607  
GO:0005515protein binding-IPI7592852  
GO:0030280structural constituent of epidermis-IDA7543090  
GO:0030674protein binding, bridging-IDA10908733  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0018149peptide cross-linking-IDA7543090  10908733  
GO:0030216keratinocyte differentiation-IBA21873635  
GO:0030216keratinocyte differentiation-IDA10908733  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IBA21873635  
GO:0001533cornified envelope-IDA7543090  10908733  11698679  
GO:0001533cornified envelope-TAS-  
GO:0005654nucleoplasm-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11698679  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23792214Optimizing anti-TNF treatments in inflammatory bowel disease. (2014 Jan)Ben-Horin SAutoimmun Rev