Gene: HACD4

401494
PTPLAD2
3-hydroxyacyl-CoA dehydratase 4
protein-coding
9p21.3
Ensembl:ENSG00000188921 MIM:615941 Vega:OTTHUMG00000021016 UniprotKB:Q5VWC8
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.734e-1 (AD)  1.417e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11789272chr9:21030852 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HACD4 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HACD4 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of HACD4 mRNA28959563
D000393Air PollutantsAir Pollutants analog results in decreased expression of HACD4 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of HACD4 mRNA28522335
C006632arsenic trioxidearsenic trioxide results in increased expression of HACD4 mRNA26705709
C015001arsenitearsenite results in decreased expression of HACD4 mRNA23974009
C015001arsenitearsenite results in increased expression of HACD4 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of HACD4 mRNA]18929588
D001280AtrazineAtrazine results in decreased expression of HACD4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HACD4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HACD4 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HACD4 mRNA20660070
D004958EstradiolEstradiol results in increased expression of HACD4 mRNA19484750
D001663BilirubinBilirubin results in decreased expression of HACD4 mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of HACD4 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HACD4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HACD4 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of HACD4 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HACD4 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HACD4 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HACD4 mRNA20938992
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HACD4 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of HACD4 mRNA23625948
D004041Dietary FatsDietary Fats results in increased expression of HACD4 mRNA25016146
C118739entinostatentinostat results in increased expression of HACD4 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HACD4 mRNA22079256
C540355fenamidonefenamidone results in increased expression of HACD4 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HACD4 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HACD4 mRNA20938992
D017313FenretinideFenretinide results in decreased expression of HACD4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of HACD4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HACD4 mRNA21179406
C492448ICG 001ICG 001 affects the expression of HACD4 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HACD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HACD4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HACD4 mRNA23086925
C008261lead acetatelead acetate results in decreased expression of HACD4 mRNA22641619
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HACD4 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HACD4 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HACD4 mRNA28001369
C523799MRK 003HACD4 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HACD4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HACD4 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of HACD4 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HACD4 mRNA25729387
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of HACD4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of HACD4 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of HACD4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of HACD4 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HACD4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HACD4 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HACD4 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of HACD4 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of HACD4 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HACD4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HACD4 mRNA19073995
D012834SilverSilver results in decreased expression of HACD4 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in increased expression of HACD4 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HACD4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HACD4 promoter]19654925
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of HACD4 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of HACD4 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HACD4 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of HACD4 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HACD4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HACD4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HACD4 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00188123-hydroxyacyl-CoA dehydratase activity-IBA21873635  
GO:00188123-hydroxyacyl-CoA dehydratase activity-IDA18554506  
GO:0019899enzyme binding-IDA18554506  
GO:0102158very-long-chain 3-hydroxyacyl-CoA dehydratase activity-IEA-  
GO:01023433-hydroxy-arachidoyl-CoA dehydratase activity-IEA-  
GO:01023443-hydroxy-behenoyl-CoA dehydratase activity-IEA-  
GO:01023453-hydroxy-lignoceroyl-CoA dehydratase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030148sphingolipid biosynthetic process-IBA21873635  
GO:0030497fatty acid elongation-IBA21873635  
GO:0030497fatty acid elongation-IDA18554506  
GO:0042761very long-chain fatty acid biosynthetic process-IBA21873635  
GO:0042761very long-chain fatty acid biosynthetic process-IDA18554506  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA18554506  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal