Gene info: ID 4015

Gene: LOX

GENE ID: 4015

Synonyms: AAT10

Description: lysyl oxidase

Gene type: protein-coding

Location: 5q23.1

dbXrefs: Ensembl:ENSG00000113083 MIM:153455 Vega:OTTHUMG00000128914 UniprotKB:P28300

RefSeq: NG_008722.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 42

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.782e-1 (AD) 4.590e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MEDAG	0.74
DKK2	0.656
FBLN5	0.655
NNMT	0.654
ITIH3	0.642
LYST	0.639
OGN	0.637
FMOD	0.636
TMEM87B	0.633
CTDSPL2	0.626

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A1	-0.301
C16orf74	-0.295
PLA2G5	-0.293
ABHD1	-0.279
ENDOU	-0.273
ADAMTSL5	-0.272
HES5	-0.269
ENHO	-0.268
PTGDR2	-0.266
REN	-0.258

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06778	Cupric sulfate	Small Molecule	7758-98-7	Approved	Enzyme
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of LOX mRNA"	19162173
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of LOX mRNA	25827057
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LOX mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of LOX mRNA"	21920950
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of LOX mRNA"	21724226
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of LOX mRNA"	25710175
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of LOX mRNA]"	26644586
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of LOX mRNA"	26644586
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of LOX protein	26194647
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LOX mRNA"	23196670
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of LOX mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of LOX mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of LOX mRNA	17202762
D020106	Acrylamide	Acrylamide results in decreased expression of LOX mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of LOX protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of LOX mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of LOX gene	27153756
D019386	Alendronate	Alendronate affects the expression of LOX mRNA	16079270
D000629	Aminopropionitrile	Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein]	25044713
D000629	Aminopropionitrile	Aminopropionitrile results in decreased activity of LOX protein	16023247
D000629	Aminopropionitrile	Aminopropionitrile results in decreased activity of LOX protein	22367676
D000629	Aminopropionitrile	Aminopropionitrile results in decreased activity of LOX protein	19524603
D000629	Aminopropionitrile	Aminopropionitrile results in decreased activity of LOX protein	18635661
D000638	Amiodarone	Amiodarone affects the expression of LOX mRNA	18355885\|1948338
D000639	Amitriptyline	Amitriptyline affects the expression of LOX mRNA	18355885
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LOX mRNA	16483693
D000667	Ampicillin	Ampicillin results in increased expression of LOX mRNA	21632981
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of LOX mRNA	24449571
C015001	arsenite	arsenite results in increased expression of LOX mRNA	23974009
C547126	AZM551248	AZM551248 results in increased expression of LOX mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of LOX mRNA	23656298
D001553	Benzbromarone	Benzbromarone affects the expression of LOX mRNA	19483382
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LOX mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LOX mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of LOX mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LOX mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LOX mRNA	21569818
D004958	Estradiol	Estradiol affects the expression of LOX mRNA	14699072
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of LOX mRNA	20404318
D004958	Estradiol	Estradiol results in decreased expression of LOX mRNA	20106945\|2163298
D004958	Estradiol	Estradiol results in increased expression of LOX mRNA	19484750
C095105	bexarotene	bexarotene results in decreased expression of LOX mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of LOX mRNA	22576693
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of LOX mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of LOX mRNA	25181051
C083806	brucine	brucine results in decreased expression of LOX mRNA	23933019
C083806	brucine	brucine results in decreased expression of LOX mRNA	23933019
C083806	brucine	brucine results in decreased expression of LOX protein	23933019
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of LOX mRNA	23410634
D002104	Cadmium	Cadmium affects the expression of LOX	25741534
D002104	Cadmium	Cadmium affects the methylation of LOX promoter	25741534
D002104	Cadmium	Cadmium results in decreased expression of LOX	19879314
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA	19840844
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]]	23161664
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of LOX	19879314
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of LOX mRNA	25993096
C032761	carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester	"carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester results in decreased activity of LOX protein"	19923012
C032761	carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester	"carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester results in increased expression of LOX mRNA"	19923012
C010059	carbamylhydrazine	carbamylhydrazine results in decreased activity of LOX protein	19524603
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of LOX mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of LOX mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of LOX mRNA	15056808\|2582705
C043211	carvedilol	carvedilol results in decreased expression of LOX mRNA	21216836
D002737	Chloroprene	Chloroprene results in increased expression of LOX mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of LOX mRNA	23125180
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of LOX mRNA	16197558
D002994	Clofibrate	Clofibrate results in increased expression of LOX mRNA	17585979
D002994	Clofibrate	Clofibrate affects the expression of LOX mRNA	19483382
D002997	Clomipramine	Clomipramine affects the expression of LOX mRNA	18355885
C480342	clothianidin	clothianidin results in increased expression of LOX mRNA	29044138
C018021	cobaltous chloride	cobaltous chloride results in increased expression of LOX mRNA	24614111
C018021	cobaltous chloride	cobaltous chloride results in increased expression of LOX protein	24614111
C018021	cobaltous chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]]	23161664
C018021	cobaltous chloride	cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]	23161664
C018021	cobaltous chloride	cobaltous chloride promotes the reaction [[HIF1A protein co-treated with ARNT protein] results in increased expression of LOX mRNA]	23161664
C018021	cobaltous chloride	cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of LOX mRNA]	23161664
C018021	cobaltous chloride	cobaltous chloride results in increased expression of LOX mRNA	23161664
C018021	cobaltous chloride	HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of LOX mRNA]	23161664
D003042	Cocaine	Cocaine results in decreased expression of LOX mRNA	17898221
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of LOX mRNA	15467011
D003300	Copper	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA	22276220
D003300	Copper	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein	22276220
D003300	Copper	Copper binds to LOX protein	25044713
D003300	Copper	Copper results in increased activity of LOX protein	22276220
D003300	Copper	Copper results in increased expression of LOX	25044713
D003300	Copper	LOX protein binds to Copper	11675877
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of LOX mRNA	19549813\|2059984
D019327	Copper Sulfate	Copper Sulfate results in increased expression of LOX mRNA	20599845
D003314	Corn Oil	Corn Oil results in increased activity of and results in increased cleavage of LOX protein	26240151
C029892	cupric chloride	cupric chloride results in increased activity of LOX protein	25044713
C029892	cupric chloride	Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein]	25044713
C029892	cupric chloride	cupric chloride results in increased activity of LOX protein	25044713
C029892	cupric chloride	cupric chloride results in increased activity of LOX protein	22367676
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in decreased expression of LOX mRNA	20106945\|2163298
D003561	Cytarabine	Cytarabine results in decreased expression of LOX mRNA	21198554
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of LOX mRNA	23640034
C014347	decitabine	decitabine affects the expression of LOX mRNA	17194187
C014347	decitabine	decitabine results in increased expression of LOX mRNA	17908484
D003676	Deferoxamine	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA	12393473
C107676	deguelin	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	22745725
D003907	Dexamethasone	Dexamethasone results in increased expression of LOX mRNA	10926554\|2273378
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of LOX mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in decreased expression of LOX mRNA	20705681
D002945	Cisplatin	Cisplatin results in decreased expression of LOX mRNA	22023808
C000944	dicrotophos	dicrotophos results in increased expression of LOX mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of LOX mRNA	18042831\|2501614
D019422	Dietary Sucrose	Dietary Sucrose results in decreased expression of LOX mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of LOX mRNA	28412506
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of LOX mRNA	21527772
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LOX mRNA	18164116
D002117	Calcitriol	Calcitriol results in increased expression of LOX mRNA	16002434
D004221	Disulfiram	LOX results in decreased susceptibility to Disulfiram	20045017
D004237	Diuron	Diuron results in decreased expression of LOX mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in decreased expression of LOX mRNA	22908232
D004317	Doxorubicin	LOX protein affects the susceptibility to Doxorubicin	16217747
D004317	Doxorubicin	Doxorubicin affects the expression of LOX mRNA	15033991
D004317	Doxorubicin	Doxorubicin results in increased expression of LOX mRNA	21040762
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of LOX mRNA	21040762
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of LOX mRNA	20064776
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LOX mRNA	22079256
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of LOX mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of LOX mRNA	16079270
D005001	Ethionine	Ethionine affects the expression of LOX mRNA	19483382
D005485	Flutamide	Flutamide results in increased expression of LOX mRNA	21525395
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of LOX mRNA	20846436\|2114984
C039281	furan	furan results in increased expression of LOX mRNA	27387713
C568713	GSK1210151A	GSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
C568713	GSK1210151A	GSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of LOX mRNA]	26644586
C568713	GSK1210151A	GSK1210151A results in decreased expression of LOX mRNA	26644586\|2729226
C554645	GSK525762A	GSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
C554645	GSK525762A	GSK525762A results in decreased expression of LOX mRNA	27292261
C010176	halofuginone	halofuginone results in increased expression of LOX mRNA	17180598
D006427	Hemin	[Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA	12393473
D017313	Fenretinide	Fenretinide results in increased expression of LOX mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of LOX mRNA	23410634
D007099	Imipramine	Imipramine affects the expression of LOX mRNA	18355885
D007501	Iron	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA	12393473
D007501	Iron	[Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA	12393473
D007545	Isoproterenol	Isoproterenol results in increased expression of LOX mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of LOX mRNA]	26644586
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of LOX mRNA	24796395\|2664458
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of LOX mRNA	26644586
C410337	K 7174	K 7174 results in decreased expression of LOX mRNA	24086573
D007654	Ketoconazole	Ketoconazole affects the expression of LOX mRNA	18355885
D007854	Lead	Lead affects the expression of LOX mRNA	28903495
D019808	Losartan	Losartan results in decreased expression of LOX mRNA	15100363
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of LOX mRNA	20353558
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of LOX mRNA	20713471
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA	19840844
D015735	Mifepristone	Mifepristone results in decreased expression of LOX mRNA	25972201
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of LOX mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LOX mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of LOX mRNA	18978301
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LOX mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of LOX mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of LOX mRNA	24136188
D009532	Nickel	Nickel results in increased expression of LOX mRNA	12540486
C022838	nickel chloride	nickel chloride results in increased expression of LOX mRNA	17312168\|2145529
C029938	nickel sulfate	nickel sulfate results in decreased expression of LOX mRNA	22714537
C029938	nickel sulfate	nickel sulfate results in increased expression of LOX mRNA	17382205
C007350	nitrofen	nitrofen results in decreased expression of LOX mRNA	25111273
C007350	nitrofen	nitrofen results in decreased expression of LOX protein	25111273
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of LOX mRNA	19716841
C558013	NSC 689534	NSC 689534 results in increased expression of LOX mRNA	20971185
D019787	Linoleic Acid	FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]	26240151
D019787	Linoleic Acid	Linoleic Acid results in increased activity of LOX protein	26240151
D019787	Linoleic Acid	TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein]	26240151
D019301	Oleic Acid	Oleic Acid results in increased activity of LOX protein	26240151
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA	19840844
D009853	Omeprazole	Omeprazole affects the expression of LOX mRNA	19483382
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of LOX mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of LOX mRNA	25729387
D010100	Oxygen	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	22745725
D010100	Oxygen	GSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
D010100	Oxygen	GSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
D010100	Oxygen	(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]	27292261
D010100	Oxygen	Oxygen deficiency results in increased activity of LOX protein	25044713
D010100	Oxygen	Oxygen deficiency results in increased expression of LOX mRNA	18924134\|2274572
D010100	Oxygen	Oxygen deficiency results in increased expression of LOX protein	24614111
D010100	Oxygen	Oxygen deficiency results in increased expression of LOX mRNA	24614111
D010100	Oxygen	Oxygen deficiency results in increased expression of LOX protein	24614111
D010126	Ozone	Ozone results in increased expression of LOX mRNA	17095637
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in decreased expression of LOX mRNA	20705681
D000073878	Palm Oil	Palm Oil results in decreased expression of LOX mRNA	18042831
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of LOX mRNA	23948077
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of LOX mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of LOX mRNA	16221955\|1916217
D010578	Petroleum	Petroleum affects the expression of LOX mRNA	25208076
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of LOX mRNA	26272509
C006253	pirinixic acid	pirinixic acid affects the expression of LOX mRNA	19483382
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LOX mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of LOX mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of LOX mRNA	23608068
D011374	Progesterone	Progesterone results in increased expression of LOX mRNA	22238285
D011441	Propylthiouracil	Propylthiouracil affects the expression of LOX mRNA	19483382\|2478091
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of LOX mRNA	27029645
C030984	pyrene	pyrene results in decreased activity of LOX protein	22336231
C030984	pyrene	pyrene results in decreased expression of LOX mRNA	22336231
D011794	Quercetin	Quercetin results in decreased expression of LOX mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of LOX mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of LOX mRNA	16079270
C042431	S-ethyl glutathione	S-ethyl glutathione results in decreased activity of LOX protein	19879314
C042431	S-ethyl glutathione	S-ethyl glutathione results in decreased expression of LOX mRNA	19879314
C009250	sevoflurane	sevoflurane affects the expression of LOX mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of LOX mRNA	25895662
D012834	Silver	Silver results in decreased expression of LOX mRNA	27131904
D019821	Simvastatin	Simvastatin results in decreased expression of LOX mRNA	16414398
C009277	sodium arsenate	sodium arsenate results in increased expression of LOX mRNA	21795629
C016104	sodium bichromate	sodium bichromate results in decreased expression of LOX mRNA	25993096
D053260	Soot	Soot results in increased expression of LOX mRNA	26551751
D013467	Sulindac	Sulindac analog results in decreased expression of LOX mRNA	18924134
D014284	Triiodothyronine	Triiodothyronine results in increased expression of LOX mRNA	22281776
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of LOX mRNA	15885361
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of LOX mRNA	26496021
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of LOX mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA	16443690\|1849575
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LOX mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of LOX mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LOX mRNA	16922920\|2756255
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LOX mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA	16054898\|2121527
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA	19840844
C020809	tetrathiomolybdate	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA	22276220
C020809	tetrathiomolybdate	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein	22276220
D013853	Thioacetamide	Thioacetamide affects the expression of LOX mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in increased expression of LOX mRNA	23411599
D013893	Thiram	LOX results in decreased susceptibility to Thiram	20045017
C009495	titanium dioxide	titanium dioxide results in decreased expression of LOX mRNA	23409001
C009495	titanium dioxide	titanium dioxide results in increased expression of LOX mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of LOX mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of LOX mRNA	20133372
D014050	Toluene	Toluene results in increased expression of LOX mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of LOX mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of LOX mRNA	25729387
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of LOX mRNA]	18635661
D014212	Tretinoin	Tretinoin results in decreased expression of LOX mRNA	23724009
C011559	tributyltin	tributyltin results in decreased expression of LOX mRNA	27614199
C011559	tributyltin	tributyltin results in increased expression of LOX mRNA	21683754
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of LOX mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA	17982090\|1820051
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LOX mRNA"	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LOX mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of LOX mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of LOX mRNA	28973697
D014520	Urethane	Urethane results in decreased expression of LOX mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of LOX mRNA	15885361
D014635	Valproic Acid	Valproic Acid results in decreased expression of LOX mRNA	23179753\|2915479
D014635	Valproic Acid	Valproic Acid results in increased expression of LOX mRNA	19101580\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of LOX mRNA	24896083
D014638	Vanadates	Vanadates results in increased expression of LOX mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of LOX gene	25487561
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of LOX gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of LOX mRNA	23034163
D014800	Vitallium	Vitallium analog results in decreased expression of LOX mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of LOX mRNA	23410634
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of LOX mRNA"	25208076
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of LOX mRNA	17506889

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004720	protein-lysine 6-oxidase activity	-	IBA	21873635
GO:0004720	protein-lysine 6-oxidase activity	-	ISS	-
GO:0005507	copper ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	19570982 19855011 21690299 25118846 26601954

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006464	cellular protein modification process	-	TAS	1685472
GO:0007507	heart development	-	IEA	-
GO:0018057	peptidyl-lysine oxidation	-	IBA	21873635
GO:0030199	collagen fibril organization	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0035904	aorta development	-	IEA	-
GO:0042060	wound healing	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0048251	elastic fiber assembly	-	IEA	-
GO:0048514	blood vessel morphogenesis	-	ISS	-
GO:0048545	response to steroid hormone	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	ISS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005581	collagen trimer	-	IEA	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IEA	-
GO:0005634	nucleus	-	IEA	-
GO:0031012	extracellular matrix	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474290	Collagen formation	TAS
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-2243919	Crosslinking of collagen fibrils	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19118493	Role of TNF-alpha in vascular dysfunction. (2009 Feb)	Zhang H	Clin Sci (Lond)
21904818	LOX-1/LOXIN: the yin/yang of atheroscleorosis. (2011 Oct)	Mango R	Cardiovasc Drugs Ther
15363593	Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. (2004 Oct 15)	Ye YN	Toxicology
23560895	Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues. (2013 May 8)	Huang CS	J Agric Food Chem
16125168	A mechanistic study of colon cancer growth promoted by cigarette smoke extract. (2005 Sep 5)	Ye YN	Eur J Pharmacol
16271949	Smoking may cause genetic alterations at 5q22.2 approximately q23.1 in clear-cell renal cell carcinoma. (2005 Nov)	Korenaga Y	Cancer Genet Cytogenet
27378943	Copper Deficiency in the Lungs of TNF-alpha Transgenic Mice. (2016)	Liu L	Front Physiol
27367711	Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population. (2016 Jun 28)	Wang G	Int J Environ Res Public Health
27684606	Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies. (2016 Nov)	Huang B	Atherosclerosis
8562290	Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension. (1995 Aug-Sep)	Vivoli G	Biol Trace Elem Res
17460548	Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (2007 Mar)	Guo Y	Pharmacogenet Genomics
28575117	Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. (2017)	Miller MA	PLoS One
19729872	Circulating soluble SR-PSOX/CXCL16 as a biomarker for acute coronary syndrome -comparison with high-sensitivity C-reactive protein. (2009 Oct)	Mitsuoka H	J Atheroscler Thromb
14569062	Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. (2004 Jan)	Ye YN	J Pharmacol Exp Ther
28761986	Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation. (2018 Jan)	Komiyama M	Heart Vessels
20023241	Is LOX-1 K167N polymorphism protective for coronary artery disease? (2009 Nov-Dec)	Kurnaz O	In Vivo
26997150	The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. (2016)	Shen J	Curr Med Chem
16541167	[Lox-1--an actor in cardiovascular disease?]. (2006 Mar 9)	Ranheim T	Tidsskr Nor Laegeforen
17909223	Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. (2008 Jan)	Tang D	J Lipid Res
20676957	Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population. (2010 Sep)	Zhang K	Heart Vessels
22209310	Influence of experimental subarachnoid hemorrhage on nicotine-induced contraction of the rat basilar artery in relation to arachidonic acid metabolites signaling pathway. (2013 Oct)	Ji X	J Stroke Cerebrovasc Dis
28202387	Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through alpha7 nAChR in macrophages. (2017 Apr 1)	Kanaoka Y	Toxicology
26892134	Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese. (2016 Jan-Feb)	Okamura T	J Clin Lipidol
18755461	Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus. (2009 Apr)	Shiu SW	Atherosclerosis
21624357	Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men. (2011 Aug 17)	Uchida K	Clin Chim Acta
20605699	Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome--comparison with other biomarkers. (2010 Sep)	Kume N	J Cardiol
20467154	Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome--a pilot study. (2010 Jul)	Kume N	Circ J
24101392	Human endothelial lecitin-like oxLDL receptor-1 (LOX-1) expression is not associated with impairment of endothelium-dependent vasoreactivity in conduit vessels. (2013 Aug)	Wetterau E	J Physiol Pharmacol
24396479	Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer. (2014 Feb)	Pimenta CA	Oncol Lett
28724635	Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. (2017 Sep 8)	Kotla S	J Biol Chem
23665840	Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers. (2013)	Takanabe-Mori R	J Atheroscler Thromb
28403941	Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE). (2017 May)	Pickens CA	Metabolism
25463747	LOX-1 in atherosclerotic disease. (2015 Feb 2)	Sawamura T	Clin Chim Acta
12384795	The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. (2002 Oct)	Schuller HM	J Cancer Res Clin Oncol
18385968	Brain renin angiotensin in disease. (2008 Jun)	Phillips MI	J Mol Med (Berl)
22682033	Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis. (2012 Aug)	Eder A	Arch Oral Biol
20388757	15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. (2010 Apr)	Yuan H	Thorax
18173546	Genetic influence in antithrombotic actions of atorvastatin in hypercholesterolaemia. (2008 Jan)	Puccetti L	Eur J Clin Invest
17920518	Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor: its versatile functions and human diseases. (2007 Nov)	Inoue N	Methods
20093560	LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. (2010 Apr)	Inoue N	Clin Chem
27525284	Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. (2016)	Madrigal-Ruiz PM	J Diabetes Res
26331820	Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer. (2015 Sep 1)	Li MY	Cancer