| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| SLIT3 | 0.694 |
| TASP1 | 0.665 |
| SOWAHB | 0.656 |
| TENM3 | 0.655 |
| AGBL4 | 0.649 |
| ERC2 | 0.649 |
| SLC26A4 | 0.648 |
| ZNF382 | 0.648 |
| PDE1A | 0.648 |
| RNMT | 0.647 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| CCDC102A | -0.452 |
| FOXJ1 | -0.408 |
| SYDE1 | -0.404 |
| HIGD1B | -0.394 |
| RAB13 | -0.388 |
| AKR1C3 | -0.385 |
| MSX1 | -0.379 |
| ROM1 | -0.377 |
| PXDC1 | -0.375 |
| EVC2 | -0.374 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB00513 | Aminocaproic Acid | Small Molecule | 60-32-2 | Approved|Investigational | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of LPA mRNA | 27153756 |
| D001241 | Aspirin | Aspirin results in decreased expression of LPA protein | 12194922|1784592 |
| D001241 | Aspirin | LPA gene SNP affects the susceptibility to Aspirin | 18775538 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] | 10856522 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] | 10856522 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein] | 10856522 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] | 10856522 |
| D002246 | Carbon Disulfide | Carbon Disulfide results in increased expression of LPA protein | 12712689 |
| D003300 | Copper | Copper results in increased oxidation of LPA protein | 11681624 |
| D003300 | Copper | [Copper results in increased oxidation of LPA protein] which results in decreased secretion of PLAT protein | 11681624 |
| D003300 | Copper | [Copper results in increased oxidation of LPA protein] which results in increased secretion of SERPINE1 protein | 11681624 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of LPA mRNA | 19549813 |
| D003613 | Danazol | Danazol results in decreased expression of LPA protein | 8529771 |
| D004397 | Fonofos | Fonofos results in increased methylation of LPA promoter | 22847954 |
| D017665 | Hydroxyl Radical | [Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein | 11681624 |
| D017665 | Hydroxyl Radical | [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein | 11681624 |
| D008148 | Lovastatin | [Lovastatin co-treated with Niacin] results in decreased expression of LPA protein | 17319473 |
| D008148 | Lovastatin | [Niacin co-treated with Lovastatin] results in decreased expression of LPA protein | 12633795 |
| C451780 | lovastatin-niacin combination | lovastatin-niacin combination results in decreased expression of LPA protein | 11897208|1268561 |
| D009525 | Niacin | [Lovastatin co-treated with Niacin] results in decreased expression of LPA protein | 17319473 |
| D009525 | Niacin | [Niacin co-treated with Lovastatin] results in decreased expression of LPA protein | 12633795 |
| D009525 | Niacin | [Niacin co-treated with Simvastatin] results in decreased expression of LPA protein | 18471454 |
| D009525 | Niacin | Niacin results in decreased expression of LPA protein | 12099974|1220075 |
| C464660 | obeticholic acid | obeticholic acid results in decreased expression of LPA mRNA | 27939613 |
| D010278 | Parathion | Parathion results in increased methylation of LPA promoter | 22847954 |
| C004479 | pimagedine | pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] | 10856522 |
| C004479 | pimagedine | pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein] | 10856522 |
| D019821 | Simvastatin | [Niacin co-treated with Simvastatin] results in decreased expression of LPA protein | 18471454 |
| D018038 | Sodium Selenite | Sodium Selenite results in decreased expression of LPA mRNA | 18175754 |
| D013481 | Superoxides | [Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein | 11681624 |
| D013481 | Superoxides | [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein | 11681624 |
| C012568 | terbufos | terbufos results in increased methylation of LPA promoter | 22847954 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001968 | fibronectin binding | - | IPI | 2531657 |
| GO:0004252 | serine-type endopeptidase activity | - | IBA | 21873635 |
| GO:0004252 | serine-type endopeptidase activity | - | IDA | 2531657 |
| GO:0004866 | endopeptidase inhibitor activity | - | TAS | 8047165 |
| GO:0005515 | protein binding | - | IPI | 2531657 9269765 |
| GO:0008201 | heparin binding | - | NAS | 2531657 |
| GO:0034185 | apolipoprotein binding | - | IPI | 9269765 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006508 | proteolysis | - | IEA | - |
| GO:0006629 | lipid metabolic process | - | NAS | 8047165 |
| GO:0006869 | lipid transport | - | IEA | - |
| GO:0008015 | blood circulation | - | TAS | 8047165 |
| GO:0010951 | negative regulation of endopeptidase activity | - | IEA | - |
| GO:0034374 | low-density lipoprotein particle remodeling | - | TAS | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | NAS | 14718574 |
| GO:0005576 | extracellular region | - | TAS | - |
| GO:0034358 | plasma lipoprotein particle | - | IDA | 2531657 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 19124843 | Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. (2009 May) | Ober C | J Lipid Res |
| 9684753 | Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. (1998 Jul) | Mero N | J Lipid Res |
| 17603063 | Fish intake and LPA 93C>T polymorphism: gene-environment interaction in modulating lipoprotein (a) concentrations. (2007 Dec) | Sofi F | Atherosclerosis |
| 27058943 | The clustering of health-related behaviours in a British population sample: Testing for cohort differences. (2016 Jul) | Mawditt C | Prev Med |
| 10962519 | Association of hypertensive status and its drug treatment with lipid and haemostatic factors in middle-aged men: the PRIME study. (2000 Aug) | Marques-Vidal P | J Hum Hypertens |
| 28167353 | Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar) | Shahid SU | Atherosclerosis |
| 12887719 | Low-density lipoprotein apheresis: an overview. (2003 Aug) | Bambauer R | Ther Apher Dial |
| 25314652 | Low "quotient" Lp(a) concentration mediates autoimmune activation and independently predicts cardiometabolic risk. (2015 Jan) | Onat A | Exp Clin Endocrinol Diabetes |
| 11472744 | Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. (2001 Aug) | Marques-Vidal P | Atherosclerosis |
| 8364758 | [Justification and imperatives of the campaign against excess cholesterol and prevention of atherosclerosis]. (1993 Apr) | de Gennes JL | Bull Acad Natl Med |
| 28566218 | Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. (2017 Jul) | Zewinger S | Lancet Diabetes Endocrinol |
| 25419416 | Copy number variation of the Lipoprotein(a) (LPA) gene is associated with coronary artery disease in a southern Han Chinese population. (2014) | Wu Z | Int J Clin Exp Med |
| 23727547 | Serum lipoprotein-A levels in healthy subjects indicate a lurking cerebro- and cardio-vascular risk in the younger population. (2013 Aug) | Oliveira SH | Brain Res Bull |
| 29030599 | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. (2017 Oct 13) | Joshi PK | Nat Commun |
| 26700247 | Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption. (2016 Apr) | Castilla-Ortega E | Neuropharmacology |
| 8123639 | Influence of HDL subfractions on erythrocyte aggregation in hypercholesterolemic men. PCVMETRA Group. (1994 Mar) | Razavian SM | Arterioscler Thromb |
| 29137260 | Pathologic subtype-defined prognosis is dependent on both tumor stage and status of oncogenic driver mutations in lung adenocarcinoma. (2017 Oct 10) | Dong Y | Oncotarget |
| 7562330 | Loss of periodontal attachment in HIV-seropositive military personnel. (1995 Jun) | Tomar SL | J Periodontol |
| 28830786 | Relation between serum levels of chemotaxis-related factors and the presence of coronary artery calcification as expression of subclinical atherosclerosis. (2017 Dec) | Munoz JC | Clin Biochem |
| 10189155 | Sister chromatid exchange analysis in workers exposed to noise and vibration. (1999 Mar) | Silva MJ | Aviat Space Environ Med |