Gene info: ID 4025

Gene: LPO

GENE ID: 4025

Synonyms: SPO

Description: lactoperoxidase

Gene type: protein-coding

Location: 17q22

dbXrefs: Ensembl:ENSG00000167419 MIM:150205 Vega:OTTHUMG00000178921 UniprotKB:P22079

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 24

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.932e-1 (AD) 7.147e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg06451745	chr17:56330960	LPO	Gene body	1.633e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TENM4	0.638
PRRG3	0.635
RYR2	0.633
AUNIP	0.632
PASK	0.625
FSTL4	0.624
CYP26B1	0.622
OCA2	0.622
SLC35F3	0.619
IGFL4	0.618

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COPZ2	-0.467
ASB4	-0.429
MYOM1	-0.408
MBNL3	-0.403
YES1	-0.398
HEY2	-0.396
SMIM10	-0.394
MYL3	-0.386
AAMDC	-0.382
PON3	-0.382

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	15606142
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"	15606142
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline"	15606142
C003898	2-anisidine	LPO protein results in increased oxidation of 2-anisidine	11890934
C475568	3-aminobenzanthrone	LPO protein affects the metabolism of and results in increased activity of 3-aminobenzanthrone	15885895
C032948	3-hydroxybenzoic acid	3-hydroxybenzoic acid results in decreased activity of LPO protein	28594102
C006757	4-biphenylamine	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 4-biphenylamine	15606142
C038193	4-hydroxybenzoic acid	4-hydroxybenzoic acid results in decreased activity of LPO protein	28594102
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]"	19825401
D000082	Acetaminophen	Acetaminophen affects the expression of LPO mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]"	19825401
D000181	Acrylonitrile	Acetylcysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Cysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Glutathione promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Indomethacin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile	19825401
D000181	Acrylonitrile	[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides	19825401
D000181	Acrylonitrile	Penicillamine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Quercetin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	resorcinol inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Sodium Azide inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D000181	Acrylonitrile	Sodium Nitrite promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of LPO mRNA	23630614
D000420	Albuterol	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D000420	Albuterol	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol	19462961
D000420	Albuterol	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D000420	Albuterol	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D000420	Albuterol	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D000420	Albuterol	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D013196	Dihydrotestosterone	bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
D013196	Dihydrotestosterone	Cyproterone Acetate inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of and results in decreased activity of LPO protein	16469299
D013196	Dihydrotestosterone	Flutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
C076950	alpha-resorcylic acid	alpha-resorcylic acid results in decreased activity of LPO protein	28594102
C029876	benzidine	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of benzidine	15606142
C029876	benzidine	LPO protein results in increased metabolism of benzidine	15606142
D004958	Estradiol	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estradiol	16944280
D004958	Estradiol	Estradiol affects the expression of LPO protein	16584521
D004958	Estradiol	[Estradiol co-treated with Medroxyprogesterone] affects the expression of LPO protein	16584521
D004958	Estradiol	Estradiol results in decreased expression of and results in decreased activity of LPO protein	16469299
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased activity of LPO protein]	16469299
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in decreased activity of LPO protein]	16469299
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in increased expression of LPO mRNA	26945725
D004958	Estradiol	Estradiol results in increased expression of LPO mRNA	26945725
C053541	bicalutamide	bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
C006780	bisphenol A	bisphenol A results in decreased expression of LPO mRNA	25181051
C026690	cerous chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of LPO mRNA	28954213
C026690	cerous chloride	cerous chloride results in increased expression of LPO mRNA	28954213
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of LPO protein	28594102
D009243	NAD	Ethinyl Estradiol promotes the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of NAD]	16944280
D003486	Cyanides	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]"	19825401
D003486	Cyanides	Acetylcysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Cysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Glutathione promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Indomethacin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides	19825401
D003486	Cyanides	Penicillamine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Quercetin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	resorcinol inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Sodium Azide inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D003486	Cyanides	Sodium Nitrite promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D017373	Cyproterone Acetate	Cyproterone Acetate inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
D003545	Cysteine	Cysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D002945	Cisplatin	Cisplatin results in decreased expression of LPO mRNA	27594783
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of LPO protein	24144777
D004052	Diethylnitrosamine	lycopene inhibits the reaction [Diethylnitrosamine results in increased expression of LPO protein]	24144777
D004964	Estriol	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estriol	16944280
D004967	Estrogens	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Estrogens	23762435
D004967	Estrogens	[[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Estrogens] which results in increased chemical synthesis of quinone methide metabolite	23762435
D004970	Estrone	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estrone	16944280
D004997	Ethinyl Estradiol	Ethinyl Estradiol promotes the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of NAD]	16944280
D004997	Ethinyl Estradiol	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Ethinyl Estradiol	16944280
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LPO mRNA	17557909
D005280	Fenoterol	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005280	Fenoterol	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol	19462961
D005280	Fenoterol	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005280	Fenoterol	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005280	Fenoterol	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005280	Fenoterol	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005485	Flutamide	Flutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of LPO protein]	16469299
C069837	fullerene C60	fullerene C60 results in decreased expression of LPO mRNA	19167457
D005978	Glutathione	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D005978	Glutathione	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D005978	Glutathione	Glutathione promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]"	19825401
D006861	Hydrogen Peroxide	Acetylcysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Cysteine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Ethinyl Estradiol promotes the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of NAD]	16944280
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D006861	Hydrogen Peroxide	Glutathione promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Indomethacin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estradiol	16944280
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estriol	16944280
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Estrone	16944280
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] affects the oxidation of Ethinyl Estradiol	16944280
D006861	Hydrogen Peroxide	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	15606142
D006861	Hydrogen Peroxide	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"	15606142
D006861	Hydrogen Peroxide	"[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline"	15606142
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of 4-biphenylamine	15606142
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of benzidine	15606142
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites	22434701
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile	19825401
D006861	Hydrogen Peroxide	[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides	19825401
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol	19462961
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol	19462961
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline	19462961
D006861	Hydrogen Peroxide	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D006861	Hydrogen Peroxide	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D006861	Hydrogen Peroxide	Penicillamine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	resorcinol inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Sodium Azide inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D006861	Hydrogen Peroxide	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D006861	Hydrogen Peroxide	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D006861	Hydrogen Peroxide	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D006861	Hydrogen Peroxide	Sodium Nitrite promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D006861	Hydrogen Peroxide	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D006861	Hydrogen Peroxide	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites	22434701
D006861	Hydrogen Peroxide	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Estrogens	23762435
D006861	Hydrogen Peroxide	[[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Estrogens] which results in increased chemical synthesis of quinone methide metabolite	23762435
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of LPO mRNA	21396975
D007213	Indomethacin	Indomethacin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
C028521	lanthanum chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of LPO mRNA	28954213
C028521	lanthanum chloride	lanthanum chloride results in increased expression of LPO mRNA	28954213
C015329	lycopene	lycopene inhibits the reaction [Diethylnitrosamine results in increased expression of LPO protein]	24144777
D008525	Medroxyprogesterone	[Estradiol co-treated with Medroxyprogesterone] affects the expression of LPO protein	16584521
D008713	Methimazole	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D008713	Methimazole	Methimazole inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D008727	Methotrexate	Methotrexate affects the expression of LPO mRNA	18502557
D016685	Mitomycin	LPO protein inhibits the reaction [sodium borohydride results in increased reduction of Mitomycin]	11457837
D019810	Sodium Azide	Sodium Azide inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D019810	Sodium Azide	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D019810	Sodium Azide	Sodium Azide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LPO mRNA"	24911292
C005273	naringenin	naringenin results in increased expression of LPO mRNA	24561720
C005273	naringenin	Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA]	24561720
C028787	N-desmethyltamoxifen	[LPO protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen	7697811
D009573	Nitrites	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites	22434701
D009573	Nitrites	[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites	22434701
D010126	Ozone	Ozone results in increased expression of LPO mRNA	27206323
D010269	Paraquat	Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA]	24561720
D010269	Paraquat	Paraquat results in increased expression of LPO mRNA	24141985
D010269	Paraquat	APOD protein affects the reaction [Paraquat results in decreased expression of LPO mRNA]	21688324
D010269	Paraquat	Paraquat results in decreased expression of LPO mRNA	21688324
D010396	Penicillamine	Penicillamine promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with PPARA] results in increased expression of LPO mRNA	20118188
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in increased expression of LPO mRNA	26945725
C009091	protocatechuic acid	protocatechuic acid results in decreased activity of LPO protein	28594102
D011794	Quercetin	Quercetin inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
C068040	quinone methide	[[LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Estrogens] which results in increased chemical synthesis of quinone methide metabolite	23762435
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased activity of LPO protein]	16469299
C031389	resorcinol	resorcinol inhibits the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
D020156	Salicylic Acid	Salicylic Acid results in decreased activity of LPO protein	28594102
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of LPO mRNA	22431001
C073734	sinapinic acid	sinapinic acid results in decreased activity of LPO protein	28594102
C025364	sodium borohydride	LPO protein inhibits the reaction [sodium borohydride results in increased reduction of Mitomycin]	11457837
D012966	Sodium Cyanide	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
D012966	Sodium Cyanide	Sodium Cyanide inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of LPO protein	9504181
D012977	Sodium Nitrite	Sodium Nitrite promotes the reaction [[[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Acrylonitrile] which results in increased chemical synthesis of Cyanides]	19825401
C024553	sodium thiocyanate	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	19462961
C024553	sodium thiocyanate	sodium thiocyanate inhibits the reaction [[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	19462961
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in decreased activity of LPO protein]	16469299
D013629	Tamoxifen	LPO protein results in increased metabolism of Tamoxifen	7697811
D013629	Tamoxifen	[LPO protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen	7697811
D013726	Terbutaline	[LPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline	19462961
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of LPO mRNA	25680692
D014635	Valproic Acid	Valproic Acid results in decreased methylation of LPO gene	29154799
D014641	Vanillic Acid	Vanillic Acid results in decreased activity of LPO protein	28594102

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004601	peroxidase activity	-	IBA	21873635
GO:0020037	heme binding	-	IEA	-
GO:0036393	thiocyanate peroxidase activity	-	IBA	21873635
GO:0036393	thiocyanate peroxidase activity	-	IDA	12626341
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	-	IDA	24248522
GO:0006979	response to oxidative stress	-	NAS	8964511
GO:0018969	thiocyanate metabolic process	-	IEA	-
GO:0042742	defense response to bacterium	-	IBA	21873635
GO:0042742	defense response to bacterium	-	IDA	12626341
GO:0042744	hydrogen peroxide catabolic process	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0098869	cellular oxidant detoxification	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	24248522
GO:0005737	cytoplasm	-	IBA	21873635
GO:0016323	basolateral plasma membrane	-	IDA	19059195
GO:0070062	extracellular exosome	-	HDA	19199708

KEGG ID	KEGG Term
hsa04970	Salivary secretion

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
11326967	[Effects of smoking on the lipid peroxides antioxidation and alpha 1-antitrypsin]. (1998 Apr)	Zhao YX	Zhonghua Jie He He Hu Xi Za Zhi
25634761	Short-term nose-only water-pipe (shisha) smoking exposure accelerates coagulation and causes cardiac inflammation and oxidative stress in mice. (2015)	Nemmar A	Cell Physiol Biochem
29284244	Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women. (2017 Dec 23)	Sagan D	Ann Agric Environ Med
24394791	Free radical and antioxidant status in urban and rural Tirupati men: interaction with nutrient intake, substance abuse, obesity and body fat distribution. (1997 Dec)	Reddy KK	Asia Pac J Clin Nutr
26812290	Higher lipid peroxidation in former-smokers vs. never-smokers - study in postmenopausal women. (2015 Dec)	Sagan D	Neuro Endocrinol Lett
27814717	Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. (2016 Nov 5)	Busch R	Respir Res
10853840	Effects of cigarette smoking and smoking cessation on plasma constituents and enzyme activities related to oxidative stress. (2000 Mar)	Zhou JF	Biomed Environ Sci
27087348	Increased levels of urinary biomarkers of lipid peroxidation products among workers occupationally exposed to diesel engine exhaust. (2016 Aug)	Bin P	Free Radic Res
8910919	Peroxidized low-density lipoprotein with four kinds of hydroperoxidized cholesteryl linoleate estimated in plasma of young heavy smokers. (1996)	Kanazawa T	Pathobiology
10684785	Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients. (2000 Jan)	Dupont I	Alcohol Alcohol
17634167	Effect of walnut-enriched restructured meat in the antioxidant status of overweight/obese senior subjects with at least one extra CHD-risk factor. (2007 Jun)	Canales A	J Am Coll Nutr
16306304	Oxidative stress and antioxidant capacity in smoking and nonsmoking men with HIV/acquired immunodeficiency syndrome. (2005 Dec)	Cole SB	Nutr Clin Pract
24648681	Cigarette smoke-induced interleukin-1 alpha may be involved in the pathogenesis of adult acne. (2014 Feb)	Yang YS	Ann Dermatol
22788373	Assessment of essential and nonessential metals and different metal exposure biomarkers in the human placenta in a population from the south of Portugal. (2012)	Serafim A	J Toxicol Environ Health A
26271244	Effect of inhaled corticosteroids on salival composition: a cross-sectional study in patients with bronchial asthma. (2015 Sep)	Navarrete BA	Clin Drug Investig
25780090	Early pulmonary events of nose-only water pipe (shisha) smoking exposure in mice. (2015 Mar)	Nemmar A	Physiol Rep
23090273	Relationship between lipid peroxidation or carcinoembryonic antigen and risk factors for non-communicable diseases in women at midlife and beyond. (2012)	Karbownik-Lewinska M	Neuro Endocrinol Lett
12875713	Beta-carotene protects rats against bronchitis induced by cigarette smoking. (2003 Apr)	Pang B	Chin Med J (Engl)
24329512	A high oxidative stress index predicts endothelial dysfunction in young male smokers. (2013)	Karahan O	Bratisl Lek Listy
20103846	Smoking intensity, oxidative stress and chemotherapy in nonsmall cell lung cancer: a correlated prognostic study. (2009 Oct)	Gupta A	Biosci Trends
8058388	[Effect of induction of the synthesis of serotonin antibodies on lipid peroxidation in experimental alcoholism]. (1993 Mar-Apr)	Kolesova OK	Patol Fiziol Eksp Ter
24726768	Analysis of smoking and LPO in ALS. (2014 May)	Anand A	Neurochem Int
28119953	Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. (2016 Sep)	Chen WY	Cell Mol Gastroenterol Hepatol
17079784	Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure. (2007 Apr)	Machiya J	Am J Respir Cell Mol Biol