Gene: LPP

4026
-
LIM domain containing preferred translocation partner in lipoma
protein-coding
3q27.3-q28
Ensembl:ENSG00000145012 MIM:600700 Vega:OTTHUMG00000156387 UniprotKB:Q93052
NG_016932.2
PubMed|SNP Mapped
2   ANCO-SNPs
CD|OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.519e-1 (AD)  2.640e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs938413chr3:188646825 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6807897chr3:188515616 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00119073chr3:187870713LPPPromoter2.227e-4Alcohol use disorders26763658
cg17585528chr3:187988060LPP2.180e-11Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPS80.862
ATP10D0.86
YAP10.86
PRKD30.845
ANO60.844
MSN0.838
MAML20.837
LTBP10.835
BNIP20.83
ARHGAP310.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.571
HAS1-0.568
SLC7A4-0.546
DLK2-0.54
CALHM1-0.536
C2CD4D-0.53
SPEF1-0.523
PIP5KL1-0.522
BCL11A-0.515
MYADML2-0.515

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in decreased expression of LPP mRNA20471460
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of LPP mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LPP mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of LPP mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LPP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LPP mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LPP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LPP mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LPP protein26597043
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LPP mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LPP mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LPP mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of LPP gene25435355
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of LPP protein modified form24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LPP mRNA19770486|2171566
D004958EstradiolEstradiol results in decreased expression of LPP mRNA19167446
C006780bisphenol Abisphenol A results in decreased expression of LPP mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of LPP mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LPP mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of LPP mRNA26079696
C584509C646 compoundC646 compound results in increased expression of LPP mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of LPP mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LPP mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LPP gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of LPP mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of LPP mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of LPP mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of LPP mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of LPP mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LPP mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LPP mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LPP mRNA19561079|2739243
C000944dicrotophosdicrotophos results in increased expression of LPP mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of LPP mRNA12875902
D004317DoxorubicinDoxorubicin affects the expression of LPP protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LPP protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LPP mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPP mRNA17942748
C540355fenamidonefenamidone results in increased expression of LPP mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LPP gene20938992
C001277geldanamycingeldanamycin results in increased expression of LPP mRNA26705709
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of LPP protein]20884965
D019833GenisteinGenistein results in decreased expression of LPP protein20884965
D017313FenretinideFenretinide results in increased expression of LPP mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of LPP mRNA17183730
C029424hydrazinehydrazine results in increased expression of LPP mRNA15282401
C492448ICG 001ICG 001 results in increased expression of LPP mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LPP mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LPP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LPP mRNA24796395
C045463leflunomideleflunomide results in increased expression of LPP mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LPP gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LPP mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LPP mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LPP mRNA"26251327
D009151Mustard GasMustard Gas affects the expression of LPP mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LPP mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of LPP mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of LPP mRNA19095052
D010634PhenobarbitalPhenobarbital results in decreased expression of LPP mRNA19363144|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LPP mRNA26272509
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of LPP mRNA21334430
D011441PropylthiouracilPropylthiouracil results in decreased expression of LPP mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of LPP mRNA23274088
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LPP mRNA27029645
C059514resveratrolresveratrol results in decreased expression of LPP mRNA25888808
C009277sodium arsenatesodium arsenate results in increased expression of LPP mRNA21795629
C016104sodium bichromatesodium bichromate results in decreased expression of LPP mRNA17685462
D012969Sodium FluorideSodium Fluoride results in increased expression of LPP protein28918527
D018038Sodium SeleniteSodium Selenite results in decreased expression of LPP mRNA23274088
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of LPP protein modified form24464499
D013629TamoxifenTamoxifen affects the expression of LPP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LPP mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LPP mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPP mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of LPP gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LPP mRNA28111298
D014212TretinoinTretinoin results in decreased expression of LPP mRNA12875902
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LPP mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of LPP mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of LPP mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of LPP mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LPP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LPP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LPP mRNA28001369
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LPP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15649318  22665060  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24837582Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. (2014 Jul 1)Moeller SJDrug Alcohol Depend
28275830Benefits of varenicline vs. bupropion for smoking cessation: a Bayesian analysis of the interaction of reward sensitivity and treatment. (2017 Jun)Cinciripini PMPsychopharmacology (Berl)
29065198Disgust but not Health Anxiety Graphic Warning Labels Reduce Motivated Attention in Smokers: A Study of P300 and Late Positive Potential Responses. (2017 Jul 7)Cochran JRNicotine Tob Res
27277662Event-related potentials reflecting smoking cue reactivity and cognitive control as predictors of smoking relapse and resumption. (2016 Aug)Luijten MPsychopharmacology (Berl)
24065931The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers. (2013)Robinson JDFront Psychiatry
23723052The effect of chronic thienorphine administration on long-term potentiation and synaptic structure in rat hippocampus. (2013 Nov)Yong ZSynapse