Gene: LRMP

4033
JAW1
lymphoid restricted membrane protein
protein-coding
12p12.1
Ensembl:ENSG00000118308 MIM:602003 Vega:OTTHUMG00000170192 UniprotKB:Q12912
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.348e-1 (AD)  1.311e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1979522chr12:25090959 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSHZ20.847
TRABD2A0.799
CAMK2D0.797
GLIPR10.794
RXFP10.783
LRRK10.78
STX30.773
SEPT60.767
ERC20.767
RASSF50.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.476
HOGA1-0.47
ACOX2-0.469
LRAT-0.457
ZFHX4-AS1-0.451
S100A1-0.446
LHFPL1-0.445
EYA1-0.445
MYOM1-0.437
RGS20-0.436

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LRMP mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of LRMP mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of LRMP mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LRMP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRMP mRNA22100608|2715375
C430898AGN 194204AGN 194204 results in increased expression of LRMP mRNA16339527
C015001arsenitearsenite results in increased methylation of LRMP promoter23974009
C547126AZM551248AZM551248 results in decreased expression of LRMP mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of LRMP mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRMP mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRMP mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LRMP mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRMP mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRMP mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRMP mRNA22228805|2719552
C006780bisphenol Abisphenol A affects the expression of LRMP mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of LRMP mRNA25181051
D002330CarmustineCarmustine results in decreased expression of LRMP mRNA15980968
D002737ChloropreneChloroprene results in decreased expression of LRMP mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRMP mRNA27858113
D003474CurcuminCurcumin results in decreased expression of LRMP mRNA17198877
D003520CyclophosphamideCyclophosphamide results in decreased expression of LRMP mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of LRMP mRNA21041162
D002945CisplatinCisplatin results in increased expression of LRMP mRNA27594783
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LRMP mRNA21041162
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LRMP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRMP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRMP mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LRMP mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of LRMP mRNA23649840
D017313FenretinideFenretinide results in decreased expression of LRMP mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LRMP mRNA25613284
C008261lead acetatelead acetate results in decreased expression of LRMP mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LRMP mRNA"24972896
C005219methyl cellosolvemethyl cellosolve results in increased expression of LRMP mRNA21061450
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LRMP mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LRMP mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of LRMP promoter"26251327
D009151Mustard GasMustard Gas results in increased expression of LRMP mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LRMP mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LRMP mRNA19812364
D009532NickelNickel results in increased expression of LRMP mRNA25583101
C507134ON 01910ON 01910 affects the expression of LRMP mRNA22351695
D010416PentachlorophenolPentachlorophenol results in increased expression of LRMP mRNA24642059
D010795Phthalic AcidsPhthalic Acids results in increased expression of LRMP mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of LRMP mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of LRMP mRNA23557933
D011794QuercetinQuercetin results in decreased expression of LRMP protein19207037
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LRMP mRNA25351596
D013629TamoxifenTamoxifen affects the expression of LRMP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRMP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRMP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LRMP mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of LRMP mRNA23411599
D014635Valproic AcidValproic Acid affects the expression of LRMP mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRMP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006903vesicle targeting-TAS8021504  
GO:0006906vesicle fusion-TAS8021504  
GO:0007338single fertilization-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005635nuclear envelope-IEA-  
GO:0005694chromosome-IEA-  
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005815microtubule organizing center-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8021504  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-TAS8798562  
GO:0035577azurophil granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16410263A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. (2006 Jul)Manenti GCarcinogenesis