Gene: LRP1

4035
A2MR|APOER|APR|CD91|IGFBP-3R|IGFBP3R|IGFBP3R1|KPA|LRP|LRP1A|TGFBR5
LDL receptor related protein 1
protein-coding
12q13.3
Ensembl:ENSG00000123384 MIM:107770 Vega:OTTHUMG00000044412 UniprotKB:Q07954
NG_016444.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.559e-1 (AD)  5.097e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24415154chr12:57592326LRP1Gene body1.036e-4Alcohol use disorders26763658
cg06715885chr12:57595392LRP1Gene body6.429e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEC0.883
ARID1A0.881
MINK10.874
DCLK20.868
LTBP30.865
ANO80.86
FARP10.86
OGDH0.859
WDR60.856
MLEC0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.692
OR4F29-0.624
OR6C74-0.363
CLEC6A-0.321
CTNNA3-0.302
KRTAP1-1-0.293
TSPAN8-0.274
ANXA13-0.271
CHP2-0.271
CETP-0.271

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00025Antihemophilic factor, human recombinantBiotechDrug139076-62-3Approved|InvestigationalTarget
DB00031TenecteplaseBiotechDrug191588-94-0ApprovedTarget
DB00100Coagulation Factor IX (Recombinant)BiotechDrug181054-95-5Approved|InvestigationalTarget
DB06245LanoteplaseBiotechDrug171870-23-8InvestigationalTarget
DB13152Coagulation Factor IX HumanBiotechDrug9001-28-9ApprovedTarget
DB13998Lonoctocog alfaBiotechDrug1388129-63-2Approved|InvestigationalTarget
DB13999Moroctocog alfaBiotechDrug284036-24-4ApprovedTarget
ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]"21908651
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LRP1 mRNA"28903501
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol binds to LRP1 protein"22384159
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LRP1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LRP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LRP1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LRP1 mRNA"15215175
C0293704-toluidine4-toluidine results in decreased expression of LRP1 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of LRP1 mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRP1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of LRP1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LRP1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LRP1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LRP1 mRNA24449571
D001151ArsenicArsenic affects the methylation of LRP1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of LRP1 mRNA22521957
D001280AtrazineLRP1 gene SNP affects the susceptibility to Atrazine22919386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRP1 mRNA22228805
D004958EstradiolEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LRP1 mRNA]16977382
D004958EstradiolEstradiol results in increased expression of LRP1 mRNA19484750
D001663BilirubinBilirubin results in decreased expression of LRP1 mRNA20196124
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of LRP1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of LRP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of LRP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of LRP1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of LRP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRP1 mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of LRP1 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of LRP1 mRNA23410634
C006862butylphenbutylphen results in increased expression of LRP1 protein15816839
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of LRP1 promoter22457795
D002211Capsaicin"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]"21908651
D002211CapsaicinAPOE affects the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D002211CapsaicinCapsaicin results in decreased expression of LRP1 protein21908651
D002211Capsaicin[Capsaicin results in decreased expression of LRP1 protein] which results in decreased uptake of Cholesterol21908651
D002211Capsaicin[Capsaicin results in decreased expression of LRP1 protein] which results in increased secretion of Cholesterol21908651
D002211CapsaicinCyclosporine inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D002211CapsaicinKT 5720 inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D002211CapsaicinLRP1 results in decreased susceptibility to Capsaicin21908651
D002211CapsaicinTRPV1 gene mutant form inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D002784Cholesterol[Capsaicin results in decreased expression of LRP1 protein] which results in decreased uptake of Cholesterol21908651
D002784Cholesterol[Capsaicin results in decreased expression of LRP1 protein] which results in increased secretion of Cholesterol21908651
D002922CiguatoxinsCiguatoxins affects the expression of LRP1 mRNA18353800
D002927CimetidineCimetidine results in decreased expression of LRP1 protein11556524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA]17585979
D002995Clofibric AcidClofibric Acid affects the expression of LRP1 mRNA17602206
D003300CopperCopper affects the reaction [LRP1 protein results in increased uptake of PRNP protein]17155929
D003300CopperCopper results in decreased expression of LRP1 protein27122238
D019327Copper SulfateCopper Sulfate results in decreased expression of LRP1 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR affects the expression of LRP1 protein26984711
D016572CyclosporineCyclosporine results in decreased expression of LRP1 mRNA20106945|2556210
D016572CyclosporineCyclosporine inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D000069439DasatinibDasatinib results in increased expression of LRP1 mRNA20579391
D013759DronabinolDronabinol results in decreased expression of LRP1 mRNA12237329
D013759DronabinolDronabinol results in decreased expression of LRP1 mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of LRP1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LRP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LRP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of LRP1 mRNA21165580|2739243
D002945Cisplatintanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]21165580
C000944dicrotophosdicrotophos results in increased expression of LRP1 mRNA28302478
D004041Dietary Fats[APOE affects the susceptibility to Dietary Fats] which affects the expression of LRP1 protein21908651
D004041Dietary FatsDietary Fats results in increased expression of LRP1 mRNA20435547
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LRP1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of LRP1 mRNA]17942915
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LRP1 mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of LRP1 mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LRP1 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LRP1 mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRP1 mRNA29097150
C082360fipronilfipronil results in decreased expression of LRP1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of LRP1 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of LRP1 mRNA19167457
C039281furanfuran results in decreased expression of LRP1 mRNA25539665
D005978GlutathioneGlutathione deficiency results in decreased expression of LRP1 mRNA20621112
D017313FenretinideFenretinide results in increased expression of LRP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LRP1 mRNA20044591|2341063
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of LRP1 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRP1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LRP1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of LRP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LRP1 mRNA23086925
C057416KT 5720KT 5720 inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]21908651
D008070LipopolysaccharidesEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LRP1 mRNA]16977382
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LRP1 mRNA16977382
D008154LucanthoneLucanthone results in increased expression of LRP1 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRP1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of LRP1 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of LRP1 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride affects the expression of LRP1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRP1 protein25809596
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of LRP125056787
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LRP1 mRNA"20188158
D009020MorphineMorphine results in decreased expression of LRP1 mRNA21178816
C500085muraglitazarmuraglitazar results in increased expression of LRP1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LRP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LRP1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of LRP1 mRNA24136188
C028007nickel monoxidenickel monoxide affects the expression of LRP1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of LRP1 mRNA26516004
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LRP1 mRNA21503142
D010575PesticidesPesticides results in decreased expression of LRP1 mRNA27406225
D010578PetroleumLRP1 gene SNP affects the susceptibility to Petroleum22919386
D010634PhenobarbitalPhenobarbital affects the expression of LRP1 mRNA23091169
C117045p-hydroxycinnamaldehydep-hydroxycinnamaldehyde binds to LRP1 protein20933287
C014153pirimiphos methylpirimiphos methyl results in increased expression of LRP1 mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of LRP1 mRNA16221962
D028321Plant PreparationsLRP1 protein binds to and results in increased uptake of Plant Preparations27262837
D028321Plant PreparationsLRP1 protein promotes the reaction [Plant Preparations results in increased cleavage of CASP9 protein]27262837
D028321Plant PreparationsLRP1 protein promotes the reaction [Plant Preparations results in increased phosphorylation of BAD protein]27262837
D028321Plant PreparationsLRP1 protein promotes the reaction [Plant Preparations results in increased phosphorylation of TP53 protein]27262837
D028321Plant PreparationsPlant Preparations binds to LRP1 protein27262837
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LRP1 mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of LRP1 mRNA21278054
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of LRP1 mRNA25626140
C502851quinocetonequinocetone results in increased expression of LRP1 mRNA27046791
C075655Recombivax HBRecombivax HB results in increased expression of LRP1 protein alternative form11527151
C059514resveratrolresveratrol results in increased expression of LRP1 mRNA25888808
C089730rosiglitazonerosiglitazone promotes the reaction [LRP1 protein results in increased uptake of APP protein]22040807
C089730rosiglitazonerosiglitazone results in increased activity of LRP1 promoter22040807
C089730rosiglitazonerosiglitazone results in increased expression of LRP1 mRNA22040807
C089730rosiglitazonerosiglitazone results in increased expression of LRP1 protein22040807
C089730rosiglitazonerosiglitazone results in increased expression of LRP1 mRNA21515302
C093642SB 203580SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]21165580
C093642SB 203580SB 203580 results in increased expression of LRP1 mRNA21165580
D019821SimvastatinSimvastatin results in increased expression of LRP119944163
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRP1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of LRP1 mRNA26378955
C021751tanshinoneSB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]21165580
C021751tanshinonetanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]21165580
C021751tanshinonetanshinone results in decreased expression of LRP1 mRNA21165580
C501413tesaglitazartesaglitazar results in increased expression of LRP1 mRNA21515302
C043062tesmilifenetesmilifene results in decreased expression of LRP1 protein11556524
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRP1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRP1 mRNA27562557|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRP1 mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA15910848
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of LRP1 protein15910848
D013755Tetradecanoylphorbol Acetatevery low density lipoprotein triglyceride promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA]15910848
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRP1 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of LRP1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LRP1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LRP1 mRNA28111298
D014241TrichloroethyleneTrichloroethylene results in increased expression of LRP1 mRNA19254012
C012589trichostatin Atrichostatin A results in increased expression of LRP1 mRNA28542535
D014311TriprolidineTriprolidine results in decreased expression of LRP1 protein11556524
D014635Valproic AcidValproic Acid results in increased methylation of LRP1 gene29154799
D014638VanadatesVanadates results in increased expression of LRP1 mRNA22714537
C030106very low density lipoprotein triglyceridevery low density lipoprotein triglyceride promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA]15910848
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of LRP1 mRNA21503142
C025643vinclozolinvinclozolin results in decreased expression of LRP1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of LRP1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of LRP1 mRNA23410634
D015034Zinc OxideZinc Oxide analog results in decreased expression of LRP1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of LRP1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO:0003723RNA binding-HDA22658674  
GO:0005041low-density lipoprotein particle receptor activity-TAS20005821  
GO:0005044scavenger receptor activity-TAS11240025  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI8626514  17326667  17360663  20472562  21054788  21968187  
26005850  
GO:0016964alpha-2 macroglobulin receptor activity-IMP26142438  
GO:0016964alpha-2 macroglobulin receptor activity-TAS21289173  
GO:0030226apolipoprotein receptor activity-TAS21289173  
GO:0032050clathrin heavy chain binding-IPI26005850  
GO:0034185apolipoprotein binding-IDA2779654  
GO:0034185apolipoprotein binding-IPI18635818  
GO:0038023signaling receptor activity-TAS10880251  
GO:0042954lipoprotein transporter activity-NAS3266596  
GO:0043395heparan sulfate proteoglycan binding-TAS21289173  
GO:0044877protein-containing complex binding-IDA8626514  
GO:0070325lipoprotein particle receptor binding-IC18635818  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0002265astrocyte activation involved in immune response-ISS-  
GO:0006629lipid metabolic process-TAS21289173  
GO:0006898receptor-mediated endocytosis-IMP23152628  24305823  26005850  
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0006909phagocytosis-NAS20199584  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007568aging-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0010715regulation of extracellular matrix disassembly-TAS14645246  
GO:0010875positive regulation of cholesterol efflux-ISS-  
GO:0010942positive regulation of cell death-IGI23386614  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0014912negative regulation of smooth muscle cell migration-ISS-  
GO:0021987cerebral cortex development-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-ISS-  
GO:0031623receptor internalization-TAS22293988  
GO:0032092positive regulation of protein binding-IGI23386614  
GO:0032370positive regulation of lipid transport-ISS-  
GO:0032374regulation of cholesterol transport-ISS-  
GO:0032429regulation of phospholipase A2 activity-ISS-  
GO:0032956regulation of actin cytoskeleton organization-ISS-  
GO:0035909aorta morphogenesis-ISS-  
GO:0042157lipoprotein metabolic process-IEA-  
GO:0042953lipoprotein transport-NAS3266596  
GO:0043277apoptotic cell clearance-ISS-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045056transcytosis-IMP26005850  
GO:0045056transcytosis-TAS22293988  
GO:0045732positive regulation of protein catabolic process-ISS-  
GO:0045807positive regulation of endocytosis-IGI23386614  
GO:0051222positive regulation of protein transport-IEA-  
GO:0051246regulation of protein metabolic process-ISS-  
GO:0097242amyloid-beta clearance-IMP24305823  
GO:0097242amyloid-beta clearance-NAS20199584  
GO:0097242amyloid-beta clearance-TAS19098903  
GO:1900223positive regulation of amyloid-beta clearance-TAS22383525  
GO:1903078positive regulation of protein localization to plasma membrane-IGI23386614  
GO:1904646cellular response to amyloid-beta-ISS-  
GO:1905167positive regulation of lysosomal protein catabolic process-IMP23152628  
GO:2000587negative regulation of platelet-derived growth factor receptor-beta signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005769early endosome-IDA26005850  
GO:0005886plasma membrane-TAS14645246  
GO:0005887integral component of plasma membrane-ISS-  
GO:0005905clathrin-coated pit-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-NAS23386614  
GO:0016323basolateral plasma membrane-IDA26005850  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0030425dendrite-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IDA23382219  
GO:0098797plasma membrane protein complex-TAS21289173  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2168880Scavenging of heme from plasmaTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28209224Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)Webb TRJ Am Coll Cardiol
26092999Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. (2015 Aug 15)Lockett ADAm J Physiol Lung Cell Mol Physiol
23993232Pathophysiology of AAA: heredity vs environment. (2013 Jul-Aug)Bjorck MProg Cardiovasc Dis
29021777Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk. (2017)Zhang LFront Neurol