Gene info: ID 4040

Gene: LRP6

GENE ID: 4040

Synonyms: ADCAD2|STHAG7

Description: LDL receptor related protein 6

Gene type: protein-coding

Location: 12p13.2

dbXrefs: Ensembl:ENSG00000070018 MIM:603507 UniprotKB:O75581

RefSeq: NG_016168.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.172e-1 (AD) 1.647e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs12307111	chr12:12205590 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NIPBL	0.834
SENP7	0.833
SMC3	0.833
ICK	0.829
ARID2	0.829
ARAP2	0.829
PHF3	0.827
DICER1	0.826
BTBD7	0.825
PHIP	0.825

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.505
OR4F29	-0.496
NPW	-0.241
PRSS56	-0.209
PPIAL4D	-0.208
NANOGNB	-0.202
EPPIN	-0.202
NANOS3	-0.195
GAL	-0.189
SHISA8	-0.187

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C493177	4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [WNT3A protein results in increased phosphorylation of LRP6 protein]"	21602191
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
C029728	4-phenylenediamine	4-phenylenediamine results in decreased phosphorylation of LRP6 protein	26784575
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of LRP6 gene	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of LRP6 mRNA	28522335
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of LRP6 mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of LRP6 mRNA	17103032
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LRP6 mRNA	20106945\|2163298
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRP6 mRNA"	19150397
C006780	bisphenol A	bisphenol A results in increased expression of LRP6 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of LRP6 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of LRP6 mRNA	25381574\|2596372
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]	25963729
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of LRP6 mRNA	12414654
C018475	butyraldehyde	butyraldehyde results in decreased expression of LRP6 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LRP6 mRNA	20478370
D002737	Chloroprene	Chloroprene results in increased expression of LRP6 mRNA	23125180
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LRP6 mRNA	17602206
C029892	cupric chloride	cupric chloride results in decreased expression of LRP6 mRNA	24650576
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]	25963729
D003474	Curcumin	Curcumin results in increased expression of LRP6 mRNA	25963729
D016572	Cyclosporine	Cyclosporine results in decreased expression of LRP6 mRNA	20106945\|2556210
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of LRP6 mRNA	21266533
D004041	Dietary Fats	Dietary Fats results in decreased expression of LRP6 mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LRP6 mRNA	17602206
D004237	Diuron	Diuron results in decreased expression of LRP6 mRNA	25152437
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LRP6 mRNA	29097150
D005013	Ethosuximide	Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]	26420483
D005013	Ethosuximide	Ethosuximide results in increased expression of LRP6 mRNA	26420483
D005485	Flutamide	Flutamide results in decreased expression of LRP6 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of LRP6 mRNA	20655997
C007845	gingerol	gingerol results in increased expression of LRP6 mRNA	26498061
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of LRP6 mRNA	12414654
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRP6 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of LRP6 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of LRP6 mRNA	24796395\|2683047
C011890	kojic acid	kojic acid results in decreased expression of LRP6 mRNA	16595896
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of LRP6 mRNA"	24972896
D018021	Lithium Chloride	Lithium Chloride results in increased expression of LRP6 mRNA	20069066
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of LRP6 mRNA	27188386
D008727	Methotrexate	Methotrexate affects the expression of LRP6 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of LRP6 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LRP6 mRNA"	26251327
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of LRP6 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of LRP6 mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of LRP6 mRNA	24136188
D009534	Niclosamide	Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein	24552774\|2473602
D010634	Phenobarbital	Phenobarbital affects the expression of LRP6 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of LRP6 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRP6 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of LRP6 mRNA	18301758
D019821	Simvastatin	Simvastatin results in decreased expression of LRP6 mRNA	25055962
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LRP6 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LRP6 mRNA	12377990
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LRP6 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRP6 mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of LRP6 mRNA	27188386
D014212	Tretinoin	Tretinoin results in increased expression of LRP6 mRNA	17064353
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of LRP6 gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP6 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of LRP6 mRNA	22723015\|2627250
C057693	troglitazone	troglitazone results in decreased expression of LRP6 mRNA	28973697
C080163	trovafloxacin	trovafloxacin results in increased expression of LRP6 mRNA	24136188
D014520	Urethane	Urethane results in increased expression of LRP6 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of LRP6 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of LRP6 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased methylation of LRP6 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of LRP6 mRNA	19136453
C025643	vinclozolin	vinclozolin affects the expression of LRP6 mRNA	19015723
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of LRP6 mRNA	12414654
C111237	vorinostat	vorinostat results in decreased expression of LRP6 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005041	low-density lipoprotein particle receptor activity	-	IBA	21873635
GO:0005041	low-density lipoprotein particle receptor activity	-	IDA	16263759
GO:0005102	signaling receptor binding	-	IPI	14739301
GO:0005109	frizzled binding	-	IPI	11029007
GO:0005515	protein binding	-	IPI	11029007 11357136 11433302 11448771 12897152 15908424 16365045 16564009 16815997 16890161 16989816 17804805 18528331 18721193 18762581 19107203 20059949 20093360 20093472 21245321 21304492 21471202 21944579 21984209 22491013 22575959 22726442 22899650 23791946 23892894 23987510 27013965
GO:0015026	coreceptor activity	-	IBA	21873635
GO:0017147	Wnt-protein binding	-	IPI	11029007 12897152 20093360
GO:0017147	Wnt-protein binding	-	TAS	22988876
GO:0019210	kinase inhibitor activity	-	IMP	16365045
GO:0019534	toxin transmembrane transporter activity	-	IMP	16564009
GO:0019534	toxin transmembrane transporter activity	NOT	IMP	18350154
GO:0034185	apolipoprotein binding	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	12897152 21984209
GO:0042803	protein homodimerization activity	-	IPI	12897152
GO:0071936	coreceptor activity involved in Wnt signaling pathway	-	IDA	11029007
GO:1904928	coreceptor activity involved in canonical Wnt signaling pathway	-	NAS	24431302

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001702	gastrulation with mouth forming second	-	IBA	21873635
GO:0001843	neural tube closure	-	IBA	21873635
GO:0001933	negative regulation of protein phosphorylation	-	IMP	16365045
GO:0003344	pericardium morphogenesis	-	IBA	21873635
GO:0006469	negative regulation of protein kinase activity	-	IMP	16365045
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0009880	embryonic pattern specification	-	IBA	21873635
GO:0009952	anterior/posterior pattern specification	-	IBA	21873635
GO:0014029	neural crest formation	-	IBA	21873635
GO:0014029	neural crest formation	-	IDA	11029007
GO:0014033	neural crest cell differentiation	-	IBA	21873635
GO:0014033	neural crest cell differentiation	-	IDA	11029007
GO:0016055	Wnt signaling pathway	-	IDA	11357136 16263759
GO:0016055	Wnt signaling pathway	-	IMP	11029007 20093472
GO:0021587	cerebellum morphogenesis	-	IBA	21873635
GO:0021794	thalamus development	-	IBA	21873635
GO:0021987	cerebral cortex development	-	IBA	21873635
GO:0030278	regulation of ossification	-	IBA	21873635
GO:0030326	embryonic limb morphogenesis	-	IBA	21873635
GO:0030901	midbrain development	-	IBA	21873635
GO:0030917	midbrain-hindbrain boundary development	-	IBA	21873635
GO:0034392	negative regulation of smooth muscle cell apoptotic process	-	IMP	15271658
GO:0035261	external genitalia morphogenesis	-	IBA	21873635
GO:0042475	odontogenesis of dentin-containing tooth	-	IBA	21873635
GO:0043434	response to peptide hormone	-	IEA	-
GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification	-	IDA	11029007
GO:0044335	canonical Wnt signaling pathway involved in neural crest cell differentiation	-	IC	11029007
GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	-	IC	15271658
GO:0045787	positive regulation of cell cycle	-	IMP	15271658
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	18215320
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	12857724
GO:0046849	bone remodeling	-	IBA	21873635
GO:0048596	embryonic camera-type eye morphogenesis	-	IBA	21873635
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IBA	21873635
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	14739301
GO:0060021	roof of mouth development	-	IBA	21873635
GO:0060026	convergent extension	-	IBA	21873635
GO:0060059	embryonic retina morphogenesis in camera-type eye	-	IBA	21873635
GO:0060070	canonical Wnt signaling pathway	-	IDA	12121999 14739301 16543246 17239604 20059949 20137080
GO:0060070	canonical Wnt signaling pathway	-	IMP	18215320
GO:0060070	canonical Wnt signaling pathway	-	TAS	22988876
GO:0060325	face morphogenesis	-	IBA	21873635
GO:0060349	bone morphogenesis	-	IBA	21873635
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IBA	21873635
GO:0060535	trachea cartilage morphogenesis	-	IBA	21873635
GO:0060828	regulation of canonical Wnt signaling pathway	-	IGI	16805831
GO:0071397	cellular response to cholesterol	-	IMP	16890161
GO:0071542	dopaminergic neuron differentiation	-	ISS	-
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IDA	19107203
GO:0072659	protein localization to plasma membrane	-	IPI	22899650
GO:0090009	primitive streak formation	-	IBA	21873635
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	-
GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	-	IBA	21873635
GO:0090244	Wnt signaling pathway involved in somitogenesis	-	IBA	21873635
GO:0090245	axis elongation involved in somitogenesis	-	IBA	21873635
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IDA	11448771 11742004 15271658 19107203 20093106
GO:0098609	cell-cell adhesion	-	IEA	-
GO:1901998	toxin transport	-	IEA	-
GO:1904886	beta-catenin destruction complex disassembly	-	TAS	-
GO:1904948	midbrain dopaminergic neuron differentiation	-	TAS	22988876
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	-	TAS	24431302
GO:2000055	positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	-	IDA	15908424

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005769	early endosome	colocalizes_with	IDA	16890161
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005794	Golgi apparatus	colocalizes_with	IDA	16890161
GO:0005886	plasma membrane	-	IDA	16263759 16890161 17569865
GO:0005886	plasma membrane	-	TAS	-
GO:0005901	caveola	-	IBA	21873635
GO:0005901	caveola	colocalizes_with	IDA	16890161 17569865
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	12897152
GO:0016021	integral component of membrane	-	IEA	-
GO:0031410	cytoplasmic vesicle	-	IDA	16890161 20093472
GO:0031901	early endosome membrane	-	TAS	-
GO:0043025	neuronal cell body	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635
GO:1990851	Wnt-Frizzled-LRP5/6 complex	-	IDA	20093360
GO:1990851	Wnt-Frizzled-LRP5/6 complex	-	IPI	11029007 11448771
GO:1990851	Wnt-Frizzled-LRP5/6 complex	-	TAS	22988876
GO:1990909	Wnt signalosome	-	IDA	22899650
GO:1990909	Wnt signalosome	-	NAS	24115276

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-4641263	Regulation of FZD by ubiquitination	TAS
R-HSA-4791275	Signaling by WNT in cancer	TAS
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	TAS
R-HSA-5663202	Diseases of signal transduction	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19833493	Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant. (2011 Feb)	Sarzani R	Nutr Metab Cardiovasc Dis
28880263	LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS. (2017 Sep 7)	Yuan Y	Cell Death Dis
23874538	CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. (2013)	Moon HG	PLoS One
20658532	Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. (2011 May 15)	Huang Y	Int J Cancer