Gene: LRP5

4041
BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2
LDL receptor related protein 5
protein-coding
11q13.2
Ensembl:ENSG00000162337 MIM:603506 Vega:OTTHUMG00000167570 UniprotKB:O75197
NG_015835.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.286e-1 (AD)  3.719e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03064005chr11:68142768LRP5Gene body8.260e-6Alcohol use disorders26763658
cg21611682chr11:68138269LRP59.770e-13Maternal smoking in pregnancy27040690
cg09578155chr11:68141470LRP55.040e-8Maternal smoking in pregnancy27040690
cg21611682chr11:68138269LRP54.320e-18Maternal smoking in pregnancy27040690
cg22151881chr11:68082621LRP57.250e-11Maternal smoking in pregnancy27040690
cg09578155chr11:68141470LRP54.040e-10Maternal smoking in pregnancy27040690
cg21611682chr11:68138269LRP51.240e-28Maternal smoking in pregnancy27040690
cg22151881chr11:68082621LRP53.340e-10Maternal smoking in pregnancy27040690
cg09578155chr11:68141470LRP54.990e-13Maternal smoking in pregnancy27040690
cg23949925chr11:68147880LRP52.470e-10Maternal smoking in pregnancy27040690
cg09578155chr11:68141470LRP51.200e-28Smoking27651444
cg14624207chr11:68142198LRP51.000e-18Smoking27651444
cg21611682chr11:68138269LRP51.300e-18Smoking27651444
cg10420527chr11:68138505LRP54.600e-8Smoking27651444
cg24051242chr11:68096138LRP59.800e-8Smoking27651444
cg00464927chr11:68139121LRP51.240e-8Alcohol consumption der day27843151
cg21611682chr11:68138269LRP55.490e-23Tobacco smoking28225026
cg14624207chr11:68142198LRP54.440e-12Tobacco smoking28225026
cg21611682chr11:68138269LRP58.040e-21Smoking28686328
cg14624207chr11:68142198LRP51.320e-14Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGB50.803
SNX330.799
EYA20.796
SLC12A40.793
TBL1X0.791
SIX50.79
ITGA70.789
RARG0.779
NOTCH10.778
FBLN10.768

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG6-0.451
NRG1-0.424
ASAH2B-0.411
PRPH2-0.407
PCSK1-0.403
ARMCX5-0.4
PPEF1-0.398
TYRP1-0.384
RBM11-0.383
PPP1R17-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of LRP5 mRNA"23829299
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of LRP5 mRNA"21920950
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LRP5 mRNA"21346803
C0293704-toluidine4-toluidine results in decreased expression of LRP5 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of LRP5 mRNA21420995|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LRP5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP5 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRP5 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LRP5 mRNA20409345|2852233
C010845aluminum chloridealuminum chloride results in decreased activity of LRP5 protein26474975
C010845aluminum chloridealuminum chloride results in decreased expression of LRP5 mRNA26474975
D000638AmiodaroneAmiodarone results in increased expression of LRP5 mRNA19774075
D001104ArbutinArbutin results in decreased expression of LRP5 mRNA17103032
D001151ArsenicArsenic affects the methylation of LRP5 gene25304211
D001280AtrazineAtrazine results in decreased expression of LRP5 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRP5 mRNA26001963
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRP5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of LRP5 mRNA19619570
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of LRP5 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of LRP5 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of LRP5 mRNA26562050
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of LRP5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LRP5 mRNA25381574|2596372
C006780bisphenol Abisphenol A results in increased expression of LRP5 mRNA25181051
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]25963729
C018475butyraldehydebutyraldehyde results in decreased expression of LRP5 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LRP5 mRNA20478370
C054133casticincasticin results in increased expression of LRP5 mRNA27862857
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of LRP5 mRNA27344345
C022990chromic chloride[cobaltous chloride co-treated with chromic chloride] affects the expression of LRP5 mRNA25966675
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LRP5 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP5 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRP5 mRNA19320972
C018021cobaltous chloridecobaltous chloride affects the expression of LRP5 mRNA25966675
C018021cobaltous chloride[cobaltous chloride co-treated with chromic chloride] affects the expression of LRP5 mRNA25966675
D019327Copper SulfateCopper Sulfate results in decreased expression of LRP5 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]25963729
D003474CurcuminCurcumin results in increased expression of LRP5 mRNA25963729
D016572CyclosporineCyclosporine results in decreased expression of LRP5 mRNA20106945|2556210
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of LRP5 mRNA20705681
C000944dicrotophosdicrotophos results in increased expression of LRP5 mRNA28302478
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to LRP5 enhancer]17293108
D002117CalcitriolCalcitriol results in increased expression of LRP5 mRNA17293108
D004317DoxorubicinDoxorubicin affects the methylation of LRP5 gene28962528
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LRP5 mRNA17351261
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of LRP5 gene18263894
C074031exenatideexenatide results in increased expression of LRP5 mRNA19586609
C540355fenamidonefenamidone results in increased expression of LRP5 mRNA27029645
D005419FlavonoidsDKK1 protein inhibits the reaction [Flavonoids results in increased expression of LRP5 mRNA]23238999
D005419FlavonoidsFlavonoids results in increased expression of LRP5 mRNA23238999
D005557FormaldehydeLRP5 gene affects the susceptibility to Formaldehyde27008852
C069837fullerene C60fullerene C60 results in increased expression of LRP5 mRNA19167457
C010974glyphosateglyphosate results in increased expression of LRP5 mRNA15654877
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of LRP5 mRNA27344345
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LRP5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LRP5 mRNA"25102311
C051752nefazodonenefazodone results in decreased expression of LRP5 mRNA24136188
D009532NickelNickel results in decreased expression of LRP5 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of LRP5 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of LRP5 mRNA24136188
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of LRP5 mRNA20705681
D052638Particulate MatterParticulate Matter results in increased expression of LRP5 mRNA17450221|2217879
D010634PhenobarbitalPhenobarbital results in decreased expression of LRP5 mRNA19270015
D019800PhenolPhenol results in increased expression of LRP5 mRNA17547211
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRP5 mRNA19710929
D011374ProgesteroneProgesterone results in increased expression of LRP5 mRNA23012394
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LRP5 mRNA27029645
C059514resveratrolresveratrol results in increased expression of LRP5 mRNA23848300
C017947sodium arsenitesodium arsenite results in increased expression of LRP5 mRNA27158593
D013311StreptozocinStreptozocin affects the expression of LRP5 mRNA18583417
C021751tanshinonetanshinone results in decreased expression of LRP5 mRNA15849732
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRP5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRP5 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRP5 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRP5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRP5 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of LRP5 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LRP5 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of LRP5 gene26756918
C406224valdecoxibvaldecoxib results in decreased expression of LRP5 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LRP5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of LRP5 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LRP5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11336703  11433302  15908424  18762581  20393562  21471202  
GO:0015026coreceptor activity-IBA21873635  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-IPI11336703  
GO:0017147Wnt-protein binding-ISS-  
GO:0017147Wnt-protein binding-TAS22988876  
GO:0019534toxin transmembrane transporter activityNOTIMP18350154  
GO:0042813Wnt-activated receptor activity-IBA21873635  
GO:0042813Wnt-activated receptor activity-ISS-  
GO:0071936coreceptor activity involved in Wnt signaling pathway-IPI11336703  
GO:1904928coreceptor activity involved in canonical Wnt signaling pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0001702gastrulation with mouth forming second-IBA21873635  
GO:0001702gastrulation with mouth forming second-IEA-  
GO:0002053positive regulation of mesenchymal cell proliferation-IMP17680723  
GO:0002076osteoblast development-IBA21873635  
GO:0006007glucose catabolic process-IMP19673927  
GO:0006897endocytosis-IEA-  
GO:0008203cholesterol metabolic process-IEA-  
GO:0008217regulation of blood pressure-IMP18721193  
GO:0008284positive regulation of cell proliferation-IDA9790987  
GO:0009314response to radiation-IEA-  
GO:0009952anterior/posterior pattern specification-IBA21873635  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0016055Wnt signaling pathway-IDA17955262  
GO:0016055Wnt signaling pathway-IGI11336703  
GO:0030278regulation of ossification-IBA21873635  
GO:0033690positive regulation of osteoblast proliferation-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035426extracellular matrix-cell signaling-IEA-  
GO:0042074cell migration involved in gastrulation-IEA-  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-IMP18721193  20146170  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0042981regulation of apoptotic process-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0044332Wnt signaling pathway involved in dorsal/ventral axis specification-IBA21873635  
GO:0044332Wnt signaling pathway involved in dorsal/ventral axis specification-IDA11029007  
GO:0045600positive regulation of fat cell differentiation-IMP17680723  
GO:0045668negative regulation of osteoblast differentiation-IMP17680723  
GO:0045840positive regulation of mitotic nuclear division-IDA9790987  
GO:0045893positive regulation of transcription, DNA-templated-IDA15035989  17955262  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12857724  
GO:0046849bone remodeling-IBA21873635  
GO:0046849bone remodeling-IEA-  
GO:0046850regulation of bone remodeling-IEA-  
GO:0048539bone marrow development-IBA21873635  
GO:0048539bone marrow development-IMP17680723  
GO:0051091positive regulation of DNA-binding transcription factor activity-IEA-  
GO:0060033anatomical structure regression-IEA-  
GO:0060042retina morphogenesis in camera-type eye-IMP15346351  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA12121999  12857724  15035989  
GO:0060070canonical Wnt signaling pathway-IMP19673927  
GO:0060349bone morphogenesis-IBA21873635  
GO:0060349bone morphogenesis-IMP19673927  20146170  20630166  
GO:0060444branching involved in mammary gland duct morphogenesis-IBA21873635  
GO:0060444branching involved in mammary gland duct morphogenesis-IEA-  
GO:0060612adipose tissue development-IBA21873635  
GO:0060612adipose tissue development-IMP17680723  
GO:0060764cell-cell signaling involved in mammary gland development-IEA-  
GO:0060828regulation of canonical Wnt signaling pathway-IGI16805831  
GO:0060828regulation of canonical Wnt signaling pathway-IMP18044981  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-IBA21873635  
GO:0061304retinal blood vessel morphogenesis-IBA21873635  
GO:0061304retinal blood vessel morphogenesis-IMP15024691  15346351  
GO:0071901negative regulation of protein serine/threonine kinase activity-IMP19107203  
GO:1902262apoptotic process involved in blood vessel morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA17680723  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA18762581  
GO:1990851Wnt-Frizzled-LRP5/6 complex-TAS20093360  22988876  
GO:1990909Wnt signalosome-NAS24115276  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneIEA
R-HSA-4641263Regulation of FZD by ubiquitinationTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingTAS
R-HSA-5340588RNF mutants show enhanced WNT signaling and proliferationTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25862628DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)Kupers LKInt J Epidemiol
22616666Smoke-induced signal molecules in bone marrow cells from altered low-density lipoprotein receptor-related protein 5 mice. (2012 Jul 6)Ma DJ Proteome Res
19506792The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort. (2010 Mar)Giampietro PFOsteoporos Int
20482464Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4+:CD8+ T-cell ratios are reversed by smoking cessation: influence of bone mass on immune cell response to and recovery from smoke exposure. (2010 Aug)Fusby JSInhal Toxicol
23490293Low-density lipoprotein receptor-related protein 5 gene polymorphisms and genetic susceptibility to abdominal aortic aneurysm. (2013 Oct)Galora SJ Vasc Surg
23054017The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. (2013 Jan)Yang CWMol Biol Rep
16713434G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years. (2006 Jun)Suwazono YMetabolism