Gene: LRPAP1

4043
A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP
LDL receptor related protein associated protein 1
protein-coding
4p16.3
Ensembl:ENSG00000163956 MIM:104225 Vega:OTTHUMG00000090299 UniprotKB:P30533
NG_033873.1
PubMed
0   ANCO-SNPs
ND
1   
6.451e-1 (AD)  4.817e-1 (ND)   (Frontal_Cortex)
9.456e-1 (AD)  5.649e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCTN30.941
ATP6V0D10.941
PPP5C0.939
TIMM500.939
MAEA0.936
MDH20.936
FARSA0.936
ABHD16A0.935
IDH3G0.935
LRRC470.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.613
OR4F29-0.562
MTRNR2L6-0.46
MTRNR2L9-0.446
CXCR2-0.444
MTRNR2L10-0.441
KCNJ15-0.44
EBF1-0.435
FCGR3B-0.429
IL18RAP-0.427

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of LRPAP1 mRNA"19162173
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LRPAP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRPAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRPAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of LRPAP1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRPAP1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LRPAP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LRPAP1 mRNA24449571
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of LRPAP1 mRNA15894607
D001194AsbestosAsbestos affects the expression of LRPAP1 mRNA17297452
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LRPAP1 mRNA"20382639
C006780bisphenol Abisphenol A affects the expression of LRPAP1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LRPAP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of LRPAP1 mRNA25270620
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRPAP1 mRNA28628672
D002104Cadmium[LRPAP1 protein affects the localization of LRP2 protein] which results in decreased uptake of Cadmium22617749
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA12634122
D002220CarbamazepineCarbamazepine affects the expression of LRPAP1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LRPAP1 mRNA17484886
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of LRPAP1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of LRPAP1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of LRPAP1 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LRPAP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRPAP1 mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of LRPAP1 mRNA19030233
D004237DiuronDiuron results in increased expression of LRPAP1 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of LRPAP1 mRNA25529476
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRPAP1 mRNA28196854
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LRPAP1 mRNA23649840
D005411Flame RetardantsFlame Retardants results in increased expression of LRPAP1 protein18550172
D005839GentamicinsGentamicins results in increased expression of LRPAP1 protein22061828
D017313FenretinideFenretinide results in decreased expression of LRPAP1 mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LRPAP1 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of LRPAP1 protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LRPAP1 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of LRPAP1 protein23178681
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LRPAP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRPAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LRPAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRPAP1 mRNA28628672
D007649KetamineKetamine results in increased expression of LRPAP1 mRNA20080153
D007854LeadLead results in decreased expression of LRPAP1 mRNA22313790
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA12634122
C045463leflunomideleflunomide results in increased expression of LRPAP1 mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LRPAP1 mRNA23649840
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LRPAP1 protein18550172
D010634PhenobarbitalPhenobarbital results in decreased expression of LRPAP1 mRNA25270620
D012402RotenoneRotenone results in decreased expression of LRPAP1 mRNA19013527
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of LRPAP1 mRNA12634122
D013605T-2 ToxinT-2 Toxin affects the expression of LRPAP1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRPAP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRPAP1 mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRPAP1 protein19492234
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of LRPAP1 protein"25852303
C009495titanium dioxidetitanium dioxide results in decreased expression of LRPAP1 mRNA23557971
D014050TolueneToluene results in increased expression of LRPAP1 mRNA22166486
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of LRPAP1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of LRPAP1 mRNA15894607
C057693troglitazonetroglitazone results in increased expression of LRPAP1 protein21315101
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRPAP1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of LRPAP1 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased expression of LRPAP1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of LRPAP1 gene29154799
D014640VancomycinVancomycin results in increased expression of LRPAP1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRPAP1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of LRPAP1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-TAS22383525  
GO:0005102signaling receptor binding-TAS14645246  
GO:0005515protein binding-IPI8083232  10085125  19122660  20223215  
GO:0008201heparin binding-IEA-  
GO:0035473lipase binding-IEA-  
GO:0048019receptor antagonist activity-IDA8083232  
GO:0048019receptor antagonist activity-TAS14645246  
GO:0050750low-density lipoprotein particle receptor binding-IDA7774585  16263759  
GO:0050750low-density lipoprotein particle receptor binding-TAS21289173  
GO:0070326very-low-density lipoprotein particle receptor binding-IPI8083232  
GO ID GO Term Qualifier Evidence PubMed
GO:0002091negative regulation of receptor internalization-IGI23386614  
GO:0010916negative regulation of very-low-density lipoprotein particle clearance-IDA8083232  
GO:0032091negative regulation of protein binding-IDA8083232  
GO:0045056transcytosis-IMP26005850  
GO:0048259regulation of receptor-mediated endocytosis-IDA7774585  
GO:0060548negative regulation of cell death-IGI23386614  
GO:1900116extracellular negative regulation of signal transduction-TAS14645246  
GO:1900222negative regulation of amyloid-beta clearance-IGI19098903  
GO:1900223positive regulation of amyloid-beta clearance-TAS22383525  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS14645246  
GO:0005768endosome-IDA7774585  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA7774585  
GO:0005794Golgi apparatus-IDA7774585  
GO:0005796Golgi lumen-IEA-  
GO:0005801cis-Golgi network-IDA7774585  
GO:0005886plasma membrane-IDA16263759  
GO:0009986cell surface-IEA-  
GO:0031904endosome lumen-IEA-  
GO:0048237rough endoplasmic reticulum lumen-IDA7774585  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29021777Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk. (2017)Zhang LFront Neurol