Gene: LSAMP

4045
IGLON3|LAMP
limbic system associated membrane protein
protein-coding
3q13.31
Ensembl:ENSG00000185565 MIM:603241 Vega:OTTHUMG00000159308 UniprotKB:Q13449
NC_000003.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.847e-1 (AD)  5.479e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs62271282chr3:116039221 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs16824395chr3:116021872 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTN10.93
WDR480.923
FAM168A0.914
MEGF90.91
CDH20.908
LONP20.907
GPM6A0.905
TRAK10.905
ATPAF10.904
CKAP50.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.711
OR4F29-0.66
TFPI2-0.412
C9orf135-0.365
SPINK8-0.359
HAS2-0.354
SLAMF6-0.344
CD3G-0.333
TBX21-0.333
GZMK-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LSAMP mRNA"21394737
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LSAMP mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of LSAMP mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LSAMP mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LSAMP mRNA24449571
D001151ArsenicArsenic affects the methylation of LSAMP gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of LSAMP mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LSAMP mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LSAMP mRNA22228805
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of LSAMP mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of LSAMP mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of LSAMP mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of LSAMP mRNA26079696
D003042CocaineCocaine results in increased expression of LSAMP mRNA17898221
D000069439DasatinibDasatinib results in increased expression of LSAMP mRNA20579391
D003630DaunorubicinLSAMP affects the susceptibility to Daunorubicin17545624
D004041Dietary FatsDietary Fats results in increased expression of LSAMP mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of LSAMP mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of LSAMP mRNA]21852083
C118739entinostatentinostat results in decreased expression of LSAMP mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LSAMP mRNA17351261
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LSAMP mRNA26752646
D007854LeadLead affects the expression of LSAMP mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of LSAMP mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of LSAMP mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LSAMP protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LSAMP mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LSAMP mRNA24810058
D009532NickelNickel results in decreased expression of LSAMP mRNA24768652|2558310
D010100OxygenOxygen deficiency results in increased expression of LSAMP mRNA24205000
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of LSAMP mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LSAMP mRNA26272509
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of LSAMP mRNA26945725
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of LSAMP mRNA]21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LSAMP mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of LSAMP mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of LSAMP gene28589171
D012999SomanSoman results in increased expression of LSAMP mRNA19281266
D019284ThapsigarginThapsigargin results in increased expression of LSAMP mRNA22378314
D014212TretinoinTretinoin results in decreased expression of LSAMP mRNA21934132
D014212TretinoinTretinoin results in increased expression of LSAMP mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LSAMP mRNA"26179874
D014403TubocurarineTubocurarine results in increased expression of LSAMP mRNA19728367
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSAMP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LSAMP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LSAMP mRNA24383497|2800136
D014635Valproic AcidValproic Acid affects the expression of LSAMP mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of LSAMP mRNA23665938

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007399nervous system development-TAS8666243  
GO:0035641locomotory exploration behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27187494Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. (2016)Dungan JRPLoS One