Gene: LSP1

4046
WP34|pp52
lymphocyte specific protein 1
protein-coding
11p15.5
Ensembl:ENSG00000130592 MIM:153432 Vega:OTTHUMG00000012252 UniprotKB:P33241
NG_011509.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.753e-1 (AD)  9.600e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11041553chr11:1867725 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09989681chr11:1892043LSP12.470e-10Maternal smoking in pregnancy27040690
cg24552015chr11:1892038LSP12.740e-10Maternal smoking in pregnancy27040690
cg26868156chr11:1892180LSP12.100e-9Maternal smoking in pregnancy27040690
cg09989681chr11:1892043LSP12.720e-11Maternal smoking in pregnancy27040690
cg24552015chr11:1892038LSP13.600e-11Maternal smoking in pregnancy27040690
cg26868156chr11:1892180LSP12.340e-9Maternal smoking in pregnancy27040690
cg20331155chr11:1892074LSP12.800e-8Maternal smoking in pregnancy27040690
cg22043296chr11:1892139LSP14.940e-8Maternal smoking in pregnancy27040690
cg09989681chr11:1892043LSP19.430e-10Maternal smoking in pregnancy27040690
cg24552015chr11:1892038LSP19.920e-10Maternal smoking in pregnancy27040690
cg04085571chr11:1872753LSP16.700e-11Smoking27651444
cg08687540chr11:1890204LSP18.930e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCR50.721
TREM10.712
FPR20.701
NABP10.699
PTPRC0.692
TLR10.691
GPR650.683
MYO1G0.683
LILRB30.682
TLR80.68

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POU3F1-0.377
ARSF-0.342
KIT-0.321
BDH1-0.314
FRMPD1-0.313
ZNF835-0.308
KCNN2-0.304
FLRT2-0.3
NEUROD6-0.298
KCNG1-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of LSP1 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LSP1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LSP1 mRNA"21346803
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of LSP1 mRNA17011747
D000082AcetaminophenAcetaminophen affects the expression of LSP1 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of LSP1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of LSP1 mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of LSP1 mRNA25064622
D001151ArsenicArsenic affects the methylation of LSP1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of LSP1 mRNA15761015
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of LSP1 mRNA15894607
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of LSP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LSP1 mRNA21871943|2231617
D004958EstradiolEstradiol results in decreased expression of LSP1 mRNA15289156
C006780bisphenol Abisphenol A results in decreased expression of LSP1 mRNA25047013
C006780bisphenol Abisphenol A affects the expression of LSP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of LSP1 mRNA26079696
D000074262Canola OilCanola Oil metabolite results in decreased expression of LSP1 mRNA27363782
D002330CarmustineCarmustine results in decreased expression of LSP1 mRNA16005536
D002737ChloropreneChloroprene results in decreased expression of LSP1 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of LSP1 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LSP1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of LSP1 mRNA17585979
D003042CocaineCocaine results in decreased expression of LSP1 mRNA27899881
D019327Copper SulfateCopper Sulfate results in increased expression of LSP1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of LSP1 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of LSP1 mRNA25064622
D016572CyclosporineCyclosporine results in decreased methylation of LSP1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LSP1 mRNA23914054
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of LSP1 protein23811945
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of LSP1 protein23352502
D003907DexamethasoneDexamethasone results in decreased expression of LSP1 mRNA25047013
D003976DiazinonDiazinon results in increased methylation of LSP1 gene22964155
D003976DiazinonDiazinon affects the expression of LSP1 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LSP1 mRNA27392435
D004026DieldrinDieldrin affects the expression of LSP1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of LSP1 mRNA18042831
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of LSP1 gene23968726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LSP1 mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LSP1 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LSP1 mRNA17011747
D002117CalcitriolCalcitriol results in decreased expression of LSP1 mRNA26485663
D002117CalcitriolCalcitriol results in increased expression of LSP1 mRNA12875902
D004237DiuronDiuron results in decreased expression of LSP1 mRNA25152437
D004237DiuronDiuron results in increased expression of LSP1 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of LSP1 mRNA25896364
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LSP1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LSP1 mRNA17557909
D015025ZearalenoneZearalenone results in decreased expression of LSP1 mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LSP1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of LSP1 mRNA24304932
D019833GenisteinGenistein results in decreased expression of LSP1 mRNA15289156
D005839GentamicinsGentamicins results in increased expression of LSP1 mRNA22061828
C004312glycidolglycidol results in increased expression of LSP1 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of LSP1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LSP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LSP1 mRNA23086925
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LSP1 mRNA21641980
D008694MethamphetamineMethamphetamine results in decreased methylation of LSP1 promoter26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LSP1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of LSP1 mRNA17400583
D008727MethotrexateMethotrexate results in decreased expression of LSP1 mRNA16005536
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LSP1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LSP1 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LSP1 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of LSP1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LSP1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LSP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased secretion of LSP1 protein"25598225
C022838nickel chloridenickel chloride affects the expression of LSP1 mRNA22546817
C029938nickel sulfatenickel sulfate results in decreased expression of LSP1 mRNA22714537
D000073878Palm OilPalm Oil results in increased expression of LSP1 mRNA18042831
D010269ParaquatParaquat affects the expression of LSP1 mRNA25064622
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of LSP1 mRNA27153767
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of LSP1 gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LSP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of LSP1 mRNA17426115
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LSP1 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of LSP1 mRNA24780913
D012643SeleniumSelenium results in increased expression of LSP1 mRNA19244175
C078903seocalcitolseocalcitol results in decreased expression of LSP1 mRNA12040012
D012715Sesame OilSesame Oil results in increased expression of LSP1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LSP1 mRNA25895662
D012834SilverSilver results in increased expression of LSP1 mRNA27131904
D012906SmokeSmoke results in increased expression of LSP1 mRNA21095227
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LSP1 mRNA21641980
C016766sulforafansulforafan results in increased expression of LSP1 mRNA26833863
C061133tamibarotenetamibarotene results in increased expression of LSP1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LSP1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LSP1 mRNA26290441
D013752TetracyclineTetracycline affects the expression of LSP1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of LSP1 mRNA25064622
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LSP1 mRNA28943392
D013866ThioguanineThioguanine results in decreased expression of LSP1 mRNA16005536
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LSP1 mRNA28065790
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of LSP1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of LSP1 mRNA12875902|1549850
D014212TretinoinTretinoin results in increased expression of LSP1 mRNA20488242
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LSP1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LSP1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of LSP1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of LSP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LSP1 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LSP1 gene25560391
C025643vinclozolinvinclozolin affects the expression of LSP1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006968cellular defense response-TAS2174784  
GO:0007165signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0015629actin cytoskeleton-TAS8274738  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24681604Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia. (2014 Apr)Park SLJ Natl Cancer Inst
23544014Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. (2013)Nickels SPLoS Genet
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst