Gene: LSS

4047
CTRCT44|OSC
lanosterol synthase
protein-coding
21q22.3
Ensembl:ENSG00000160285 MIM:600909 Vega:OTTHUMG00000090633 UniprotKB:P48449
NG_011510.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.829e-1 (AD)  8.353e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTS20.89
GTF3C50.878
CYTH10.877
PCBP40.862
RNH10.856
ABCA20.856
PRKCSH0.853
SLC48A10.849
CCDC1590.844
HIP1R0.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.667
OR4F5-0.661
FER1L6-0.298
MTRNR2L6-0.274
TTLL10-AS1-0.269
MTRNR2L9-0.268
OR4F16-0.255
SULT1E1-0.253
FMO1-0.247
KRT73-0.247

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02016R048-8071Small Molecule161582-11-2ExperimentalTarget
DB03696LanosterolSmall Molecule79-63-0ExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of LSS mRNA"19162173
C0317631,3-butadiene"1,3-butadiene results in decreased expression of LSS mRNA"21147608
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LSS mRNA"21354444
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of LSS mRNA26821219
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LSS mRNA28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of LSS mRNA"23829299
C00358522-hydroxycholesterol22-hydroxycholesterol results in decreased expression of LSS mRNA19426978
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LSS mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LSS mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of LSS mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LSS mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LSS mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of LSS mRNA16788091
C000615602AB-FUBINACAAB-FUBINACA affects the expression of LSS mRNA26517302
D000082AcetaminophenAcetaminophen results in decreased expression of LSS mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of LSS mRNA11264010
C560978aegeline[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LSS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LSS mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LSS gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LSS mRNA19770486
D000452AldrinAldrin results in increased expression of LSS mRNA18579281
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of LSS protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of LSS protein26597043
D000638AmiodaroneAmiodarone affects the expression of LSS mRNA29248575
D000638AmiodaroneAmiodarone results in increased expression of LSS mRNA15342952|1756758
D000638AmiodaroneAmiodarone results in increased expression of LSS mRNA24489787
D000638AmiodaroneAmiodarone results in increased expression of LSS mRNA19224547
D000639AmitriptylineAmitriptyline results in increased expression of LSS mRNA15342952|1717555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LSS mRNA16483693
D000965AntimonyAntimony results in decreased expression of LSS mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of LSS mRNA17547211
D016718Arachidonic AcidArachidonic Acid results in decreased expression of LSS mRNA16704987
C519728archazolid Barchazolid B results in increased expression of LSS mRNA25218289
D001507BeclomethasoneBeclomethasone results in increased expression of LSS mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of LSS mRNA26377693
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of LSS mRNA22234961
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of LSS mRNA22234961
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LSS mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LSS mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LSS mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LSS mRNA21964900
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of LSS mRNA20660070
D004958EstradiolEstradiol results in decreased expression of LSS mRNA19484750
C006780bisphenol Abisphenol A affects the expression of LSS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LSS mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of LSS mRNA21932408|2516818
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LSS mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of LSS mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LSS gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of LSS mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LSS mRNA14729362
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of LSS promoter22457795
D002110Caffeine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LSS mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of LSS mRNA19224547
C084597chlorcyclizinechlorcyclizine results in increased expression of LSS mRNA15342952
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of LSS mRNA18178546
D002746ChlorpromazineChlorpromazine results in increased expression of LSS mRNA15342952|1717555
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LSS mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of LSS mRNA18353800
D017291ClarithromycinClarithromycin results in decreased expression of LSS mRNA15342952
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LSS mRNA17602206
D002997ClomipramineClomipramine results in increased expression of LSS mRNA15342952
D003024ClozapineClozapine results in increased expression of LSS mRNA15342952|1717555
C018021cobaltous chloridecobaltous chloride results in decreased expression of LSS mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of LSS mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of LSS mRNA24386269
C004690coclaurine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LSS mRNA20971185
D003300CopperCopper results in decreased expression of LSS mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of LSS mRNA19549813
D003471CuprizoneCuprizone results in increased expression of LSS mRNA26577399
D003474CurcuminCurcumin affects the expression of LSS mRNA27208389
D003474CurcuminCurcumin results in decreased expression of LSS mRNA27208389
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of LSS mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of LSS mRNA19770486
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of LSS mRNA29038839
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LSS mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LSS mRNA]27941970
D003907DexamethasoneDexamethasone affects the expression of LSS mRNA15102944
D003976DiazinonDiazinon results in increased methylation of LSS gene22964155
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of LSS mRNA"25908611
C016366dibenzothiophenedibenzothiophene results in decreased expression of LSS mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LSS mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LSS mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LSS mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LSS mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LSS mRNA26924002
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LSS mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of LSS mRNA19030233|2260994
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of LSS mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LSS mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LSS mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LSS mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LSS mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LSS mRNA17602206
D002117CalcitriolCalcitriol results in increased expression of LSS mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LSS mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of LSS mRNA17547211
D004316DoxepinDoxepin results in increased expression of LSS mRNA17567588
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of LSS mRNA29038839
D004917ErythromycinErythromycin results in increased expression of LSS mRNA17175557
D000431EthanolEthanol results in increased expression of LSS mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LSS mRNA24992288
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LSS mRNA17351261
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of LSS mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LSS mRNA23649840
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of LSS mRNA"23333450
D011345FenofibrateFenofibrate results in increased expression of LSS mRNA23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]23063693
D005424FlecainideFlecainide results in increased expression of LSS mRNA17175557
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LSS mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of LSS mRNA28329830
D005472FluorouracilLSS protein affects the susceptibility to Fluorouracil16217747
D005473FluoxetineFluoxetine results in increased expression of LSS mRNA15342952|1756758
C061365flusilazoleflusilazole results in increased expression of LSS mRNA22382673
C061365flusilazoleflusilazole affects the expression of LSS mRNA21195148
D005485FlutamideFlutamide results in increased expression of LSS mRNA19299419
D005557FormaldehydeFormaldehyde results in decreased expression of LSS mRNA23649840
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA28433809
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of LSS mRNA16206274
C409722hexaconazolehexaconazole affects the expression of LSS mRNA21195148
C012348higenamine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
D017313FenretinideFenretinide results in decreased expression of LSS mRNA28973697
D047348Hydrolyzable Tannins[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of LSS mRNA16849584
D007099ImipramineImipramine results in increased expression of LSS mRNA15342952|1756758
D007213IndomethacinIndomethacin affects the expression of LSS mRNA17546600
D007213IndomethacinIndomethacin results in increased expression of LSS mRNA28201806
D007529IsoflavonesIsoflavones results in increased expression of LSS mRNA17374662
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LSS mRNA27392435
C544151jinfukangjinfukang results in increased expression of LSS mRNA27392435
D007654KetoconazoleKetoconazole results in increased expression of LSS mRNA15342952|1717555
C099406L 742694L 742694 affects the expression of LSS mRNA15102944
D007854LeadLead affects the splicing of LSS mRNA28903495
D017336LoratadineLoratadine results in increased expression of LSS mRNA15342952
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LSS mRNA21641980
D008752Methylene ChlorideMethylene Chloride affects the expression of LSS mRNA28392392
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of LSS mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LSS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LSS mRNA23649840
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LSS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LSS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LSS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LSS mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of LSS mRNA27344345
D009532NickelNickel results in decreased expression of LSS mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of LSS mRNA17547211
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LSS mRNA20971185
C464660obeticholic acidobeticholic acid results in decreased expression of LSS mRNA27939613
D010126OzoneOzone results in decreased expression of LSS mRNA25838073
D010419PentamidinePentamidine results in decreased expression of LSS mRNA15342952
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of LSS mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of LSS mRNA19429403|2093613
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of LSS mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LSS protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LSS mRNA17681415|1942940
C023036perfluorooctanoic acidPPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of LSS mRNA]20936131
D010480PerhexilinePerhexiline results in increased expression of LSS mRNA15342952|1717555
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LSS mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of LSS mRNA19136022|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of LSS mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LSS mRNA19162173
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of LSS mRNA27756839
D010795Phthalic AcidsPhthalic Acids results in decreased expression of LSS mRNA15728792
C006253pirinixic acidpirinixic acid affects the expression of LSS mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of LSS mRNA20936131
C006253pirinixic acidpirinixic acid results in increased expression of LSS mRNA19162173
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA28433809
D011192Potassium DichromatePotassium Dichromate results in increased expression of LSS protein23718831
D017035PravastatinPravastatin results in increased expression of LSS mRNA27225895
D017035PravastatinPravastatin results in increased expression of LSS mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LSS mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of LSS mRNA19162173
C045362prochlorazprochloraz results in increased expression of LSS mRNA21470553
D011374ProgesteroneProgesterone results in increased expression of LSS mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of LSS mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of LSS mRNA18070364
C030984pyrenepyrene results in decreased expression of LSS mRNA23656968
D011794QuercetinQuercetin results in decreased expression of LSS mRNA21632981
C502851quinocetonequinocetone results in increased expression of LSS mRNA27046791
C105726Ro 48-8071Ro 48-8071 results in decreased activity of LSS protein9763219
C106263rostafuroxin[LSS gene polymorphism co-treated with HSD3B1 gene polymorphism co-treated with ABCB1 gene polymorphism co-treated with ADD1 gene polymorphism co-treated with ADD3 gene polymorphism] affects the susceptibility to rostafuroxin21106941
D020280SertralineSertraline results in increased expression of LSS mRNA15342952|1756758
D012834SilverSilver results in decreased expression of LSS mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of LSS mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of LSS mRNA25524072
C016104sodium bichromatesodium bichromate results in decreased expression of LSS mRNA24612858
D053260SootSoot results in increased expression of LSS mRNA22461453
D013015SotalolSotalol results in decreased expression of LSS mRNA15342952
C075117squalestatin 1squalestatin 1 results in increased expression of LSS mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of LSS mRNA27225895
D010042OuabainLSS protein results in increased abundance of Ouabain21106941
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LSS mRNA21641980
D014284TriiodothyronineTriiodothyronine results in increased expression of LSS mRNA15953391
D013629TamoxifenTamoxifen results in decreased expression of LSS mRNA15590111
D013629TamoxifenTamoxifen results in increased expression of LSS mRNA15342952|1756758
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LSS mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LSS mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LSS mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LSS mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LSS mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LSS mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LSS mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of LSS mRNA27188386
D013881ThioridazineThioridazine results in increased expression of LSS mRNA15342952|1717555
C009495titanium dioxidetitanium dioxide results in increased expression of LSS mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LSS mRNA28065790
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of LSS mRNA"15342952|1717555
C034613triacsin Ctriacsin C results in decreased expression of LSS mRNA16704987
C032910triadimefontriadimefon affects the expression of LSS mRNA21195148
C012589trichostatin Atrichostatin A affects the expression of LSS mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LSS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LSS mRNA"24407104
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of LSS mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of LSS mRNA25572481
C057693troglitazonetroglitazone results in increased expression of LSS protein21315101
D014415TunicamycinTunicamycin results in decreased expression of LSS mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of LSS mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LSS mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LSS gene25560391
C025643vinclozolinvinclozolin results in decreased expression of LSS mRNA23034163
D014812Vitamin KVitamin K affects the expression of LSS mRNA16844298
C111237vorinostatvorinostat results in decreased expression of LSS mRNA27188386
D015016Yohimbine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA28843594
D015031ZimeldineZimeldine results in increased expression of LSS mRNA17175557
D015034Zinc OxideZinc Oxide affects the expression of LSS mRNA28648595
C088658zoledronic acidzoledronic acid results in increased expression of LSS mRNA24714768
C088658zoledronic acidzoledronic acid results in increased expression of LSS mRNA18325729

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000250lanosterol synthase activity-IGI7639730  
GO:0000250lanosterol synthase activity-IMP26200341  
GO:0000250lanosterol synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006694steroid biosynthetic process-IMP26200341  
GO:0006695cholesterol biosynthetic process-IMP17186944  
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0031647regulation of protein stability-IMP26200341  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005811lipid droplet-IDA14741744  21498505  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16798059Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. (2007 Feb)Chen HHOral Oncol
28323575Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009. (2017 May)Cahoon EKRadiat Res
28149327In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. (2017)Chatterton ZEpigenetics Chromatin
28593118Ideal cardiovascular health and peripheral artery disease in African Americans: Results from the Jackson Heart Study. (2017 Sep)Collins TCPrev Med Rep