Gene: LTA4H

4048
-
leukotriene A4 hydrolase
protein-coding
12q23.1
Ensembl:ENSG00000111144 MIM:151570 Vega:OTTHUMG00000170355 UniprotKB:P09960
NC_000012.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.383e-1 (AD)  9.859e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNOT110.917
GDI20.917
RBBP70.916
TXNDC120.911
HEXB0.91
CDC1230.908
PSMD60.908
PMPCB0.908
GNPAT0.907
BLMH0.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.72
OR4F29-0.684
ZBTB20-0.214
MTRNR2L6-0.204
C5orf64-0.199
KLRB1-0.192
C9orf153-0.189
HPSE2-0.181
TRPV5-0.178
TCL1A-0.173

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01197CaptoprilSmall Molecule62571-86-2ApprovedTarget
DB02062N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]AlanineSmall MoleculeExperimentalTarget
DB023523-(Benzyloxy)Pyridin-2-AmineSmall MoleculeExperimentalTarget
DB03366ImidazoleSmall Molecule288-32-4Experimental|InvestigationalTarget
DB03424UbenimexSmall Molecule58970-76-6Experimental|InvestigationalTarget
DB05177DG051Small Molecule-InvestigationalTarget
DB068285-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indoleSmall MoleculeExperimentalTarget
DB06851N-(pyridin-3-ylmethyl)anilineSmall MoleculeExperimentalTarget
DB06917(4-fluorophenyl)(pyridin-4-yl)methanoneSmall MoleculeExperimentalTarget
DB070941-(2,2'-bithiophen-5-yl)methanamineSmall MoleculeExperimentalTarget
DB07099N-[4-(benzyloxy)phenyl]glycinamideSmall MoleculeExperimentalTarget
DB07102(2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acidSmall MoleculeExperimentalTarget
DB071044-amino-N-[4-(benzyloxy)phenyl]butanamideSmall MoleculeExperimentalTarget
DB07196N-methyl-1-(2-thiophen-2-ylphenyl)methanamineSmall MoleculeExperimentalTarget
DB07237{4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanoneSmall MoleculeExperimentalTarget
DB07258(R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanolSmall MoleculeExperimentalTarget
DB072591-(4-thiophen-2-ylphenyl)methanamineSmall MoleculeExperimentalTarget
DB07260N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]anilineSmall MoleculeExperimentalTarget
DB072924-(2-amino-1,3-thiazol-4-yl)phenolSmall MoleculeExperimentalTarget
DB08040N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanineSmall MoleculeExperimentalTarget
DB084665-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diolSmall MoleculeExperimentalTarget
DB11781TosedostatSmall Molecule238750-77-1InvestigationalTarget
ID Drug Name Action PubMed
C5213391-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]17371808
C5213391-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid results in decreased activity of LTA4H protein17371808
C5213391-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid results in decreased activity of LTA4H protein17371808
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LTA4H mRNA"21346803
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of LTA4H mRNA20840853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of LTA4H mRNA20382172
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of LTA4H protein20382172
C0312782-chloroethyl ethyl sulfideSB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTA4H mRNA]20382172
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of LTA4H mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LTA4H mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTA4H mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTA4H mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of LTA4H protein22230336
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of LTA4H mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LTA4H mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LTA4H mRNA24449571
C006632arsenic trioxideLTA4H protein results in decreased susceptibility to arsenic trioxide20707922
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LTA4H mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LTA4H mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of LTA4H mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LTA4H mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of LTA4H mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of LTA4H mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of LTA4H protein28903499
D002065BuspironeBuspirone results in decreased expression of LTA4H mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LTA4H protein24527689
D002220CarbamazepineCarbamazepine affects the expression of LTA4H mRNA25979313
C100187chloropicrinchloropicrin results in increased expression of LTA4H mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of LTA4H mRNA17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LTA4H mRNA17602206
D003035CobaltCobalt results in increased activity of LTA4H protein21670530
D019327Copper SulfateCopper Sulfate results in decreased expression of LTA4H mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of LTA4H mRNA24650576
C052568cyclohexenecyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
C052568cyclohexenecyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D016572CyclosporineCyclosporine results in decreased expression of LTA4H mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LTA4H mRNA24317228
C014347decitabinedecitabine affects the expression of LTA4H mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LTA4H mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of LTA4H mRNA14618091
C016366dibenzothiophenedibenzothiophene results in decreased expression of LTA4H mRNA23656968
D002945CisplatinCisplatin affects the expression of LTA4H mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LTA4H mRNA27392435
D002945CisplatinCisplatin results in increased expression of LTA4H mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of LTA4H mRNA28302478
D004026DieldrinDieldrin results in increased expression of LTA4H mRNA20438755
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LTA4H mRNA17602206
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LTA4H mRNA25380136
D004492Edetic AcidEdetic Acid results in decreased activity of LTA4H protein21670530
D007975Leukotriene B41-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]17371808
D007975Leukotriene B4cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D007975Leukotriene B4LTA4H protein results in increased chemical synthesis of Leukotriene B417371808|2827578
D007975Leukotriene B4Oxygen inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D007975Leukotriene B4Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D007975Leukotriene B4propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D007975Leukotriene B4LTA4H protein results in increased chemical synthesis of Leukotriene B420840853
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LTA4H mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LTA4H mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of LTA4H mRNA24796395
D017572Leukotriene A4cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D017572Leukotriene A4LTA4H protein results in increased hydrolysis of Leukotriene A42827578
D017572Leukotriene A4Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D017572Leukotriene A4Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D017572Leukotriene A4propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D017572Leukotriene A4LTA4H protein results in increased metabolism of Leukotriene A420840853
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LTA4H mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LTA4H mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of LTA4H mRNA29191790
D015741MetriboloneMetribolone results in increased expression of LTA4H protein17152098
C093875montelukastLTA4H gene SNP affects the susceptibility to montelukast16293801
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LTA4H mRNA25380136
C051752nefazodonenefazodone results in decreased expression of LTA4H mRNA24136188
D009532NickelNickel results in decreased expression of LTA4H mRNA23195993
C012655nimesulidenimesulide results in decreased expression of LTA4H mRNA24136188
C014707nitrosobenzylmethylamine[Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of LTA4H protein17985342
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LTA4H mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LTA4H mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LTA4H mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LTA4H mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LTA4H mRNA]17655762
D010100OxygenOxygen inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D010100OxygenOxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LTA4H mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of LTA4H mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LTA4H mRNA]17655762
C031375pepstatinpepstatin results in decreased activity of LTA4H protein21670530
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of LTA4H mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of LTA4H mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LTA4H protein28126411
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LTA4H mRNA19162173
D010578PetroleumPetroleum affects the expression of LTA4H mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTA4H mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LTA4H mRNA26272509
D010852PicrotoxinPicrotoxin results in increased expression of LTA4H mRNA15170462
D010882Piperonyl ButoxidePiperonyl Butoxide inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
D010882Piperonyl ButoxidePiperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
C006253pirinixic acidpirinixic acid results in decreased expression of LTA4H mRNA17426115
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LTA4H mRNA19162173
C030762propanethiolpropanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]2827578
C030762propanethiolpropanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]2827578
C037219quinolinequinoline analog results in increased expression of LTA4H protein18645022
C093642SB 203580SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTA4H mRNA]20382172
D012715Sesame OilSesame Oil results in increased expression of LTA4H mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of LTA4H mRNA18685790
D012999SomanSoman results in decreased expression of LTA4H mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTA4H mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LTA4H mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LTA4H mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of LTA4H protein20109541
D013849ThimerosalThimerosal results in decreased expression of LTA4H mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of LTA4H mRNA"19682533
C012589trichostatin Atrichostatin A affects the expression of LTA4H mRNA28542535
C080163trovafloxacintrovafloxacin results in decreased expression of LTA4H mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LTA4H mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LTA4H mRNA29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LTA4H mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of LTA4H mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LTA4H mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LTA4H gene25560391
C025643vinclozolinvinclozolin affects the expression of LTA4H mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of LTA4H mRNA20044591
C111237vorinostatvorinostat results in decreased expression of LTA4H protein20543569
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of LTA4H mRNA"25208076
D015032Zinc[Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of LTA4H protein17985342
D015032ZincZinc results in decreased activity of LTA4H protein21670530

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004177aminopeptidase activity-IDA9774412  15078870  18804029  
GO:0004301epoxide hydrolase activity-IBA21873635  
GO:0004301epoxide hydrolase activity-IDA15078870  
GO:0004301epoxide hydrolase activity-IMP11675384  
GO:0004301epoxide hydrolase activity-TAS11154734  
GO:0004463leukotriene-A4 hydrolase activity-IBA21873635  
GO:0004463leukotriene-A4 hydrolase activity-IDA9774412  15078870  
GO:0004463leukotriene-A4 hydrolase activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO:0008233peptidase activity-TAS1881903  
GO:0008270zinc ion binding-IDA15078870  18804029  
GO:0008270zinc ion binding-IMP11675384  
GO:0070006metalloaminopeptidase activity-IMP11675384  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006691leukotriene metabolic process-TAS-  
GO:0019370leukotriene biosynthetic process-IBA21873635  
GO:0019370leukotriene biosynthetic process-IDA9774412  15078870  
GO:0019370leukotriene biosynthetic process-IMP11675384  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043171peptide catabolic process-IDA9774412  15078870  18804029  
GO:0043312neutrophil degranulation-TAS-  
GO:0044255cellular lipid metabolic process-IBA21873635  
GO:0044267cellular protein metabolic process-IMP11675384  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018676Biosynthesis of D-series resolvinsTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018679Biosynthesis of EPA-derived SPMsTAS
R-HSA-9018681Biosynthesis of protectinsTAS
R-HSA-9018896Biosynthesis of E-series 18(S)-resolvinsTAS
R-HSA-9020265Biosynthesis of aspirin-triggered D-series resolvinsTAS
R-HSA-9023661Biosynthesis of E-series 18(R)-resolvinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27990118Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)Thompson MDFront Pharmacol
22206291The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. (2011 Dec 29)Tulah ASBMC Med Genet
25902778Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. (2015 Jun)Merhi MInflamm Res
24874071An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. (2014 Jul 1)Wells JMAm J Respir Crit Care Med