Gene info: ID 4049

Gene: LTA

GENE ID: 4049

Synonyms: LT|TNFB|TNFSF1|TNLG1E

Description: lymphotoxin alpha

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000226979 MIM:153440 Vega:OTTHUMG00000031135 UniprotKB:P01374

RefSeq: NG_012010.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 27

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03599224	chr6:31541349	LTA		2.600e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SERPINH1	0.735
DNAJB1	0.717
BAG3	0.708
NPC1L1	0.708
HSPA6	0.706
WNT11	0.705
HSPA1A	0.698
SNAI1	0.697
NFKB2	0.692
SESN2	0.686

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NXPH1	-0.46
HAPLN1	-0.458
PLD5	-0.395
IGF1	-0.39
LHX6	-0.387
GAD2	-0.381
OSTN	-0.379
VWC2	-0.376
GRIK1	-0.374
SLC35G1	-0.368

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00005	Etanercept	BiotechDrug	185243-69-0	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of LTA mRNA	19435785
C032668	1-nitropyrene	1-nitropyrene results in decreased expression of LTA mRNA	19428942
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of LTA mRNA"	20638727
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid affects the reaction [Lipopolysaccharides results in increased expression of LTA mRNA]"	25843059
C549066	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of LTA mRNA]"	26546572
D000082	Acetaminophen	LTA polymorphism affects the susceptibility to Acetaminophen	9696492
D000082	Acetaminophen	Acetaminophen results in increased expression of LTA mRNA	12540782
D000082	Acetaminophen	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LTA mRNA]"	12540782
C430898	AGN 194204	AGN 194204 results in decreased expression of LTA mRNA	16339527
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of LTA mRNA	28070108
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LTA mRNA	16483693
D000894	Anti-Inflammatory Agents, Non-Steroidal	"LTA gene SNP affects the susceptibility to Anti-Inflammatory Agents, Non-Steroidal"	16931544
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in decreased expression of LTA mRNA	19962721
D001151	Arsenic	Arsenic results in decreased expression of LTA mRNA	19962721
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of LTA mRNA	20458559
C006632	arsenic trioxide	arsenic trioxide results in increased expression of LTA mRNA	19730151
D001194	Asbestos	Asbestos results in increased expression of LTA mRNA	22398240
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of LTA protein"	20855422
D001241	Aspirin	LTA gene SNP affects the susceptibility to Aspirin	16931544
D004958	Estradiol	Estradiol results in increased expression of LTA mRNA	23373633
C006780	bisphenol A	bisphenol A results in decreased expression of LTA mRNA	25181051
C016274	bromoacetate	bromoacetate results in decreased expression of LTA mRNA	19753638
C016274	bromoacetate	bromoacetate results in increased expression of LTA mRNA	19753638
C028031	cadmium acetate	cadmium acetate affects the expression of LTA mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of LTA promoter	22457795
D002858	Chromium Alloys	[Chromium Alloys co-treated with cobaltous chloride] results in increased expression of LTA mRNA	25281833
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of LTA mRNA	19000754
C000488	cladosporin	cladosporin results in increased expression of LTA mRNA	19818335
D060729	Coal Ash	Coal Ash results in increased expression of LTA mRNA	19000753
D003035	Cobalt	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
C018021	cobaltous chloride	[Chromium Alloys co-treated with cobaltous chloride] results in increased expression of LTA mRNA	25281833
D003471	Cuprizone	Cuprizone results in decreased expression of LTA mRNA	27523638
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein	27430728
D003474	Curcumin	Curcumin results in decreased expression of LTA mRNA	16101141
D003474	Curcumin	Curcumin results in increased expression of LTA mRNA	17198877
C038459	curdlan	curdlan affects the expression of LTA mRNA	19904525
D016572	Cyclosporine	"Cyclosporine inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein]"	1371491
D016572	Cyclosporine	Cyclosporine results in decreased expression of LTA mRNA	25596134
D003703	Demecolcine	Demecolcine results in increased expression of LTA mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol results in increased expression of LTA mRNA	22968694
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of LTA mRNA	20079348
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of LTA mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of LTA mRNA	27392435
D002945	Cisplatin	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of LTA mRNA]"	26546572
D002945	Cisplatin	Cisplatin results in increased expression of LTA mRNA	26546572
D004041	Dietary Fats	Dietary Fats results in increased expression of LTA mRNA	23118937
C026066	enterotoxin A, Staphylococcal	"Cyclosporine inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein]"	1371491
C026066	enterotoxin A, Staphylococcal	"enterotoxin A, Staphylococcal results in increased expression of LTA protein"	1371491
C026066	enterotoxin A, Staphylococcal	"Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein]"	1371491
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of LTA protein	19180809
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of LTA gene	18384745
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of LTA mRNA	19428942
C020748	ferrous sulfate	ferrous sulfate results in increased expression of LTA mRNA	21540303
D005419	Flavonoids	Flavonoids results in increased expression of LTA mRNA	18035473
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in decreased expression of LTA mRNA	19962721
D005459	Fluorides	Fluorides results in decreased expression of LTA mRNA	19962721
D005665	Furosemide	Furosemide affects the expression of LTA mRNA	17497460
C043055	gallium arsenide	gallium arsenide results in decreased expression of LTA mRNA	14560044
C056507	gemcitabine	gemcitabine results in increased expression of LTA protein	20531411
D007052	Ibuprofen	LTA gene SNP affects the susceptibility to Ibuprofen	16931544
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased expression of BIRC3 protein]	17873517
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased expression of CFLAR protein]	17873517
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased expression of XIAP protein]	17873517
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of NFKBIA protein]	17873517
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of RELA protein]	17873517
D007213	Indomethacin	Indomethacin promotes the reaction [LTA protein results in increased cleavage of CASP3 protein]	17873517
D007213	Indomethacin	Indomethacin promotes the reaction [LTA protein results in increased cleavage of PARP1 protein]	17873517
D007501	Iron	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of LTA mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of LTA mRNA	27392435
C017461	lead nitrate	lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]	11891201
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of LTA mRNA"	23090859
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA	22777745
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid affects the reaction [Lipopolysaccharides results in increased expression of LTA mRNA]"	25843059
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LTA mRNA	12057914\|2584305
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LTA protein	21135813
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of LTA mRNA	26011545
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of LTA protein	20045430
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of LTA mRNA	19818335
D009532	Nickel	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
D009532	Nickel	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LTA mRNA"	12888634
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LTA mRNA]"	12540782
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of LTA mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of LTA mRNA"	22937105
D010126	Ozone	[H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of LTA mRNA]	20032013
D010126	Ozone	[LTA gene mutant form co-treated with Ozone] results in decreased expression of H2-EB1 mRNA	20032013
D010126	Ozone	[[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] co-treated with Ozone] results in decreased expression of H2-EB1 mRNA	20032013
D010126	Ozone	[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] inhibits the reaction [Ozone results in increased expression of H2-EB2 mRNA]	20032013
D010126	Ozone	[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] results in decreased susceptibility to Ozone	20032013
D010126	Ozone	LTA gene mutant form inhibits the reaction [Ozone results in increased expression of H2-EB2 mRNA]	20032013
D010126	Ozone	LTA gene mutant form results in decreased susceptibility to Ozone	20032013
D010126	Ozone	Ozone results in increased expression of LTA mRNA	20032013
D010269	Paraquat	Paraquat results in decreased expression of LTA mRNA	18836921
D052638	Particulate Matter	LTA protein affects the reaction [Particulate Matter results in decreased expression of UCP1]	28917655
D052638	Particulate Matter	LTA protein affects the susceptibility to Particulate Matter	28917655
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LTA mRNA"	25510870
D010936	Plant Extracts	Plant Extracts results in decreased expression of LTA mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of LTA mRNA	18332044
D011374	Progesterone	Progesterone results in increased expression of LTA mRNA	21549006
C010423	pyrithione zinc	pyrithione zinc results in increased expression of LTA mRNA	21424779
C059514	resveratrol	resveratrol results in decreased expression of LTA mRNA	23224687
C042734	rifaximin	[NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of LTA mRNA	22790967
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of LTA mRNA	19428942
C017947	sodium arsenite	sodium arsenite results in increased expression of LTA mRNA	21281968
D015086	2,6-Dichloroindophenol	"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA"	21034357
D053260	Soot	Soot results in decreased expression of LTA mRNA	19428942
D053260	Soot	Soot results in increased expression of LTA mRNA	26551751
D053260	Soot	Soot results in decreased expression of LTA mRNA	21914721
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of LTA mRNA	19818335
D016559	Tacrolimus	"Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein]"	1371491
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LTA mRNA	12167310
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LTA mRNA	19520675
C402696	TMC 120A	TMC 120A results in decreased expression of LTA mRNA	19818335
D014051	Toluene 2,4-Diisocyanate	"TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA]"	12356572
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA"	12356572
D014118	Toxins, Biological	"Toxins, Biological affects the expression of LTA mRNA"	19682533
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of LTA mRNA	22407948
C057693	troglitazone	troglitazone results in increased expression of LTA mRNA	19631733
C057693	troglitazone	troglitazone results in decreased expression of LTA mRNA	17569031
D014414	Tungsten	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
D014414	Tungsten	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of LTA mRNA	22198552
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA	22777745
D014750	Vincristine	Vincristine results in increased expression of LTA mRNA	23649840
C016837	zinc chloride	zinc chloride results in decreased expression of LTA mRNA	19428942
C016837	zinc chloride	zinc chloride results in increased expression of LTA mRNA	21540303

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	3001529
GO:0005125	cytokine activity	-	IEA	-
GO:0005164	tumor necrosis factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	15129282

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	-	IEA	-
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	-	IEA	-
GO:0006915	apoptotic process	-	TAS	6334807
GO:0006959	humoral immune response	-	IEA	-
GO:0007165	signal transduction	-	TAS	6334807
GO:0007267	cell-cell signaling	-	TAS	6334807
GO:0007584	response to nutrient	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032729	positive regulation of interferon-gamma production	-	IEA	-
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0042493	response to drug	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0044130	negative regulation of growth of symbiont in host	-	IEA	-
GO:0048147	negative regulation of fibroblast proliferation	-	IEA	-
GO:0048535	lymph node development	-	IEA	-
GO:0050830	defense response to Gram-positive bacterium	-	IEA	-
GO:0060252	positive regulation of glial cell proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04940	Type I diabetes mellitus

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	IEA
R-HSA-5669034	TNFs bind their physiological receptors	TAS
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TAS
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21686124	Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma. (2011)	Cerhan JR	Int J Mol Epidemiol Genet
17700210	Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. (2007 Sep)	Park S	Coron Artery Dis
16814297	Association between TNF and IL-1 bloc polymorphisms and plasma MCP-1 concentration. (2007 Jun)	Berrahmoune H	Atherosclerosis
25902778	Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. (2015 Jun)	Merhi M	Inflamm Res
12566517	Effect of TNF and LTA polymorphisms on biological markers of response to oxidative stimuli in coal miners: a model of gene-environment interaction. Tumour necrosis factor and lymphotoxin alpha. (2003 Feb)	Nadif R	J Med Genet
21621250	The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent. (2011 Oct)	Gremmel T	Thromb Res
22012847	Personality traits and coping compensate for disadvantageous decision-making in long-term alcohol abstinence. (2012 Jan-Feb)	Ando B	Alcohol Alcohol
19585495	Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach. (2009 Oct 15)	Castro FA	Int J Cancer
16164697	No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease. (2005 Oct)	Garcia-Gonzalez MA	Int J Immunogenet
22216278	Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)	Saade S	PLoS One
17036337	Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)	Carmichael SL	Am J Med Genet A
21163112	Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary artery disease. (2010 Nov)	Liu XL	Chin Med J (Engl)
28877606	Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction. (2018 Jan)	Sun J	Clin Appl Thromb Hemost
17040205	Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. (2007 Mar)	Asselbergs FW	Clin Sci (Lond)
17113059	Effect of the 252A>G polymorphism of the lymphotoxin-alpha gene on inflammatory markers of response to cigarette smoking in Korean healthy men. (2007 Feb)	Jang Y	Clin Chim Acta
26747782	Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. (2016 Mar 15)	Gaydos J	Am J Physiol Lung Cell Mol Physiol
21425908	Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)	El-Hage N	Immunol Invest
28063392	Differences in the verbal fluency, working memory and executive functions in alcoholics: Short-term vs. long-term abstainers. (2017 Mar)	Nowakowska-Domagala K	Psychiatry Res
16298864	Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. (2005 Dec)	Nadif R	Free Radic Res
17212707	Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (2007 Jan)	Palikhe A	Tissue Antigens
18032375	Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. (2008 Jan)	Blasko B	Int Immunol
18704761	Molecular genetics of myocardial infarction. (2008 Jan)	Yamada Y	Genomic Med
19365711	Association of LT-alpha Ala252Gly gene polymorphism and the genetic predisposition of coronary heart disease in Chinese. (2010 Jan)	Gao H	Mol Biol Rep
17640324	Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. (2007 Sep)	Garcia-Gonzalez MA	Am J Gastroenterol
22835628	Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk. (2012 Sep)	Camacho M	Atherosclerosis
17450233	Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. (2007 Apr)	Wu H	Environ Health Perspect
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res