Gene: ARNT

405
HIF-1-beta|HIF-1beta|HIF1-beta|HIF1B|HIF1BETA|TANGO|bHLHe2
aryl hydrocarbon receptor nuclear translocator
protein-coding
1q21.3
Ensembl:ENSG00000143437 MIM:126110 Vega:OTTHUMG00000035011 UniprotKB:P27540
NG_028248.1
PubMed
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.081e-1 (AD)  9.758e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13896879chr1:150785718ARNTGene body2.661e-4Alcohol use disorders26763658
cg13357341chr1:150849964ARNTPromoter4.494e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC170.901
ANKHD10.901
SF3B10.896
PIAS30.896
DDX50.896
CNOT10.891
SETDB10.888
SON0.887
FKBP150.886
SNRNP2000.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.678
OR4F29-0.661
KLRC2-0.185
NANOGNB-0.179
PLA2G5-0.146
HMHB1-0.146
CARD17-0.144
OR4F16-0.137
HES5-0.135
CNBD2-0.135

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C54112011-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of ARNT mRNA]"22127542
C0407561,2-naphthoquinone"1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein]"26558468|2785310
C1214071-ethylpyrene1-ethylpyrene results in increased activity of [AHR protein co-treated with ARNT protein]10581206
C0428811-ethynylpyrene1-ethynylpyrene results in increased activity of [AHR protein co-treated with ARNT protein]10581206
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]15313166
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]"21703235
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1B1 promoter]"21703235
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]"21703235
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1B1 promoter]"21703235
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ARNT mRNA"16111922
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [AHR protein binds to ARNT protein]"20951181
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"ARNT protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"23208499
C0512902-tert-butyl-4-quinone2-tert-butyl-4-quinone affects the reaction [AHR protein binds to ARNT protein]27853106
C0512902-tert-butyl-4-quinone2-tert-butyl-4-quinone promotes the reaction [AHR protein binds to ARNT protein]26558468
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]"20846786
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]"20846786
C0163923,3'-diindolylmethane"3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter]"16972788
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]"18708364
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ARNT protein binds to CYP1A1 promoter]"16972788
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased activity of [AHR protein binds to ARNT protein]"11294989
C0284513,4,3',4'-tetrachlorobiphenyl"resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]"18708364
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]"18708364
C0284513,4,3',4'-tetrachlorobiphenyl"resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]"18708364
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNA"17291011
C0284513,4,3',4'-tetrachlorobiphenyl"alpha-naphthoflavone affects the reaction [3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNA]"17291011
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of ARNT mRNA"26363503
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]"22138065
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]"22138065
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone results in decreased expression of ARNT protein"22138065
C5758943,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide"3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide inhibits the reaction [[HIF1A protein binds to ARNT protein] binds to [EP300 protein binds to CREBBP protein]]"22032632
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of ARNT protein"18682687
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone affects the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12644593
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12644593
C0917683'-methoxy-4'-nitroflavoneARNT protein promotes the reaction [3'-methoxy-4'-nitroflavone results in increased expression of CYP1A1 protein]12859983
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of ARNT mRNA14610520
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ARNT mRNA20829426
C5466076,2',4'-trimethoxyflavone"6,2',4'-trimethoxyflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to IL6 promoter]"21104991
C5466076,2',4'-trimethoxyflavone"6,2',4'-trimethoxyflavone inhibits the reaction [ARNT protein binds to CYP1A1 promoter]"19828881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased localization of ARNT protein"21756928
C1118556-formylindolo(3,2-b)carbazole"Quercetin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of ARNT protein]"21756928
C0549236-methyl-1,3,8-trichlorodibenzofuran"6-methyl-1,3,8-trichlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]"16972788
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]16880289
C058956acteosideacteoside results in increased localization of ARNT protein21756928
D000242Cyclic AMPCyclic AMP inhibits the reaction [AHR protein binds to ARNT protein]12859982
C016601afimoxifeneafimoxifene promotes the reaction [AHR protein binds to ARNT protein]19901195
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ARNT gene27153756
D016604Aflatoxin B1ARNT protein affects the reaction [Aflatoxin B1 results in increased phosphorylation of H2AFX protein]28882572
D016604Aflatoxin B1ARNT protein affects the susceptibility to Aflatoxin B128882572
C412373AG 1879AG 1879 promotes the reaction [AHR protein binds to ARNT protein]25082669
C011512alpha-naphthoflavonealpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]21127131
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]11768231
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]11768231
C011512alpha-naphthoflavonealpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]21127131
C011512alpha-naphthoflavone"alpha-naphthoflavone affects the reaction [3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNA]"17291011
C005197alternariolARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]22120949
C005197alternariolARNT protein affects the susceptibility to alternariol22120949
C018206alternariol monomethyl etherARNT protein affects the reaction [alternariol monomethyl ether results in increased expression of CYP1A1 protein]22120949
D000666Amphotericin BAmphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]16189267
C034020anthracene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein28710019
C034020anthracene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA28710019
C034020anthracene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA28710019
D047310ApigeninApigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
D047310ApigeninApigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
C015001arsenitearsenite inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter]]22159698
C015001arsenitearsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of and results in increased localization of [AHR protein co-treated with ARNT protein]]22159698
D001280AtrazineAtrazine results in increased expression of ARNT mRNA22378314
C406592azaspiracidazaspiracid results in decreased expression of ARNT mRNA28939011
C076588benzo(a)pyrene-7,8-dione"ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]"10706104
D019324beta-NaphthoflavoneARNT protein affects the susceptibility to beta-Naphthoflavone20554057
D019324beta-NaphthoflavoneAHR gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]24486526
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]19901195
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]21127131|2448652
D019324beta-NaphthoflavoneARNT affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]21849270
D019324beta-NaphthoflavoneARNT promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid]21849270
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]17012224
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]17012224
D019324beta-Naphthoflavonekaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]17012224
D019324beta-Naphthoflavonekaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]17012224
D001564Benzo(a)pyrene[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Benzo(a)pyrene24486526
D001564Benzo(a)pyreneARNT protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]28882572
D001564Benzo(a)pyreneARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneARNT protein affects the susceptibility to Benzo(a)pyrene28882572
D001564Benzo(a)pyreneBenzo(a)pyrene affects the localization of ARNT protein26350169
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]20228066
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]11768231
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]26303333
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]16972788
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARNT mRNA21256954
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARNT mRNA18247414
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]21507987
D001564Benzo(a)pyreneQuercetin promotes the reaction [Benzo(a)pyrene results in decreased expression of ARNT mRNA]21256954
D001564Benzo(a)pyreneARNT protein results in increased susceptibility to Benzo(a)pyrene19755658
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARNT mRNA22228805
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of ARNT mRNA"28987381
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [ARNT protein binds to GNMT protein]21445860
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[AHR protein co-treated with ARNT protein] results in increased expression of SLC13A5 mRNA]26303333
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARNT mRNA26303333|2646635
D001564Benzo(a)pyreneINS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]26466350
D001564Benzo(a)pyreneSulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]26466350
D001564Benzo(a)pyrenewortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]26466350
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]16880289
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARNT protein15899923
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]14529614
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA14529614
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA]14529614
D004958EstradiolEstradiol affects the expression of ARNT mRNA23557687
D004958EstradiolAHR gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]]24299737
D004958EstradiolAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]]]24299737
D004958EstradiolARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]24299737
D004958EstradiolARNT protein affects the reaction [Estradiol results in increased expression of CTSD mRNA]22235307
D004958EstradiolARNT protein affects the reaction [Estradiol results in increased expression of TFF1 mRNA]22235307
D004958EstradiolARNT protein affects the susceptibility to Estradiol22235307
D004958EstradiolEstradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]24299737
D004958EstradiolEstradiol promotes the reaction [ARNT protein binds to HSPB8 promoter]22071320
D004958EstradiolEstradiol promotes the reaction [ARNT protein binds to TFF1 promoter]22071320|2223530
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]16675542
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]24299737
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]22235307|2429973
D004958Estradiol[Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]11165043
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]]24299737
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]24299737
D004958EstradiolEstradiol promotes the reaction [ARNT protein binds to FOS promoter]17991765
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]17991765
D004958EstradiolEstradiol promotes the reaction [[ARNT protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]15774498
D004958Estradiol"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of ARNT mRNA]"22127542
D004958EstradiolEstradiol affects the expression of ARNT mRNA24777823
D004958EstradiolEstradiol results in decreased expression of ARNT mRNA22127542
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of ARNT mRNA24777823
C099952bifenthrinbifenthrin results in increased expression of ARNT mRNA26071804
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA]14529614
C006780bisphenol Abisphenol A affects the methylation of ARNT promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ARNT mRNA23928317
C006780bisphenol Abisphenol A results in increased expression of ARNT mRNA16284450
C006780bisphenol Abisphenol A results in decreased expression of ARNT mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of ARNT protein16880289
C027561butylbenzyl phthalate"3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]"22138065
C027561butylbenzyl phthalate"3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]"22138065
C027561butylbenzyl phthalateAHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]22138065
C027561butylbenzyl phthalateAHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]22138065
C027561butylbenzyl phthalatebutylbenzyl phthalate promotes the reaction [AHR protein binds to ARNT protein]22138065
C027561butylbenzyl phthalatebutylbenzyl phthalate results in increased expression of ARNT mRNA22138065
C027561butylbenzyl phthalatebutylbenzyl phthalate results in increased expression of ARNT protein22138065
D002220CarbamazepineCarbamazepine affects the expression of ARNT mRNA24752500
D057846Cell-Penetrating PeptidesCell-Penetrating Peptides binds to ARNT protein23454269
D057846Cell-Penetrating Peptides[Cell-Penetrating Peptides binds to ARNT protein] inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]23454269
D057846Cell-Penetrating Peptides[Cell-Penetrating Peptides binds to ARNT protein] inhibits the reaction [HIF1A protein binds to ARNT protein]23454269
D057846Cell-Penetrating Peptides[[Cell-Penetrating Peptides binds to ARNT protein] inhibits the reaction [HIF1A protein binds to ARNT protein]] which results in decreased activity of HIF1A protein23454269
D057846Cell-Penetrating Peptides[Cell-Penetrating Peptides binds to ARNT protein] which results in decreased activity of HIF1A protein23454269
D002518CeramidesARNT protein affects the abundance of Ceramides14597763
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]18708364
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of ARNT mRNA]"22079312
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of ARNT protein17382205
C043561chrysinchrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]16972788
D003035CobaltCobalt results in increased activity of [ARNT protein binds to HIF1A protein]11739637
C018021cobaltous chlorideARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]24299737
C018021cobaltous chlorideARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]24299737
C018021cobaltous chlorideBenzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]20228066
C018021cobaltous chloridecobaltous chloride affects the localization of ARNT protein25826687|2635016
C018021cobaltous chloridecobaltous chloride promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]17599377
C018021cobaltous chloridecobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]20228066
C018021cobaltous chloridecobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]10939628
C018021cobaltous chlorideGenistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
C018021cobaltous chlorideARNT affects the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]11043581
C018021cobaltous chlorideARNT affects the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA]11043581
C018021cobaltous chloridecobaltous chloride promotes the reaction [HIF3A protein binds to ARNT protein]14729976
C018021cobaltous chloride[cobaltous chloride promotes the reaction [HIF3A protein binds to ARNT protein]] which results in increased expression of ALDH1A1 mRNA14729976
C018021cobaltous chloridecobaltous chloride promotes the reaction [[HIF1A protein co-treated with ARNT protein] results in increased expression of LOX mRNA]23161664
C018021cobaltous chloridecobaltous chloride results in increased expression of ARNT protein10559391
C018021cobaltous chloride[Cell-Penetrating Peptides binds to ARNT protein] inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]23454269
D003300CopperCopper results in increased activity of [AHR protein binds to ARNT protein]16093525
D003300CopperCopper results in increased activity of [AHR protein binds to ARNT protein]16093525
D003375CoumestrolCoumestrol results in decreased expression of ARNT mRNA19167446
D003474CurcuminAcetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]16880289
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]16880289
D003474CurcuminCurcumin results in decreased expression of ARNT protein18682687
D003474CurcuminCurcumin results in increased degradation of ARNT protein19018768
D003474CurcuminCurcumin results in increased ubiquitination of and results in increased degradation of ARNT protein16880289
D003474CurcuminCurcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]17880909
D003474CurcuminCurcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]17880909
D003474CurcuminCurcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]17880909
D003513CycloheximideCycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]20570689
D003513CycloheximideCycloheximide results in increased activity of [AHR protein binds to ARNT protein]12002481
D003513Cycloheximide[Cycloheximide results in increased activity of [AHR protein binds to ARNT protein]] which results in increased expression of CYP1A1 mRNA12002481
C108338cyprodinilARNT protein affects the reaction [cyprodinil results in increased expression of CYP1A1 protein]23228475
D003609DactinomycinARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]]16226227
D003634DDTDDT analog results in increased expression of ARNT mRNA24213010
D003676DeferoxamineDeferoxamine results in increased activity of ARNT protein10559391
C017185delphinidindelphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein]18603805
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ARNT mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ARNT mRNA19615983
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of ARNT mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of ARNT mRNA"22079312
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARNT mRNA21266533
D004008DiclofenacDiclofenac affects the expression of ARNT mRNA24752500
C121718dicyclanil[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of ARNT mRNA19182440
C121718dicyclanilPlant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]19182440
D004041Dietary FatsDietary Fats results in decreased expression of ARNT mRNA18042831
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of ARNT mRNA"23626681
D004052Diethylnitrosamine[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of ARNT mRNA19182440
D004052DiethylnitrosaminePlant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]19182440
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]16675542
C070609EMD 53998EMD 53998 analog results in decreased expression of ARNT mRNA24977338
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of ARNT mRNA25398874
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ARNT protein23301498
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARNT mRNA22079256
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D000431EthanolEthanol results in decreased expression of ARNT mRNA15353170
D000431EthanolEthanol results in increased expression of ARNT mRNA23273579
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARNT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARNT mRNA17207528
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of ARNT mRNA22711419
D015025ZearalenoneZearalenone results in increased expression of ARNT mRNA20607812
D015725Fluconazole[Fluconazole binds to and results in increased activity of AHR protein] results in increased activity of [AHR protein binds to ARNT protein]17283379
C007738fluoranthene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein28710019
C007738fluoranthene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA28710019
C007738fluoranthene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA28710019
C056507gemcitabinegemcitabine results in increased expression of ARNT mRNA20103597
D019833GenisteinGenistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D019833GenisteinGenistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D005947GlucoseGlucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]15767253
D005947Glucose[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]18227068
D005947GlucoseGlucose results in increased activity of ARNT protein15767253
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]]18227068
D006246HarmalineHarmaline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]22037238
C007904harmalolharmalol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]22037238
D006247HarmineHarmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]22001777
C001326harmolharmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]22001777
D006861Hydrogen Peroxidedelphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein]18603805
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARNT protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ARNT protein16880289|2238769
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ARNT protein18603805
D007200IndicanIndican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]26259605
C027185indirubinindirubin results in increased activity of ARNT protein12972062
C027185indirubinindirubin promotes the reaction [AHR protein binds to ARNT protein]20951181
C030374indoleindole results in increased activity of [AHR protein binds to ARNT protein]9407059
C030737indoleacetic acidindoleacetic acid results in increased activity of [AHR protein binds to ARNT protein]9407059
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]"26259605
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter]"27226639
D007501IronARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter]10777486
D017964Itraconazole[Itraconazole binds to and results in increased activity of AHR protein] results in increased activity of [AHR protein binds to ARNT protein]17283379
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]]27292261
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]20846786
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]20846786
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]20846786
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]20846786
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
C006552kaempferolkaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]17012224
C006552kaempferolkaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]17012224
C006552kaempferolkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D007654Ketoconazole[Ketoconazole binds to and results in increased activity of AHR protein] results in increased activity of [AHR protein binds to ARNT protein]17283379
D019344Lactic AcidARNT promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid]21849270
D007854LeadLead results in increased activity of [AHR protein binds to ARNT protein]16093525
D007854LeadLead results in increased expression of ARNT mRNA19921347
D007854LeadLead results in increased activity of [AHR protein binds to ARNT protein]16093525
D001556LindaneLindane results in increased expression of ARNT mRNA25572523
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of ARNT mRNA"28987381
C025340manganese chlorideARNT gene mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]19263519
D008628MercuryMercury results in increased activity of [AHR protein binds to ARNT protein]16093525
D008628MercuryMercury results in increased activity of [AHR protein binds to ARNT protein]16093525
D008727MethotrexateMethotrexate results in decreased expression of ARNT mRNA24449571
D008727MethotrexateMethotrexate affects the expression of ARNT mRNA18502557
D008731MethoxychlorMethoxychlor results in decreased expression of ARNT mRNA23303685
D008748Methylcholanthrene[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene24486526
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]11768231
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]11768231
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased localization of ARNT protein21756928
D008748MethylcholanthreneCycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]20570689
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]20570689
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ARNT mRNA19951702|2327357
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARNT mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ARNT mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of ARNT mRNA29191790
D008898MimosineMimosine results in increased activity of ARNT protein10559391
C031721naphthalene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein28710019
C031721naphthalene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA28710019
C031721naphthalene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA28710019
C005273naringeninnaringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
C005273naringeninnaringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D019829NevirapineNevirapine metabolite results in increased expression of ARNT mRNA23947594
D009532NickelNickel results in increased activity of [ARNT protein binds to HIF1A protein]11739637
C022838nickel chlorideHIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]12729255
C029938nickel sulfatenickel sulfate affects the localization of ARNT protein17382205
C010615Nonidet P-40Nonidet P-40 results in decreased expression of ARNT mRNA26552463
C464745norisoboldinenorisoboldine promotes the reaction [AHR protein binds to ARNT protein]26221077
D019319Okadaic AcidOkadaic Acid results in increased expression of ARNT mRNA28939011
D009853OmeprazoleOmeprazole affects the localization of ARNT protein25826687
D009853OmeprazoleOmeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]21703235
D009853OmeprazoleOmeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]21703235
D009853OmeprazoleOmeprazole affects the localization of [ARNT protein co-treated with AHR protein]9395520
C016340o,p'-DDT"o,p'-DDT results in decreased expression of ARNT mRNA"28263910
C016340o,p'-DDT"o,p'-DDT results in decreased expression of ARNT protein"28263910
D010069OxadiazolesARNT mutant form inhibits the reaction [[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of DSG1A mRNA]23212921
D010069OxadiazolesARNT protein affects the reaction [Oxadiazoles analog results in increased expression of CYP1A1 protein]23212921
D010100OxygenOxygen deficiency results in decreased expression of ARNT mRNA11401503
D010100OxygenARNT protein affects the reaction [Oxygen deficiency results in increased activity of CP promoter]10777486
D010100OxygenARNT protein inhibits the reaction [Oxygen deficiency results in decreased activity of AHR protein]24355420
D010100OxygenARNT protein results in decreased susceptibility to Oxygen deficiency24355420
D010100OxygenGenistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D010100OxygenHIF1A protein alternative form inhibits the reaction [Oxygen deficiency affects the localization of ARNT protein]11739637
D010100Oxygen[HIF1A protein alternative form inhibits the reaction [Oxygen deficiency affects the localization of ARNT protein]] promotes the reaction [HIF1A protein alternative form binds to ARNT protein]11739637
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]]27292261
D010100OxygenOxygen deficiency affects the localization of ARNT protein11739637
D010100OxygenOxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]27292261
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]10939628
D010100OxygenOxygen deficiency promotes the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]16189267
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of ANGPT1 mRNA]20412331
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]20412331
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]20412331
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]20412331
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]20412331
D010100OxygenARNT gene mutant form results in decreased susceptibility to Oxygen deficiency20412331
D010100OxygenARNT protein affects the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
D010100Oxygen[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]18227068
D010100Oxygen[ARNT protein binds to HIF1A protein] which affects the susceptibility to Oxygen deficiency22387692
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]]18227068
D010100Oxygen[Oxygen deficiency affects the localization of ARNT protein] promotes the reaction [ARNT protein binds to HIF1A protein]11739637
D010100Oxygen[Oxygen deficiency affects the localization of ARNT protein] results in increased activity of [ARNT protein binds to HIF1A protein]11739637
D010100OxygenOxygen deficiency promotes the reaction [ARNT protein binds to HIF1A protein]11739637
D010100OxygenOxygen deficiency results in increased activity of [ARNT protein binds to HIF1A protein]11739637
D010100Oxygen[Oxygen deficiency results in increased expression of and affects the localization of HIF1A protein] promotes the reaction [HIF1A protein binds to ARNT protein]19263519
D010126OzoneOzone results in increased expression of ARNT mRNA27206323
D000073878Palm OilPalm Oil results in decreased expression of ARNT mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of ARNT mRNA22352393|2421647
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of ARNT mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ARNT mRNA23626681
C031181phenanthrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein28710019
C031181phenanthrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA28710019
C031181phenanthrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA28710019
D010634PhenobarbitalPhenobarbital results in increased expression of ARNT mRNA23273579
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARNT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ARNT mRNA26272509
D010936Plant ExtractsPlant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]19182440
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls metabolite affects the expression of ARNT mRNA17207528
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of ARNT protein28710019
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons promotes the reaction [AHR protein binds to ARNT protein]15832810
C058229polydatinpolydatin results in increased localization of ARNT protein21756928
C027373potassium chromate(VI)potassium chromate(VI) affects the localization of ARNT protein17382205
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARNT mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARNT mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of ARNT mRNA23608068
C045362prochlorazprochloraz affects the expression of ARNT mRNA25182419
D011374ProgesteroneProgesterone affects the expression of ARNT mRNA24777823
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of ARNT mRNA24777823
C030984pyrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein28710019
C030984pyrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA28710019
C030984pyrene[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA28710019
D011794Quercetin"Quercetin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of ARNT protein]"21756928
D011794QuercetinQuercetin promotes the reaction [Benzo(a)pyrene results in decreased expression of ARNT mRNA]21256954
D011794QuercetinQuercetin results in decreased expression of ARNT mRNA21256954
D011794QuercetinQuercetin results in increased localization of ARNT protein21756928
C059514resveratrol"resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]"18708364
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]19376845|2084678
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]20846786
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]19376845|2084678
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]20846786
C059514resveratrolresveratrol results in increased localization of ARNT protein21756928
C059514resveratrol"resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]"18708364
C488333Ro 65-7199Ro 65-7199 affects the expression of ARNT mRNA14610520
D012431RutinRutin results in increased localization of ARNT protein21756928
C005705sanguinarinesanguinarine promotes the reaction [AHR protein binds to ARNT protein]15993743
C093642SB 203580SB 203580 results in increased activity of [AHR protein binds to ARNT protein]21732638
C417521SB 216763ARNT protein promotes the reaction [SB 216763 results in increased expression of CYP1A1 mRNA]19448134
D012715Sesame OilSesame Oil results in decreased expression of ARNT mRNA29191790
D012906SmokeSmoke results in increased expression of ARNT mRNA23069111
C033006sudan III[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]22287322
D013469SulpirideSulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]26466350
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ARNT mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of ARNT mRNA17555576
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone affects the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12644593
D013749TetrachlorodibenzodioxinHarmaline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]22037238
D013749Tetrachlorodibenzodioxinharmalol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]22037238
D013749TetrachlorodibenzodioxinHarmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]22001777
D013749Tetrachlorodibenzodioxinharmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]22001777
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] results in increased activity of [AHR protein binds to ARNT protein]17283379
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]22037238|2328814
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]12644593|2200177
D013749TetrachlorodibenzodioxinARNT protein affects the susceptibility to Tetrachlorodibenzodioxin16306231|1693622
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A protein]16214955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR2 protein binds to ARNT protein]16214955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[ARNT protein alternative form binds to AHR2 protein] which binds to CYP1A promoter]16306231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]11606800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]11606800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARNT mRNA26043675
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [LHB protein affects the expression of ARNT mRNA]26043675
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR1 protein binds to ARNT protein] which binds to CYP1A5 promoter]18948129
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]21134488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]11294989|2113448
D013749Tetrachlorodibenzodioxin"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]"20846786
D013749Tetrachlorodibenzodioxin"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]"20846786
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]]24299737
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]24299737
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]]24299737
D013749TetrachlorodibenzodioxinApigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]24299737
D013749TetrachlorodibenzodioxinARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]24299737
D013749TetrachlorodibenzodioxinARNT mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]20511231
D013749TetrachlorodibenzodioxinARNT mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]20511231
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]]16567799
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein]19131362
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]19147701
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]11165043
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]28673560
D013749Tetrachlorodibenzodioxinepigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]16675542
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]24299737
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]22235307|2429973
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]20846786
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]20846786
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]20846786
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]20846786
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
D013749Tetrachlorodibenzodioxinnaringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]20450880
D013749TetrachlorodibenzodioxinNCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12024042
D013749TetrachlorodibenzodioxinNCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12024042
D013749TetrachlorodibenzodioxinNCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12024042
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]19376845|2084678
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]20846786
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]19376845|2084678
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]20846786
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of ARNT protein25826687
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]11165043
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]11165043
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of ARNT mRNA15075337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]17823304|8397410
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CTSD promoter]11165043
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]11368516|1531316
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]17599377|1854169
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer]12801909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in decreased expression of CTSD mRNA]11165043
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]11368516|1202404
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]19376845|2084678
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 gene]24806346
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]16567799|1697278
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]19376845|2084678
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 gene]24806346
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]16567799|2084678
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to HSPB8 promoter]22071320
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]22071320|2223530
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TSKU promoter]22071320
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to UGT1A1 promoter]16399344
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA15075337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARNT protein9783729
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]11294989|1136851
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of ARNT protein15982688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT mRNA12727795|2199813
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT protein9787404
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein20450880
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12644593
D013749TetrachlorodibenzodioxinApigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D013749TetrachlorodibenzodioxinARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]20935161
D013749TetrachlorodibenzodioxinARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]11043581|2093516
D013749TetrachlorodibenzodioxinARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]11043581|2093516
D013749TetrachlorodibenzodioxinARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]20935161
D013749TetrachlorodibenzodioxinARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]11043581
D013749TetrachlorodibenzodioxinARNT mutant form inhibits the reaction [[Tetrachlorodibenzodioxin analog co-treated with FGF2 protein] results in increased expression of DSG1A mRNA]23212921
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of H2-Q1 mRNA]9368027
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of ENTPD2 protein]9624117
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]23212921
D013749TetrachlorodibenzodioxinARNT protein affects the susceptibility to Tetrachlorodibenzodioxin14530333|9624117
D013749TetrachlorodibenzodioxinARNT protein inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN2 protein]]25265996
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]]16226227
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]7828219
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]12111005|1285998
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]12111005
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]12111005
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA]12147270
D013749TetrachlorodibenzodioxinARNT results in increased susceptibility to Tetrachlorodibenzodioxin20935161
D013749TetrachlorodibenzodioxinCurcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]17880909
D013749TetrachlorodibenzodioxinCurcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]17880909
D013749TetrachlorodibenzodioxinCurcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]17880909
D013749Tetrachlorodibenzodioxinepigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D013749Tetrachlorodibenzodioxinkaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D013749TetrachlorodibenzodioxinMAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]]20450880
D013749TetrachlorodibenzodioxinMAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]]20450880
D013749TetrachlorodibenzodioxinMAP2K2 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]]20450880
D013749TetrachlorodibenzodioxinMAP2K2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]]20450880
D013749Tetrachlorodibenzodioxinnaringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]20450880
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARNT mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to [AHR protein binds to ARNT protein]] which results in increased expression of CYP2A5 mRNA15657367
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]17991765
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]12139968|1223732
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]26259605
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CXCL5 promoter]28973351
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]10871357|1160680
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP2S1 promoter]17277313
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter]27226639
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUND mRNA8917696
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUN mRNA8917696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 enhancer]7791778
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]20450880
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 5' UTR]12917420
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to FMO3 enhancer]18765683
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CHUK protein binds to AHR protein binds to ARNT protein]24519526
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA10048155|2470967
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]12644593
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]10581206|1069256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]20450880
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT mRNA15667827|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased localization of ARNT protein14761680
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein17880909
D013749TetrachlorodibenzodioxinU 0126 inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]]20450880
D013749TetrachlorodibenzodioxinU 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]]20450880
D013749TetrachlorodibenzodioxinUrsodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein]14761680
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of ARNT protein alternative form8940073
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR1 protein binds to ARNT protein] which binds to CYP1A5 promoter]18948129
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]23196670
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]23196670
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FOXQ1 mRNA]23196670
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]23196670
D013749Tetrachlorodibenzodioxinarsenite inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter]]22159698
D013749Tetrachlorodibenzodioxinarsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of and results in increased localization of [AHR protein co-treated with ARNT protein]]22159698
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which binds to ARNT protein7808420|9056263
D013749Tetrachlorodibenzodioxin[[Tetrachlorodibenzodioxin binds to AHR protein] which binds to ARNT protein] which binds to CYP1A1 enhancer7808420
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer]12859982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter]22159698
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA20959002|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]9056263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of and results in increased localization of [AHR protein co-treated with ARNT protein]22159698
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT mRNA28341572
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARNT protein12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein23298284
D013749Tetrachlorodibenzodioxin[AHR protein co-treated with ARNT protein] affects the susceptibility to Tetrachlorodibenzodioxin22903824
D013752TetracyclineTetracycline results in increased expression of ARNT mRNA16917069
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARNT protein18951874
D013849ThimerosalThimerosal results in decreased expression of ARNT mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARNT mRNA27404394|2786577
D014212Tretinoin[Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of ARNT mRNA15075337
C046243tryptanthrinetryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]26259605
C113580U 0126U 0126 inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]]20450880
C113580U 0126U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]]20450880
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein]14761680
C406224valdecoxibvaldecoxib results in decreased expression of ARNT mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ARNT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARNT mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of ARNT gene29154799
D014639VanadiumVanadium inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]18541696
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of ARNT mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARNT gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ARNT mRNA22352393|2421647
C499198WAY-169916[AHR protein binds to ARNT protein] which affects the susceptibility to WAY-16991619903824
C009687wortmanninwortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]26466350
C009687wortmanninwortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]26466350
D015032ZincZinc inhibits the reaction [ARNT protein binds to HIF1A protein]11739637
D015032ZincZinc results in decreased localization of ARNT protein11739637
D015032Zinc[Zinc results in decreased localization of ARNT protein] inhibits the reaction [ARNT protein binds to HIF1A protein]11739637
D015032Zinc[Zinc results in increased expression of HIF1A mRNA alternative form] which results in decreased localization of ARNT protein11739637

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000989transcription factor activity, transcription factor binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS1317062  10777486  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingcontributes_toIDA7539918  8756616  
GO:0003713transcription coactivator activity-IEA-  
GO:0004874aryl hydrocarbon receptor activity-IEA-  
GO:0005515protein binding-IPI9704006  10395741  11018023  16181639  19129502  19168635  
20562859  20603618  20932347  21620138  23434853  24434214  
28396409  
GO:0008134transcription factor binding-IPI7539918  9079689  10692439  
GO:0017162aryl hydrocarbon receptor binding-IPI9079689  
GO:0035326enhancer binding-IDA23275542  
GO:0042803protein homodimerization activity-IDA16181639  
GO:0043565sequence-specific DNA bindingcontributes_toIDA7539918  
GO:0046982protein heterodimerization activity-IDA16181639  
GO:0046982protein heterodimerization activity-IPI9079689  
GO:1990837sequence-specific double-stranded DNA binding-IDA28396409  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA8756616  
GO:0001892embryonic placenta development-IEA-  
GO:0001938positive regulation of endothelial cell proliferation-IC8756616  
GO:0006351transcription, DNA-templated-TAS1317062  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0010575positive regulation of vascular endothelial growth factor production-IDA8756616  
GO:0030154cell differentiation-IEA-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IC8756616  
GO:0033235positive regulation of protein sumoylation-IEA-  
GO:0042789mRNA transcription by RNA polymerase II-IC7539918  
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IDA8089148  
GO:0045648positive regulation of erythrocyte differentiation-IC1448077  
GO:0045821positive regulation of glycolytic process-IC8089148  
GO:0045893positive regulation of transcription, DNA-templated-IDA8089148  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046886positive regulation of hormone biosynthetic process-IDA1448077  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA8089148  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016604nuclear body-IDA-  
GO:0090575RNA polymerase II transcription factor complex-IDA7539918  8756616  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1234158Regulation of gene expression by Hypoxia-inducible FactorTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-211981XenobioticsTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8937144Aryl hydrocarbon receptor signallingTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10837748The expression and regulation of drug metabolism in human placenta. (1999 Jun 14)Pasanen MAdv Drug Deliv Rev
27129092Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor. (2016 Jul)Hong CHInt Immunopharmacol
7581493Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. (1995)Kawajiri KPharmacogenetics
29459183Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018 Apr)Nikodemova MEnviron Int
27977510A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility. (2017 Feb)Polonikov AVPharmacogenet Genomics
12520072Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes. (2003 Jan)Lin PToxicol Sci
11186136An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or CYP1A1 genes. (2000 Nov)Anttila SPharmacogenetics
7515333Interindividual difference in expression of human Ah receptor and related P450 genes. (1994 May)Hayashi SCarcinogenesis
21081473Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. (2011 Feb)Wang HCarcinogenesis
23069111Cigarette smoke condensate induces aryl hydrocarbon receptor-dependent changes in gene expression in spermatocytes. (2012 Dec)Esakky PReprod Toxicol
11455387Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. (2001 Aug)Matikainen TNat Genet