Gene: LTB

4050
TNFC|TNFSF3|TNLG1C|p33
lymphotoxin beta
protein-coding
6p21.33
Ensembl:ENSG00000227507 MIM:600978 Vega:OTTHUMG00000031136 UniprotKB:Q06643
NC_000006.12
PubMed
0   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC11A0.561
ZFPM10.549
MOSPD30.547
TRAPPC50.542
PPP1R350.54
C1QL10.533
NT5C0.532
VMO10.531
TMEM1600.53
C4orf480.52

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD8-0.305
SIGLEC6-0.292
OR4F5-0.284
APOOL-0.258
USP37-0.253
NEB-0.247
CCDC7-0.245
OR4F29-0.245
IRS4-0.242
RBM41-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of LTB mRNA19428942|1987928
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LTB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LTB mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LTB mRNA"28351761
C0336433-nitrofluoranthene3-nitrofluoranthene results in increased expression of LTB mRNA19879285
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of LTB mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LTB mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTB mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LTB mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LTB mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTB mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LTB mRNA17562736
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of LTB mRNA18247414
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LTB mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LTB mRNA24449571
D001151ArsenicArsenic affects the expression of LTB protein24675094
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of LTB mRNA19962721
C006632arsenic trioxidearsenic trioxide results in increased expression of LTB mRNA24345465
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA24345465
D001554BenzeneBenzene results in decreased expression of LTB mRNA15120971
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LTB mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LTB mRNA28351761
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LTB mRNA21569818|2261060
D004958EstradiolEstradiol results in increased expression of LTB mRNA23373633
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of LTB mRNA18192240
C006780bisphenol Abisphenol A affects the expression of LTB mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of LTB mRNA19818335
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LTB mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of LTB promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LTB mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LTB mRNA17125873|1839528
D002251Carbon TetrachlorideCCL2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of LTB mRNA]17125873
D002251Carbon TetrachlorideCD44 protein affects the reaction [Carbon Tetrachloride results in increased expression of LTB mRNA]18395288
D002737ChloropreneChloroprene results in decreased expression of LTB mRNA23125180
D002738ChloroquineChloroquine results in increased expression of LTB15139008
C000488cladosporincladosporin results in increased expression of LTB mRNA19818335
D003010ClorgylineClorgyline results in increased expression of LTB mRNA19691856
C060728cobalt oxidecobalt oxide analog results in decreased expression of LTB mRNA24821434
D003436Croton OilCroton Oil results in increased expression of LTB mRNA19647056
D003474CurcuminCurcumin results in increased expression of LTB mRNA17198877
D003474CurcuminCurcumin results in decreased expression of LTB mRNA16751071
C038459curdlancurdlan affects the expression of LTB mRNA19904525
C007262deoxynivalenoldeoxynivalenol results in decreased expression of LTB mRNA22968694
D003907DexamethasoneDexamethasone results in decreased expression of LTB mRNA12782123
D003907DexamethasoneDexamethasone results in increased expression of LTB mRNA21041162
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of LTB mRNA"25908611
D002945CisplatinCisplatin results in increased expression of LTB mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of LTB mRNA19030233
D019422Dietary SucroseDietary Sucrose results in increased expression of LTB mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LTB mRNA15765122|2453584
D002117CalcitriolCalcitriol results in increased expression of LTB mRNA22615136
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LTB mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of LTB mRNA19647056
D004317DoxorubicinDoxorubicin inhibits the reaction [Fungal Polysaccharides results in increased expression of LTB mRNA]27181935
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTB mRNA17942748
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of LTB mRNA19962721
D005459FluoridesFluorides results in decreased expression of LTB mRNA19962721
C056933fumonisin B1fumonisin B1 results in increased expression of LTB mRNA15590129
D062610Fungal PolysaccharidesDoxorubicin inhibits the reaction [Fungal Polysaccharides results in increased expression of LTB mRNA]27181935
D062610Fungal PolysaccharidesFungal Polysaccharides results in increased expression of LTB mRNA27181935
C039281furanfuran results in increased expression of LTB mRNA27387713
D005665FurosemideFurosemide affects the expression of LTB mRNA17497460
C038958gadolinium chloridegadolinium chloride results in increased expression of LTB mRNA15590129
D005897GlafenineGlafenine results in increased expression of LTB mRNA24136188
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LTB protein18951874
C492448ICG 001ICG 001 results in increased expression of LTB mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTB mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LTB mRNA23086925
C045463leflunomideleflunomide results in decreased expression of LTB mRNA28988120
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of LTB mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LTB mRNA19428942
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LTB mRNA14644621
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LTB protein21135813
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LTB mRNA21641980
D008770MethylnitrosoureaLTB protein results in decreased susceptibility to Methylnitrosourea15240709
C500085muraglitazarmuraglitazar affects the expression of LTB mRNA21515302
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of LTB mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of LTB mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LTB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of LTB mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LTB mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LTB mRNA19812364
C015380neoechinulinneoechinulin results in increased expression of LTB mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of LTB mRNA19818335
D009532NickelNickel results in increased expression of LTB mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of LTB mRNA17312168
D009538NicotineNicotine results in decreased expression of LTB mRNA18247414
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of LTB mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LTB mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LTB mRNA25729387
D010081OxazoloneOxazolone results in increased expression of LTB mRNA19647056
D010126Ozone[[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] co-treated with Ozone] results in decreased expression of H2-EB1 mRNA20032013
D010126Ozone[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] inhibits the reaction [Ozone results in increased expression of H2-EB2 mRNA]20032013
D010126Ozone[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] results in decreased susceptibility to Ozone20032013
D010126OzoneOzone results in decreased expression of LTB mRNA12763052
D010938Plant OilsPlant Oils results in increased expression of LTB mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of LTB mRNA24888373
D011374ProgesteroneProgesterone results in increased expression of LTB mRNA22615136
D011441PropylthiouracilPropylthiouracil results in increased expression of LTB mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of LTB mRNA19429434
C089730rosiglitazonerosiglitazone results in increased expression of LTB mRNA21515302
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of LTB mRNA"16678137
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA24345465
C005705sanguinarinesanguinarine results in increased expression of LTB mRNA24345465
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LTB mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of LTB mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of LTB mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of LTB mRNA22431001
D012834SilverSilver results in decreased expression of LTB mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of LTB mRNA17428261
C017947sodium arsenitesodium arsenite results in increased expression of LTB mRNA21911445
D018038Sodium SeleniteSodium Selenite results in decreased expression of LTB mRNA16705456
D053260SootSoot results in increased expression of LTB mRNA19428942
C075117squalestatin 1squalestatin 1 results in decreased expression of LTB mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of LTB mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LTB mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LTB mRNA28351761
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTB mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LTB mRNA21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTB mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTB mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LTB protein18951874
C009495titanium dioxidetitanium dioxide results in decreased expression of LTB mRNA27760801
C402696TMC 120ATMC 120A results in decreased expression of LTB mRNA19818335
D014051Toluene 2,4-Diisocyanate"TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA]"12356572
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA"11467998|1235657
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LTB mRNA25729387
D019772TopotecanTopotecan results in increased expression of LTB mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LTB mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTB mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LTB mRNA24935251|2627250
D017974Uranium CompoundsUranium Compounds results in increased expression of LTB mRNA19654044
D014635Valproic AcidValproic Acid results in decreased expression of LTB mRNA29154799
D014810Vitamin EVitamin E results in increased expression of LTB mRNA19244175
C088658zoledronic acidzoledronic acid results in increased expression of LTB mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS7916655  
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-IEA-  
GO:0007165signal transduction-TAS7916655  
GO:0007267cell-cell signaling-TAS7916655  
GO:0010467gene expression-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0043588skin development-IEA-  
GO:0045084positive regulation of interleukin-12 biosynthetic process-ISS-  
GO:0048535lymph node development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayIEA
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22537113Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. (2012 Aug)Ro MScand J Immunol
24849681Cytokine and eicosanoid profiles of phosphate mine workers. (2014 Jun)Khelifi MJ Toxicol Sci
22835628Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk. (2012 Sep)Camacho MAtherosclerosis
11351145Aggravating effect of cigarette smoke exposure on experimental colitis is associated with leukotriene B(4) and reactive oxygen metabolites. (2001)Guo XDigestion
10600885Smoke extract stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activities. (1999 Dec)Sato EAm J Physiol
15174894The effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trial. (2004)Banerjee DTreat Respir Med
25428131Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults. (2015 Feb)Khawcharoenporn TRespirology
11978916Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. (2002 May)Tanino MThorax
25170988Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol. (2016 Jan)Herman MAAddict Biol
18949517Influence of smoking status on cough reflex sensitivity in subjects with COPD. (2009 Jan-Feb)Stravinskaite KLung
19187324Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking. (2009 Mar)Tanou KClin Exp Allergy