Gene: CYP4F3

4051
CPF3|CYP4F|LTB4H
cytochrome P450 family 4 subfamily F member 3
protein-coding
19p13.12
Ensembl:ENSG00000186529 MIM:601270 Vega:OTTHUMG00000182374 UniprotKB:Q08477
NG_007964.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
1.694e-2 (AD)  7.390e-1 (ND)   (Frontal_Cortex)
1.333e-1 (AD)  1.058e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3794987chr19:15640081 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP4F120.588
ZNF518A0.552
CA5B0.54
RGS90.535
ZNF4310.532
ZMAT10.526
C10orf1050.519
CTPS20.516
CCDC1700.504
RHCE0.501

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LCN1-0.274
MUC12-0.226
SULT2B1-0.223
TTLL10-0.215
CYP1A1-0.215
MIP-0.207
DIO2-0.207
KCNK12-0.203
RNF223-0.202
ETV4-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP4F3 mRNA"25614096
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of CYP4F3 mRNA"24172598
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of CYP4F3 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of CYP4F3 mRNA22230336
D000393Air PollutantsAir Pollutants analog results in decreased expression of CYP4F3 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CYP4F3 mRNA24449571
C526219apple polyphenol extractapple polyphenol extract results in increased expression of CYP4F3 mRNA16369997
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of CYP4F3 mRNA"18687144|2535159
D001554BenzeneBenzene results in increased expression of CYP4F3 mRNA20036648
D001554BenzeneBenzene results in increased expression of CYP4F3 protein20036648
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CYP4F3 mRNA28601433
D004958EstradiolEstradiol results in decreased expression of CYP4F3 mRNA17982697
D004958Estradiol[Parathion co-treated with Estradiol] results in increased expression of CYP4F3 mRNA17982697
C006780bisphenol Abisphenol A affects the expression of CYP4F3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CYP4F3 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of CYP4F3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CYP4F3 mRNA26079696
D002104CadmiumCadmium results in increased expression of CYP4F3 mRNA21120746
D002220CarbamazepineCarbamazepine results in increased expression of CYP4F3 mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP4F3 mRNA15963578
D000068579CelecoxibCelecoxib results in decreased expression of CYP4F3 mRNA28201806
D019327Copper SulfateCopper Sulfate results in decreased expression of CYP4F3 mRNA19549813
D003703DemecolcineDemecolcine results in increased expression of CYP4F3 mRNA23649840
C007262deoxynivalenol[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP4F3 mRNA28865950
C007262deoxynivalenol[deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP4F3 mRNA28935499
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CYP4F3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CYP4F3 mRNA27392435
D004237DiuronDiuron metabolite results in increased expression of CYP4F3 mRNA24172598
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CYP4F3 mRNA23649840
D015025Zearalenone[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP4F3 mRNA28865950
D015025Zearalenone[deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP4F3 mRNA28935499
D015025ZearalenoneZearalenone results in decreased expression of CYP4F3 mRNA28865950
D005557FormaldehydeFormaldehyde results in decreased expression of CYP4F3 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of CYP4F3 mRNA23649840
C010178heliotrineheliotrine results in decreased expression of CYP4F3 mRNA26100227
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CYP4F3 mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of CYP4F3 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CYP4F3 mRNA23649840
D009538NicotineNicotine results in increased expression of CYP4F3 mRNA23825647
C464660obeticholic acidobeticholic acid results in decreased expression of CYP4F3 mRNA27939613
D010278Parathion[Parathion co-treated with Estradiol] results in increased expression of CYP4F3 mRNA17982697
D010278ParathionParathion results in increased expression of CYP4F3 mRNA17982697
D010634PhenobarbitalPhenobarbital affects the expression of CYP4F3 mRNA19084549
D019800PhenolPhenol results in increased expression of CYP4F3 mRNA19029204|2003664
D019800PhenolPhenol results in increased expression of CYP4F3 protein19029204|2003664
C030984pyrenepyrene results in decreased expression of CYP4F3 mRNA15963578
D015474IsotretinoinIsotretinoin results in decreased expression of CYP4F3 mRNA20436886
C009238senkirkinesenkirkine results in decreased expression of CYP4F3 mRNA26100227
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CYP4F3 mRNA25351596
C016766sulforafansulforafan results in increased expression of CYP4F3 mRNA26833863
D019284ThapsigarginThapsigargin results in decreased expression of CYP4F3 mRNA19442820
D014212TretinoinTretinoin results in increased expression of CYP4F3 mRNA17218384|1902920
D014212TretinoinTretinoin results in increased expression of CYP4F3 protein19029204|2003664
D014520UrethaneUrethane affects the expression of CYP4F3 mRNA28818685
D014750VincristineVincristine results in increased expression of CYP4F3 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0050051leukotriene-B4 20-monooxygenase activity-TAS-  
GO:0052871alpha-tocopherol omega-hydroxylase activity-IEA-  
GO:009725820-hydroxy-leukotriene B4 omega oxidase activity-TAS-  
GO:009725920-aldehyde-leukotriene B4 20-monooxygenase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006690icosanoid metabolic process-TAS-  
GO:0006691leukotriene metabolic process-TAS-  
GO:0036101leukotriene B4 catabolic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23846787Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma. (2013 Dec)Gandhi AVAnn Surg Oncol