Gene: LTBP1

4052
-
latent transforming growth factor beta binding protein 1
protein-coding
2p22.3
Ensembl:ENSG00000049323 MIM:150390 Vega:OTTHUMG00000152118 UniprotKB:Q14766
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.957e-1 (AD)  4.708e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10432656chr2:33149965 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LPP0.835
FSTL10.786
ROCK10.779
EPS80.777
BNIP20.767
MSRB30.766
DDR20.763
TTC230.762
ANO60.761
PRRX10.757

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.48
SPEF1-0.467
ABCC12-0.453
GSG1-0.447
DLK2-0.446
KCNB2-0.441
SMIM18-0.427
SLC7A4-0.425
BCL11A-0.424
KLHL35-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of LTBP1 mRNA25827057
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LTBP1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LTBP1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of LTBP1 mRNA"20852150
C0293704-toluidine4-toluidine results in decreased expression of LTBP1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of LTBP1 mRNA29067470
D047310ApigeninApigenin results in decreased expression of LTBP1 mRNA22359648
D001151ArsenicArsenic affects the methylation of LTBP1 gene25304211
D001194AsbestosAsbestos results in decreased expression of LTBP1 mRNA21563230
D001554BenzeneBenzene results in decreased expression of LTBP1 mRNA19162166
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of LTBP1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LTBP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LTBP1 mRNA"19150397|2001819
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of LTBP1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of LTBP1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of LTBP1 mRNA19167446
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of LTBP1 mRNA17404688
D004958EstradiolEstradiol results in increased expression of LTBP1 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LTBP1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LTBP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of LTBP1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of LTBP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LTBP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LTBP1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of LTBP1 mRNA26079696
D002087ButyratesButyrates results in increased expression of LTBP1 mRNA14674679
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of LTBP1 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LTBP1 mRNA25827057
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LTBP1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of LTBP1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of LTBP1 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of LTBP1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of LTBP1 mRNA27989131
C014347decitabinedecitabine results in decreased expression of LTBP1 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LTBP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LTBP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LTBP1 mRNA28628672
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of LTBP1 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LTBP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LTBP1 mRNA27392435
D002945CisplatinLTBP1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of LTBP1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LTBP1 mRNA26924002
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP1 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LTBP1 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LTBP1 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of LTBP1 mRNA26924002
D004237DiuronDiuron results in decreased expression of LTBP1 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased secretion of LTBP1 protein7603044
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LTBP1 mRNA12655037|1557682
D005419FlavonoidsFlavonoids results in increased expression of LTBP1 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LTBP1 mRNA20938992
C039281furanfuran results in increased expression of LTBP1 mRNA27387713
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of LTBP1 mRNA21782745
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of LTBP1 mRNA22634610
C412815GW 4064GW 4064 results in increased expression of LTBP1 mRNA26655953
C010176halofuginonehalofuginone results in increased expression of LTBP1 mRNA17180598
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LTBP1 mRNA20044591
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of LTBP1 mRNA16849584
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LTBP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LTBP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LTBP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LTBP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LTBP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LTBP1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LTBP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LTBP1 mRNA26644586
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of LTBP1 mRNA20823114
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of LTBP1 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of LTBP1 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LTBP1 mRNA20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of LTBP1 mRNA21782745
D008748MethylcholanthreneMethylcholanthrene results in increased expression of LTBP1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LTBP1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LTBP1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of LTBP1 promoter"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of LTBP1 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LTBP1 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of LTBP1 mRNA21515302
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LTBP1 mRNA25380136
D009532NickelNickel results in increased expression of LTBP1 mRNA12540486
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of LTBP1 mRNA17616710
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LTBP1 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LTBP1 mRNA28511854
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LTBP1 mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of LTBP1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of LTBP1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of LTBP1 mRNA17404688|2179573
D011441PropylthiouracilPropylthiouracil results in decreased expression of LTBP1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LTBP1 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of LTBP1 mRNA14699072
D015474IsotretinoinIsotretinoin results in increased expression of LTBP1 mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of LTBP1 mRNA21515302
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of LTBP1 mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of LTBP1 mRNA19564919
D012715Sesame OilSesame Oil results in increased expression of LTBP1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LTBP1 mRNA25895662
D012906SmokeSmoke results in increased expression of LTBP1 mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of LTBP1 mRNA25879800
D018038Sodium SeleniteSodium Selenite results in decreased expression of LTBP1 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of LTBP1 mRNA14699072
C501413tesaglitazartesaglitazar results in increased expression of LTBP1 mRNA21515302
C004648testosterone enanthatetestosterone enanthate affects the expression of LTBP1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTBP1 mRNA23152189
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LTBP1 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTBP1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTBP1 mRNA14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LTBP1 mRNA20959002
D019284ThapsigarginThapsigargin results in increased expression of LTBP1 protein24648495
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of LTBP1 mRNA23825117
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LTBP1 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LTBP1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LTBP1 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LTBP1 mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LTBP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LTBP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LTBP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LTBP1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased expression of LTBP1 mRNA24896083
D014638VanadatesVanadates results in increased expression of LTBP1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LTBP1 gene25560391
C025643vinclozolinvinclozolin affects the expression of LTBP1 mRNA19015723
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of LTBP1 mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005024transforming growth factor beta-activated receptor activity-NAS8537398  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI12429738  17293099  18677313  
GO:0050431transforming growth factor beta binding-IPI10930463  18672106  
GO:0050436microfibril binding-IDA12429738  
GO ID GO Term Qualifier Evidence PubMed
GO:0003281ventricular septum development-IEA-  
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway-IEA-  
GO:0035583sequestering of TGFbeta in extracellular matrix-TAS18677313  
GO:0035904aorta development-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0060976coronary vasculature development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001527microfibril-IDA12429738  
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-IDA16157329  
GO:0031012extracellular matrix-NAS8537398  
GO:0032991protein-containing complex-IDA12429738  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22295116Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. (2012)Pei YFPLoS One