Gene: LTC4S

4056
-
leukotriene C4 synthase
protein-coding
5q35.3
Ensembl:ENSG00000213316 MIM:246530 Vega:OTTHUMG00000150314 UniprotKB:Q16873
NG_028161.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.896e-1 (AD)  8.449e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of LTC4S mRNA"26377693
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of LTC4S mRNA20840853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of LTC4S mRNA20382172
C0312782-chloroethyl ethyl sulfideSB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTC4S mRNA]20382172
C014949acetylhydrazineacetylhydrazine results in decreased expression of LTC4S mRNA15282401
D020106AcrylamideAcrylamide results in decreased expression of LTC4S mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LTC4S mRNA16483693
C000228aristolochic acid Iaristolochic acid I results in decreased expression of LTC4S protein21658425
C006632arsenic trioxidearsenic trioxide results in decreased expression of LTC4S mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of LTC4S mRNA15761015
D001241AspirinLTC4S affects the susceptibility to Aspirin19767084
D001241AspirinLTC4S gene SNP affects the susceptibility to Aspirin20485159
D001241AspirinLTC4S polymorphism affects the susceptibility to Aspirin15100686|1643379
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LTC4S mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LTC4S mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LTC4S mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LTC4S mRNA18164116
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LTC4S mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LTC4S mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LTC4S mRNA21964900|2261060
C472777bisperoxovanadiumbisperoxovanadium results in decreased expression of LTC4S mRNA12574384
C006780bisphenol Abisphenol A affects the expression of LTC4S mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LTC4S gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LTC4S mRNA25432964
D002251Carbon TetrachloridePTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LTC4S mRNA]25432964
D002251Carbon TetrachlorideSC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of LTC4S mRNA]25432964
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LTC4S mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LTC4S mRNA27858113
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LTC4S mRNA17602206
D005576ColforsinColforsin results in decreased secretion of LTC4S protein16083514
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LTC4S mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of LTC4S mRNA12891383
D003994BucladesineBucladesine results in decreased secretion of LTC4S protein16083514
D004041Dietary FatsDietary Fats results in decreased expression of LTC4S mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of LTC4S mRNA18457598
C014476diethyl maleatediethyl maleate results in decreased expression of LTC4S mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LTC4S mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LTC4S mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of LTC4S mRNA"19480007
D004121Dimethyl Sulfoxide"[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA"23751068
D004121Dimethyl Sulfoxide"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
D004121Dimethyl Sulfoxide"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
C031818enterotoxin B, staphylococcal"[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA"23751068
C031818enterotoxin B, staphylococcal"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
C031818enterotoxin B, staphylococcal"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
D004974EtazolateEtazolate results in decreased secretion of LTC4S protein16083514
D005419FlavonoidsFlavonoids results in decreased expression of LTC4S mRNA18035473
C039281furanfuran results in decreased expression of LTC4S mRNA26194646
D006632HistamineLTC4S polymorphism results in decreased susceptibility to Histamine19862937
D007657Ketone BodiesKetone Bodies results in decreased expression of LTC4S mRNA16807920
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LTC4S mRNA12574384
D008070Lipopolysaccharidesparthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA]12574384
D008070LipopolysaccharidesTLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA]12574384
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LTC4S mRNA21461237
D017572Leukotriene A4LTC4S protein results in increased metabolism of Leukotriene A420840853
D017997Leukotriene C4LTC4S protein affects the chemical synthesis of Leukotriene C410666225
D017997Leukotriene C4LTC4S protein results in increased chemical synthesis of Leukotriene C420840853
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of LTC4S mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of LTC4S mRNA19564919
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LTC4S mRNA"26251327
C093875montelukastLTC4S gene SNP affects the susceptibility to montelukast16293801
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LTC4S mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LTC4S mRNA"25554681
D009966OrphenadrineOrphenadrine affects the expression of LTC4S mRNA23665939
D010047OvalbuminLTC4S promotes the reaction [Ovalbumin results in increased expression of IL13 protein]21429049
D010047OvalbuminLTC4S promotes the reaction [Ovalbumin results in increased expression of IL4 protein]21429049
D010047OvalbuminLTC4S promotes the reaction [Ovalbumin results in increased expression of IL5 protein]21429049
D000073878Palm OilPalm Oil results in decreased expression of LTC4S mRNA18042831
C002669parthenolideparthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA]12574384
C047681pranlukastLTC4S gene polymorphism affects the susceptibility to pranlukast12360108
C059514resveratrol"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
D020889RolipramRolipram results in decreased secretion of LTC4S protein16083514
C093642SB 203580SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTC4S mRNA]20382172
C115461SC 560SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of LTC4S mRNA]25432964
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of LTC4S mRNA19564919
C016104sodium bichromatesodium bichromate results in decreased expression of LTC4S mRNA25993096
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of LTC4S mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTC4S mRNA21570461
D013749TetrachlorodibenzodioxinAHR mRNA promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LTC4S mRNA]28487374
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of LTC4S mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTC4S mRNA21215274|2848737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTC4S protein28487374
D013806TheophyllineTheophylline results in decreased secretion of LTC4S protein16083514
C009495titanium dioxidetitanium dioxide results in decreased expression of LTC4S mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LTC4S mRNA28111298
D014222Triamcinolone Acetonide"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA]"23751068
C057693troglitazonetroglitazone results in increased expression of LTC4S mRNA28973697
C057693troglitazone[troglitazone co-treated with TNF protein] results in increased expression of LTC4S mRNA12732648
D014635Valproic AcidValproic Acid results in increased methylation of LTC4S gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LTC4S gene25560391
D015054ZymosanLTC4S protein affects the susceptibility to Zymosan11319240

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004364glutathione transferase activity-TAS-  
GO:0004464leukotriene-C4 synthase activity-IBA21873635  
GO:0004464leukotriene-C4 synthase activity-IDA8706658  
GO:0004602glutathione peroxidase activity-IBA21873635  
GO:0005515protein binding-IPI19233132  
GO:0008047enzyme activator activity-IEA-  
GO:0008289lipid binding-IDA8706658  
GO:0042802identical protein binding-IPI15530365  17632546  17632548  
GO ID GO Term Qualifier Evidence PubMed
GO:0006691leukotriene metabolic process-IDA8706658  
GO:0019370leukotriene biosynthetic process-IBA21873635  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IBA21873635  
GO:0005635nuclear envelope-IDA7599836  19233132  
GO:0005635nuclear envelope-TAS-  
GO:0005640nuclear outer membrane-IEA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA19233132  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-TAS1454853  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142688Synthesis of 5-eicosatetraenoic acidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142700Synthesis of Lipoxins (LX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9026395Biosynthesis of DHA-derived sulfido conjugatesTAS
R-HSA-9026762Biosynthesis of maresin conjugates in tissue regeneration (MCTR)TAS
R-HSA-9026766Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27990118Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)Thompson MDFront Pharmacol
25902778Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. (2015 Jun)Merhi MInflamm Res