Gene: LTF

4057
GIG12|HEL110|HLF2|LF
lactotransferrin
protein-coding
3p21.31
Ensembl:ENSG00000012223 MIM:150210 Vega:OTTHUMG00000156325 UniprotKB:P02788
NG_023257.2
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.300e-1 (AD)  8.336e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEACAM80.733
MMP80.727
VNN10.709
DEFA40.706
DEFA30.705
MMP90.675
BPI0.67
LCN20.65
CTSG0.633
CAMP0.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP9-0.4
TUBA8-0.354
HIPK4-0.352
PABPC1L2B-0.348
PRKCZ-0.348
RIPPLY2-0.348
KCNC2-0.347
STAR-0.344
HRH3-0.343
SVOP-0.342

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018113h-Indole-5,6-DiolSmall Molecule3131-52-0ExperimentalTarget
DB03017Lauric AcidSmall Molecule143-07-7Approved|ExperimentalTarget
DB03040Nitrilotriacetic AcidSmall MoleculeExperimentalTarget
DB03485Alpha-D-FucoseSmall MoleculeExperimentalTarget
DB04743NimesulideSmall Molecule51803-78-2Approved|Investigational|WithdrawnTarget
DB069872-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDESmall MoleculeExperimentalTarget
DB08439ParecoxibSmall Molecule198470-84-7ApprovedTarget
ID Drug Name Action PubMed
C5575311,7-diphenyl-5-heptene-3-one"1,7-diphenyl-5-heptene-3-one results in increased expression of LTF mRNA"19654927
C5575311,7-diphenyl-5-heptene-3-one"fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of LTF mRNA]"19654927
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of LTF mRNA"11908639
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of LTF protein"11390168
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]"12079509
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein]"12079509
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of LTF mRNA"25575267
C0140364-hydroxyestradiol4-hydroxyestradiol results in increased expression of LTF mRNA9371753|9607801
C0415944-nonylphenol[4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
C0415944-nonylphenol[4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
C0804174-octylphenol[4-octylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
C0804174-octylphenol[4-octylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
D000082AcetaminophenAcetaminophen affects the expression of LTF mRNA17562736
C016601afimoxifeneafimoxifene results in increased expression of LTF protein11390168
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LTF mRNA19770486
D000535AluminumLTF protein binds to Aluminum16301797
D000537Aluminum Oxide"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LTF protein"25598225
D047310ApigeninApigenin results in increased expression of LTF protein24487097
D001151ArsenicArsenic results in decreased expression of LTF protein19167470
D001151ArsenicArsenic results in increased expression of LTF mRNA19654921
D001280AtrazineAtrazine results in increased expression of LTF mRNA22378314
D001285AtropineAtropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
D001379AzathioprineAzathioprine results in decreased expression of LTF mRNA21621594
D001507BeclomethasoneBeclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
D001507BeclomethasoneBeclomethasone results in decreased secretion of LTF protein11112886
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of LTF mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LTF mRNA15034205|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LTF mRNA19770486
D004958Estradiol[Estradiol co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
D004958Estradiol[Estradiol co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
D004958EstradiolAHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LTF mRNA]]11006360
D004958EstradiolESR1 protein affects the reaction [Estradiol results in increased expression of LTF mRNA]10433208
D004958EstradiolEstradiol affects the expression of LTF mRNA15598610
D004958EstradiolEstradiol results in increased expression of LTF mRNA10433208|1100636
D004958EstradiolEstradiol results in increased expression of LTF protein11390168
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of LTF mRNA]10433208|1764099
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LTF mRNA]11006360|2405256
C006780bisphenol A[bisphenol A co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
C006780bisphenol A[bisphenol A co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
C006780bisphenol Abisphenol A results in decreased expression of LTF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LTF gene28505145
D019819BudesonideBudesonide inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
D019819BudesonideBudesonide results in decreased secretion of LTF protein11112886
D002211CapsaicinCapsaicin results in increased expression of LTF protein9537786
C026690cerous chloridecerous chloride results in increased expression of LTF mRNA23573234
D007631ChlordeconeChlordecone results in increased expression of LTF78523
D007631ChlordeconeTamoxifen inhibits the reaction [Chlordecone results in increased expression of LTF]78523
D007631ChlordeconeChlordecone results in increased expression of LTF mRNA9371753|9607801
D007631Chlordeconefulvestrant inhibits the reaction [Chlordecone results in increased expression of LTF mRNA]9607801
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LTF mRNA23650126
D002857ChromiumChromium binds to LTF protein16936800
D003300Copper[LTF protein binds to Copper] promotes the reaction [LTF protein binds to Superoxides]17919719
D003300Copper[LTF protein binds to Copper] which results in increased chemical synthesis of Hydrogen Peroxide17919719
D003520CyclophosphamideCyclophosphamide results in decreased expression of LTF mRNA21621594
D016572CyclosporineCyclosporine results in increased expression of LTF mRNA21621594
D003634DDTDDT results in increased expression of LTF mRNA9607801
D003907DexamethasoneLTF protein inhibits the reaction [Dexamethasone results in increased abundance of Reactive Oxygen Species]24587916
D003976DiazinonDiazinon results in increased methylation of LTF gene22964155
D002945CisplatinCisplatin results in decreased expression of LTF mRNA11099651
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LTF mRNA26924002
D004054Diethylstilbestrol[Diethylstilbestrol co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
D004054Diethylstilbestrol[Diethylstilbestrol co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LTF protein16439099
D004054DiethylstilbestrolDiethylstilbestrol affects the methylation of LTF promoter24316720
D004054Diethylstilbestrol[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of LTF mRNA16452187
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LTF protein15082075
D004054DiethylstilbestrolDiethylstilbestrol results in decreased methylation of LTF promoter9331098
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LTF22275727
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LTF mRNA15289156|1559153
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LTF protein11390168|1508207
D004054DiethylstilbestrolESR1 mutant form inhibits the reaction [Diethylstilbestrol affects the methylation of LTF promoter]24316720
D004054DiethylstilbestrolESR1 protein affects the reaction [Diethylstilbestrol results in increased expression of LTF]22275727
D002117CalcitriolCalcitriol results in increased expression of LTF mRNA26485663
D004126DimethylformamideDimethylformamide results in increased expression of LTF mRNA18063697
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of LTF mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LTF protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LTF mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LTF mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTF mRNA17942748
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Tamoxifen] results in increased expression of LTF protein24487097
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LTF protein24487097
C033789fenarimolfenarimol results in decreased expression of LTF mRNA16324804
D004397FonofosFonofos results in increased methylation of LTF promoter22847954
C070081fulvestrant"fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of LTF mRNA]"19654927
C070081fulvestrantfulvestrant inhibits the reaction [Chlordecone results in increased expression of LTF mRNA]9607801
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of LTF mRNA]10433208|1764099
C070081fulvestrant"fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA]"9607801
D019833Genistein[Genistein co-treated with ESR1 protein] results in increased expression of LTF mRNA21783566
D019833Genistein[Genistein co-treated with ESR2 protein] results in increased expression of LTF mRNA21783566
D019833GenisteinGenistein results in increased expression of LTF mRNA15289156|2255321
D019833GenisteinGenistein results in increased expression of LTF mRNA29217487
D019833GenisteinGenistein results in increased expression of LTF protein24487097
C040641genistingenistin results in increased expression of LTF mRNA20049207
D006861Hydrogen Peroxide[LTF protein binds to Copper] which results in increased chemical synthesis of Hydrogen Peroxide17919719
D006861Hydrogen Peroxide[LTF protein binds to Manganese] which results in increased chemical synthesis of Hydrogen Peroxide17919719
D006861Hydrogen Peroxide[LTF protein binds to Zinc] which results in increased chemical synthesis of Hydrogen Peroxide17919719
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTF mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of LTF mRNA15956246
C051890irinotecanirinotecan results in decreased expression of LTF mRNA15956246
D007501IronIron binds to LTF protein16936800|1693681
D007501IronLTF binds to Iron24587916
D007501Iron[LTF protein binds to Iron] promotes the reaction [LTF protein binds to Superoxides]17919719
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LTF mRNA22032363
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LTF mRNA22235868
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of LTF protein11302825
D008070LipopolysaccharidesThalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]11302825
D008070Lipopolysaccharides[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]16141546
C009900lipoteichoic acidlipoteichoic acid results in decreased expression of LTF mRNA22032363
C009900lipoteichoic acidlipoteichoic acid results in increased secretion of LTF protein11302825
C009900lipoteichoic acidThalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein]11302825
D008345ManganeseManganese binds to LTF protein16936800
D008345Manganese[LTF protein binds to Manganese] promotes the reaction [LTF protein binds to Superoxides]17919719
D008345Manganese[LTF protein binds to Manganese] which results in increased chemical synthesis of Hydrogen Peroxide17919719
D008727MethotrexateMethotrexate results in decreased expression of LTF mRNA21621594
D008731MethoxychlorMethoxychlor metabolite results in increased expression of LTF mRNA11908639
D008731MethoxychlorMethoxychlor metabolite results in increased expression of LTF protein11390168
D008731MethoxychlorMethoxychlor results in increased expression of LTF mRNA10433208|1190863
D008731MethoxychlorMethoxychlor results in increased expression of LTF protein11390168
C017506methylcholineAtropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
C017506methylcholineBeclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
C017506methylcholineBudesonide inhibits the reaction [methylcholine results in increased secretion of LTF protein]11112886
C017506methylcholinemethylcholine results in increased secretion of LTF protein11112886
C517284monomethyl phthalatemonomethyl phthalate affects the expression of LTF mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of LTF mRNA15674844
C040015myricetinmyricetin results in increased expression of LTF protein24487097
D009270NaloxoneNaloxone results in decreased activity of LTF protein14563657
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LTF mRNA"25554681
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LTF protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LTF mRNA"25554681|2710602
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of LTF protein"25598225
D009532NickelNickel results in increased expression of LTF mRNA25583101
D009532NickelNickel results in increased expression of LTF mRNA12540486
D009538NicotineNicotine results in decreased expression of LTF mRNA23825647
D009569Nitric OxideLTF protein results in increased chemical synthesis of Nitric Oxide14563657
D009569Nitric OxideNitric Oxide deficiency results in decreased activity of LTF protein14563657
C025256nonylphenolnonylphenol results in increased expression of LTF protein11390168
C016340o,p'-DDT"fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA]"9607801
C016340o,p'-DDT"o,p'-DDT results in increased expression of LTF mRNA"9607801
C016340o,p'-DDT"o,p'-DDT results in increased expression of LTF protein"11390168
D010126OzoneOzone results in increased expression of LTF mRNA12763052
D010278ParathionParathion results in increased methylation of LTF promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of LTF mRNA17132714
D010693PhloretinPhloretin results in increased expression of LTF protein24487097
D010713Phosphatidylcholines[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]16141546
D010840Phytosterols[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]16141546
C009007potassium persulfatepotassium persulfate results in increased expression of LTF protein20815409
D011239PrednisolonePrednisolone results in decreased expression of LTF mRNA21621594
D011374ProgesteroneProgesterone results in decreased expression of LTF mRNA23012394
D011374ProgesteroneProgesterone affects the expression of LTF mRNA17251523
C428725pyridabenpyridaben results in increased expression of LTF mRNA22563483
D017382Reactive Oxygen SpeciesLTF protein inhibits the reaction [Dexamethasone results in increased abundance of Reactive Oxygen Species]24587916
D012834SilverSilver results in increased expression of LTF mRNA27131904
D012906SmokeSmoke affects the expression of LTF mRNA23693141
C017947sodium arsenite[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of LTF mRNA16452187
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of LTF mRNA21621594
D012969Sodium FluorideSodium Fluoride results in increased expression of LTF protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of LTF mRNA18175754
D013481Superoxides[LTF protein binds to Copper] promotes the reaction [LTF protein binds to Superoxides]17919719
D013481Superoxides[LTF protein binds to Iron] promotes the reaction [LTF protein binds to Superoxides]17919719
D013481Superoxides[LTF protein binds to Manganese] promotes the reaction [LTF protein binds to Superoxides]17919719
D013481SuperoxidesLTF protein binds to Superoxides17919719
D013481Superoxides[LTF protein binds to Zinc] promotes the reaction [LTF protein binds to Superoxides]17919719
D016559TacrolimusTacrolimus results in increased expression of LTF mRNA21621594
D013629TamoxifenTamoxifen inhibits the reaction [Chlordecone results in increased expression of LTF]78523
D013629TamoxifenTamoxifen affects the expression of LTF mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of LTF protein11390168
D013629Tamoxifen[Ethinyl Estradiol co-treated with Tamoxifen] results in increased expression of LTF protein24487097
C012568terbufosterbufos results in increased methylation of LTF promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of LTF mRNA25461914
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LTF mRNA]]11006360
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTF mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTF mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LTF mRNA]11006360|2405256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTF mRNA15034205|2821309
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTF mRNA25613284
D013792ThalidomideThalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]11302825
D013792ThalidomideThalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein]11302825
D013806TheophyllineTheophylline results in decreased expression of LTF protein12016098
C009495titanium dioxidetitanium dioxide results in decreased expression of LTF mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of LTF mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LTF mRNA20133372
C034697transplatintransplatin results in decreased expression of LTF mRNA11099651
D014212TretinoinLTF protein inhibits the reaction [Tretinoin results in decreased expression of MKI67 protein]16168621
D014212TretinoinLTF protein inhibits the reaction [Tretinoin results in increased cleavage of PARP1 protein]16168621
D014212TretinoinTretinoin results in increased uptake of and affects the localization of LTF protein16168621
D014212TretinoinLTF protein inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]16168621
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LTF gene25560391
D015032Zinc[LTF protein binds to Zinc] promotes the reaction [LTF protein binds to Superoxides]17919719
D015032Zinc[LTF protein binds to Zinc] which results in increased chemical synthesis of Hydrogen Peroxide17919719
C088658zoledronic acidzoledronic acid results in increased expression of LTF protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IMP15155221  
GO:0003677DNA binding-IEA-  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0004869cysteine-type endopeptidase inhibitor activity-IDA12788072  
GO:0005047signal recognition particle binding-IBA21873635  
GO:0005506iron ion binding-IDA12037568  
GO:0005515protein binding-IPI1544444  9223490  12522210  17567961  25193851  27616280  
GO:0008201heparin binding-IDA11907569  
GO:0043539protein serine/threonine kinase activator activity-IDA20345905  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0001817regulation of cytokine production-IDA20345905  
GO:0001895retina homeostasis-HEP23580065  
GO:0002227innate immune response in mucosa-IDA12037568  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006508proteolysis-IEA-  
GO:0006811ion transport-IEA-  
GO:0006959humoral immune response-TAS9770539  
GO:0019730antimicrobial humoral response-TAS-  
GO:0019731antibacterial humoral response-IDA1599934  18714013  
GO:0019732antifungal humoral response-IDA11083624  
GO:0031640killing of cells of other organism-IDA9727055  
GO:0031640killing of cells of other organism-IMP15155221  
GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway-IDA20345905  
GO:0032680regulation of tumor necrosis factor production-IDA20345905  
GO:0032780negative regulation of ATPase activity-IMP25193851  
GO:0033214iron assimilation by chelation and transport-TAS-  
GO:0033690positive regulation of osteoblast proliferation-IDA15166119  
GO:0034145positive regulation of toll-like receptor 4 signaling pathway-IMP20345905  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA20345905  
GO:0043312neutrophil degranulation-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044793negative regulation by host of viral process-IMP12522210  
GO:0045071negative regulation of viral genome replication-IMP25193851  
GO:0045669positive regulation of osteoblast differentiation-IDA15166119  
GO:0048525negative regulation of viral process-IMP25193851  
GO:0050829defense response to Gram-negative bacterium-IMP15155221  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA20345905  
GO:0051673membrane disruption in other organism-IMP15155221  
GO:0060349bone morphogenesis-IDA15166119  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IMP15155221  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA20345905  
GO:1900159positive regulation of bone mineralization involved in bone maturation-ISS-  
GO:1900229negative regulation of single-species biofilm formation in or on host organism-IDA12037568  
GO:1902732positive regulation of chondrocyte proliferation-IDA15166119  
GO:2000117negative regulation of cysteine-type endopeptidase activity-IDA12788072  
GO:2000308negative regulation of tumor necrosis factor (ligand) superfamily member 11 production-ISS-  
GO:2001205negative regulation of osteoclast development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  22664934  23580065  
GO:0005615extracellular space-IDA12788072  17567961  18714013  
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IMP25193851  
GO:0005785signal recognition particle receptor complex-IBA21873635  
GO:0009986cell surface-IDA17567961  
GO:0030141secretory granule-IDA11907569  
GO:0032991protein-containing complex-IDA17567961  
GO:0035580specific granule lumen-TAS-  
GO:0042581specific granule-IDA2981589  
GO:0044218other organism cell membrane-IMP15155221  
GO:0070062extracellular exosome-HDA19199708  23533145  
GO:0097013phagocytic vesicle lumen-TAS-  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1222352Latent infection of Homo sapiens with Mycobacterium tuberculosisTAS
R-HSA-1222449Mtb iron assimilation by chelationTAS
R-HSA-1222499Response of Mtb to phagocytosisTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6799990Metal sequestration by antimicrobial proteinsTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18156281Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. (2008 Feb)Moreno-Navarrete JMClin Chem
28549746Infant, Maternal, and Hospital Factors' Role in Loss to Follow-up After Failed Newborn Hearing Screening. (2018 Mar)Cunningham MAcad Pediatr
28485077LTF and DEFB1 polymorphisms are associated with susceptibility toward chronic periodontitis development. (2017 Oct)Zupin LOral Dis