Gene info: ID 406

Gene: ARNTL

GENE ID: 406

Synonyms: BMAL1|BMAL1c|JAP3|MOP3|PASD3|TIC|bHLHe5

Description: aryl hydrocarbon receptor nuclear translocator like

Gene type: protein-coding

Location: 11p15.3

dbXrefs: Ensembl:ENSG00000133794 MIM:602550 Vega:OTTHUMG00000150623 UniprotKB:O00327

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.880e-1 (AD) 7.118e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg15603424	chr11:13300592	ARNTL	Promoter	3.369e-4	Alcohol use disorders	26763658
cg14794298	chr11:13336674	ARNTL	Promoter	5.011e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2A2	0.888
PPID	0.888
NPEPPS	0.887
ZADH2	0.883
LUZP1	0.882
KCND3	0.882
PNMA1	0.879
NMT1	0.878
IP6K1	0.877
MARS	0.875

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.577
OR4F29	-0.52
KLRB1	-0.437
SH2D1A	-0.432
CTNNA3	-0.423
KLRF1	-0.412
CD2	-0.408
C5orf64	-0.399
TFPI2	-0.393
KLF17	-0.388

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of ARNTL mRNA"	26377693
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ARNTL mRNA	19933214
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in increased expression of ARNTL mRNA	22923002
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of ARNTL mRNA	22923002
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ARNTL mRNA"	28433925
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of ARNTL mRNA"	20406850
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ARNTL mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARNTL mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARNTL mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of ARNTL mRNA	17562736
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA	22129741
D020106	Acrylamide	Acrylamide results in increased expression of ARNTL mRNA	28959563
C116917	acylcarnitine	ARNTL gene mutant form affects the abundance of acylcarnitine	27056296
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ARNTL gene	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of ARNTL mRNA	28522335
D000596	Amino Acids	ARNTL gene mutant form results in increased abundance of Amino Acids	27056296
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ARNTL mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ARNTL mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of ARNTL gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of ARNTL mRNA	22378314
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of ARNTL mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ARNTL mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ARNTL mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ARNTL mRNA	26377693
D019324	beta-Naphthoflavone	ARNTL affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]	21849270
D019324	beta-Naphthoflavone	beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to ARNTL protein]	20106950
D019324	beta-Naphthoflavone	beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNTL protein]	20106950
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ARNTL mRNA	18164116
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of ARNTL mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ARNTL mRNA	21632981\|2231617
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ARNTL mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ARNTL mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ARNTL mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARNTL mRNA"	19150397
D001629	Bezafibrate	[CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20400680
D001629	Bezafibrate	[CLOCK protein binds to ARNTL protein] promotes the reaction [[PPARA protein binds to RXRA protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]]	20400680
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARNTL mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of ARNTL mRNA	25594700
C006780	bisphenol A	bisphenol A results in increased methylation of ARNTL promoter	27312807
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ARNTL mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of ARNTL mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ARNTL	23085516
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ARNTL mRNA	21442002
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ARNTL mRNA	20107868
D019256	Cadmium Chloride	Melatonin inhibits the reaction [Cadmium Chloride affects the expression of ARNTL]	23085516
D002330	Carmustine	Carmustine results in decreased expression of ARNTL mRNA	16005536
D002336	Carnosine	ARNTL gene mutant form results in increased abundance of Carnosine	27056296
C054133	casticin	casticin results in decreased expression of ARNTL mRNA	28444820
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ARNTL mRNA	23650126
D002737	Chloroprene	Chloroprene results in decreased expression of ARNTL mRNA	23125180
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ARNTL mRNA	27858113
C031180	chrysene	chrysene results in decreased expression of ARNTL mRNA	26377693
C418118	CI 1044	CI 1044 results in increased expression of ARNTL mRNA	17569694
D002994	Clofibrate	Clofibrate results in decreased expression of ARNTL mRNA	17585979
D003033	Coal Tar	Coal Tar results in decreased expression of ARNTL mRNA	27858113
D003042	Cocaine	Cocaine results in decreased expression of ARNTL mRNA	15994025
D009243	NAD	ARNTL gene mutant form results in decreased oxidation of NAD	27056296
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of ARNTL mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ARNTL mRNA	19549813
D003404	Creatinine	ARNTL gene mutant form results in increased abundance of Creatinine	27056296
D016572	Cyclosporine	Cyclosporine results in decreased expression of ARNTL mRNA	25562108
D003907	Dexamethasone	Dexamethasone affects the expression of ARNTL mRNA	23251369
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARNTL mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of ARNTL mRNA	25270620
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ARNTL mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in decreased expression of ARNTL mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in decreased expression of ARNTL mRNA	23537522
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ARNTL mRNA	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ARNTL mRNA	19245819
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ARNTL mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ARNTL mRNA	28871463
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ARNTL mRNA	18164116
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA	22129741
C118739	entinostat	entinostat results in increased expression of ARNTL mRNA	27188386
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]	29061316
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]	29061316
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL mRNA]	29061316
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL protein]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL mRNA]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL protein]	29061316
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARNTL mRNA	22079256
D005419	Flavonoids	Flavonoids results in decreased expression of ARNTL mRNA	18035473
D005473	Fluoxetine	Fluoxetine results in increased expression of ARNTL mRNA	15994025
C069837	fullerene C60	fullerene C60 results in decreased expression of ARNTL mRNA	19167457
C039281	furan	furan results in increased expression of ARNTL mRNA	24183702
D005665	Furosemide	ARNTL gene mutant form results in decreased secretion of Furosemide	27056296
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]	29061316
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]	29061316
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL mRNA]	29061316
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL protein]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL mRNA]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL protein]	29061316
D005944	Glucosamine	Glucosamine results in decreased expression of ARNTL mRNA	24442997
D005944	Glucosamine	Glucosamine results in decreased expression of ARNTL protein	24442997
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARNTL mRNA	19695318
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of ARNTL mRNA	21980503
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]	29061316
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]	29061316
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL mRNA]	29061316
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of ARNTL protein]	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ARNTL mRNA	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ARNTL protein	29061316
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of ARNTL mRNA"	26377693
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA	22129741
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARNTL mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARNTL mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ARNTL mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of ARNTL mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ARNTL mRNA	26254443
D007854	Lead	Lead affects the expression of ARNTL mRNA	28903495
D008244	Lysophosphatidylcholines	ARNTL gene mutant form affects the abundance of Lysophosphatidylcholines	27056296
C025340	manganese chloride	manganese chloride results in decreased expression of ARNTL mRNA	28511934
D008550	Melatonin	Melatonin affects the reaction [Rotenone affects the expression of ARNTL mRNA]	25430725
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium Chloride affects the expression of ARNTL]	23085516
D008727	Methotrexate	Methotrexate results in decreased expression of ARNTL mRNA	24449571
D008727	Methotrexate	Methotrexate affects the expression of ARNTL mRNA	18502557
D008727	Methotrexate	Methotrexate results in decreased expression of ARNTL mRNA	16005536
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of ARNTL mRNA	28392392
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARNTL mRNA"	26251327
D016685	Mitomycin	Mitomycin results in decreased expression of ARNTL mRNA	25270620
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ARNTL mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ARNTL mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ARNTL mRNA"	25554681\|2562005
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of ARNTL mRNA	20971185
D019308	Palmitic Acid	Palmitic Acid results in decreased expression of ARNTL mRNA	24442997
D019308	Palmitic Acid	Palmitic Acid results in decreased expression of ARNTL protein	24442997
D000073878	Palm Oil	Palm Oil results in decreased expression of ARNTL mRNA	18042831
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ARNTL mRNA	18593933
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ARNTL mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ARNTL mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of ARNTL mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of ARNTL mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of ARNTL mRNA	19270015
D010713	Phosphatidylcholines	ARNTL gene mutant form results in increased abundance of Phosphatidylcholines	27056296
C006253	pirinixic acid	pirinixic acid results in decreased expression of ARNTL mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of ARNTL mRNA	18445702\|2381119
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of ARNTL mRNA	23147375
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARNTL mRNA	19695318
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARNTL mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ARNTL mRNA	22079256
D011239	Prednisolone	Prednisolone results in increased expression of ARNTL mRNA	16269518
D011239	Prednisolone	Prednisolone results in increased expression of ARNTL mRNA	16269518
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ARNTL mRNA	27413110
D011374	Progesterone	Progesterone results in increased expression of ARNTL mRNA	20096720
D011794	Quercetin	Quercetin results in increased expression of ARNTL mRNA	21632981
D012402	Rotenone	Melatonin affects the reaction [Rotenone affects the expression of ARNTL mRNA]	25430725
D012402	Rotenone	Rotenone affects the expression of ARNTL mRNA	25430725
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in decreased expression of ARNTL mRNA	19122877
C009250	sevoflurane	sevoflurane affects the expression of ARNTL mRNA	15967596
D012834	Silver	Silver results in decreased expression of ARNTL mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in increased expression of ARNTL mRNA	18812580
D053260	Soot	Soot affects the expression of ARNTL mRNA	26551751
D013109	Sphingomyelins	ARNTL gene mutant form results in increased abundance of Sphingomyelins	27056296
D020058	Styrene	Styrene results in decreased expression of ARNTL mRNA	28951217
D013654	Taurine	ARNTL gene mutant form results in increased abundance of Taurine	27056296
D013739	Testosterone	Testosterone results in increased expression of ARNTL mRNA	22539767
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of ARNTL mRNA	28300664
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ARNTL mRNA	21182907\|2157046
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ARNTL protein	21182907
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ARNTL mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNTL protein]	21182907
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ARNTL mRNA	18295293\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ARNTL mRNA	18487412
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ARNTL mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARNTL mRNA	25613284
D013866	Thioguanine	Thioguanine results in decreased expression of ARNTL mRNA	16005536
C009495	titanium dioxide	titanium dioxide results in increased expression of ARNTL mRNA	23557971
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of ARNTL mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of ARNTL mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ARNTL mRNA	28111298
D014212	Tretinoin	Tretinoin results in decreased expression of ARNTL mRNA	23724009
D014212	Tretinoin	RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]]	17069763
D014212	Tretinoin	Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]	17069763
D014212	Tretinoin	Tretinoin results in increased expression of ARNTL mRNA	9704006
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ARNTL mRNA	29024780
D014508	Urea	ARNTL gene mutant form results in increased abundance of Urea	27056296
D014520	Urethane	Urethane results in increased expression of ARNTL mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARNTL mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ARNTL mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ARNTL gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ARNTL mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of ARNTL mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in increased expression of ARNTL mRNA	29229235
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of ARNTL mRNA	19165385
C111237	vorinostat	vorinostat results in increased expression of ARNTL mRNA	29229235
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in decreased expression of ARNTL mRNA]"	24525044
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of ARNTL mRNA"	24525044
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ARNTL mRNA	18593933
C088658	zoledronic acid	zoledronic acid results in increased expression of ARNTL mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	ISS	-
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	ISS	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	-	IEA	-
GO:0003677	DNA binding	-	IDA	11441146
GO:0003677	DNA binding	-	IGI	9576906
GO:0005515	protein binding	-	IPI	14645221 21960634 24385426 24728990 25416956 28985504
GO:0017162	aryl hydrocarbon receptor binding	-	IPI	9079689
GO:0043425	bHLH transcription factor binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	ISS	-
GO:0046982	protein heterodimerization activity	-	IEA	-
GO:0051879	Hsp90 protein binding	-	IDA	9079689
GO:0070491	repressing transcription factor binding	-	IPI	25936801
GO:0070888	E-box binding	-	IDA	12738229 23785138

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000060	protein import into nucleus, translocation	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	ISS	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007283	spermatogenesis	-	ISS	-
GO:0007623	circadian rhythm	-	TAS	-
GO:0032007	negative regulation of TOR signaling	-	ISS	-
GO:0032922	circadian regulation of gene expression	-	IDA	24005054
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0042176	regulation of protein catabolic process	-	IEA	-
GO:0042634	regulation of hair cycle	-	IMP	24005054
GO:0042753	positive regulation of circadian rhythm	-	ISS	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	ISS	-
GO:0045599	negative regulation of fat cell differentiation	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	11441146 12738229 23785138
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	21628546
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	20093779
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	9576906
GO:0050767	regulation of neurogenesis	-	ISS	-
GO:0050796	regulation of insulin secretion	-	ISS	-
GO:0051726	regulation of cell cycle	-	ISS	-
GO:0051775	response to redox state	-	IDA	11441146
GO:0060137	maternal process involved in parturition	-	IEA	-
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	ISS	-
GO:0090403	oxidative stress-induced premature senescence	-	ISS	-
GO:1901985	positive regulation of protein acetylation	-	IMP	28985504
GO:2000074	regulation of type B pancreatic cell development	-	ISS	-
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	-	ISS	-
GO:2000772	regulation of cellular senescence	-	ISS	-
GO:2001016	positive regulation of skeletal muscle cell differentiation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	24005054
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IPI	9576906
GO:0016605	PML body	-	IEA	-
GO:0033391	chromatoid body	-	ISS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa04710	Circadian rhythm

Reactome ID	Reactome Term	Evidence
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	IEA
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1989781	PPARA activates gene expression	IEA
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	IEA
R-HSA-400253	Circadian Clock	IEA
R-HSA-400253	Circadian Clock	TAS
R-HSA-556833	Metabolism of lipids	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25677407	Clock genes in human alcohol abuse and comorbid conditions. (2015 Jun)	Partonen T	Alcohol
20554694	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)	Kovanen L	Alcohol Alcohol
27739341	Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL. (2016 Oct 14)	Bengesser SA	World J Biol Psychiatry
28296937	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)	Lin E	PLoS One