Gene: LY6H

4062
NMLY6
lymphocyte antigen 6 family member H
protein-coding
8q24.3
Ensembl:ENSG00000176956 MIM:603625 Vega:OTTHUMG00000154890 UniprotKB:O94772
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.897e-1 (AD)  8.761e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCEA20.923
MAP2K20.901
NAT140.9
HCFC1R10.899
LSM40.896
ABHD14A0.896
CLTB0.895
TWF20.895
CALY0.893
STMN30.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.687
OR4F29-0.656
KCNJ15-0.419
EBF1-0.409
PABPC4L-0.406
PZP-0.4
FOLR3-0.398
TFPI2-0.396
CASP10-0.391
SIX1-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of LY6H mRNA17562736
C547126AZM551248AZM551248 results in decreased expression of LY6H mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LY6H mRNA27195522
C006780bisphenol Abisphenol A affects the expression of LY6H mRNA25181051
D003042CocaineCocaine results in increased expression of LY6H protein25100957
D003471CuprizoneCuprizone results in decreased expression of LY6H mRNA26577399
D003561CytarabineCytarabine results in decreased expression of LY6H mRNA21198554
C039281furanfuran results in decreased methylation of LY6H gene27387713
C039281furanfuran results in increased expression of LY6H mRNA27387713
D017313FenretinideFenretinide results in decreased expression of LY6H mRNA28973697
D007854LeadLead affects the expression of LY6H mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of LY6H mRNA"24972896
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LY6H mRNA"20188158
D010936Plant ExtractsPlant Extracts results in decreased expression of LY6H mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of LY6H mRNA24780913
D012402RotenoneRotenone results in decreased expression of LY6H mRNA19013527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LY6H mRNA24680724
D014635Valproic AcidValproic Acid results in increased expression of LY6H mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of LY6H gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0030550acetylcholine receptor inhibitor activity-IBA21873635  
GO:0033130acetylcholine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS9799603  
GO:0009887animal organ morphogenesis-TAS9799603  
GO:0095500acetylcholine receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26276394Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic acetylcholine receptors by members of the Ly6 protein family. (2015 Oct 2)Wu MJ Biol Chem