Gene: LYN

4067
JTK8|p53Lyn|p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
protein-coding
8q12.1
Ensembl:ENSG00000254087 MIM:165120 Vega:OTTHUMG00000044345 UniprotKB:P07948
NG_029593.1
PubMed
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.339e-1 (AD)  7.421e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11982546chr8:56832362LYNPromoter2.173e-4Alcohol use disorders26763658
cg02508743chr8:56903623LYN8.100e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL160.882
MYD880.851
TGFB10.833
CMTM60.826
PIK3AP10.822
PLEK0.817
PTPN60.813
LTBR0.81
RIN30.809
ADAP20.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.562
DRD5-0.532
HAS1-0.532
CALHM1-0.532
TMEFF2-0.531
KCNB2-0.524
ADTRP-0.523
DLK2-0.519
GPR61-0.516
TMEM179-0.511

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB030231-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineSmall MoleculeExperimentalTarget
DB06616BosutinibSmall Molecule380843-75-4ApprovedTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB09079NintedanibSmall Molecule656247-17-5ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LYN mRNA"19114083
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of LYN mRNA19643169
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of LYN mRNA"20702594
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LYN mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of LYN protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LYN mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LYN mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of LYN mRNA26690555
C016601afimoxifeneLYN results in decreased susceptibility to afimoxifene21233418
C412373AG 1879AG 1879 inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C412373AG 1879AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]25980585
C412373AG 1879AG 1879 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
C412373AG 1879AG 1879 results in decreased phosphorylation of LYN protein15175350
C412373AG 1879AG 1879 results in decreased activity of LYN protein25980585
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
C032311aluminum fluoridealuminum fluoride results in increased phosphorylation of LYN protein8559152
C077990alvocidib[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein15039284
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LYN mRNA16483693
D000941AntigensAntigens results in increased activity of LYN protein21958720
D000941AntigensQuinoxalines analog affects the reaction [Antigens results in increased activity of LYN protein]21958720
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LYN mRNA24449571
D047310ApigeninApigenin results in decreased activity of LYN protein19814731
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D001241AspirinAspirin results in increased expression of LYN mRNA15928584
C547126AZM551248AZM551248 results in increased expression of LYN mRNA22323515
C037689benzamidebenzamide analog results in decreased activity of LYN protein17376680
C012768benzanthronebenzanthrone results in increased phosphorylation of LYN protein28495615
C012768benzanthroneethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased phosphorylation of LYN protein]28495615
D001554BenzeneBenzene results in increased expression of LYN mRNA16188089
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LYN mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LYN mRNA"19150397|2001819
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LYN mRNA19619570
D004958EstradiolEstradiol results in decreased expression of LYN mRNA19619570
D004958Estradiol[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA21185374
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)AG 1879 inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)Ascorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein14572611
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)CAT protein inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C083520bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
C006780bisphenol Abisphenol A results in decreased expression of LYN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LYN gene28505145
D000069286Bortezomib[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein15039284
C471992bosutinibbosutinib results in decreased activity of LYN protein17114238
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of LYN mRNA12419474
D002392CatechinCatechin results in decreased expression of LYN mRNA15465739
D002713ChlorineChlorine results in increased expression of LYN mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of LYN mRNA18636392
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LYN mRNA28472532
D019327Copper SulfateCopper Sulfate results in increased expression of LYN mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of LYN mRNA19167446
D003471CuprizoneCuprizone results in increased expression of LYN mRNA27523638
D003561CytarabineCytarabine results in decreased expression of LYN mRNA21198554
D000069439DasatinibDasatinib binds to and results in decreased phosphorylation of LYN protein18180381
D000069439DasatinibDasatinib results in decreased activity of LYN protein18550857
D000069439DasatinibDasatinib results in decreased phosphorylation of and results in decreased activity of LYN protein17020995
D000069439DasatinibDasatinib results in decreased activity of LYN protein17114238
D003907DexamethasoneDexamethasone affects the expression of LYN mRNA12732289
D003907DexamethasoneDexamethasone results in increased phosphorylation of LYN protein15187100
D003976DiazinonDiazinon results in increased methylation of LYN gene22964155
D002945CisplatinCisplatin results in decreased expression of LYN mRNA21603599
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LYN mRNA15766595
D002117CalcitriolCalcitriol results in increased expression of LYN mRNA12875902
C034638dinitrophenyl-bovine serum albumindinitrophenyl-bovine serum albumin results in increased expression of LYN protein7730640
C034638dinitrophenyl-bovine serum albumindinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of LYN protein19794068
C034638dinitrophenyl-bovine serum albuminPLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of LYN protein]19794068
C034638dinitrophenyl-bovine serum albuminPLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of LYN protein]19794068
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of LYN protein"25856345
C118739entinostatentinostat results in increased expression of LYN mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
D000431EthanolEthanol results in decreased expression of LYN mRNA15353170
D000431EthanolEthanol results in increased expression of [ITGA2 protein binds to LYN protein binds to TRPV4 protein]18234883
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LYN mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LYN mRNA15834898|1755790
C507035ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased phosphorylation of LYN protein]28495615
D005485FlutamideFlutamide results in decreased expression of LYN mRNA24793618
D005485FlutamideFlutamide results in increased expression of LYN mRNA24136188
D009240N-Formylmethionine Leucyl-PhenylalanineAG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]25980585
D009240N-Formylmethionine Leucyl-Phenylalaninehonokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]25980585
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein25980585
D005978GlutathioneGlutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]14572611
D005978GlutathioneGlutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
C005499honokiolhonokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]25980585
C005499honokiolhonokiol results in decreased activity of LYN protein25980585
C492448ICG 001ICG 001 affects the expression of LYN mRNA26191083
D000068877Imatinib MesylateLYN protein results in decreased susceptibility to Imatinib Mesylate17432977
D000068877Imatinib MesylateLYN results in decreased susceptibility to Imatinib Mesylate17595328
D000068877Imatinib Mesylate[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein15604220
D007213IndomethacinIndomethacin results in decreased expression of LYN mRNA16984733
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LYN mRNA25613284
C045463leflunomideleflunomide results in increased expression of LYN mRNA24136188
C533894LG 100815LG 100815 results in increased expression of LYN mRNA16951191
C025340manganese chloridemanganese chloride results in decreased methylation of LYN gene27913844
D008628MercuryMercury results in increased phosphorylation of and results in increased activity of LYN protein24440445
C005219methyl cellosolvemethyl cellosolve results in increased expression of LYN mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LYN mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LYN mRNA26272509|2800136
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LYN mRNA23649840
D009173Mycophenolic Acid[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein15604220
D009532NickelNickel results in increased expression of LYN mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of LYN mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of LYN mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of LYN mRNA22714537
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of LYN mRNA"16951191
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LYN mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of LYN mRNA18636392
D010126OzoneOzone results in decreased expression of LYN mRNA16330353
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of LYN mRNA26272509
D010634PhenobarbitalPhenobarbital results in decreased expression of LYN mRNA12807726
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LYN mRNA26272509
D010705PhosgenePhosgene affects the expression of LYN mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of LYN mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of LYN mRNA23557933
C545373ponatinibponatinib results in decreased activity of LYN protein19878872
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LYN mRNA22714537
D011192Potassium DichromateAG 1879 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D011192Potassium Dichromatealpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D011192Potassium DichromateAscorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D011192Potassium DichromateCAT protein inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D011192Potassium DichromateGlutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]14572611
D011192Potassium DichromatePotassium Dichromate results in increased phosphorylation of LYN protein14572611
D011794QuercetinQuercetin results in increased expression of LYN mRNA21632981
D011794QuercetinQuercetin results in decreased activity of LYN protein19814731
D011810QuinoxalinesQuinoxalines analog affects the reaction [Antigens results in increased activity of LYN protein]21958720
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA21185374
D015474IsotretinoinIsotretinoin results in increased expression of LYN mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in increased expression of LYN mRNA25351596
D012999SomanSoman results in increased expression of LYN mRNA19281266
C061133tamibarotenetamibarotene results in increased expression of LYN mRNA15498508
D013629TamoxifenTamoxifen affects the expression of LYN mRNA17555576
D013654TaurineTaurine results in decreased expression of LYN mRNA16579726
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LYN mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LYN mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LYN mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LYN mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LYN mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LYN mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LYN mRNA25613284
D013893ThiramThiram results in increased expression of LYN mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LYN mRNA25729387
D019772TopotecanTopotecan results in decreased expression of LYN mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LYN mRNA21934132
D014212TretinoinTretinoin results in increased expression of LYN mRNA12875902|1549850
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LYN mRNA24935251|2627250
C084079triptonidetriptonide results in decreased expression of and results in decreased phosphorylation of LYN protein28666825
C084079triptonidetriptonide results in decreased expression of LYN mRNA28666825
D014415TunicamycinTunicamycin results in decreased expression of LYN mRNA22378314
D014520UrethaneUrethane results in increased expression of LYN mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LYN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LYN mRNA23179753|2438349
D014638VanadatesVanadates results in increased phosphorylation of LYN protein8559152
D014640VancomycinVancomycin results in decreased expression of LYN mRNA18930951
D014810Vitamin EVitamin E results in decreased expression of LYN mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA"27188386
C111237vorinostatvorinostat results in increased expression of LYN mRNA26272509
D015034Zinc OxideZinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein]25127755
C088658zoledronic acidzoledronic acid results in increased expression of LYN mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-EXP1381360  7526393  9799234  10861086  11110698  11358993  
11448999  12670955  12923167  16921024  17462920  18697750  
GO:0004713protein tyrosine kinase activity-IDA7682714  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005161platelet-derived growth factor receptor binding-IEA-  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI1715582  7516469  7859737  8647200  8753773  9020138  
9045636  11306681  11389892  11517336  12456510  14993658  
15491611  15546919  15784897  15795233  16155203  16799092  
17254966  17640867  18070987  19940238  20037584  20159608  
22581261  22624718  22731636  23001182  23764002  23866081  
24658140  24728074  25814554  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-NAS24217950  
GO:0017124SH3 domain binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0043015gamma-tubulin binding-IEA-  
GO:0043208glycosphingolipid binding-IEA-  
GO:0044325ion channel binding-IPI12538589  
GO:0046875ephrin receptor binding-IPI24217950  
GO:0051219phosphoprotein binding-IEA-  
GO:0140031phosphorylation-dependent protein binding-IPI11782428  
GO ID GO Term Qualifier Evidence PubMed
GO:0001782B cell homeostasis-ISS-  
GO:0001817regulation of cytokine production-ISS-  
GO:0001932regulation of protein phosphorylation-TAS15489917  
GO:0001933negative regulation of protein phosphorylation-ISS-  
GO:0001934positive regulation of protein phosphorylation-IGI24217950  
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0002250adaptive immune response-IEA-  
GO:0002431Fc receptor mediated stimulatory signaling pathway-IBA21873635  
GO:0002431Fc receptor mediated stimulatory signaling pathway-ISS-  
GO:0002513tolerance induction to self antigen-IBA21873635  
GO:0002513tolerance induction to self antigen-ISS-  
GO:0002513tolerance induction to self antigen-TAS15489917  
GO:0002553histamine secretion by mast cell-IEA-  
GO:0002576platelet degranulation-IBA21873635  
GO:0002576platelet degranulation-ISS-  
GO:0002762negative regulation of myeloid leukocyte differentiation-IEA-  
GO:0002768immune response-regulating cell surface receptor signaling pathway-ISS-  
GO:0002768immune response-regulating cell surface receptor signaling pathway-TAS15489917  
GO:0002774Fc receptor mediated inhibitory signaling pathway-ISS-  
GO:0002902regulation of B cell apoptotic process-IBA21873635  
GO:0006468protein phosphorylation-IDA11517336  
GO:0006974cellular response to DNA damage stimulus-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA10891478  11517336  
GO:0006991response to sterol depletion-IEA-  
GO:0007165signal transduction-TAS7650013  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IMP14726379  
GO:0007596blood coagulation-TAS-  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0008285negative regulation of cell proliferation-IMP14726379  
GO:0009636response to toxic substance-IEA-  
GO:0009725response to hormone-ISS-  
GO:0009743response to carbohydrate-IEA-  
GO:0010976positive regulation of neuron projection development-IMP17910947  
GO:0014003oligodendrocyte development-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0016032viral process-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IDA7682714  11782428  
GO:0030154cell differentiation-IBA21873635  
GO:0030168platelet activation-TAS-  
GO:0030218erythrocyte differentiation-ISS-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030889negative regulation of B cell proliferation-IBA21873635  
GO:0031175neuron projection development-IBA21873635  
GO:0031175neuron projection development-IEA-  
GO:0031295T cell costimulation-TAS-  
GO:0031663lipopolysaccharide-mediated signaling pathway-ISS-  
GO:0031668cellular response to extracellular stimulus-IEA-  
GO:0032868response to insulin-IEA-  
GO:0033003regulation of mast cell activation-ISS-  
GO:0033628regulation of cell adhesion mediated by integrin-IMP18802065  
GO:0034136negative regulation of toll-like receptor 2 signaling pathway-ISS-  
GO:0034144negative regulation of toll-like receptor 4 signaling pathway-ISS-  
GO:0034605cellular response to heat-IEA-  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-ISS-  
GO:0043200response to amino acid-IEA-  
GO:0043304regulation of mast cell degranulation-IBA21873635  
GO:0043304regulation of mast cell degranulation-ISS-  
GO:0043407negative regulation of MAP kinase activity-ISS-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IEA-  
GO:0045087innate immune response-IBA21873635  
GO:0045646regulation of erythrocyte differentiation-ISS-  
GO:0046777protein autophosphorylation-IDA7682714  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048678response to axon injury-IEA-  
GO:0050663cytokine secretion-IEA-  
GO:0050707regulation of cytokine secretion-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0050777negative regulation of immune response-TAS15489917  
GO:0050853B cell receptor signaling pathway-IEA-  
GO:0050855regulation of B cell receptor signaling pathway-IBA21873635  
GO:0050855regulation of B cell receptor signaling pathway-ISS-  
GO:0050861positive regulation of B cell receptor signaling pathway-IEA-  
GO:0050900leukocyte migration-TAS-  
GO:0051272positive regulation of cellular component movement-IDA16467205  
GO:0051279regulation of release of sequestered calcium ion into cytosol-IEA-  
GO:0060252positive regulation of glial cell proliferation-IEA-  
GO:0060369positive regulation of Fc receptor mediated stimulatory signaling pathway-IEA-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO:0070304positive regulation of stress-activated protein kinase signaling cascade-IDA10891478  
GO:0070372regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070447positive regulation of oligodendrocyte progenitor proliferation-IEA-  
GO:0070667negative regulation of mast cell proliferation-IBA21873635  
GO:0070667negative regulation of mast cell proliferation-ISS-  
GO:0070668positive regulation of mast cell proliferation-IMP11435302  
GO:0071300cellular response to retinoic acid-IMP17910947  
GO:0090025regulation of monocyte chemotaxis-IMP18802065  
GO:0090330regulation of platelet aggregation-IBA21873635  
GO:0090330regulation of platelet aggregation-ISS-  
GO:0097028dendritic cell differentiation-IBA21873635  
GO:0097028dendritic cell differentiation-ISS-  
GO:1902532negative regulation of intracellular signal transduction-ISS-  
GO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IMP24217950  
GO:2000670positive regulation of dendritic cell apoptotic process-IBA21873635  
GO:2000670positive regulation of dendritic cell apoptotic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18817770  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005758mitochondrial intermembrane space-IEA-  
GO:0005794Golgi apparatus-IDA15173188  20605918  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA15173188  20605918  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0030061mitochondrial crista-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0034666integrin alpha2-beta1 complex-IEA-  
GO:0042629mast cell granule-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045121membrane raft-IDA11313396  
GO:0045121membrane raft-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA20605918  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04730Long-term depression
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114604GPVI-mediated activation cascadeTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-1433557Signaling by SCF-KITIEA
R-HSA-1433559Regulation of KIT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029481FCGR activationTAS
R-HSA-210990PECAM1 interactionsTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationTAS
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationIEA
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389513CTLA4 inhibitory signalingTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5621480Dectin-2 familyTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5621575CD209 (DC-SIGN) signalingTAS
R-HSA-5690714CD22 mediated BCR regulationTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-75892Platelet Adhesion to exposed collagenTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-912631Regulation of signaling by CBLIEA
R-HSA-912631Regulation of signaling by CBLTAS
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-982772Growth hormone receptor signalingTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29520592Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats. (2018 May)Belin-Rauscent APsychopharmacology (Berl)
24894179Lyn regulates cytotoxicity in respiratory epithelial cells challenged by cigarette smoke extracts. (2014)Wang WCurr Mol Med
18234883Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. (2008 Jan 30)Alessandri-Haber NJ Neurosci
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS