Gene: EPCAM

4072
DIAR5|EGP-2|EGP314|EGP40|ESA|HNPCC8|KS1/4|KSA|M4S1|MIC18|MK-1|TACSTD1|TROP1
epithelial cell adhesion molecule
protein-coding
2p21
Ensembl:ENSG00000119888 MIM:185535 Vega:OTTHUMG00000128853 UniprotKB:P16422
NG_012352.2
PubMed
0   ANCO-SNPs
ND
7   
2.695e-1 (AD)  6.395e-1 (ND)   (Frontal_Cortex)
3.519e-1 (AD)  5.399e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PENK0.519
IGSF50.505
COCH0.495
IL13RA20.494
LHX80.47
SLC5A70.466
SLC35F40.464
POLR1E0.463
CXorf570.458
FAM183A0.455

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYSLTR2-0.3
SYPL2-0.29
HIGD1B-0.29
P2RY14-0.278
GJC1-0.277
KIR2DL3-0.269
COL5A3-0.269
SLC6A12-0.267
PDGFRB-0.265
GLI1-0.261

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05319oportuzumab monatoxBiotechDrug-InvestigationalTarget
DB05831ING-1Small Molecule-InvestigationalTarget
DB06607CatumaxomabBiotechDrug509077-98-9Approved|Investigational|WithdrawnTarget
DB09336Technetium Tc-99m nofetumomab merpentanSmall Molecule165942-79-0Approved|WithdrawnTarget
DB11075HypromelloseSmall Molecule9004-65-3ApprovedTarget
ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of EPCAM mRNA"23826121
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of EPCAM mRNA"17070881
C0353141-nitropropane1-nitropropane results in decreased expression of EPCAM mRNA17070881
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EPCAM mRNA"25614096
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of EPCAM mRNA"20959002
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of EPCAM mRNA"17070881
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EPCAM mRNA"21346803
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of EPCAM mRNA"17070881
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EPCAM mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of EPCAM mRNA25088246
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in increased expression of EPCAM mRNA17070881
C0166172-nitropropane2-nitropropane results in increased expression of EPCAM mRNA17070881
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of EPCAM mRNA"20959002
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM mRNA"21826054
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein"27052460
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]"27052460
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]"27052460
C0414773-hydroxyflavone3-hydroxyflavone results in decreased expression of EPCAM protein27600294
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EPCAM mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of EPCAM protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of EPCAM mRNA17070881
C0293704-toluidine4-toluidine results in increased expression of EPCAM mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EPCAM mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of EPCAM mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EPCAM mRNA23630614
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA17785943
D000638AmiodaroneAmiodarone affects the expression of EPCAM mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPCAM mRNA16483693
D001151ArsenicArsenic affects the methylation of EPCAM gene25304211
C006632arsenic trioxideEPCAM protein results in decreased susceptibility to arsenic trioxide20707922
C487081belinostatbelinostat results in increased expression of EPCAM mRNA26272509
D001553BenzbromaroneBenzbromarone affects the expression of EPCAM mRNA19483382
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPCAM mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EPCAM promoter]19654925
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of EPCAM mRNA23041725
D004958EstradiolEstradiol results in increased expression of EPCAM mRNA15289156|1948475
C006780bisphenol Abisphenol A results in increased expression of EPCAM mRNA27740625
C006780bisphenol Abisphenol A results in decreased expression of EPCAM mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of EPCAM mRNA18180321
D002273CarcinogensCarcinogens results in increased expression of EPCAM mRNA16316942
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EPCAM mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of EPCAM mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EPCAM mRNA20938992
D002994ClofibrateClofibrate affects the expression of EPCAM mRNA19483382
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EPCAM mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of EPCAM mRNA19549813
C551994crizotinibcrizotinib results in decreased expression of EPCAM mRNA22973962
C551994crizotinibcrizotinib results in decreased expression of EPCAM protein22973962
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of EPCAM mRNA18648096
D016572CyclosporineCyclosporine results in decreased expression of EPCAM mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EPCAM mRNA24317228
C014347decitabinedecitabine affects the expression of EPCAM mRNA16624485
C014347decitabinedecitabine affects the expression of EPCAM protein16624485
C014347decitabine[decitabine affects the methylation of EPCAM promoter] which affects the expression of EPCAM mRNA18398839|1839883
C014347decitabine[decitabine affects the methylation of EPCAM promoter] which affects the expression of EPCAM protein18398839|1839883
D013759DronabinolDronabinol results in increased expression of EPCAM mRNA18454173
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EPCAM mRNA]27941970
D016190Carboplatin[Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein12695858
D002945CisplatinCisplatin results in increased expression of EPCAM protein21618587
D002945Cisplatin[vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein12695858
C000944dicrotophosdicrotophos results in decreased expression of EPCAM mRNA28302478
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of EPCAM mRNA23041725
D004041Dietary FatsDietary Fats results in increased expression of EPCAM mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of EPCAM mRNA]21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPCAM mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EPCAM mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EPCAM mRNA15289156
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of EPCAM mRNA27638505
D004147DioxinsDioxins affects the expression of EPCAM mRNA20463971
D004317DoxorubicinEPCAM protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in increased expression of EPCAM mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EPCAM mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPCAM mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EPCAM mRNA17557909
D005001EthionineEthionine affects the expression of EPCAM mRNA19483382
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of EPCAM mRNA17070881|1718741
D005485FlutamideFlutamide results in increased expression of EPCAM mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EPCAM mRNA20938992
C039281furanfuran results in decreased methylation of EPCAM gene27387713
C039281furanfuran results in increased expression of EPCAM mRNA26194646|2738771
D019833GenisteinGenistein results in increased expression of EPCAM mRNA15289156
C473027GW 3965"GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]"27052460
D017313FenretinideFenretinide results in decreased expression of EPCAM mRNA28973697
D017313FenretinideFenretinide results in increased expression of EPCAM mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of EPCAM mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of EPCAM mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of EPCAM mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EPCAM mRNA26752646
D007854LeadLead affects the expression of EPCAM mRNA28903495
C042720mercuric bromidemercuric bromide results in increased expression of EPCAM mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of EPCAM mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of EPCAM mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EPCAM mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EPCAM mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPCAM mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EPCAM mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of EPCAM mRNA12634122
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of EPCAM mRNA24128854
C000621033napabucasinnapabucasin results in decreased expression of EPCAM mRNA25605917
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of EPCAM mRNA25380136
D009532NickelNickel results in decreased expression of EPCAM mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of EPCAM mRNA22714537
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of EPCAM mRNA27148699
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of EPCAM mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EPCAM mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of EPCAM mRNA19483382
D017239Paclitaxel[Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein12695858
D017239PaclitaxelPaclitaxel results in decreased expression of EPCAM mRNA19682730
D017239PaclitaxelPaclitaxel results in decreased expression of EPCAM protein15907983
D017239PaclitaxelPaclitaxel results in increased expression of EPCAM protein12695858
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EPCAM mRNA26272509
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EPCAM mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of EPCAM mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EPCAM mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of EPCAM mRNA19483382
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of EPCAM mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of EPCAM mRNA11678601
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of EPCAM mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of EPCAM mRNA23012394
D011441PropylthiouracilPropylthiouracil affects the expression of EPCAM mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of EPCAM mRNA24780913
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of EPCAM mRNA25905778
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of EPCAM mRNA]21852083
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of EPCAM mRNA19564919
C078903seocalcitolseocalcitol results in decreased expression of EPCAM mRNA12040012
D012715Sesame OilSesame Oil results in decreased expression of EPCAM mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EPCAM mRNA25895662
D012906SmokeSmoke results in decreased expression of EPCAM mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of EPCAM mRNA23922661
C017947sodium arseniteMIR191 mRNA promotes the reaction [sodium arsenite results in increased expression of EPCAM mRNA]29277653
C017947sodium arsenitesodium arsenite results in decreased expression of EPCAM mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of EPCAM mRNA29277653
C017947sodium arsenitesodium arsenite results in increased expression of EPCAM mRNA17350061
C016104sodium bichromatesodium bichromate results in increased expression of EPCAM mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of EPCAM protein27548804
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of EPCAM mRNA25905778
D013629TamoxifenTamoxifen results in increased expression of EPCAM mRNA26908177
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPCAM mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EPCAM mRNA20959002
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of EPCAM mRNA25613284
D013849ThimerosalThimerosal results in increased expression of EPCAM mRNA24675092
D013853ThioacetamideThioacetamide affects the expression of EPCAM mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of EPCAM mRNA23411599
D019772TopotecanEPCAM protein affects the susceptibility to Topotecan16217747
D014118Toxins, Biological"Toxins, Biological affects the expression of EPCAM mRNA"19682533
D014212TretinoinTretinoin results in increased expression of EPCAM mRNA21934132
D014212TretinoinTretinoin results in decreased expression of EPCAM mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EPCAM mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EPCAM mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EPCAM mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of EPCAM mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of EPCAM gene29154799
D014638VanadatesVanadates results in decreased expression of EPCAM mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EPCAM gene25560391
D014747VinblastineEPCAM protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of EPCAM mRNA19015723
C030852vinorelbine[vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein12695858
C030852vinorelbinevinorelbine results in increased expression of EPCAM protein12695858
C029297vinylidene chloridevinylidene chloride results in decreased expression of EPCAM mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPCAM mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16054130  
GO:0044877protein-containing complex binding-IDA19136966  
GO:0098641cadherin binding involved in cell-cell adhesion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-IEA-  
GO:0008284positive regulation of cell proliferation-IDA15195135  
GO:0023019signal transduction involved in regulation of gene expression-IMP19136966  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15195135  15922867  
GO:0048863stem cell differentiation-IMP19785009  
GO:0050900leukocyte migration-TAS-  
GO:0098609cell-cell adhesion-IEA-  
GO:2000048negative regulation of cell-cell adhesion mediated by cadherin-IDA9382878  
GO:2000648positive regulation of stem cell proliferation-IMP19785009  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA15195135  19785009  
GO:0005886plasma membrane-TAS-  
GO:0005923bicellular tight junction-IBA21873635  
GO:0005923bicellular tight junction-IDA16054130  
GO:0009986cell surface-IEA-  
GO:0016323basolateral plasma membrane-IDA18025791  
GO:0016324apical plasma membrane-IDA18025791  
GO:0016328lateral plasma membrane-IDA16054130  
GO:0070062extracellular exosome-HDA11487543  19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28559012Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. (2017 Jun)Wang SJOral Oncol
22201943Hepatocellular carcinoma stem cells: origins and roles in hepatocarcinogenesis and disease progression. (2012 Jan 1)Shen YFront Biosci (Elite Ed)
20301390Lynch Syndrome (1993)Kohlmann W-
24030743Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature. (2014 Apr)Haninger DMMod Pathol
27528600The Impact of Receiving Predictive Genetic Information about Lynch Syndrome on Individual Colonoscopy and Smoking Behaviors. (2016 Nov)Kim JSCancer Epidemiol Biomarkers Prev
28560677Mesenchymal-Epithelial Transition and Circulating Tumor Cells in Small Cell Lung Cancer. (2017)Hamilton GAdv Exp Med Biol
24787949Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer. (2014)Wang XPLoS One