Gene: FAM19A1

407738
TAFA-1|TAFA1
family with sequence similarity 19 member A1, C-C motif chemokine like
protein-coding
3p14.1
Ensembl:ENSG00000183662 MIM:617495 Vega:OTTHUMG00000158745 UniprotKB:Q7Z5A9
NC_000003.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.697e-4 (AD)  8.634e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7650009chr3:68203529 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9990002chr3:68116622 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRM30.953
EPHA40.953
OLFM30.95
LRFN50.948
CBLN20.946
KIAA1549L0.945
LRRTM40.945
CDH180.944
KCNJ30.944
HTR2A0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.637
RAI14-0.615
REST-0.61
YES1-0.602
WWTR1-0.592
CNN2-0.578
ACAP1-0.574
FAM114A1-0.568
SNHG18-0.559
RNF135-0.557

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of FAM19A1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of FAM19A1 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of FAM19A1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of FAM19A1 mRNA26577399
C016366dibenzothiophenedibenzothiophene results in decreased expression of FAM19A1 mRNA23656968
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of FAM19A1 mRNA17183730
C016517indole-3-carbinolindole-3-carbinol affects the expression of FAM19A1 mRNA21396975
D007649KetamineKetamine results in decreased expression of FAM19A1 mRNA20080153
D011192Potassium DichromatePotassium Dichromate results in increased expression of FAM19A1 mRNA23608068
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of FAM19A1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of FAM19A1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FAM19A1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005783endoplasmic reticulum-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal