Gene: ARRB1

408
ARB1|ARR1
arrestin beta 1
protein-coding
11q13.4
Ensembl:ENSG00000137486 MIM:107940 Vega:OTTHUMG00000165444 UniprotKB:P49407
NG_028118.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.460e-1 (AD)  4.325e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs512797chr11:75285037 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01901332chr11:75031054ARRB11.800e-13Smoking27651444
cg01901332chr11:75031054ARRB11.350e-11Tobacco smoking28225026
cg01901332chr11:75031054ARRB13.410e-22Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABAT0.853
TNPO20.841
ARHGAP350.835
SMARCC20.831
AGPAT30.82
GABBR10.82
CDC42BPB0.817
ABR0.814
C1orf210.812
ZC3H7B0.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.552
CLEC2B-0.397
BEST3-0.387
SFN-0.381
IL24-0.381
PLEKHA4-0.375
CHI3L2-0.374
TFPI2-0.356
SPOCD1-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of ARRB1 mRNA"26186136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of ARRB1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]19407222
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]19407222
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]19407222
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of ARRB1 protein19407222
D000082AcetaminophenAcetaminophen results in increased expression of ARRB1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ARRB1 mRNA17562736
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]19407222
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]19407222
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]19407222
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of ARRB1 protein19407222
D000393Air PollutantsAir Pollutants analog results in decreased expression of ARRB1 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of ARRB1 mRNA25014914
D000526Alprenolol[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA24334028
D000526Alprenolol[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA24334028
D000526Alprenolol[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA24334028
D000526Alprenolol[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA24334028
D000526AlprenololAlprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]18787115
D000526AlprenololARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
D000526AlprenololARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ARRB1 mRNA21298039
D019804MesalamineMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA]24637189
D019804MesalamineMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein]24637189
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARRB1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of ARRB1 mRNA25929836
C487081belinostatbelinostat results in increased expression of ARRB1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of ARRB1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARRB1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARRB1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARRB1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ARRB1 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of ARRB1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ARRB1 mRNA24066056|2518105
D000069286BortezomibBortezomib results in decreased expression of ARRB1 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of ARRB1 mRNA26079696
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ARRB1 mRNA20360939
C043211carvedilolARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
C043211carvedilolARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
C043211carvedilol[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA24334028
C043211carvedilol[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA24334028
C043211carvedilol[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA24334028
C043211carvedilol[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA24334028
C043211carvedilol[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA24334028
C043211carvedilolcarvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]18787115
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]24334028
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]24334028
C043211carvedilolColforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
C043211carvedilolGRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
C043211carvedilolGRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
C043211carvedilolMetoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
C043211carvedilolARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]24334028
C043211carvedilolARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]24334028
C043211carvedilolARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]24334028
C043211carvedilolARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]24334028
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]24334028
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]24334028
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ARRB1 mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ARRB1 mRNA17452286
D005576ColforsinColforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ARRB1 mRNA20971185
D003345CorticosteroneCorticosterone results in decreased expression of ARRB1 mRNA19477151
D003345CorticosteroneFluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB1 mRNA]19477151
D016572CyclosporineCyclosporine results in decreased expression of ARRB1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of ARRB1 mRNA19770486
C014347decitabinedecitabine affects the expression of ARRB1 mRNA23300844
D003976DiazinonDiazinon results in decreased expression of ARRB1 mRNA17452286
D002945CisplatinCisplatin affects the expression of ARRB1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ARRB1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ARRB1 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ARRB1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB1 mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ARRB1 mRNA20360939
D004280DobutamineARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
D004280DobutamineARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
D007980LevodopaLevodopa results in decreased expression of ARRB1 protein15885624
C118739entinostatentinostat results in increased expression of ARRB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARRB1 mRNA22079256
D000431EthanolEthanol results in decreased expression of ARRB1 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARRB1 mRNA17555576
D005473FluoxetineFluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB1 mRNA]19477151
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of ARRB1 mRNA21782745
D019833GenisteinGenistein results in decreased expression of ARRB1 mRNA21782745
D017313FenretinideFenretinide results in decreased expression of ARRB1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARRB1 mRNA25613284
D007545IsoproterenolIsoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]18787115
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ARRB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARRB1 mRNA23086925|2675264
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ARRB1 mRNA27339419
C042720mercuric bromidemercuric bromide results in increased expression of ARRB1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of ARRB1 mRNA24449571
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of ARRB1 mRNA21782745
D008731MethoxychlorMethoxychlor results in decreased expression of ARRB1 mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARRB1 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ARRB1 protein"15885624
D008790MetoprololMetoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARRB1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARRB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARRB1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ARRB1 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of ARRB1 mRNA22714537
D009538NicotineARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]16862215
D009538NicotineARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein]16862215
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ARRB1 mRNA20971185
D010126OzoneOzone results in increased expression of ARRB1 mRNA16330353
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ARRB1 mRNA26272509
D052638Particulate MatterARRB1 protein promotes the reaction [Particulate Matter affects the localization of MAPK1 protein modified form]19337515
D052638Particulate MatterARRB1 protein promotes the reaction [Particulate Matter affects the localization of MAPK3 protein modified form]19337515
D052638Particulate MatterARRB1 protein promotes the reaction [Particulate Matter results in increased expression of MMP1 mRNA polymorphism]19337515
D052638Particulate MatterARRB1 protein promotes the reaction [Particulate Matter results in increased secretion of MMP1 protein]19337515
C046012pentanalpentanal results in decreased expression of ARRB1 mRNA26079696
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARRB1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ARRB1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARRB1 mRNA26272509
D010705PhosgenePhosgene affects the expression of ARRB1 mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of ARRB1 mRNA17426115
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARRB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARRB1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ARRB1 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of ARRB1 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of ARRB1 mRNA26079696
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [FASN protein affects the localization of ARRB1 protein]26670611
C000594493qingre zaoshi liangxue fangqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA]24637189
C000594493qingre zaoshi liangxue fangqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein]24637189
D011794QuercetinQuercetin results in decreased expression of ARRB1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ARRB1 mRNA25895662
D010042OuabainOuabain results in increased expression of ARRB1 mRNA16412265
D013629TamoxifenTamoxifen affects the expression of ARRB1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARRB1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARRB1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARRB1 mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ARRB1 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA]24637189
D014302Trinitrobenzenesulfonic AcidMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein]24637189
D014302Trinitrobenzenesulfonic Acidqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA]24637189
D014302Trinitrobenzenesulfonic Acidqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein]24637189
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of ARRB1 mRNA24637189
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of ARRB1 protein24637189
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ARRB1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ARRB1 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARRB1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ARRB1 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004402histone acetyltransferase activityNOTIDA16325578  
GO:0004857enzyme inhibitor activity-TAS2163110  
GO:0005096GTPase activator activity-IMP15611106  
GO:0005159insulin-like growth factor receptor binding-IPI15878855  
GO:0005515protein binding-IPI16189514  16378096  16432186  16524428  17353931  17620599  
19202075  19363159  19782076  19879840  21685944  21857681  
21988832  22457824  23341447  23353685  24069330  24502978  
25416956  25519916  26871637  
GO:0008134transcription factor binding-IPI16325578  
GO:0030331estrogen receptor binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI15878855  
GO:0031691alpha-1A adrenergic receptor binding-IEA-  
GO:0031692alpha-1B adrenergic receptor binding-IEA-  
GO:0031701angiotensin receptor binding-IPI15611106  
GO:0031762follicle-stimulating hormone receptor binding-IEA-  
GO:0031896V2 vasopressin receptor binding-IEA-  
GO:0035612AP-2 adaptor complex binding-IEA-  
GO:0035615clathrin adaptor activity-IEA-  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IEA-  
GO:0044212transcription regulatory region DNA binding-IMP16325578  
GO:0044325ion channel binding-IEA-  
GO:0045309protein phosphorylated amino acid binding-IEA-  
GO:1990763arrestin family protein binding-IPI23886940  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0001934positive regulation of protein phosphorylation-IMP23633677  
GO:0002031G-protein coupled receptor internalization-IMP10521508  12582207  
GO:0002092positive regulation of receptor internalization-IMP22457824  
GO:0006366transcription by RNA polymerase II-IMP16325578  
GO:0006511ubiquitin-dependent protein catabolic process-IMP23886940  
GO:0006915apoptotic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007602phototransduction-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0015031protein transport-IEA-  
GO:0016567protein ubiquitination-IMP15878855  
GO:0030168platelet activation-TAS-  
GO:0031397negative regulation of protein ubiquitination-IDA16378096  
GO:0031398positive regulation of protein ubiquitination-IEA-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA16378096  
GO:0032092positive regulation of protein binding-IEA-  
GO:0032715negative regulation of interleukin-6 production-IDA16378096  
GO:0032717negative regulation of interleukin-8 production-IDA16378096  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0034393positive regulation of smooth muscle cell apoptotic process-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-IMP15611106  
GO:0035066positive regulation of histone acetylation-IMP16325578  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IEA-  
GO:0042493response to drug-IEA-  
GO:0042699follicle-stimulating hormone signaling pathway-IEA-  
GO:0043149stress fiber assembly-IMP15611106  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP15878855  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IMP23886940  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16325578  
GO:0061024membrane organization-TAS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA10644702  
GO:0090240positive regulation of histone H4 acetylation-IMP16325578  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0000785chromatin-IDA16325578  
GO:0005634nucleus-IDA16325578  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA10823817  15611106  16325578  
GO:0005765lysosomal membrane-TAS-  
GO:0005768endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005834heterotrimeric G-protein complexcolocalizes_withTAS10823817  
GO:0005886plasma membrane-TAS9924018  
GO:0005905clathrin-coated pit-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016604nuclear body-IDA-  
GO:0030659cytoplasmic vesicle membrane-TAS-  
GO:0031143pseudopodium-IEA-  
GO:0031410cytoplasmic vesicle-IDA15611106  
GO:0043197dendritic spine-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432720Lysosome Vesicle BiogenesisTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOTAS
R-HSA-5635838Activation of SMOIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17579607Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. (2008 Apr)Sun DMol Psychiatry