Gene: MXD1

4084
BHLHC58|MAD|MAD1
MAX dimerization protein 1
protein-coding
2p13.3
Ensembl:ENSG00000059728 MIM:600021 Vega:OTTHUMG00000129646 UniprotKB:Q05195
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.753e-1 (AD)  8.417e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJB40.777
DCUN1D30.776
USPL10.775
DNAJB10.754
NAA160.752
CCDC1170.745
PPP1R15B0.736
ZCCHC80.734
NUP980.733
NUFIP20.733

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.428
OR4F29-0.408
SPRR2A-0.222
CHP2-0.221
GSDMC-0.215
KCNK17-0.205
KRTAP19-1-0.198
LELP1-0.187
NKX2-8-0.183
SPRR2D-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [MXD1 protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D promotes the reaction [MXD1 protein binds to VDR protein]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D results in decreased degradation of and results in increased expression of MXD1 protein"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D results in increased expression of MXD1 mRNA"23112173
C0979491,25-dihydroxyvitamin D"FBXW7 protein affects the reaction [1,25-dihydroxyvitamin D results in decreased degradation of and results in increased expression of MXD1 protein]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D results in increased expression of MXD1 protein"23112173
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of MXD1 mRNA23792671
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MXD1 mRNA"19095052
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MXD1 mRNA"21703328
C0127962-butenal2-butenal results in increased expression of MXD1 mRNA20471460
C0261142-xylene2-xylene results in increased expression of MXD1 mRNA20359517
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MXD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MXD1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MXD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of MXD1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of MXD1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of MXD1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MXD1 mRNA11752693
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MXD1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of MXD1 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MXD1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of MXD1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in increased expression of MXD1 mRNA25258189|2670570
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MXD1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of MXD1 mRNA25929836
D001379AzathioprineAzathioprine results in increased expression of MXD1 mRNA22623647
D001554BenzeneBenzene results in increased expression of MXD1 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MXD1 mRNA20064835|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MXD1 mRNA20127859
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of MXD1 mRNA]20404318
C006780bisphenol Abisphenol A affects the methylation of MXD1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of MXD1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MXD1 mRNA25181051
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
D020122tert-Butylhydroperoxidepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MXD1 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
D002104CadmiumCadmium results in increased expression of MXD1 mRNA21120746
C037123cadmium sulfatecadmium sulfate results in increased expression of MXD1 mRNA21783983
D002220CarbamazepineCarbamazepine affects the expression of MXD1 mRNA24752500
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MXD1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of MXD1 mRNA19320972
D003042CocaineCocaine results in increased expression of MXD1 mRNA27506785
D003300CopperCopper results in decreased expression of MXD1 mRNA16391388
D003300CopperCopper results in increased expression of MXD1 mRNA19747488
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MXD1 mRNA20971185
D003300CopperCopper deficiency results in increased expression of MXD1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of MXD1 mRNA19549813
D003474CurcuminCurcumin results in increased expression of MXD1 mRNA15713895
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MXD1 mRNA]11007951
D016572CyclosporineCyclosporine results in increased expression of MXD1 mRNA20106945|2556210
D003703DemecolcineDemecolcine results in increased expression of MXD1 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of MXD1 gene22964155
D004008DiclofenacDiclofenac affects the expression of MXD1 mRNA24752500
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MXD1 mRNA15171707
D002117CalcitriolCalcitriol results in increased expression of MXD1 mRNA16002434
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of MXD1 mRNA21362464
D004237DiuronDiuron results in increased expression of MXD1 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MXD1 mRNA"23811387
C118739entinostatentinostat results in decreased expression of MXD1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MXD1 mRNA"27188386
C004912ethylbenzeneethylbenzene results in increased expression of MXD1 mRNA20359517
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MXD1 mRNA23649840
D005054EugenolEugenol results in increased expression of MXD1 mRNA20713136
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of MXD1 mRNA24657277
D005557FormaldehydeFormaldehyde results in increased expression of MXD1 mRNA23416264|2364984
C069837fullerene C60fullerene C60 results in decreased expression of MXD1 mRNA19167457
C039281furanfuran results in increased expression of MXD1 mRNA25539665
D019833GenisteinGenistein results in increased expression of MXD1 mRNA26865667
D007052IbuprofenIbuprofen results in increased expression of MXD1 mRNA17070997
C492448ICG 001ICG 001 results in decreased expression of MXD1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MXD1 mRNA25613284
D007559IvermectinIvermectin inhibits the reaction [MXD1 protein binds to SIN3A protein]26078298
D007559IvermectinIvermectin inhibits the reaction [MXD1 protein binds to SIN3A protein]26078298
C544151jinfukangjinfukang results in decreased expression of MXD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MXD1 mRNA22904298|2479639
C045463leflunomideleflunomide results in increased expression of MXD1 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MXD1 mRNA21362464
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of MXD1 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of MXD1 mRNA21678067|2465727
D008727MethotrexateMXD1 mRNA affects the susceptibility to Methotrexate22753658
D008752Methylene ChlorideMethylene Chloride results in increased expression of MXD1 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MXD1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MXD1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MXD1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MXD1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of MXD1 promoter"26251327
C008493methylselenic acidmethylselenic acid affects the expression of MXD1 mRNA14617803
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MXD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MXD1 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of MXD1 mRNA23811387
C028007nickel monoxidenickel monoxide results in decreased expression of MXD1 mRNA19167457
C570897NSC668394NSC668394 results in increased expression of MXD1 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MXD1 mRNA20971185
C410127PCB 180PCB 180 affects the expression of MXD1 mRNA21703328
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MXD1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MXD1 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of MXD1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MXD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MXD1 mRNA26272509
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
C060836pioglitazonepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
C006253pirinixic acidpirinixic acid results in decreased expression of MXD1 mRNA17426115
D010938Plant OilsPlant Oils results in increased expression of MXD1 mRNA23370395
D011794QuercetinQuercetin results in increased expression of MXD1 mRNA21632981
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
C414354selamectinselamectin inhibits the reaction [MXD1 protein binds to SIN3A protein]26078298
C414354selamectinselamectin inhibits the reaction [MXD1 protein binds to SIN3A protein]26078298
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MXD1 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide results in increased expression of MXD1 mRNA23221170
D012834SilverSilver results in increased expression of MXD1 mRNA26014281
D012834SilverSilver results in decreased expression of MXD1 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of MXD1 mRNA12377979
C017947sodium arsenitesodium arsenite results in increased expression of MXD1 mRNA12760830
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of MXD1 mRNA20713136
D012969Sodium FluorideSodium Fluoride results in increased expression of MXD1 mRNA27862939
D012999SomanSoman results in increased expression of MXD1 mRNA19281266
C016766sulforafansulforafan results in increased expression of MXD1 mRNA26833863
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MXD1 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MXD1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MXD1 mRNA11007951
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MXD1 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of MXD1 mRNA16870260
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MXD1 mRNA22363418|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MXD1 mRNA20133372
D014050TolueneToluene results in increased expression of MXD1 mRNA20359517
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of MXD1 mRNA"17951470
D014212TretinoinTretinoin results in increased expression of MXD1 mRNA15770638
D014212TretinoinTretinoin results in increased expression of MXD1 protein15770638
D014241TrichloroethyleneTrichloroethylene results in increased expression of MXD1 mRNA20359517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MXD1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of MXD1 mRNA29024780
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of MXD1 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of MXD1 mRNA]20847119
D014520UrethaneUrethane results in increased expression of MXD1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MXD1 mRNA23179753|2915479
D014750VincristineVincristine results in increased expression of MXD1 mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of MXD1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of MXD1 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MXD1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10723141  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10723141  
GO:0003700DNA-binding transcription factor activity-TAS7829091  8425218  
GO:0003712transcription coregulator activity-TAS7829091  
GO:0003714transcription corepressor activity-TAS8425218  
GO:0005515protein binding-IPI17418410  27705803  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10723141  12837246  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS7829091  
GO:0008283cell proliferation-TAS7829091  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA12837246  
GO:0005634nucleus-TAS8425218  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24954085Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. (2014 Sep 15)Della-Morte DJ Neurol Sci