Gene: SMAD1

4086
BSP-1|BSP1|JV4-1|JV41|MADH1|MADR1
SMAD family member 1
protein-coding
4q31.21
Ensembl:ENSG00000170365 MIM:601595 Vega:OTTHUMG00000161592 UniprotKB:Q15797
NG_042284.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.983e-1 (AD)  3.432e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEPT10.859
DENND4A0.848
AP3M10.835
COG50.826
AFF40.824
KIAA05860.823
GNS0.823
ATF60.823
SEC24B0.82
ZNF5500.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.391
RERGL-0.372
OR4F29-0.361
MUSTN1-0.286
HES5-0.285
REM1-0.28
SNX22-0.268
REN-0.248
CTNNA3-0.245
NEU4-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SMAD1 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SMAD1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SMAD1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SMAD1 mRNA12419474
C0229095-methoxypsoralen5-methoxypsoralen results in increased phosphorylation of SMAD1 protein17980360
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD1 protein]"23936038
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SMAD1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased phosphorylation of [SMAD1 protein binds to SMAD5 protein binds to SMAD9 protein]22610607
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD1 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of SMAD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SMAD1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMAD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMAD1 mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in decreased expression of SMAD1 protein modified form22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD1 protein modified form]22525892
D001151ArsenicArsenic affects the expression of SMAD1 protein24675094
D001151ArsenicArsenic results in increased phosphorylation of SMAD1 protein28903487
C006632arsenic trioxidearsenic trioxide results in decreased expression of SMAD1 mRNA15761015
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased phosphorylation of SMAD1 protein"17975199
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMAD1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMAD1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD1 mRNA"19150397|2038263
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMAD1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SMAD1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of SMAD1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SMAD1 mRNA26063408
C006780bisphenol Abisphenol A results in increased phosphorylation of and results in increased activity of SMAD1 protein16860915|1721026
C006780bisphenol ATamoxifen inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of SMAD1 protein]16860915
C006780bisphenol Abisphenol A results in increased expression of SMAD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SMAD1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMAD1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SMAD1 mRNA12419474
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA]"20230807
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of and results in increased localization of and results in increased activity of SMAD1 protein17525996
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD1 mRNA17525996
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD1 protein17158861
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of SMAD1 protein17158861
C054133casticincasticin results in increased expression of SMAD1 mRNA27862857
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of SMAD1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SMAD1 mRNA23650126
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD1 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SMAD1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMAD1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of SMAD1 mRNA19549813
D015638Cytochalasin DCytochalasin D affects the localization of SMAD1 protein25756282
D003703DemecolcineDemecolcine results in increased expression of SMAD1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMAD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMAD1 mRNA28628672
D004008DiclofenacDiclofenac results in increased expression of SMAD1 mRNA26934552
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SMAD1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SMAD1 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SMAD1 mRNA"22485181
C118739entinostatentinostat results in decreased expression of SMAD1 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMAD1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD1 mRNA17942748
D005473FluoxetineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]21619414
D005473FluoxetineFluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein]21619414
C037032galangingalangin results in increased expression of SMAD1 mRNA25268046
C037032galangingalangin results in increased phosphorylation of SMAD1 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD1 protein]25268046
D017313FenretinideFenretinide results in increased expression of SMAD1 mRNA28973697
C082359imidaclopridimidacloprid results in decreased expression of SMAD1 protein27444676
C031534imperatorinimperatorin results in increased phosphorylation of SMAD1 protein17980360
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMAD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMAD1 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of SMAD1 mRNA21335049
C554430LDN 193189LDN 193189 inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD1 protein]23936038
C008261lead acetatelead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD1 protein]17805416
C045463leflunomideleflunomide results in increased expression of SMAD1 mRNA28988120
D008070LipopolysaccharidesSMAD1 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]21131441
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD1 protein]25268046
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA]"20230807
D016686MonocrotalineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]21619414
D016686MonocrotalineFluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein]21619414
D016686MonocrotalineMonocrotaline results in decreased expression of SMAD1 mRNA21619414
D016686MonocrotalineMonocrotaline results in decreased phosphorylation of SMAD1 protein21619414
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SMAD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMAD1 mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA]"20230807
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SMAD1 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of SMAD1 mRNA18636392
D010269ParaquatParaquat results in increased expression of SMAD1 mRNA12595580
C008776pelargonic acidpelargonic acid results in increased expression of SMAD1 mRNA11379042
C011272perfosfamideperfosfamide results in decreased expression of SMAD1 mRNA19429390
D010634PhenobarbitalPhenobarbital affects the expression of SMAD1 mRNA23091169
D010852PicrotoxinPicrotoxin results in decreased expression of SMAD1 mRNA15170462
C006253pirinixic acidpirinixic acid results in decreased expression of SMAD1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of SMAD1 mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMAD1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SMAD1 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of SMAD1 mRNA21278054
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of SMAD1 mRNA17803470
C059514resveratrolresveratrol results in increased phosphorylation of SMAD1 protein21745208
C009172rhodiolosiderhodioloside results in increased expression of SMAD1 mRNA24929042
C009172rhodiolosiderhodioloside results in increased phosphorylation of and results in increased expression of SMAD1 protein24929042
D019821SimvastatinSimvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]18310456
D019821SimvastatinSimvastatin results in increased expression of SMAD1 mRNA18310456
D019821SimvastatinSimvastatin results in increased phosphorylation of SMAD1 protein20417880
C439060sirtinolsirtinol results in decreased phosphorylation of SMAD1 protein21745208
C017947sodium arseniteEGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD1 protein]]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD1 protein]23566955
C017947sodium arsenitesodium arsenite results in increased expression of SMAD1 mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of SMAD1 mRNA16014739
D012999SomanSoman results in increased expression of SMAD1 mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of SMAD125617480
D013629TamoxifenTamoxifen inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of SMAD1 protein]16860915
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD1 mRNA24058054
D013853ThioacetamideThioacetamide results in increased expression of SMAD1 mRNA23411599
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of SMAD1 mRNA"11379042
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SMAD1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SMAD1 protein19058293
D014212TretinoinTretinoin results in increased phosphorylation of SMAD1 protein19058293
C012589trichostatin Atrichostatin A results in increased expression of SMAD1 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SMAD1 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in increased expression of SMAD1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SMAD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SMAD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of SMAD1 gene29154799
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of SMAD1 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMAD1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SMAD1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of SMAD1 mRNA22615374
D014750VincristineVincristine results in increased expression of SMAD1 mRNA23649840
D002762CholecalciferolCholecalciferol results in increased expression of SMAD1 mRNA17170073
D015032ZincZinc results in increased phosphorylation of SMAD1 protein22228435

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12270938  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12270938  
GO:0003700DNA-binding transcription factor activity-IDA9389648  
GO:0005515protein binding-IPI9436979  11278251  11779505  15231748  15647271  15781469  
16882717  17183365  17292623  18045539  18548003  19914168  
20937913  21453705  21708152  21947082  24412244  24554596  
25241761  25755279  26878725  
GO:0017151DEAD/H-box RNA helicase binding-IPI18548003  
GO:0019901protein kinase binding-IPI12874272  
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity-TAS19018011  
GO:0042802identical protein binding-IPI9111321  11779505  15231748  
GO:0042803protein homodimerization activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0070410co-SMAD binding-IPI9111321  
GO:0070411I-SMAD binding-IPI9436979  
GO:0070878primary miRNA binding-IPI18548003  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0001710mesodermal cell fate commitment-IEA-  
GO:0002051osteoblast fate commitment-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007165signal transduction-NAS9759503  
GO:0007179transforming growth factor beta receptor signaling pathway-NAS8663601  
GO:0007183SMAD protein complex assembly-IDA9111321  
GO:0007276gamete generation-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009880embryonic pattern specification-ISS-  
GO:0010628positive regulation of gene expression-IDA19664780  
GO:0016579protein deubiquitination-TAS-  
GO:0030509BMP signaling pathway-IDA8653785  9389648  18548003  
GO:0030509BMP signaling pathway-IMP19664780  
GO:0030509BMP signaling pathway-ISS-  
GO:0030509BMP signaling pathway-TAS19018011  
GO:0030901midbrain development-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0031053primary miRNA processing-TAS19018011  
GO:0042592homeostatic process-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IC19664780  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12270938  
GO:0051216cartilage development-IEA-  
GO:0060038cardiac muscle cell proliferation-IEA-  
GO:0060348bone development-IEA-  
GO:0060395SMAD protein signal transduction-ISS-  
GO:0060395SMAD protein signal transduction-NAS14687659  
GO:0061036positive regulation of cartilage development-IEA-  
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-ISS-  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IEA-  
GO:1903672positive regulation of sprouting angiogenesis-IMP24047927  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS10647776  
GO:0005634nucleus-IDA8653785  9389648  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-NAS9759503  
GO:0005634nucleus-TAS19018011  
GO:0005637nuclear inner membrane-IDA15647271  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-IDA9389648  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0016021integral component of membrane-NAS8663601  
GO:0032991protein-containing complex-IDA23610558  
GO:0071141SMAD protein complex-NAS14687659  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8941326RUNX2 regulates bone developmentTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28852126Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. (2017 Aug 29)Chiou JSci Rep
21068203Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. (2011 Jan)Slattery MLCancer Epidemiol Biomarkers Prev