Gene: SMAD2

4087
JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2
SMAD family member 2
protein-coding
18q21.1
Ensembl:ENSG00000175387 MIM:601366 Vega:OTTHUMG00000132652 UniprotKB:Q15796
NG_029946.1
PubMed
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.939e-1 (AD)  4.400e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC50.916
SYNCRIP0.899
RAD210.897
NUCKS10.885
RAB100.88
PCGF50.879
SERBP10.877
NCOA40.874
POLR2M0.874
UBE2E10.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.72
OR4F29-0.715
PTGDR2-0.164
LCN1-0.146
PABPN1L-0.143
MMP23B-0.142
AZU1-0.134
MUC6-0.131
OR1J4-0.129
VCX3A-0.128

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04522DexfosfoserineSmall Molecule407-41-0ExperimentalTarget
ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]28694203
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SMAD2 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SMAD2 protein modified form"21705713
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of SMAD2 mRNA26821219
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]"19429239
C09724015-deoxy-delta(12,14)-prostaglandin J2"SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CTGF]]"19429239
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of SMAD2 protein"23628706
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of SMAD2 protein"23628706
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD2 mRNA"19167446
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein]27856280
C0473683-methylquercetin3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]27151496
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the phosphorylation of SMAD2 protein"22363485
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein]"22363485
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein]"20458730
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [INHBA protein results in increased phosphorylation of SMAD2 protein]"20074812
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Melphalan results in increased phosphorylation of SMAD2 protein]"22363485
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased expression of HAS2 mRNA]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased expression of TNFAIP6 mRNA]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which co-treated with FSHB protein] results in increased expression of PTX3 mRNA"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which results in decreased susceptibility to FSHB protein"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased localization of SMAD2 protein]"20852150
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD2 protein"20852150
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein]"28982980
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD2 protein"28982980
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of SMAD2 protein"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which results in decreased susceptibility to EGF protein"21520325
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SMAD2 mRNA16701773
C058956acteosideacteoside results in increased phosphorylation of SMAD2 protein17634406
C010845aluminum chloridealuminum chloride inhibits the reaction [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]26658030
C010845aluminum chloridealuminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]27720690
C010845aluminum chlorideTGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]]27720690
D017311AmlodipineAmlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]21337027
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMAD2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMAD2 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of SMAD2 mRNA18585445
D001151ArsenicArsenic results in increased expression of SMAD2 protein modified form24348802
D001151ArsenicGrape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD2 protein modified form]24348802
C006632arsenic trioxidearsenic trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]24762191
C006632arsenic trioxidearsenic trioxide results in decreased expression of SMAD2 mRNA25258189
C015001arsenitearsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]26354774
C015001arsenitearsenite inhibits the reaction [TGFB2 protein results in increased localization of SMAD2 protein]25145660
C015001arsenitearsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]26354774
C015001arseniteleptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
C015001arseniteleptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]26354774
C015001arseniteZinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
D001194Asbestos"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased expression of SMAD2 mRNA"25358858
D001194Asbestos"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased phosphorylation of SMAD2 protein"25358858
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of SMAD2 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased phosphorylation of SMAD2 protein"17975199
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of SMAD2 mRNA18585445
C044946benazeprilbenazepril affects the expression of SMAD2 mRNA16635409
C044946benazeprilbenazepril affects the expression of SMAD2 protein16635409
C044946benazepril[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA16635409
C044946benazepril[benazepril co-treated with irbesartan] affects the expression of SMAD2 protein16635409
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD2 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SMAD2 mRNA"28529061
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SMAD2 protein"28529061
D004958EstradiolEstradiol results in decreased phosphorylation of SMAD2 protein17255206
D001688Biological ProductsBiological Products results in decreased expression of SMAD2 mRNA23624380
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
C006780bisphenol Abisphenol A affects the expression of SMAD2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SMAD2 mRNA29027980
C006780bisphenol Abisphenol A results in increased methylation of SMAD2 promoter27271280
C006780bisphenol Abisphenol A affects the methylation of SMAD2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of SMAD2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SMAD2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SMAD2 mRNA26079696
D002235Carbofuran"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein]"28982980
D002235CarbofuranCarbofuran results in increased expression of SMAD2 mRNA28982980
D002235CarbofuranCarbofuran results in increased phosphorylation of SMAD2 protein28982980
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SMAD2 protein modified form25566828
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD2 mRNA26297989
D002251Carbon Tetrachloridechrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA]26297989
D002251Carbon TetrachlorideSilymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA]26297989
D002251Carbon TetrachlorideSMAD2 protein affects the susceptibility to Carbon Tetrachloride16382155
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD2 mRNA16570350
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of SMAD2 protein24211420|2515014
D002336CarnosineCarnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]28266762
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of SMAD2 mRNA"27239252
D002791Cholesterol, Dietary"Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA]"27239252
D002857ChromiumChromium results in increased expression of SMAD2 mRNA17692352
C043561chrysinchrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA]26297989
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of SMAD2 mRNA19524605
D002994ClofibrateClofibrate results in increased expression of SMAD2 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMAD2 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of SMAD2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of SMAD2 mRNA19789285
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD2 mRNA"19167446
C057862cyanoginosin LR2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein]27856280
C057862cyanoginosin LRcyanoginosin LR results in increased expression of and results in increased phosphorylation of SMAD2 protein27856280
C057862cyanoginosin LRSMAD2 protein affects the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]27856280
C057862cyanoginosin LRSMAD2 protein affects the reaction [cyanoginosin LR results in increased expression of SNAI1 protein]27856280
C057862cyanoginosin LRSMAD2 protein affects the reaction [cyanoginosin LR results in increased expression of VIM protein]27856280
D016572Cyclosporinebisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
D016572CyclosporineCyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein22155090
D016572Cyclosporinehispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
D016572Cyclosporinesalubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
D015638Cytochalasin DCytochalasin D affects the localization of SMAD2 protein25756282
C014347decitabinedecitabine results in increased expression of SMAD2 mRNA27915011
C014347decitabinedecitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]24211420
D002945CisplatinCisplatin results in decreased expression of SMAD2 protein23628706
D002945CisplatinCisplatin results in decreased expression of SMAD2 protein23628706
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SMAD2 mRNA26924002
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein15368444
D004052DiethylnitrosamineDiethylnitrosamine results in decreased phosphorylation of SMAD2 protein18971187
D004052DiethylnitrosamineIFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]15368444
D004054DiethylstilbestrolDiethylstilbestrol results in decreased phosphorylation of SMAD2 protein17255206
D004128DimethylnitrosamineDimethylnitrosamine results in increased phosphorylation of SMAD2 protein14568256
D004128DimethylnitrosamineLeu-Ser-Lys-Leu peptide inhibits the reaction [Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein]14568256
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SMAD2 mRNA26924002
D004317DoxorubicinAmlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]21337027
D004317Doxorubicin[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD2 mRNA21337027
D004317Doxorubicin[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD2 protein21337027
D004317Doxorubicin[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein21337027
D004317DoxorubicinDoxorubicin results in decreased expression of SMAD2 protein18606404
D004317DoxorubicinDoxorubicin results in increased expression of SMAD2 mRNA21337027
D004656EnalaprilEnalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]17513326
C118739entinostatentinostat results in decreased expression of SMAD2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
D000431EthanolEthanol results in decreased expression of SMAD2 mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMAD2 mRNA17606305
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SMAD2 gene16724327
D005047Etoposide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein]"22363485
D005047EtoposideEtoposide results in increased phosphorylation of SMAD2 protein22363485
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein15368444
D0150732-AcetylaminofluoreneIFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]15368444
D005688GalactosamineGalactosamine results in increased phosphorylation of SMAD2 protein27876602
D005688GalactosamineGenistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD2 protein]27876602
C037032galangingalangin results in increased expression of SMAD2 mRNA25268046
C037032galangingalangin results in increased phosphorylation of SMAD2 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein]25268046
D019833GenisteinGenistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD2 protein]27876602
D005839GentamicinsGentamicins results in increased expression of SMAD2 mRNA22061828
C097367ginsenoside Rg3ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]24793912
D005944Glucosamine"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein]"20458730
D005944GlucosamineGlucosamine analog results in increased phosphorylation of SMAD2 protein20458730
D005947GlucoseGlucose results in increased phosphorylation of and affects the localization of SMAD2 protein17597607
D005947GlucoseGlucose results in increased phosphorylation of SMAD2 protein21367880
D005947Glucoseisoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]21367880
D005947Glucoseprotocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]17597607
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of SMAD2 mRNA22467014
D056604Grape Seed ExtractGrape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD2 protein modified form]24348802
D056604Grape Seed ExtractGrape Seed Extract inhibits the reaction [sodium arsenite results in increased phosphorylation of SMAD2 protein]21605584
C007946hispidinhispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
C005499honokiolhonokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]21265825
D006820Hyaluronic Acid"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006820Hyaluronic Acid"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of SMAD2 protein15147944
C081309irbesartan[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA16635409
C081309irbesartan[benazepril co-treated with irbesartan] affects the expression of SMAD2 protein16635409
C081309irbesartanirbesartan affects the expression of SMAD2 mRNA16635409
C081309irbesartanirbesartan affects the expression of SMAD2 protein16635409
C551631isoangustone Aisoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]21367880
C038753leptomycin Bleptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]26354774
C487834Leu-Ser-Lys-Leu peptideLeu-Ser-Lys-Leu peptide inhibits the reaction [Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein]14568256
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD2 protein"25234611
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD2 protein]"25234611
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SMAD2 mRNA10975854
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Thioacetamide results in increased expression of SMAD2 mRNA]17621560
D018021Lithium ChlorideLithium Chloride results in decreased expression of SMAD2 mRNA17506889
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein]25268046
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]24727557
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]25566828
C520284Ly-364947Ly-364947 results in decreased expression of SMAD2 protein modified form25566828
D008558Melphalan"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Melphalan results in increased phosphorylation of SMAD2 protein]"22363485
D008558MelphalanMelphalan results in increased phosphorylation of SMAD2 protein22363485
D008628MercuryMercury results in increased expression of SMAD2 mRNA19937285
C014085methotrexate polyglutamateSMAD2 gene affects the abundance of methotrexate polyglutamate19066393
D008731MethoxychlorMethoxychlor results in decreased expression of SMAD2 mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of SMAD2 gene23303685
C005219methyl cellosolvemethyl cellosolve results in increased expression of SMAD2 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SMAD2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SMAD2 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of SMAD2 mRNA12634122
D008942MitoxantroneSMAD2 protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
C406082monomethylarsonous acidleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]26354774
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]26354774
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [TGFB2 protein results in increased localization of SMAD2 protein]25145660
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]26354774
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased activity of SMAD2 protein25145660
C406082monomethylarsonous acidZinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SMAD2 mRNA26924002
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
D0150581-NaphthylisothiocyanateF3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
D0150581-Naphthylisothiocyanate[ITGA5 protein co-treated with ITGB6 protein] promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
D0150581-NaphthylisothiocyanateTGFB1 protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
C007350nitrofennitrofen results in decreased expression of SMAD2 mRNA12149686
D010100OxygenOxygen deficiency results in increased phosphorylation of SMAD2 protein23725749
D010100OxygenOxygen deficiency results in increased phosphorylation of SMAD2 protein21531777
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased phosphorylation of SMAD2 protein]21531777
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SMAD2 mRNA26272509
D010269ParaquatParaquat results in increased expression of SMAD2 protein modified form27682480
D010269ParaquatTGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD2 protein modified form]27682480
D010269Paraquat2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
D010269ParaquatParaquat results in increased phosphorylation of SMAD2 protein25873302
D010269Paraquat[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
D010269ParaquatSB 203580 inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
C084656paricalcitolEnalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]17513326
C084656paricalcitolparicalcitol results in decreased phosphorylation of SMAD2 protein17513326
D010416PentachlorophenolPentachlorophenol results in increased expression of SMAD2 mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of SMAD2 mRNA19159669
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein19443575
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SMAD2 mRNA26272509
D010696PhloroglucinolPhloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]26054450
D010795Phthalic AcidsPhthalic Acids results in increased expression of SMAD2 mRNA21061450
C035988procymidoneprocymidone results in decreased expression of SMAD2 mRNA15686871
D011374Progesterone"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
D011374ProgesteroneProgesterone affects the expression of SMAD2 mRNA17251523
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]17597607
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]17597607
D011794QuercetinQuercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein]15580028
D011794QuercetinQuercetin results in decreased expression of SMAD2 protein15580028
D011794QuercetinQuercetin results in decreased expression of SMAD2 protein modified form15580028
D011794QuercetinQuercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]21216973
C059514resveratrolresveratrol results in decreased expression of SMAD2 mRNA18089832|2572186
C059514resveratrolresveratrol results in decreased expression of SMAD2 protein18089832|2572186
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD2 protein]"25234611
C059514resveratrolresveratrol results in decreased phosphorylation of SMAD2 protein21679764
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein]21300041
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased phosphorylation of SMAD2 protein]21531777
D012431Rutin"Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA]"27239252
C496827salubrinalsalubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]22155090
C410958sauchinonesauchinone inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]25451574
C093642SB 203580[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
C093642SB 203580SB 203580 inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]25873302
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the localization of SMAD2 protein modified form"26685284
D017632Asbestos, Serpentine"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased expression of SMAD2 mRNA"25358858
D017632Asbestos, Serpentine"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased phosphorylation of SMAD2 protein"25358858
D012835Silver NitrateSilver Nitrate analog results in decreased expression of SMAD2 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of SMAD2 mRNA22831968
D012838SilymarinSilymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA]26297989
D019821SimvastatinSimvastatin results in increased expression of SMAD2 mRNA18310456
D019821SimvastatinSimvastatin results in decreased phosphorylation of SMAD2 protein19659652
C017947sodium arsenitesodium arsenite affects the expression of and affects the phosphorylation of SMAD2 protein28206643
C017947sodium arsenitesodium arsenite inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]23732083
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of SMAD2 protein23732083
C017947sodium arseniteGrape Seed Extract inhibits the reaction [sodium arsenite results in increased phosphorylation of SMAD2 protein]21605584
C017947sodium arsenitesodium arsenite results in increased phosphorylation of SMAD2 protein21605584
D012977Sodium NitriteCarnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]28266762
D012977Sodium NitriteSodium Nitrite results in increased expression of SMAD2 protein28266762
D012999SomanSoman results in increased expression of SMAD2 mRNA19281266
D053260SootSoot results in decreased expression of SMAD2 mRNA23634900
C471405sorafenibsorafenib affects the localization of SMAD2 protein21360571
C471405sorafenibsorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]21360571
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein]21300041
D013311StreptozocinStreptozocin results in increased phosphorylation of SMAD2 protein21300041
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of SMAD2 mRNA22467014
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of SMAD2 mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of SMAD2 mRNA15498508
C061133tamibarotenetamibarotene results in increased phosphorylation of SMAD2 protein17611697
D013629TamoxifenTamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein]17098229
D013629TamoxifenTamoxifen results in increased phosphorylation of SMAD2 protein17098229
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of SMAD2 protein18467041
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD2 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD2 protein18467041
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of TGFB1 protein] which results in increased activity of SMAD2 protein18467041
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of and affects the localization of SMAD2 protein20172950
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of SMAD2 protein20172950
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of SMAD2 protein20172950
D013755Tetradecanoylphorbol AcetateTGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of SMAD2 protein]20172950
D013755Tetradecanoylphorbol AcetateTGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of SMAD2 protein]20172950
D013755Tetradecanoylphorbol AcetateTGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SMAD2 protein]20172950
D013755Tetradecanoylphorbol AcetateTGFB1 promotes the reaction [Tetradecanoylphorbol Acetate affects the localization of SMAD2 protein modified form]20172950
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein18951874
D013853ThioacetamideLipopolysaccharides promotes the reaction [Thioacetamide results in increased expression of SMAD2 mRNA]17621560
D013853ThioacetamideThioacetamide results in increased expression of SMAD2 mRNA17621560|2341159
D013893ThiramThiram results in decreased expression of SMAD2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased localization of SMAD2 protein15994428
D014212TretinoinTamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein]17098229
D014212TretinoinTretinoin inhibits the reaction [TGFB1 results in increased phosphorylation of and results in increased localization of SMAD2 protein]21274875
D014212TretinoinTretinoin results in decreased expression of SMAD2 mRNA15498508
D014212TretinoinTretinoin results in decreased phosphorylation of SMAD2 protein24374174
D014212TretinoinTretinoin results in increased phosphorylation of SMAD2 protein17098229
D014212TretinoinTretinoin results in decreased expression of SMAD2 mRNA18703560
D014212TretinoinTretinoin results in decreased phosphorylation of SMAD2 protein16410076
D014241TrichloroethyleneTrichloroethylene results in increased expression of SMAD2 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SMAD2 mRNA24935251|2627250
C057693troglitazonetroglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]18253093
C057693troglitazonetroglitazone inhibits the reaction [TGFB1 protein results in increased expression of SMAD2 protein]19120328
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SMAD2 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of SMAD2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of SMAD2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of SMAD2 mRNA21427059
D014640VancomycinVancomycin results in decreased expression of SMAD2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMAD2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SMAD2 mRNA15686871
D014750VincristineVincristine results in decreased expression of SMAD2 mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of SMAD2 mRNA26272509
D014873Water PollutantsWater Pollutants results in decreased expression of SMAD2 mRNA23591932
D014873Water PollutantsWater Pollutants results in decreased expression of SMAD2 protein23591932
C521629Wen-pi-tang-Hab-Wu-ling-sanWen-pi-tang-Hab-Wu-ling-san affects the phosphorylation of SMAD2 protein19913069
C000588914WJ1376-1WJ1376-1 inhibits the reaction [TGFB1 protein results in increased activity of SMAD2 protein]24727557
C000588914WJ1376-1WJ1376-1 inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]24727557
C000588915WJ1398-1WJ1398-1 inhibits the reaction [TGFB1 protein results in increased activity of SMAD2 protein]24727557
C000588915WJ1398-1WJ1398-1 inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]24727557
D015032ZincZinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
D015032ZincZinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]26354774
D015032ZincZinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]22228435
D015032ZincZinc results in increased stability of and results in increased activity of SMAD2 protein26354774

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9389648  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9389648  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-ISS24964035  
GO:0003677DNA bindingcontributes_toIDA9389648  
GO:0003682chromatin binding-IEA-  
GO:0003690double-stranded DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA9389648  
GO:0003700DNA-binding transcription factor activitycontributes_toIDA17438144  
GO:0005160transforming growth factor beta receptor binding-IPI9311995  
GO:0005515protein binding-IPI9389648  9702198  9865696  9892009  11278756  11387212  
12167862  12764135  15107821  15231748  15350224  15647271  
16200078  16751101  17099224  17292623  18268325  18511908  
18568018  18729074  18832382  18923419  19032343  19049980  
19122240  19135894  19289081  19345189  20061380  20129061  
20195357  20603019  20937913  21258410  21297662  21532621  
21599657  21741598  21947082  21960005  21988832  22045334  
22442258  24627487  25241761  25609649  25670079  26977879  
GO:0008134transcription factor binding-IPI9702198  
GO:0019902phosphatase binding-IPI16751101  
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity-IDA9256479  9389648  
GO:0031625ubiquitin protein ligase binding-IPI19122240  
GO:0033613activating transcription factor binding-IPI11160896  
GO:0034713type I transforming growth factor beta receptor binding-IPI8980228  
GO:0035326enhancer binding-IC21828274  
GO:0042803protein homodimerization activity-IEA-  
GO:0046332SMAD binding-IPI11160896  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0048156tau protein binding-ISS24964035  
GO:0070410co-SMAD binding-IPI9111321  9311995  
GO:0070411I-SMAD binding-IPI9256479  
GO:0070412R-SMAD binding-IPI9311995  
GO:0070878primary miRNA binding-IPI18548003  
GO:0097718disordered domain specific binding-IPI15231848  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0001657ureteric bud development-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001706endoderm formation-IEA-  
GO:0001707mesoderm formation-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA8752209  9389648  9732876  18548003  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP8980228  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007182common-partner SMAD protein phosphorylation-IDA16806156  
GO:0007183SMAD protein complex assembly-IDA9111321  
GO:0007352zygotic specification of dorsal/ventral axis-IMP9436979  
GO:0007369gastrulation-TAS19018011  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009749response to glucose-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0009952anterior/posterior pattern specification-ISS-  
GO:0010718positive regulation of epithelial to mesenchymal transition-ISS-  
GO:0016579protein deubiquitination-TAS-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IMP14555988  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030073insulin secretion-IEA-  
GO:0030324lung development-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0030513positive regulation of BMP signaling pathway-IMP19366699  
GO:0031016pancreas development-IEA-  
GO:0031053primary miRNA processing-TAS19018011  
GO:0032924activin receptor signaling pathway-IMP15150278  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0035265organ growth-IEA-  
GO:0035556intracellular signal transduction-ISS-  
GO:0038092nodal signaling pathway-IMP15150278  
GO:0042060wound healing-IEA-  
GO:0045165cell fate commitment-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IMP14555988  
GO:0045893positive regulation of transcription, DNA-templated-IDA9311995  9389648  9732876  
GO:0045893positive regulation of transcription, DNA-templated-IMP14555988  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9389648  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048340paraxial mesoderm morphogenesis-ISS-  
GO:0048617embryonic foregut morphogenesis-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0051098regulation of binding-ISS-  
GO:0060039pericardium development-IEA-  
GO:0060395SMAD protein signal transduction-IEA-  
GO:0062009secondary palate development-ISS-  
GO:0070723response to cholesterol-IDA17878231  
GO:1900224positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry-IMP17239842  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA21828274  
GO:0005634nucleus-IDA8980228  9311995  9389648  12411310  16751101  21599657  25893292  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA17438144  
GO:0005737cytoplasm-IDA9311995  9389648  12411310  
GO:0005829cytosol-TAS-  
GO:0032444activin responsive factor complex-IDA9389648  
GO:0032991protein-containing complex-IMP15231848  
GO:0071141SMAD protein complex-IDA18832382  
GO:0071144heteromeric SMAD protein complex-IDA21828274  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04144Endocytosis
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04520Adherens junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-1181150Signaling by NODALIEA
R-HSA-1181150Signaling by NODALTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1502540Signaling by ActivinTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerIEA
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityIEA
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-3304347Loss of Function of SMAD4 in CancerTAS
R-HSA-3304349Loss of Function of SMAD2/3 in CancerTAS
R-HSA-3304351Signaling by TGF-beta Receptor Complex in CancerTAS
R-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in CancerTAS
R-HSA-3311021SMAD4 MH2 Domain Mutants in CancerTAS
R-HSA-3315487SMAD2/3 MH2 Domain Mutants in CancerTAS
R-HSA-3656532TGFBR1 KD Mutants in CancerTAS
R-HSA-3656534Loss of Function of TGFBR1 in CancerTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29286114Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. (2018 Mar)Park GBMol Med Rep
22675530Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors. (2012)Roth CPLoS One
22117501Prognostic factors for idiopathic pulmonary fibrosis: clinical, physiologic, pathologic, and molecular aspects. (2011 Oct)Lee SHSarcoidosis Vasc Diffuse Lung Dis
22768115Vessel-associated transforming growth factor-beta1 (TGF-beta1) is increased in the bronchial reticular basement membrane in COPD and normal smokers. (2012)Soltani APLoS One
29089751Characteristics and potential role of M2 macrophages in COPD. (2017)He SInt J Chron Obstruct Pulmon Dis
26612555Secondhand smoke induces hepatic apoptosis and fibrosis in hamster fetus. (2016 Sep)Huang CWHum Exp Toxicol
21068203Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. (2011 Jan)Slattery MLCancer Epidemiol Biomarkers Prev
28345812Reduced expression of let-7f activates TGF-beta/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure. (2017 Sep)Dhahri WJ Cell Mol Med
24508121Cigarette smoke-induced alveolar epithelial-mesenchymal transition is mediated by Rac1 activation. (2014 Jun)Shen HJBiochim Biophys Acta
12518864Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer. (2002)Ho WLCancer Detect Prev
28898507Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)Koo BKLiver Int
26281600[R-value comprehensive evaluation of effect of three methods for lung-kidney comprehensive evaluation study on R value of three methods for regulating and invigorating lung and kidney in regulating lung inflammation signaling pathways in COPD rats]. (2015 Apr)Cui HXZhongguo Zhong Yao Za Zhi
21496353Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. (2011 Apr 18)Kim DYRespir Res
28341147Cadmium stimulates myofibroblast differentiation and mouse lung fibrosis. (2017 May 15)Hu XToxicology
19659652Simvastatin attenuates experimental small airway remodelling in rats. (2009 Jul)Ou XMRespirology