Gene: SMAD3

4088
HSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3
SMAD family member 3
protein-coding
15q22.33
Ensembl:ENSG00000166949 MIM:603109 Vega:OTTHUMG00000133230 UniprotKB:P84022
NG_011990.1
PubMed
ND|AD
18   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.286e-2 (AD)  1.600e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03480935chr15:67417860SMAD31.500e-11Smoking27651444
cg00604410chr15:67417899SMAD32.800e-11Smoking27651444
cg25793587chr15:67383147SMAD31.600e-8Smoking27651444
cg26430287chr15:67439567SMAD31.710e-10Alcohol consumption der day27843151
cg03480935chr15:67417860SMAD33.560e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMG70.866
KDM5B0.865
BAHD10.862
CELF10.861
MBD10.859
SIPA1L10.855
TMEM1270.853
ZMIZ10.853
BCL90.852
ERGIC10.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.559
CTNNA3-0.37
SH2D1A-0.316
KLRC2-0.313
MYOT-0.309
ANXA13-0.306
C5orf64-0.295
PDE11A-0.285
KLRC3-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]28694203
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA"18711122
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA"22129739
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of SMAD3 protein"23628706
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of SMAD3 protein"23628706
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA28329830
C0828231-oleoyl lysophosphatidylcholineSMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine23034213
C0892151-palmitoyl-2-lysophosphatidylcholineSMAD3 protein results in decreased abundance of 1-palmitoyl-2-lysophosphatidylcholine23034213
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of SMAD3 mRNA25827057
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SMAD3 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA"19167446
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of SMAD3 protein]"22063920
C0005952302-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one"2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]"27704718
C0473683-methylquercetin3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]27151496
C0473683-methylquercetinNFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]27151496
C5729614-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid4-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid results in decreased expression of SMAD3 protein modified form25377915
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]"28871336
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein]"28871336
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased expression of HAS2 mRNA]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased expression of TNFAIP6 mRNA]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which co-treated with FSHB protein] results in increased expression of PTX3 mRNA"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which results in decreased susceptibility to FSHB protein"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Sodium Fluoride] results in decreased phosphorylation of SMAD3 protein"29127033
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of SMAD3 mRNA]"29127033
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD3 protein]"21586554
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD3 protein modified form]"21586554
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein"29127033
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein]"28982980
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein"28982980
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which results in decreased susceptibility to EGF protein"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of SMAD3 protein"21520325
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SMAD3 mRNA"19561079
C0415944-nonylphenol4-nonylphenol results in decreased phosphorylation of SMAD3 protein24308608
C0415944-nonylphenolfulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein]24308608
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA20829426
C0986575-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide promotes the reaction [5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of SMAD3 protein]"22063920
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] which results in decreased susceptibility to FSHB protein"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] which results in increased susceptibility to FSHB protein"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein"21480330
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased expression of SMAD3 protein"20682692
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] which results in decreased susceptibility to EGF protein"21520325
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] which results in increased susceptibility to EGF protein"21520325
C5700198-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide binds to and results in decreased activity of SMAD3 protein"22063920
C5700198-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of SMAD3 protein]"22063920
C5700198-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]"22063920
C5700198-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide promotes the reaction [5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of SMAD3 protein]"22063920
C5700198-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide results in decreased phosphorylation of SMAD3 protein"22063920
D000079AcetaldehydeAcetaldehyde results in increased phosphorylation of SMAD3 protein16025520
D000079AcetaldehydeSMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]16025520
D000082AcetaminophenAcetaminophen results in decreased expression of SMAD3 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SMAD3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SMAD3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of SMAD3 mRNA11752693
D000111AcetylcysteineAcetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21131394
C058956acteosideacteoside results in increased phosphorylation of SMAD3 protein17634406
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SMAD3 mRNA21641981|2210060
C412373AG 1879AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]27519288
C103303alitretinoin[TO-901317 co-treated with alitretinoin] results in increased expression of SMAD3 protein17194744
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SMAD3 mRNA16597033
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]27519288
C010845aluminum chloridealuminum chloride inhibits the reaction [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]26658030
C010845aluminum chloridealuminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]27720690
C010845aluminum chlorideTGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]]27720690
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SMAD3 mRNA24449571
D001151ArsenicArsenic results in increased expression of SMAD3 protein modified form24348802
D001151ArsenicGrape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form]24348802
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein]24762191
C006632arsenic trioxidearsenic trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]24762191|2519664
C006632arsenic trioxidearsenic trioxide results in decreased expression of SMAD3 mRNA25196641|2530421
C006632arsenic trioxidearsenic trioxide results in decreased expression of SMAD3 protein25196641
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased phosphorylation of SMAD3 protein21649584
C006632arsenic trioxide[arsenic trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA25196641
C006632arsenic trioxideHydrogen Peroxide inhibits the reaction [arsenic trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]24762191
C006632arsenic trioxideMIR491 affects the reaction [arsenic trioxide results in decreased expression of SMAD3 mRNA]25304214
C006632arsenic trioxideMIR491 mRNA promotes the reaction [arsenic trioxide results in decreased expression of SMAD3 mRNA]25196641
C006632arsenic trioxideSMAD3 protein promotes the reaction [arsenic trioxide results in increased expression of CDKN1A mRNA]21649584
C006632arsenic trioxideSMAD3 protein promotes the reaction [arsenic trioxide results in increased expression of CDKN1A protein]21649584
C006632arsenic trioxideSMAD3 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]26354774
C015001arsenitearsenite inhibits the reaction [TGFB2 protein results in increased localization of SMAD3 protein]25145660
C015001arsenitearsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]26354774
C015001arseniteleptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
C015001arseniteleptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]26354774
C015001arseniteZinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
D001194Asbestos"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein"25358858
D001194Asbestos"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of SMAD3 mRNA"25358858
C044946benazeprilbenazepril affects the expression of SMAD3 mRNA16635409
C044946benazeprilbenazepril affects the expression of SMAD3 protein16635409
C044946benazepril[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein19487956
C044946benazepril[benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA16635409
C044946benazepril[benazepril co-treated with irbesartan] affects the expression of SMAD3 protein16635409
D001554BenzeneBenzene results in increased expression of SMAD3 mRNA19162166
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA18711122
C047723benzophenonebenzophenone results in decreased phosphorylation of SMAD3 protein24308608
C047723benzophenonefulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein]24308608
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMAD3 mRNA22228805
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA18711122
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SMAD3 mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA18711122
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD3 mRNA"19150397|2001819
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of SMAD3 mRNA]24758408
D004958EstradiolEstradiol affects the expression of SMAD3 mRNA14699072|2257421
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of SMAD3 mRNA19167446|2475840
D004958EstradiolEstradiol results in decreased phosphorylation of SMAD3 protein24308608|2640794
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased phosphorylation of SMAD3 protein]24308608|2640794
D004958EstradiolGenistein inhibits the reaction [Estradiol results in decreased phosphorylation of SMAD3 protein]26407941
C002503betulinbetulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]21172400
C002070betulinic acidbetulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]21172400
D001647Bile Acids and SaltsSMAD3 protein results in increased metabolism of Bile Acids and Salts23034213
D001688Biological ProductsBiological Products results in decreased expression of SMAD3 mRNA23624380
C006780bisphenol Abisphenol A results in decreased phosphorylation of SMAD3 protein24308608|2640794
C006780bisphenol Abisphenol A results in increased methylation of SMAD3 promoter27271280
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]24308608|2640794
C006780bisphenol AGenistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]26407941
C006780bisphenol Abisphenol A affects the methylation of SMAD3 promoter27334623
D001761Bleomycin"2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]"27704718
D001761BleomycinBleomycin results in increased phosphorylation of SMAD3 protein27704718
D001761BleomycinBleomycin results in increased expression of SMAD3 mRNA26093215
D001761BleomycinPhytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA]26093215
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SMAD3 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of SMAD3 gene27509014
C018475butyraldehydebutyraldehyde results in decreased expression of SMAD3 mRNA26079696
C584509C646 compoundC646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein]26045780
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]"20230807
C081643candesartan[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein19487956
C077793candesartan cilexetilcandesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form]27889505
D002220CarbamazepineCarbamazepine affects the expression of SMAD3 mRNA25979313
D002235Carbofuran"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein]"28982980
D002235CarbofuranCarbofuran results in increased expression of SMAD3 mRNA28982980
D002235CarbofuranCarbofuran results in increased phosphorylation of SMAD3 protein28982980
D002251Carbon TetrachlorideCarbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein]18395096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD3 mRNA18395914|2629798
D002251Carbon Tetrachloridechrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]26297989
D002251Carbon Tetrachlorideoxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]18395914
D002251Carbon TetrachlorideSilymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]26297989
D002251Carbon TetrachlorideSMAD3 protein affects the susceptibility to Carbon Tetrachloride16382155
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of SMAD3 protein17009398
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD3 mRNA15818738
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD3 protein15818738|1687230
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of SMAD3 protein24211420|2515014
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]"15818738
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]"15818738|1716359
D002251Carbon TetrachloridePerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]16872305
D002251Carbon TetrachlorideValsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]16872305
C054133casticincasticin results in increased expression of SMAD3 mRNA27862857
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA"22129739
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA22915297
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA]22915297
C043561chrysinchrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]26297989
D003042CocaineCocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]27422367
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]27174133
D003300Copper[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SMAD3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of SMAD3 mRNA19167446
D003474CurcuminCurcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]16959952
D016572CyclosporineCyclosporine results in increased expression of SMAD3 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of SMAD3 promoter27989131
D015638Cytochalasin DCytochalasin D affects the localization of SMAD3 protein25756282
C014347decitabinedecitabine results in increased expression of SMAD3 mRNA27915011
C014347decitabinedecitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]24211420
C107676deguelindeguelin results in decreased phosphorylation of SMAD3 protein22986522
D003907DexamethasoneDexamethasone affects the expression of SMAD3 mRNA21277400
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SMAD3 mRNA"18711122
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SMAD3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA20705681
D002945CisplatinCisplatin results in decreased expression of SMAD3 mRNA19561079
D002945CisplatinCisplatin results in increased expression of SMAD3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SMAD3 protein23628706
D004041Dietary FatsDietary Fats results in decreased expression of SMAD3 mRNA18042831
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein15368444
D004052DiethylnitrosamineDiethylnitrosamine affects the phosphorylation of SMAD3 protein19418558
D004052DiethylnitrosamineIFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]15368444
D004052Diethylnitrosaminepyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]19418558
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA24690739
D004281Docosahexaenoic AcidsSMAD3 protein results in decreased abundance of Docosahexaenoic Acids23034213
D004317DoxorubicinDoxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein]18606404
D004317DoxorubicinDoxorubicin results in decreased expression of SMAD3 protein18606404
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]"15818738
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]"15818738|1716359
C042986ebselenebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21131394
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in decreased expression of SMAD3 mRNA"25556216
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA22079256
D000431Ethanol"8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]"22063920
D000431Ethanolbetulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]21172400
D000431Ethanolbetulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]21172400
D000431EthanolEthanol results in increased expression of SMAD3 protein23274713
D000431EthanolEthanol results in increased phosphorylation of SMAD3 protein21172400|2206392
D000431EthanolGenistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein]23274713
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SMAD3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SMAD3 mRNA23649840
D011345FenofibrateFenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]19593819
D011345FenofibrateNR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]19593819
C082360fipronilfipronil results in decreased expression of SMAD3 mRNA23962444
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA28329830
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA18711122
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein15368444
D0150732-AcetylaminofluoreneIFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]15368444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of SMAD3 mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein]24308608
C070081fulvestrantfulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein]24308608
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]24308608|2640794
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased phosphorylation of SMAD3 protein]24308608|2640794
C070081fulvestrantfulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]26407941
D005688GalactosamineGalactosamine results in increased phosphorylation of SMAD3 protein27876602
D005688GalactosamineGenistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein]27876602
C037032galangingalangin results in increased expression of SMAD3 mRNA25268046
C037032galangingalangin results in increased phosphorylation of SMAD3 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein]25268046
D019833GenisteinGenistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]26407941
D019833GenisteinGenistein inhibits the reaction [Estradiol results in decreased phosphorylation of SMAD3 protein]26407941
D019833GenisteinGenistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]26407941
D019833GenisteinGenistein results in decreased expression of SMAD3 mRNA22228119
D019833GenisteinGenistein results in decreased expression of SMAD3 protein22228119
D019833GenisteinSMAD3 protein affects the susceptibility to Genistein22228119
D019833GenisteinGenistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein]23274713
D019833GenisteinGenistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein]27876602
D005947GlucoseC646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein]26045780
D005947GlucoseGlucose results in increased phosphorylation of and affects the localization of SMAD3 protein17597607
D005947GlucoseGlucose results in increased phosphorylation of SMAD3 protein26045780
D005947Glucoseprotocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]17597607
D056604Grape Seed ExtractGrape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form]24348802
D056604Grape Seed ExtractGrape Seed Extract inhibits the reaction [sodium arsenite results in increased phosphorylation of SMAD3 protein]21605584
C010176halofuginonehalofuginone inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]17180598
C010176halofuginonehalofuginone inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD3 protein]11874485
D006581HexachlorobenzeneAG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]27519288
D006581Hexachlorobenzenealpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]27519288
D006581HexachlorobenzeneHexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 protein27519288
D006581HexachlorobenzeneHexachlorobenzene results in increased phosphorylation of SMAD3 protein28923513
C005499honokiolhonokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21265825
D017313FenretinideFenretinide results in increased expression of SMAD3 mRNA28973697
D006820Hyaluronic Acid"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006820Hyaluronic Acid"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006820Hyaluronic Acid"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006820Hyaluronic Acid"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [EGF protein results in increased chemical synthesis of Hyaluronic Acid]"21520325
D006861Hydrogen Peroxidearsenic trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein]24762191
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [arsenic trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]24762191
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]24762191
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of SMAD3 protein15147944|2476219
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of SMAD3 mRNA21179422
C081309irbesartan[benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA16635409
C081309irbesartan[benazepril co-treated with irbesartan] affects the expression of SMAD3 protein16635409
C081309irbesartanirbesartan affects the expression of SMAD3 mRNA16635409
C081309irbesartanirbesartan affects the expression of SMAD3 protein16635409
C051890irinotecanirinotecan analog results in decreased expression of SMAD3 mRNA18927307
C038753leptomycin Bleptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
C038753leptomycin Bleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]26354774
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SMAD3 mRNA"26961602
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SMAD3 protein"26961602
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein"25234611
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein]"25234611
D008070LipopolysaccharidesIRAK1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]21295571
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [TGFB1 protein results in increased activity of SMAD3 protein]21295571
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of SMAD3 protein21295571
D008070Lipopolysaccharides[Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesMAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]21295571
D008070LipopolysaccharidesSMAD3 protein modified form promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesSMAD3 protein results in increased susceptibility to Lipopolysaccharides21131441
D008070LipopolysaccharidesTLR4 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]21295571
D008070LipopolysaccharidesU 0126 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]21295571
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]23034213
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]23034213
D008095Lithocholic AcidSMAD3 protein results in increased susceptibility to Lithocholic Acid23034213
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein]25268046
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form]25566828
C015329lycopenelycopene results in increased expression of SMAD3 mRNA16886892
D008558MelphalanMelphalan results in decreased expression of SMAD3 mRNA22363485
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of SMAD3 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA22915297
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA]22915297
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of SMAD3 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SMAD3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMAD3 mRNA20061341
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]"20230807
C035133mirtazapinemirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form]28623179
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SMAD3 mRNA19945496
C406082monomethylarsonous acidleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
C406082monomethylarsonous acidleptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]26354774
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]26354774
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [TGFB2 protein results in increased localization of SMAD3 protein]25145660
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]26354774
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased activity of SMAD3 protein25145660
C406082monomethylarsonous acidZinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
C500085muraglitazarmuraglitazar results in decreased expression of SMAD3 mRNA21515302
D009151Mustard GasMustard Gas results in decreased expression of SMAD3 mRNA15674843
C005274naringinnaringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]27174133
D064729Neurokinin-1 Receptor AntagonistsNeurokinin-1 Receptor Antagonists inhibits the reaction [TAC1 protein modified form results in increased phosphorylation of SMAD3 protein]28647476
D064729Neurokinin-1 Receptor AntagonistsNeurokinin-1 Receptor Antagonists inhibits the reaction [TAC1 protein modified form results in increased phosphorylation of SMAD3 protein]28647476
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]"20230807
D009569Nitric OxideNitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]15949472
D009569Nitric Oxide[SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide15949472
C007350nitrofennitrofen results in decreased expression of SMAD3 mRNA12149686
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of SMAD3 mRNA27935865
C025256nonylphenolfulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]26407941
C025256nonylphenolGenistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]26407941
C025256nonylphenolnonylphenol results in decreased phosphorylation of SMAD3 protein26407941
C559056NPLC 0393NPLC 0393 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21151953
C559056NPLC 0393NPLC 0393 results in decreased phosphorylation of and results in decreased localization of SMAD3 protein21151953
C559056NPLC 0393PPP2CA protein affects the reaction [NPLC 0393 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]21151953
C559056NPLC 0393PPP2CA protein affects the reaction [NPLC 0393 results in decreased phosphorylation of and results in decreased localization of SMAD3 protein]21151953
C559056NPLC 0393NPLC 0393 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21151953
C559056NPLC 0393NPLC 0393 results in decreased phosphorylation of and results in decreased localization of SMAD3 protein21151953
D019787Linoleic AcidSMAD3 protein results in decreased abundance of Linoleic Acid23034213
D010100OxygenOxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA]27103661
D010100OxygenOxygen deficiency results in increased expression of SMAD3 mRNA24205000
C037573oxymatrineoxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]18395914
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA20705681
D000073878Palm OilPalm Oil results in decreased expression of SMAD3 mRNA18042831
D010269ParaquatParaquat results in increased expression of SMAD3 protein modified form27682480
D010269ParaquatTGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD3 protein modified form]27682480
D010269ParaquatSMAD3 protein results in increased susceptibility to Paraquat22581813
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SMAD3 mRNA28973697
D020913PerindoprilPerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]16872305
D020913PerindoprilPerindopril results in decreased expression of SMAD3 protein15619341
D010696PhloroglucinolPhloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]26054450
D010743PhospholipidsSMAD3 protein results in increased metabolism of Phospholipids23034213
D064209PhytochemicalsPhytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA]26093215
D010852PicrotoxinPicrotoxin results in increased expression of SMAD3 mRNA15170462
C006253pirinixic acidpirinixic acid results in decreased expression of SMAD3 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMAD3 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in decreased expression of SMAD3 mRNA20631399
D011374Progesterone"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
D011374Progesterone"[6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]"21520325
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of SMAD3 mRNA20864642
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]17597607
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein]17597607
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]19418558
D011794QuercetinQuercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein]15580028
D011794QuercetinQuercetin results in decreased expression of SMAD3 protein15580028
D011794QuercetinQuercetin results in decreased expression of SMAD3 protein modified form15580028
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA]22915297
D011794QuercetinQuercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21216973
C012526quercitrinquercitrin results in increased expression of SMAD3 mRNA25193878
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of SMAD3 mRNA25800948
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]27345520
C059514resveratrolresveratrol results in decreased expression of SMAD3 mRNA25721869
C059514resveratrolresveratrol results in decreased expression of SMAD3 protein18089832|2572186
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein]"25234611
C059514resveratrolresveratrol results in decreased acetylation of SMAD3 protein20651248
C059514resveratrolresveratrol results in decreased phosphorylation of SMAD3 protein21679764
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein]21300041
C059514resveratrolresveratrol results in decreased acetylation of SMAD3 protein20651248
C059514resveratrolresveratrol inhibits the reaction [TGFB1 protein results in increased acetylation of SMAD3 protein]20651248
C059514resveratrolSIRT1 protein affects the reaction [resveratrol inhibits the reaction [TGFB1 protein results in increased acetylation of SMAD3 protein]]20651248
C089730rosiglitazonerosiglitazone results in decreased expression of SMAD3 mRNA21515302
C410958sauchinonesauchinone inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]25451574
C093642SB 203580SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein]18253093
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of SMAD3 mRNA19564919
D017632Asbestos, Serpentine"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein"25358858
D017632Asbestos, Serpentine"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of SMAD3 mRNA"25358858
C009250sevofluraneSMAD3 protein affects the susceptibility to sevoflurane18434384
C009250sevofluraneTGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]18434384
D012834SilverSilver results in increased expression of SMAD3 mRNA28959546
D012835Silver NitrateSilver Nitrate analog results in decreased expression of SMAD3 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of SMAD3 mRNA22831968
D012838SilymarinSilymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]26297989
D019821SimvastatinSimvastatin results in increased expression of SMAD3 mRNA18310456
D019821SimvastatinSimvastatin results in decreased phosphorylation of SMAD3 protein19659652
C110881S-nitro-N-acetylpenicillamineS-nitro-N-acetylpenicillamine results in increased activity of [SMAD4 protein binds to SMAD3 protein]15949472
C009277sodium arsenatesodium arsenate results in increased expression of SMAD3 mRNA21795629
C017947sodium arseniteIFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein]17003472
C017947sodium arsenitesodium arsenite inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein]23732083
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of SMAD3 protein23732083
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein17003472
C017947sodium arsenitecandesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form]27889505
C017947sodium arsenitecoenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]27174133
C017947sodium arseniteGrape Seed Extract inhibits the reaction [sodium arsenite results in increased phosphorylation of SMAD3 protein]21605584
C017947sodium arsenitenaringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]27174133
C017947sodium arsenitesodium arsenite results in increased expression of SMAD3 mRNA27174133
C017947sodium arsenitesodium arsenite results in increased expression of SMAD3 protein modified form27889505
C017947sodium arsenitesodium arsenite results in increased phosphorylation of SMAD3 protein21605584
D012969Sodium Fluoride"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Sodium Fluoride] results in decreased phosphorylation of SMAD3 protein"29127033
D012969Sodium Fluoride"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of SMAD3 mRNA]"29127033
D012969Sodium FluorideSodium Fluoride results in increased expression of SMAD3 mRNA29127033
D018038Sodium SeleniteSodium Selenite results in increased expression of SMAD3 mRNA18175754
C471405sorafenibsorafenib affects the localization of SMAD3 protein21360571
C471405sorafenibsorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]21360571
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein]21300041
D013311StreptozocinStreptozocin results in increased phosphorylation of SMAD3 protein21300041
D013629TamoxifenTamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein]17098229
D013629TamoxifenTamoxifen results in increased phosphorylation of SMAD3 protein17098229
D013655Taurochenodeoxycholic AcidSMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid23034213
D013658Taurolithocholic AcidSMAD3 protein results in increased abundance of Taurolithocholic Acid23034213
C037351tauromuricholic acidSMAD3 protein results in increased abundance of tauromuricholic acid23034213
C031655tauroursodeoxycholic acidSMAD3 protein results in increased abundance of tauroursodeoxycholic acid23034213
C501413tesaglitazartesaglitazar results in decreased expression of SMAD3 mRNA21515302
D013739TestosteroneTestosterone results in increased expression of SMAD3 mRNA22138414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SMAD3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA24058054
D013853Thioacetamidemirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form]28623179
D013853ThioacetamideThioacetamide results in increased expression of SMAD3 protein modified form28623179
C423915TO-901317[TO-901317 co-treated with alitretinoin] results in increased expression of SMAD3 protein17194744
D014028Tobacco Smoke PollutionSMAD3 protein affects the reaction [Tobacco Smoke Pollution results in increased secretion of VEGFA protein]23618901
D014212TretinoinSMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2]24374174
D014212TretinoinSMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FN1]24374174
D014212TretinoinSMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of TNC]24374174
D014212TretinoinTamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein]17098229
D014212TretinoinTretinoin results in decreased phosphorylation of SMAD3 protein24374174
D014212TretinoinTretinoin results in increased expression of SMAD3 mRNA16012519|1743110
D014212TretinoinTretinoin results in increased phosphorylation of SMAD3 protein17098229
D014212TretinoinTretinoin results in decreased phosphorylation of SMAD3 protein16410076
C012589trichostatin Atrichostatin A affects the expression of SMAD3 mRNA28542535
C057693troglitazonetroglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein]18253093
C057693troglitazonetroglitazone results in decreased expression of SMAD3 mRNA21515302
C057693troglitazonetroglitazone inhibits the reaction [TGFB1 protein results in increased expression of SMAD3 protein]19120328
C113580U 0126U 0126 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]21295571
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of SMAD3 mRNA19493473
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of SMAD3 protein19493473
D014635Valproic AcidValproic Acid results in increased methylation of SMAD3 gene28853863|2915479
D000068756ValsartanValsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]16872305
D000068756ValsartanValsartan results in decreased expression of SMAD3 protein15619341
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMAD3 gene25560391
D014810Vitamin EVitamin E results in increased expression of SMAD3 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of SMAD3 mRNA20044591
C521629Wen-pi-tang-Hab-Wu-ling-sanWen-pi-tang-Hab-Wu-ling-san affects the phosphorylation of SMAD3 protein19913069
D015032ZincZinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
D015032ZincZinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]26354774
D015032ZincZinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]22228435
D015032ZincZinc results in increased stability of and results in increased activity of SMAD3 protein26354774
C088658zoledronic acid"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein]"28871336
C088658zoledronic acidzoledronic acid results in increased expression of SMAD3 mRNA24714768
C088658zoledronic acidzoledronic acid results in increased phosphorylation of SMAD3 protein28871336
C088658zoledronic acidzoledronic acid results in increased phosphorylation of SMAD3 protein28871336
C088658zoledronic acidzoledronic acid results in increased phosphorylation of SMAD3 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21947082  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding-IDA21947082  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding-IMP26311719  
GO:0000987proximal promoter sequence-specific DNA binding-IDA18832382  21947082  
GO:0000989transcription factor activity, transcription factor bindingcontributes_toIDA18832382  
GO:0001102RNA polymerase II activating transcription factor binding-IPI17251190  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-ISS24964035  
GO:0003700DNA-binding transcription factor activity-IDA9732876  10823886  21947082  
GO:0003700DNA-binding transcription factor activitycontributes_toIDA9111321  
GO:0005160transforming growth factor beta receptor binding-IPI9311995  
GO:0005515protein binding-IPI9865696  9892009  10681527  11274402  11278756  11387212  
12154125  12650946  12857746  14525983  14612439  15084259  
15231748  15350224  15527767  15588252  15647271  15897867  
16007207  16200078  17099224  17292623  17469184  18548003  
18568018  18729074  18832382  19032343  19049980  19122240  
19135894  19289081  20061380  20129061  21258410  21297662  
21307346  21532621  21597466  21828274  21947082  21988832  
22045334  22442258  24613385  24627487  25241761  25416956  
25556234  25609649  25670079  25910212  26680585  27107012  
GO:0005518collagen binding-IEA-  
GO:0008013beta-catenin binding-IEA-  
GO:0008134transcription factor binding-IPI9732876  21828274  
GO:0008270zinc ion binding-IDA12686552  
GO:0017151DEAD/H-box RNA helicase binding-IPI18548003  
GO:0019901protein kinase binding-IPI12874272  
GO:0019902phosphatase binding-IPI16751101  
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity-IDA9111321  
GO:0031490chromatin DNA binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI11278251  19122240  
GO:0031962mineralocorticoid receptor binding-IPI12902338  
GO:0035259glucocorticoid receptor binding-IPI12902338  
GO:0035326enhancer binding-IC21828274  
GO:0042802identical protein binding-IPI18729074  22045334  
GO:0042803protein homodimerization activity-IPI8774881  
GO:0043130ubiquitin binding-IDA18794808  
GO:0043425bHLH transcription factor binding-IPI21828274  
GO:0043565sequence-specific DNA binding-IDA10823886  
GO:0044212transcription regulatory region DNA binding-IDA9732876  
GO:0046982protein heterodimerization activity-IEA-  
GO:0070410co-SMAD binding-IPI8774881  9111321  9311995  9732876  
GO:0070412R-SMAD binding-IPI9311995  20129061  
GO:0070878primary miRNA binding-IPI18548003  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA8774881  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP14555988  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0001657ureteric bud development-IEA-  
GO:0001666response to hypoxia-IMP12411310  
GO:0001701in utero embryonic development-IEA-  
GO:0001707mesoderm formation-IEA-  
GO:0001756somitogenesis-IEA-  
GO:0001889liver development-IEA-  
GO:0001947heart looping-IEA-  
GO:0002076osteoblast development-IEA-  
GO:0002520immune system development-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA21947082  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IMP15107418  
GO:0006955immune response-IMP16886151  
GO:0007050cell cycle arrest-IMP14555988  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA9732876  18548003  21947082  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007183SMAD protein complex assembly-IDA9111321  10823886  
GO:0007492endoderm development-IEA-  
GO:0009880embryonic pattern specification-IEA-  
GO:0010628positive regulation of gene expression-IDA21307346  
GO:0010694positive regulation of alkaline phosphatase activity-IEA-  
GO:0010718positive regulation of epithelial to mesenchymal transition-IDA21307346  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP18505915  
GO:0016202regulation of striated muscle tissue development-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IMP8774881  
GO:0019049evasion or tolerance of host defenses by virus-IDA15334054  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030308negative regulation of cell growth-IDA8774881  
GO:0030325adrenal gland development-IEA-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030501positive regulation of bone mineralization-IEA-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0030878thyroid gland development-IEA-  
GO:0031053primary miRNA processing-TAS19018011  
GO:0032332positive regulation of chondrocyte differentiation-IEA-  
GO:0032731positive regulation of interleukin-1 beta production-IEA-  
GO:0032909regulation of transforming growth factor beta2 production-IMP12411310  
GO:0032916positive regulation of transforming growth factor beta3 production-IEA-  
GO:0032924activin receptor signaling pathway-IMP15150278  
GO:0033689negative regulation of osteoblast proliferation-IEA-  
GO:0038092nodal signaling pathway-IMP15150278  
GO:0042060wound healing-TAS19018011  
GO:0042110T cell activation-IEA-  
GO:0042177negative regulation of protein catabolic process-IEA-  
GO:0042307positive regulation of protein import into nucleus-NAS15799969  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045216cell-cell junction organization-IMP18505915  
GO:0045429positive regulation of nitric oxide biosynthetic process-IDA27038547  
GO:0045599negative regulation of fat cell differentiation-IDA19816956  
GO:0045668negative regulation of osteoblast differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA9111321  9311995  9732876  
GO:0045930negative regulation of mitotic cell cycle-IMP14555988  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8774881  18832382  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP14555988  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048340paraxial mesoderm morphogenesis-IEA-  
GO:0048589developmental growth-IEA-  
GO:0048617embryonic foregut morphogenesis-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0050678regulation of epithelial cell proliferation-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050776regulation of immune response-IEA-  
GO:0050821protein stabilization-IEA-  
GO:0050927positive regulation of positive chemotaxis-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-NAS15799969  
GO:0051098regulation of binding-IEA-  
GO:0051481negative regulation of cytosolic calcium ion concentration-IDA27038547  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051894positive regulation of focal adhesion assembly-IEA-  
GO:0060039pericardium development-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060290transdifferentiation-IEA-  
GO:0060395SMAD protein signal transduction-NAS15799969  
GO:0061045negative regulation of wound healing-IEA-  
GO:0061767negative regulation of lung blood pressure-IEA-  
GO:0070306lens fiber cell differentiation-IEA-  
GO:0071345cellular response to cytokine stimulus-TAS-  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA12902338  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:0097191extrinsic apoptotic signaling pathway-IMP15334054  
GO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IEA-  
GO:1901203positive regulation of extracellular matrix assembly-IDA21307346  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IMP26311719  
GO:1903243negative regulation of cardiac muscle hypertrophy in response to stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA21828274  
GO:0005634nucleus-IDA9311995  12446380  16007207  21947082  25893292  
GO:0005637nuclear inner membrane-IDA15647271  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA21947082  
GO:0005737cytoplasm-IDA9311995  12446380  21947082  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0043235receptor complex-IMP8774881  
GO:0071141SMAD protein complex-IDA18832382  21947082  
GO:0071144heteromeric SMAD protein complex-IDA21828274  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04144Endocytosis
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04520Adherens junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1181150Signaling by NODALIEA
R-HSA-1181150Signaling by NODALTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1502540Signaling by ActivinTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerIEA
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityIEA
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-3304347Loss of Function of SMAD4 in CancerTAS
R-HSA-3304349Loss of Function of SMAD2/3 in CancerTAS
R-HSA-3304351Signaling by TGF-beta Receptor Complex in CancerTAS
R-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in CancerTAS
R-HSA-3311021SMAD4 MH2 Domain Mutants in CancerTAS
R-HSA-3315487SMAD2/3 MH2 Domain Mutants in CancerTAS
R-HSA-3656532TGFBR1 KD Mutants in CancerTAS
R-HSA-3656534Loss of Function of TGFBR1 in CancerTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941855RUNX3 regulates CDKN1A transcriptionTAS
R-HSA-8952158RUNX3 regulates BCL2L11 (BIM) transcriptionTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA
R-HSA-9008059Interleukin-37 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24461721SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease. (2014 Aug)Fowler SAJ Crohns Colitis
29089751Characteristics and potential role of M2 macrophages in COPD. (2017)He SInt J Chron Obstruct Pulmon Dis
27126693Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD. (2016 Aug)Heijink IHEur Respir J
19659652Simvastatin attenuates experimental small airway remodelling in rats. (2009 Jul)Ou XMRespirology
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet
21496353Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. (2011 Apr 18)Kim DYRespir Res
21068203Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. (2011 Jan)Slattery MLCancer Epidemiol Biomarkers Prev
22232600Smoking attenuates transforming growth factor-beta-mediated tumor suppression function through downregulation of Smad3 in lung cancer. (2012 Mar)Samanta DCancer Prev Res (Phila)
22691361Developmental nicotine exposure results in programming of alveolar simplification and interstitial pulmonary fibrosis in adult male rats. (2012 Nov)Dasgupta CReprod Toxicol
19087346Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD. (2008 Dec 16)Zandvoort ARespir Res
28874823Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells. (2017 Sep 5)Sailland JSci Rep
28898507Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)Koo BKLiver Int
17093064Smoking induces glomerulosclerosis in aging estrogen-deficient mice through cross-talk between TGF-beta1 and IGF-I signaling pathways. (2006 Dec)Elliot SJJ Am Soc Nephrol
29315347Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (2018)Osterndorff-Kahanek EAPLoS One
23299965Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. (2013 May)Milara JThorax
22904681Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer. (2012 Jul)Samanta DNeoplasia
27060571Airway smooth muscle inflammation is regulated by microRNA-145 in COPD. (2016 May)O'Leary LFEBS Lett
28167353Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)Shahid SUAtherosclerosis