Gene info: ID 4089

Gene: SMAD4

GENE ID: 4089

Synonyms: DPC4|JIP|MADH4|MYHRS

Description: SMAD family member 4

Gene type: protein-coding

Location: 18q21.2

dbXrefs: Ensembl:ENSG00000141646 MIM:600993 Vega:OTTHUMG00000132696 UniprotKB:Q13485

RefSeq: NG_013013.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 15

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.085e-1 (AD) 3.097e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNOT6	0.893
NIPBL	0.875
G3BP1	0.875
PKN2	0.873
LRRC58	0.865
SUPT20H	0.864
C5orf51	0.862
USP47	0.861
UBR5	0.858
AHCTF1	0.857

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.618
OR4F29	-0.599
CRH	-0.298
MYLK2	-0.23
VGF	-0.211
CHST13	-0.205
HCRTR1	-0.195
GGN	-0.19
LCN1	-0.189
ADRA1D	-0.185

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of SMAD4 mRNA"	19162173
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SMAD4 mRNA"	21346803
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of SMAD4 mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD4 protein]"	21586554
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
D000079	Acetaldehyde	SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	16025520
D000082	Acetaminophen	Acetaminophen results in decreased expression of SMAD4 mRNA	27761495
D000082	Acetaminophen	Acetaminophen results in decreased expression of SMAD4 mRNA	22610607
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SMAD4 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SMAD4 mRNA	19770486
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of SMAD4 mRNA	16597033
D024502	alpha-Tocopherol	SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol]	20562578
C010845	aluminum chloride	aluminum chloride inhibits the reaction [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]	26658030
C010845	aluminum chloride	aluminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]	27720690
C010845	aluminum chloride	aluminum chloride results in decreased expression of SMAD4 mRNA	26658030\|2772069
C010845	aluminum chloride	aluminum chloride results in increased expression of SMAD4 mRNA	26658030
C010845	aluminum chloride	TGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of [SMAD2 protein binds to SMAD3 protein binds to SMAD4 protein]]	27720690
D017311	Amlodipine	Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]	21337027
D017311	Amlodipine	Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]	21337027
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SMAD4 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of SMAD4 protein	16483693
D001151	Arsenic	Arsenic affects the methylation of SMAD4 gene	25304211
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD4 mRNA"	20018196
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of SMAD4 mRNA	25912373
C006780	bisphenol A	bisphenol A affects the expression of SMAD4 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the methylation of SMAD4 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of SMAD4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SMAD4 gene	28505145
C077793	candesartan cilexetil	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD4 protein]	27889505
D002220	Carbamazepine	Carbamazepine affects the expression of SMAD4 mRNA	24752500\|2597931
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SMAD4 mRNA	16570350
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SMAD4 protein	17334410\|2515014
D002251	Carbon Tetrachloride	FR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein]	17334410
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SMAD4 mRNA	16934159
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of SMAD4 mRNA"	27239252
D002791	Cholesterol, Dietary	"Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA]"	27239252
D002857	Chromium	Chromium results in increased expression of SMAD4 mRNA	17692352
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SMAD4 mRNA	19549813
D003474	Curcumin	Curcumin results in decreased expression of SMAD4 mRNA	27237783
D003474	Curcumin	Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]	16959952
D016572	Cyclosporine	Cyclosporine results in increased expression of SMAD4 mRNA	20106945
C107676	deguelin	deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]	22986522
D003703	Demecolcine	Demecolcine results in increased expression of SMAD4 mRNA	23649840
D004008	Diclofenac	Diclofenac affects the expression of SMAD4 mRNA	24752500
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of SMAD4 protein	18971187
C547156	dimethylthioarsinic acid	dimethylthioarsinic acid results in increased expression of SMAD4 mRNA	19945496
D017292	Doxazosin	Doxazosin results in increased expression of SMAD4 mRNA	12771931\|1600721
D017292	Doxazosin	Doxazosin results in increased expression of SMAD4 protein	12771931\|1600721
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]	16007219
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]	16007219
D004317	Doxorubicin	Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]	21337027
D004317	Doxorubicin	Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]	21337027
D004317	Doxorubicin	[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA	21337027
D004317	Doxorubicin	[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein	21337027
D004317	Doxorubicin	Doxorubicin results in decreased expression of SMAD4 protein	18606404
D004317	Doxorubicin	Doxorubicin results in increased expression of SMAD4 mRNA	21337027
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMAD4 protein	23301498
D000431	Ethanol	BMP6 protein inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]	24746831
D000431	Ethanol	BMP6 protein affects the reaction [Ethanol affects the localization of SMAD4 protein]	24746831
D000431	Ethanol	BMP6 protein affects the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D000431	Ethanol	Ethanol affects the localization of SMAD4 protein	24746831
D000431	Ethanol	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]	24746831
D000431	Ethanol	Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]	24746831
D000431	Ethanol	Ethanol results in decreased expression of SMAD4 mRNA	24746831
D000431	Ethanol	Ethanol results in decreased expression of SMAD4 protein	24746831
D000431	Ethanol	Quercetin affects the reaction [Ethanol affects the localization of SMAD4 protein]	24746831
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]	24746831
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 protein]	24746831
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SMAD4 mRNA	17606305
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNA	17942748
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of SMAD4 gene	16724327
D011345	Fenofibrate	Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]	19593819
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA	22213190
D005472	Fluorouracil	SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol]	20562578
C104334	FR 167653	FR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein]	17334410
C037032	galangin	galangin results in increased expression of SMAD4 mRNA	25268046
C037032	galangin	SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]	25268046
C037032	galangin	SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]	25268046
C037032	galangin	SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]	25268046
C037032	galangin	SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]	25268046
D005839	Gentamicins	Gentamicins results in increased expression of SMAD4 mRNA	22061828
D005947	Glucose	Glucose results in increased expression of SMAD4 protein	21367880
D005947	Glucose	isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein]	21367880
C010974	glyphosate	glyphosate results in increased expression of SMAD4 mRNA	17984146
C056599	icariin	icariin results in increased expression of SMAD4 mRNA	19747809
C056599	icariin	NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]	19747809
D054354	Iron Carbonyl Compounds	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]	24746831
D054354	Iron Carbonyl Compounds	Iron Carbonyl Compounds results in increased expression of SMAD4 protein	24746831
D054354	Iron Carbonyl Compounds	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]	24746831
C551631	isoangustone A	isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein]	21367880
C410337	K 7174	K 7174 results in increased expression of SMAD4 mRNA	24086573
C038753	leptomycin B	[leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein	26354774
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SMAD4 protein"	25234611
C440499	lipopolysaccharide, Escherichia coli O111 B4	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SMAD4 protein]"	25234611
C014085	methotrexate polyglutamate	SMAD4 gene affects the abundance of methotrexate polyglutamate	19066393
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate affects the expression of SMAD4 mRNA	28349193
C005219	methyl cellosolve	methyl cellosolve results in increased expression of SMAD4 mRNA	19643169
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SMAD4 mRNA	26272509\|2800136
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SMAD4 mRNA	20061341
D008770	Methylnitrosourea	SMAD4 gene mutant form results in increased susceptibility to Methylnitrosourea	12096346
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of SMAD4 mRNA	25234470
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of SMAD4 protein	24625837
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of SMAD4 mRNA"	23845593
D009569	Nitric Oxide	Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]	15949472
D009569	Nitric Oxide	[SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide	15949472
C007350	nitrofen	nitrofen results in decreased expression of SMAD4 mRNA	12149686
C572573	N-nitroso-tris-chloroethylurea	N-nitroso-tris-chloroethylurea results in increased expression of SMAD4 mRNA	27935865
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of SMAD4 mRNA	26272509
D011374	Progesterone	Progesterone affects the expression of SMAD4 mRNA	17251523
D011794	Quercetin	Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein]	15580028
D011794	Quercetin	Quercetin results in decreased expression of SMAD4 protein	15580028
D011794	Quercetin	Quercetin affects the reaction [Ethanol affects the localization of SMAD4 protein]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 protein]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]	24746831
C059514	resveratrol	resveratrol results in decreased expression of SMAD4 mRNA	18089832\|2572186
C059514	resveratrol	resveratrol results in decreased expression of SMAD4 protein	25721869\|2700865
C059514	resveratrol	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SMAD4 protein]"	25234611
C059514	resveratrol	resveratrol results in increased expression of SMAD4 mRNA	19228061
D012431	Rutin	"Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA]"	27239252
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased activity of [SMAD4 protein binds to SMAD3 protein]	15949472
C017947	sodium arsenite	sodium arsenite results in increased expression of SMAD4 mRNA	12016162\|1276083
C017947	sodium arsenite	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD4 protein]	27889505
C017947	sodium arsenite	sodium arsenite results in increased expression of SMAD4 protein	27889505
D013311	Streptozocin	SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of SMAD4 mRNA]	27629361
D013311	Streptozocin	Streptozocin results in decreased expression of SMAD4 mRNA	27629361
D013311	Streptozocin	Streptozocin results in increased expression of SMAD4 mRNA	16973718\|1824667
D013311	Streptozocin	Streptozocin results in increased expression of SMAD4 protein	18246672
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]	16973718
D010042	Ouabain	Ouabain results in decreased expression of SMAD4 mRNA	28795476
C061133	tamibarotene	tamibarotene results in decreased expression of SMAD4 mRNA	15498508
C004648	testosterone enanthate	testosterone enanthate affects the expression of SMAD4 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SMAD4 mRNA	24058054\|2821309
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SMAD4 mRNA	11752688
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SMAD4 mRNA	27237783
D014112	Toxaphene	Toxaphene results in increased expression of SMAD4 mRNA	21220043
D014212	Tretinoin	Tretinoin inhibits the reaction [TGFB1 results in increased expression of SMAD4 protein]	21274875
D014212	Tretinoin	Tretinoin results in decreased expression of SMAD4 mRNA	15498508
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SMAD4 mRNA	26272509
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]	16973718
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SMAD4 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of SMAD4 mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SMAD4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SMAD4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased expression of SMAD4 mRNA	20546886\|2142705
D014635	Valproic Acid	Valproic Acid results in increased expression of SMAD4 mRNA	27237783
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of SMAD4 mRNA	16330358
D014750	Vincristine	Vincristine results in increased expression of SMAD4 mRNA	23649840
C111237	vorinostat	vorinostat results in decreased expression of SMAD4 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	9389648
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000987	proximal promoter sequence-specific DNA binding	-	IDA	18832382
GO:0000989	transcription factor activity, transcription factor binding	contributes_to	IDA	18832382
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	9389648
GO:0001085	RNA polymerase II transcription factor binding	-	IEA	-
GO:0003677	DNA binding	contributes_to	IDA	9389648
GO:0003682	chromatin binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	contributes_to	IDA	10823886 17438144
GO:0005515	protein binding	-	IPI	9389648 9436979 9707553 11278302 11779505 12167862 12202226 12419246 14525983 14612439 14671321 15084259 15231748 15350224 15781469 16189514 16959612 17099224 17183365 17469184 18511908 18568018 18729074 18832382 19032343 19135894 20603019 21297662 21532621 21597466 21988832 22045334 22442258 23201680 23397142 23602568 24412244 25310401 25416956 25609649 25910212 26878725 26977879 27107012
GO:0005518	collagen binding	-	IEA	-
GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	-	IDA	9389648
GO:0042802	identical protein binding	-	IMP	10647180
GO:0042802	identical protein binding	-	IPI	9111321 21988832 25609649
GO:0042803	protein homodimerization activity	-	IPI	8774881
GO:0043199	sulfate binding	-	IMP	10647180
GO:0043565	sequence-specific DNA binding	contributes_to	IDA	10823886
GO:0044212	transcription regulatory region DNA binding	-	IDA	17438144
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IEA	-
GO:0070411	I-SMAD binding	-	IPI	9256479
GO:0070412	R-SMAD binding	-	IPI	8774881 9111321 9311995 9732876

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	-
GO:0001541	ovarian follicle development	-	IEA	-
GO:0001658	branching involved in ureteric bud morphogenesis	-	IEA	-
GO:0001666	response to hypoxia	-	IMP	12411310
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001702	gastrulation with mouth forming second	-	IEA	-
GO:0003148	outflow tract septum morphogenesis	-	ISS	-
GO:0003190	atrioventricular valve formation	-	IEA	-
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	-	IEA	-
GO:0003220	left ventricular cardiac muscle tissue morphogenesis	-	ISS	-
GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	-	IEA	-
GO:0003360	brainstem development	-	IEA	-
GO:0006879	cellular iron ion homeostasis	-	ISS	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IDA	9389648 9732876
GO:0007179	transforming growth factor beta receptor signaling pathway	-	ISS	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	-
GO:0007183	SMAD protein complex assembly	-	IDA	10823886
GO:0007283	spermatogenesis	-	IEA	-
GO:0007338	single fertilization	-	IEA	-
GO:0007411	axon guidance	-	IEA	-
GO:0007492	endoderm development	-	IEA	-
GO:0007498	mesoderm development	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0010614	negative regulation of cardiac muscle hypertrophy	-	ISS	-
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	ISS	-
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	ISS	-
GO:0014033	neural crest cell differentiation	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	-	IMP	8774881
GO:0030308	negative regulation of cell growth	-	IDA	8774881
GO:0030509	BMP signaling pathway	-	IDA	9389648
GO:0030509	BMP signaling pathway	-	ISS	-
GO:0030509	BMP signaling pathway	-	TAS	-
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	-	IDA	19328798
GO:0030513	positive regulation of BMP signaling pathway	-	IMP	19366699
GO:0032525	somite rostral/caudal axis specification	-	IEA	-
GO:0032909	regulation of transforming growth factor beta2 production	-	IMP	12411310
GO:0033686	positive regulation of luteinizing hormone secretion	-	IEA	-
GO:0035019	somatic stem cell population maintenance	-	TAS	-
GO:0035556	intracellular signal transduction	-	IMP	22316667
GO:0036302	atrioventricular canal development	-	IEA	-
GO:0042118	endothelial cell activation	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	8774881
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	8774881 9311995 9389648 9707553 9732876
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	9389648 18832382
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0046881	positive regulation of follicle-stimulating hormone secretion	-	IEA	-
GO:0048589	developmental growth	-	IEA	-
GO:0048663	neuron fate commitment	-	IEA	-
GO:0048733	sebaceous gland development	-	IEA	-
GO:0048859	formation of anatomical boundary	-	IEA	-
GO:0051098	regulation of binding	-	IEA	-
GO:0051571	positive regulation of histone H3-K4 methylation	-	ISS	-
GO:0051797	regulation of hair follicle development	-	IEA	-
GO:0060065	uterus development	-	IEA	-
GO:0060391	positive regulation of SMAD protein signal transduction	-	ISS	-
GO:0060395	SMAD protein signal transduction	-	IDA	9707553 9732876
GO:0060412	ventricular septum morphogenesis	-	ISS	-
GO:0060548	negative regulation of cell death	-	IEA	-
GO:0060956	endocardial cell differentiation	-	IEA	-
GO:0061040	female gonad morphogenesis	-	IEA	-
GO:0061614	pri-miRNA transcription by RNA polymerase II	-	IEA	-
GO:0062009	secondary palate development	-	ISS	-
GO:0070102	interleukin-6-mediated signaling pathway	-	ISS	-
GO:0070207	protein homotrimerization	-	IMP	10647180
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0071559	response to transforming growth factor beta	-	IDA	9707553
GO:0071773	cellular response to BMP stimulus	-	NAS	14687659
GO:0072133	metanephric mesenchyme morphogenesis	-	IEA	-
GO:0072134	nephrogenic mesenchyme morphogenesis	-	IEA	-
GO:0072520	seminiferous tubule development	-	IEA	-
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	-	TAS	14687659
GO:1905305	negative regulation of cardiac myofibril assembly	-	ISS	-
GO:2000617	positive regulation of histone H3-K9 acetylation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	21828274
GO:0005634	nucleus	-	IDA	9311995 9389648 12161428 16007207
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IDA	17438144
GO:0005667	transcription factor complex	-	IPI	12374795
GO:0005737	cytoplasm	-	IDA	9311995 9389648 12161428
GO:0005813	centrosome	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0032444	activin responsive factor complex	-	IDA	9389648
GO:0071141	SMAD protein complex	-	IDA	18832382
GO:0071141	SMAD protein complex	-	IMP	10647180

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04520	Adherens junction
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-1181150	Signaling by NODAL	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1502540	Signaling by Activin	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	IEA
R-HSA-201451	Signaling by BMP	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	IEA
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	TAS
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	IEA
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	TAS
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	TAS
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	TAS
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	TAS
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8941326	RUNX2 regulates bone development	TAS
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	TAS
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9006936	Signaling by TGF-beta family members	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27161973	Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study. (2016 Jul 1)	Kawaguchi T	J Clin Oncol
26518718	Identification of gene markers in the development of smoking-induced lung cancer. (2016 Jan 15)	Yang Z	Gene
26378065	Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma. (2015 Nov)	Huang J	Clin Chem
28852126	Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. (2017 Aug 29)	Chiou J	Sci Rep
28067794	The TGF-beta/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance. (2017 Jan 5)	Ahmed S	J Clin Med
16337851	Deletion mapping of 18q in conventional renal cell carcinoma. (2005 Dec)	Hirata H	Cancer Genet Cytogenet
25911935	[Genetic aspects of pancreatic cancer]. (2014)	Grigor'eva IN	Eksp Klin Gastroenterol
21068203	Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. (2011 Jan)	Slattery ML	Cancer Epidemiol Biomarkers Prev
14657708	p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. (2003 Dec)	Rosty C	Am J Surg Pathol
19351817	Genetic mutations associated with cigarette smoking in pancreatic cancer. (2009 Apr 15)	Blackford A	Cancer Res
27237783	Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. (2016 May 16)	Cheng W	Toxicology
28406602	Myhre Syndrome (1993)	Starr LJ	-
25355724	Small-cell lung cancer detection in never-smokers: clinical characteristics and multigene mutation profiling using targeted next-generation sequencing. (2015 Jan)	Sun JM	Ann Oncol
18824881	Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. (2008)	Ishida M	Pancreatology
22232600	Smoking attenuates transforming growth factor-beta-mediated tumor suppression function through downregulation of Smad3 in lung cancer. (2012 Mar)	Samanta D	Cancer Prev Res (Phila)