Gene: ARRB2

409
ARB2|ARR2|BARR2
arrestin beta 2
protein-coding
17p13.2
Ensembl:ENSG00000141480 MIM:107941 Vega:OTTHUMG00000090759 UniprotKB:P32121
NC_000017.11
PubMed|SNP Mapped
2   ANCO-SNPs
CD|OD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.129e-1 (AD)  6.325e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1045280chr17:4719343 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3786047chr17:4711803 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APMAP0.917
SMAP20.917
FLOT20.914
CAPZB0.91
CORO1A0.91
CDC370.907
PRKACA0.906
AP2M10.905
ATP6AP10.905
TCF250.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.67
LRAT-0.323
CTNNA3-0.312
ASB4-0.289
HEY2-0.285
RAI14-0.284
C5orf64-0.263
ZBTB20-0.255
SH2D1A-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of ARRB2 mRNA"23174265
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of ARRB2 protein"23174265
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"CNR2 mutant form inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of ARRB2 mRNA]"23174265
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ARRB2 mRNA"19114083
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid affects the activity of ARRB2 protein16624952
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [ARRB2 protein binds to MAPK1 protein binds to MAPK3 protein]"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of ARRB2 mRNA"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of ARRB2 protein"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"ARRB2 mutant form inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of MAPK1 protein]"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"ARRB2 mutant form inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of MAPK3 protein]"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR2 mutant form inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of ARRB2 mRNA]"23174265
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"JTE 907 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of ARRB2 mRNA]"23174265
C586842((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine"((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]"23300227
C586842((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine[OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased activity of ARRB2 protein23300227
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of ARRB2 mRNA"26186136
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ARRB2 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of ARRB2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ARRB2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ARRB2 mRNA17562736
D000242Cyclic AMP[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [ARRB2 protein binds to GLP1R protein]25191754
D000242Cyclic AMP[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] which affects the localization of ARRB2 protein25191754
D000255Adenosine TriphosphateAdenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]21464294
D000255Adenosine TriphosphateARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]21464294
D000255Adenosine TriphosphateARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]21464294
D000255Adenosine TriphosphateARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]21464294
D000255Adenosine TriphosphateARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]21464294
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]"23300227
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein"27030709
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein]"27030709
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein"23300227|2719261
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Sodium Chloride affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein]"27030709
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"mitragynine pseudoindoxyl inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]"27556704
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein"27556704
D000526AlprenololAlprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]18787115
D000526AlprenololARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
D000526AlprenololARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARRB2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARRB2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of ARRB2 mRNA25929836
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ARRB2 mRNA26271895
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of ARRB2 mRNA26186136
C006780bisphenol Abisphenol A results in decreased expression of ARRB2 protein28739533
C006780bisphenol Abisphenol A results in increased expression of ARRB2 mRNA25181051
D001966BromineBromine results in increased expression of ARRB2 mRNA21391292
D002110CaffeineCaffeine results in increased expression of ARRB2 mRNA20864626
D002118CalciumARRB2 protein affects the abundance of and affects the localization of Calcium16210646
D002118CalciumARRB2 promotes the reaction [carvedilol results in increased uptake of Calcium]21078978
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARRB2 mRNA27339419
C043211carvedilolARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
C043211carvedilolARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
C043211carvedilolARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]17925438
C043211carvedilolARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]17925438
C043211carvedilolcarvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]18787115
C043211carvedilolcarvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]17925438
C043211carvedilolICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]17925438
C043211carvedilolPropranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]17925438
C043211carvedilolARRB2 promotes the reaction [carvedilol results in increased uptake of Calcium]21078978
C043211carvedilolcarvedilol affects the localization of ARRB2 protein21078978
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of ARRB2 mRNA18636392
C043561chrysinchrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]21167192
C043561chrysinchrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]21167192
D003345CorticosteroneCorticosterone results in decreased expression of ARRB2 mRNA19477151
D003345CorticosteroneFluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB2 mRNA]19477151
C000541cyclopaminecyclopamine inhibits the reaction [SMO protein binds to ARRB2 protein]22552772
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ARRB2 mRNA26271895
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARRB2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ARRB2 mRNA27594783
D004026DieldrinDieldrin results in increased expression of ARRB2 mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of ARRB2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased expression of ARRB2 protein]28526321
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ARRB2 protein21911000
D004052Diethylnitrosaminechrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]21167192
D004052Diethylnitrosaminechrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]21167192
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ARRB2 mRNA21167192|2239330
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ARRB2 protein21167192|2239330
D004052DiethylnitrosaminePlant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]22393308
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ARRB2 mRNA25380136
D004147DioxinsDioxins affects the expression of ARRB2 mRNA20463971
D004280DobutamineARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]18787115
D004280DobutamineARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]18787115
C105294endomorphin 2[OPRM1 protein co-treated with endomorphin 2] results in increased activity of ARRB2 protein27556704
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ARRB2 protein23301498
D000431EthanolEthanol affects the expression of ARRB2 mRNA11772933
D000431EthanolEthanol results in increased expression of ARRB2 mRNA20655511
D005283FentanylFentanyl affects the localization of ARRB2 protein27030709
D005419FlavonoidsFlavonoids results in decreased expression of ARRB2 mRNA18035473
D005473FluoxetineARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]19477151
D005473FluoxetineARRB2 protein promotes the reaction [Fluoxetine results in increased expression of MAPK3 protein]19477151
D005473FluoxetineARRB2 protein results in increased susceptibility to Fluoxetine19477151
D005473FluoxetineFluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB2 mRNA]19477151
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA"19477204
C026777ICI 118551ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]17925438
D007545IsoproterenolARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]17925438
D007545IsoproterenolARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]17925438
D007545IsoproterenolIsoproterenol affects the localization of ARRB2 protein17482545
D007545IsoproterenolIsoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]18787115
D007545IsoproterenolIsoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]17925438
D007545IsoproterenolS-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein]17482545
D007545IsoproterenolIsoproterenol affects the localization of ARRB2 protein21078978
C422645JTE 907"JTE 907 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of ARRB2 mRNA]"23174265
C422645JTE 907"JTE 907 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
C410337K 7174K 7174 results in increased expression of ARRB2 mRNA24086573
D008694MethamphetamineARRB2 gene SNP results in increased susceptibility to Methamphetamine17233643
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of ARRB2 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ARRB2 mRNA20864626
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ARRB2 mRNA"20188158|2625132
D008790MetoprololARRB2 protein affects the susceptibility to Metoprolol22888001
D008790MetoprololGRK5 protein affects the reaction [Metoprolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]]22888001
D008790MetoprololMetoprolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]22888001
C121049mitragynine pseudoindoxyl"mitragynine pseudoindoxyl inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]"27556704
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased expression of ARRB2 protein]28526321
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of ARRB2 mRNA20864626
D009020MorphineARRB2 gene SNP affects the susceptibility to Morphine16103897
D009020MorphineARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]19239323
D009020MorphineARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]19239323
D009020Morphine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA"19477204
D009020Morphine[OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein23300227
D009020MorphineARRB2 protein affects the susceptibility to Morphine23300227|2406343
C511794N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein]"27030709
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARRB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARRB2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ARRB2 mRNA25380136
D009532NickelNickel results in increased expression of ARRB2 mRNA25583101
C022838nickel chloridenickel chloride affects the localization of ARRB2 protein16959833
C028007nickel monoxidenickel monoxide results in increased expression of ARRB2 mRNA19167457
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"ARRB2 mutant form inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide affects the localization of MAPK1 protein]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"ARRB2 mutant form inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide affects the localization of MAPK3 protein]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"ARRB2 mutant form inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"CNR2 mutant form inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"JTE 907 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 protein"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
C553580N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide"SR 11302 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of ARRB2 mRNA18636392
D010126OzoneOzone results in increased expression of ARRB2 mRNA16330353
D000073878Palm OilPalm Oil results in decreased expression of ARRB2 mRNA18042831
C004368pamoic acidpamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein]20826425
D052638Particulate MatterARRB2 protein promotes the reaction [Particulate Matter affects the localization of MAPK1 protein]19337515
D052638Particulate MatterARRB2 protein promotes the reaction [Particulate Matter affects the localization of MAPK3 protein modified form]19337515
D052638Particulate MatterARRB2 protein promotes the reaction [Particulate Matter results in increased expression of MMP1 mRNA polymorphism]19337515
D052638Particulate MatterARRB2 protein promotes the reaction [Particulate Matter results in increased secretion of MMP1 protein]19337515
D052638Particulate MatterParticulate Matter results in increased expression of ARRB2 mRNA28412507
C475178PD 198306"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
D010882Piperonyl ButoxidePiperonyl Butoxide inhibits the reaction [SMO protein binds to ARRB2 protein]22552772
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARRB2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ARRB2 mRNA23557933
D010938Plant OilsPlant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]22393308
D059808PolyphenolsPolyphenols results in decreased expression of ARRB2 mRNA16293270
D011433PropranololPropranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]17925438
C059514resveratrolARRB2 protein affects the reaction [resveratrol results in decreased expression of GSK3B protein modified form]20457218
C059514resveratrolARRB2 protein affects the susceptibility to resveratrol20457218
C021315S-nitrosocysteineS-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein]17482545
D012965Sodium Chloride"Sodium Chloride affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein]"27030709
C106195SR 11302"SR 11302 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of ARRB2 mRNA]"23174265
D013481SuperoxidesARRB2 protein affects the abundance of Superoxides16210646
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ARRB2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARRB2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARRB2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARRB2 mRNA19770486
D013893ThiramThiram results in increased expression of ARRB2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of ARRB2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of ARRB2 mRNA23724009
D014635Valproic AcidValproic Acid results in increased expression of ARRB2 mRNA29154799
D014640VancomycinVancomycin results in decreased expression of ARRB2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARRB2 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of ARRB2 mRNA26682919
D015032ZincZinc affects the localization of ARRB2 protein16959833
C016837zinc chloridezinc chloride affects the localization of ARRB2 protein16959833

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI10644702  
GO:0005102signaling receptor binding-IPI18604210  
GO:0005515protein binding-IPI11588219  12958365  15125834  16051150  16378096  16524428  
16820410  17148612  17353931  17620599  19060904  19122674  
19202075  19363159  19372219  19782076  19955404  20664520  
20802461  21988832  22190034  22300987  22457824  23208550  
23341447  24069330  24157794  25241761  25416956  
GO:0019899enzyme binding-IPI23382074  
GO:0019904protein domain specific binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI15878855  19372219  
GO:0031691alpha-1A adrenergic receptor binding-IEA-  
GO:0031692alpha-1B adrenergic receptor binding-IEA-  
GO:0031701angiotensin receptor binding-IPI15611106  
GO:0031702type 1 angiotensin receptor binding-IEA-  
GO:0031748D1 dopamine receptor binding-IEA-  
GO:0031762follicle-stimulating hormone receptor binding-IEA-  
GO:0031826type 2A serotonin receptor binding-IEA-  
GO:0031859platelet activating factor receptor binding-IEA-  
GO:0032947protein-containing complex scaffold activity-IDA19372219  
GO:0042802identical protein binding-IEA-  
GO:0043422protein kinase B binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0051019mitogen-activated protein kinase binding-IEA-  
GO:007188914-3-3 protein binding-IEA-  
GO:1990763arrestin family protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0002031G-protein coupled receptor internalization-IDA10644702  
GO:0002031G-protein coupled receptor internalization-IMP12582207  
GO:0002031G-protein coupled receptor internalization-TAS24157794  
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestin-IMP12582207  
GO:0002092positive regulation of receptor internalization-IMP22457824  
GO:0006366transcription by RNA polymerase II-IDA16820410  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA12958365  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007212dopamine receptor signaling pathway-NAS21711983  
GO:0007420brain development-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0015031protein transport-IEA-  
GO:0016567protein ubiquitination-IMP15878855  
GO:0016579protein deubiquitination-TAS-  
GO:0030168platelet activation-TAS-  
GO:0031397negative regulation of protein ubiquitination-IDA16378096  
GO:0031398positive regulation of protein ubiquitination-IGI19372219  
GO:0031623receptor internalization-IDA12958365  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA15125834  16378096  
GO:0032226positive regulation of synaptic transmission, dopaminergic-IEA-  
GO:0032691negative regulation of interleukin-1 beta production-IEA-  
GO:0032695negative regulation of interleukin-12 production-IEA-  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0032967positive regulation of collagen biosynthetic process-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0034122negative regulation of toll-like receptor signaling pathway-IEA-  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0034392negative regulation of smooth muscle cell apoptotic process-IEA-  
GO:0042699follicle-stimulating hormone signaling pathway-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP15878855  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045953negative regulation of natural killer cell mediated cytotoxicity-IMP18604210  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0051898negative regulation of protein kinase B signaling-NAS21711983  
GO:0051928positive regulation of calcium ion transport-IEA-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0060079excitatory postsynaptic potential-NAS21711983  
GO:0060326cell chemotaxis-IMP15635042  
GO:0060765regulation of androgen receptor signaling pathway-IDA19372219  
GO:0061024membrane organization-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA10644702  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP12582207  
GO:0090201negative regulation of release of cytochrome c from mitochondria-IEA-  
GO:1904037positive regulation of epithelial cell apoptotic process-IEA-  
GO:2000573positive regulation of DNA biosynthetic process-IEA-  
GO:2000727positive regulation of cardiac muscle cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16820410  
GO:0005737cytoplasm-IDA12958365  15611106  16325578  16820410  23341447  
GO:0005768endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA18604210  
GO:0005886plasma membrane-TAS21149639  
GO:0005905clathrin-coated pit-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0030139endocytic vesicle-IDA23341447  
GO:0031410cytoplasmic vesicle-IDA12958365  15611106  
GO:0043197dendritic spine-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04740Olfactory transduction
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOTAS
R-HSA-5635838Activation of SMOIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20864483Lack of association between genetic polymorphisms of ARRB2 and alcohol dependence in a Caucasian population. (2010 Nov-Dec)Oneda BAlcohol Alcohol
17978999Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial. (2007 Nov)Ray RNicotine Tob Res
24956254Pharmacogenomics of methadone maintenance treatment. (2014 May)Somogyi AAPharmacogenomics
24447405Association between common genetic variants in the opioid pathway and smoking behaviors in Chinese men. (2014 Jan 21)Fang JBehav Brain Funct
29781244OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. (2018 May 20)Muriel JAnn N Y Acad Sci
22472784Association study of the beta-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. (2012 Jun)Ambrose-Lanci LMPsychiatr Genet
17579607Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. (2008 Apr)Sun DMol Psychiatry
20813242Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. (2010)Bjork KInt Rev Neurobiol