Gene: SMAD5

4090
DWFC|JV5-1|MADH5
SMAD family member 5
protein-coding
5q31.1
Ensembl:ENSG00000113658 MIM:603110 Vega:OTTHUMG00000163212 UniprotKB:Q99717
NG_032037.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.244e-1 (AD)  8.569e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABPA0.912
SH3GLB10.904
TWSG10.892
IL6ST0.889
ATL30.889
RASSF80.885
BNIP20.883
STAG20.883
CPNE30.881
NFE2L20.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.465
ABCC12-0.461
OR4F29-0.451
ADRA1D-0.449
KCNG2-0.431
DLK2-0.412
SPEF1-0.412
RHO-0.409
C2CD4D-0.408
GSG1-0.406

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolSMAD5 protein results in decreased susceptibility to 1-UFT protocol16734730
C0229095-methoxypsoralen5-methoxypsoralen results in increased phosphorylation of SMAD5 protein17980360
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD5 protein]"23936038
D000082AcetaminophenAcetaminophen results in decreased phosphorylation of [SMAD1 protein binds to SMAD5 protein binds to SMAD9 protein]22610607
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SMAD5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SMAD5 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMAD5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMAD5 mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in decreased expression of SMAD5 protein modified form22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD5 protein modified form]22525892
D001151ArsenicArsenic affects the expression of SMAD5 protein24675094
D001151ArsenicArsenic results in increased phosphorylation of SMAD5 protein28903487
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased phosphorylation of SMAD5 protein"17975199
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD5 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SMAD5 mRNA"26238291
D004958EstradiolEstradiol results in increased expression of SMAD5 mRNA25210133
C095105bexarotenebexarotene results in increased expression of SMAD5 mRNA17178900
C006780bisphenol Abisphenol A affects the expression of SMAD5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SMAD5 mRNA22576693
C006780bisphenol Abisphenol A affects the methylation of SMAD5 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of SMAD5 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of SMAD5 mRNA21786754
D001786Blood GlucoseSMAD5 gene mutant form inhibits the reaction [INS1 protein results in increased uptake of Blood Glucose]20079400
D001786Blood Glucose[SMAD5 gene mutant form results in decreased expression of and results in decreased phosphorylation of AKT2 protein] inhibits the reaction [INS1 protein results in increased uptake of Blood Glucose]20079400
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased methylation of SMAD5 gene27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SMAD5 mRNA27509014
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SMAD5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SMAD5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SMAD5 mRNA27989131
C014347decitabinedecitabine results in decreased expression of SMAD5 mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SMAD5 mRNA]27941970
D003907DexamethasoneDexamethasone inhibits the reaction [SMAD5 protein binds to AKT2 gene]20079400
D003907DexamethasoneDexamethasone results in decreased expression of SMAD520079400
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SMAD5 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SMAD5 mRNA23649840
D017313FenretinideFenretinide results in increased expression of SMAD5 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein18951874
C082359imidaclopridimidacloprid results in decreased expression of SMAD5 protein27444676
C031534imperatorinimperatorin results in increased phosphorylation of SMAD5 protein17980360
C554430LDN 193189LDN 193189 inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD5 protein]23936038
C008261lead acetatelead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD5 protein]17805416
C045463leflunomideleflunomide results in increased expression of SMAD5 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SMAD5 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMAD5 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMAD5 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SMAD5 mRNA20971185
D010575PesticidesPesticides results in decreased methylation of SMAD5 gene28396702
D010622PhencyclidinePhencyclidine results in decreased expression of SMAD5 mRNA12105081
D010634PhenobarbitalPhenobarbital affects the expression of SMAD5 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of SMAD5 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in increased expression of SMAD5 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SMAD5 mRNA15309432
C059514resveratrolresveratrol results in increased phosphorylation of SMAD5 protein21745208
C059514resveratrolresveratrol results in decreased expression of SMAD5 mRNA25905778
C009172rhodiolosiderhodioloside results in increased expression of SMAD5 mRNA24929042
C009172rhodiolosiderhodioloside results in increased phosphorylation of and results in increased expression of SMAD5 protein24929042
D019821SimvastatinSimvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]18310456
C439060sirtinolsirtinol results in decreased phosphorylation of SMAD5 protein21745208
C017947sodium arseniteEGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein]]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein]23566955
C017947sodium arsenitesodium arsenite results in decreased expression of SMAD5 mRNA16014739
C004648testosterone enanthatetestosterone enanthate affects the expression of SMAD5 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD5 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD5 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMAD5 mRNA19490992
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein18951874
D014118Toxins, Biological"Toxins, Biological affects the expression of SMAD5 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SMAD5 gene27618143
D014635Valproic AcidValproic Acid results in decreased expression of SMAD5 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of SMAD5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SMAD5 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMAD5 gene25560391
D014810Vitamin EVitamin E results in decreased expression of SMAD5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI15647271  18548003  25755279  
GO:0017151DEAD/H-box RNA helicase binding-IPI18548003  
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity-TAS19018011  
GO:0031625ubiquitin protein ligase binding-IPI11278251  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0001880Mullerian duct regression-IEA-  
GO:0002051osteoblast fate commitment-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-NAS9759503  
GO:0007179transforming growth factor beta receptor signaling pathway-NAS10708948  
GO:0007281germ cell development-IEA-  
GO:0009880embryonic pattern specification-ISS-  
GO:0030218erythrocyte differentiation-IEA-  
GO:0030509BMP signaling pathway-ISS-  
GO:0030509BMP signaling pathway-TAS19018011  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-NAS10708949  
GO:0051216cartilage development-IEA-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0060348bone development-IEA-  
GO:0060395SMAD protein signal transduction-ISS-  
GO:0060395SMAD protein signal transduction-NAS14687659  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-ISS-  
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-TAS14687659  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS9759503  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-NAS9759503  
GO:0005634nucleus-TAS19018011  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IDA23610558  
GO:0071141SMAD protein complex-NAS14687659  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29387395Two-stage study of lung cancer risk modification by a functional variant in the 3'-untranslated region of SMAD5 based on the bone morphogenetic protein pathway. (2018 Jan)Zhang ZMol Clin Oncol