Gene: SMAD6

4091
AOVD2|HsT17432|MADH6|MADH7
SMAD family member 6
protein-coding
15q22.31
Ensembl:ENSG00000137834 MIM:602931 Vega:OTTHUMG00000133218 UniprotKB:O43541
NG_012244.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.008e-1 (AD)  3.541e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27514333chr15:66996626SMAD61.000e-17Smoking27651444
cg17232357chr15:67012832SMAD65.500e-14Smoking27651444
cg27514333chr15:66996626SMAD62.770e-12Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENG0.796
TGFB1I10.773
ACVRL10.743
GATA20.728
MYO1C0.721
TCIRG10.71
KANK20.702
HSPG20.698
PLCG20.695
GIMAP10.694

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.368
ST6GAL2-0.366
ATOH7-0.358
ABCC12-0.352
ZSCAN1-0.349
CHML-0.344
NEUROD6-0.34
SLC7A4-0.34
SFTPD-0.34
SMIM18-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SMAD6 mRNA28329830
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of SMAD6 mRNA25827057
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SMAD6 mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of SMAD6 mRNA25088246
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD6 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of SMAD6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SMAD6 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of SMAD6 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SMAD6 mRNA"23634900
D001554BenzeneTRP53 protein inhibits the reaction [Benzene results in increased expression of SMAD6]15935813
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SMAD6 mRNA26377693
C006780bisphenol Abisphenol A affects the expression of SMAD6 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of SMAD6 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of SMAD6 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SMAD6 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of SMAD6 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of SMAD6 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SMAD6 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD6 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMAD6 mRNA]17585979
D016572CyclosporineCyclosporine results in decreased expression of SMAD6 mRNA27989131
D003561CytarabineCytarabine results in decreased expression of SMAD6 mRNA21198554
D003994BucladesineBucladesine inhibits the reaction [BMP4 protein results in increased expression of SMAD6 mRNA]20522807
D002945CisplatinCisplatin results in decreased expression of SMAD6 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SMAD6 mRNA26924002
D002117CalcitriolCalcitriol results in decreased expression of SMAD6 mRNA16002434
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD6 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SMAD6 mRNA20170705
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SMAD6 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD6 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of SMAD6 mRNA19167457
C039281furanfuran results in decreased expression of SMAD6 mRNA26194646
C037032galangingalangin results in decreased expression of SMAD6 mRNA25268046
C056599icariinSMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]18295595
C056599icariinSMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]18295595
D016285IloprostIloprost inhibits the reaction [BMP4 protein results in increased expression of SMAD6 mRNA]20522807
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SMAD6 mRNA25613284
D058085Iron CompoundsIron Compounds results in decreased expression of SMAD6 mRNA28483490
D008070LipopolysaccharidesIRAK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]21295571
D008070Lipopolysaccharides[Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesMAP2K1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesMAPK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesMAPK3 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesSMAD3 protein modified form promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesTLR4 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D008070LipopolysaccharidesU 0126 inhibits the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD6 mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SMAD6 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD6 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD6 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of SMAD6 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SMAD6 mRNA23179753
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SMAD6 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of SMAD6 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SMAD6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SMAD6 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of SMAD6 mRNA19167457
D015282OctreotideOctreotide results in decreased expression of SMAD6 mRNA23137853
D009966OrphenadrineOrphenadrine affects the expression of SMAD6 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SMAD6 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SMAD6 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of SMAD6 mRNA]26476374
D010269ParaquatParaquat affects the expression of SMAD6 mRNA16854511
D052638Particulate MatterParticulate Matter results in decreased expression of SMAD6 mRNA23085030
C517782pasireotidepasireotide results in decreased expression of SMAD6 mRNA23137853
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMAD6 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in decreased expression of SMAD6 mRNA21795739
C045950propiconazolepropiconazole results in decreased expression of SMAD6 mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SMAD6 mRNA27029645
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of SMAD6 mRNA]26476374
C089730rosiglitazonerosiglitazone results in increased expression of SMAD6 mRNA16185530
C017947sodium arsenitesodium arsenite results in increased expression of SMAD6 mRNA12016162|1696609
D013311StreptozocinStreptozocin results in increased expression of SMAD6 protein17437042
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD6 mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SMAD6 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD6 mRNA26378955
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SMAD6 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD6 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SMAD6 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMAD6 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SMAD6 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SMAD6 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SMAD6 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SMAD6 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SMAD6 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of SMAD6 protein19058293
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SMAD6 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of SMAD6 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SMAD6 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of SMAD6 mRNA28973697
C113580U 0126U 0126 inhibits the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]21295571
D014635Valproic AcidValproic Acid results in decreased expression of SMAD6 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SMAD6 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of SMAD6 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMAD6 gene25560391
D015032ZincZinc deficiency results in increased expression of SMAD6 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16491121  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003682chromatin binding-IDA16491121  
GO:0005515protein binding-IPI9436979  16299379  16491121  
GO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity-IDA9256479  
GO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity-IMP19047146  
GO:0031625ubiquitin protein ligase binding-IPI11278251  
GO:0034713type I transforming growth factor beta receptor binding-IDA9436979  
GO:0042802identical protein binding-IPI9436979  
GO:0044212transcription regulatory region DNA binding-IDA16491121  
GO:0046872metal ion binding-IEA-  
GO:0070410co-SMAD binding-IPI9256479  
GO:0070411I-SMAD binding-IPI9256479  
GO:0070412R-SMAD binding-IPI9256479  9436979  
GO:0070698type I activin receptor binding-IDA9436979  
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-IEA-  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003180aortic valve morphogenesis-IMP22275001  
GO:0003183mitral valve morphogenesis-ISS-  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0003281ventricular septum development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006955immune response-IMP16886151  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0007352zygotic specification of dorsal/ventral axis-IMP9436979  
GO:0008285negative regulation of cell proliferation-IMP19047146  
GO:0010991negative regulation of SMAD protein complex assembly-IDA9436979  
GO:0030279negative regulation of ossification-ISS-  
GO:0030509BMP signaling pathway-IDA23455153  
GO:0030509BMP signaling pathway-TAS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IMP19047146  
GO:0030514negative regulation of BMP signaling pathway-IDA9436979  
GO:0030514negative regulation of BMP signaling pathway-IMP22275001  
GO:0031589cell-substrate adhesion-IMP16491121  
GO:0034616response to laminar fluid shear stress-IEP9256479  
GO:0035904aorta development-IEA-  
GO:0043066negative regulation of apoptotic process-IMP19047146  
GO:0043627response to estrogen-IEA-  
GO:0045444fat cell differentiation-IDA23455153  
GO:0045668negative regulation of osteoblast differentiation-IMP22275001  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IDA9436979  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IMP19047146  
GO:0060976coronary vasculature development-IEA-  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16491121  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-TAS19018011  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA-  
GO:0032991protein-containing complex-IDA23610558  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8941326RUNX2 regulates bone developmentTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21310029Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway. (2011 Feb 10)Dimitriou RBMC Musculoskelet Disord