Gene: SMAD7

4092
CRCS3|MADH7|MADH8
SMAD family member 7
protein-coding
18q21.1
Ensembl:ENSG00000101665 MIM:602932 Vega:OTTHUMG00000132655 UniprotKB:O15105
NG_023330.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.245e-1 (AD)  1.104e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12953717chr18:48927559 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1090.742
COLGALT10.737
IFNGR20.729
PPT20.716
MYH90.714
GOLPH30.702
CDC42SE10.701
GRN0.699
NUMB0.699
RBMS10.694

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.543
OR4F29-0.514
SOX3-0.281
NPFFR1-0.274
HPDL-0.222
ACOT6-0.219
HKDC1-0.214
ZFHX4-AS1-0.203
LRAT-0.185
PRSS35-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of SMAD7 mRNA25827057
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SMAD7 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SMAD7 mRNA"19114083
C1152842-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide results in increased expression of SMAD7 protein17028423
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SMAD7 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of SMAD7 mRNA22841810
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SMAD7 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SMAD7 mRNA"20852150
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SMAD7 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SMAD7 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SMAD7 gene28458013
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SMAD7 mRNA"23195993
C010845aluminum chloridealuminum chloride results in increased expression of SMAD7 mRNA27720690
C010845aluminum chlorideTGFB1 protein inhibits the reaction [aluminum chloride results in increased expression of SMAD7 mRNA]27720690
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMAD7 mRNA16483693
D001151ArsenicArsenic affects the methylation of SMAD7 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SMAD7 mRNA"23634900
D001280AtrazineAtrazine results in increased expression of SMAD7 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMAD7 mRNA26238291
D004958EstradiolEstradiol affects the expression of SMAD7 mRNA15598610
D001688Biological ProductsBiological Products results in increased expression of SMAD7 mRNA23624380
D001688Biological ProductsBiological Products results in increased expression of SMAD7 protein23624380
C006780bisphenol Abisphenol A results in increased expression of SMAD7 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of SMAD7 promoter27334623
C006780bisphenol Abisphenol A affects the expression of SMAD7 mRNA25181051
D001761BleomycinBleomycin results in increased expression of SMAD7 mRNA29033951
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of SMAD7 mRNA]29033951
D001761BleomycinBleomycin results in decreased expression of SMAD7 mRNA26093215
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SMAD7 mRNA15336504
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SMAD7 mRNA]16221973
D002220CarbamazepineCarbamazepine affects the expression of SMAD7 mRNA25979313
D002235CarbofuranCarbofuran results in decreased expression of SMAD7 mRNA28982980
D002235CarbofuranCarbofuran results in decreased expression of SMAD7 protein28982980
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SMAD7 mRNA25912033
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD7 mRNA25827057
D002251Carbon TetrachlorideSMAD7 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of CTGF protein]17657819
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SMAD7 mRNA24211420
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SMAD7 protein16872305|1716359
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMAD7 mRNA12445421
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased methylation of SMAD7 promoter24211420
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]"17163593
D002251Carbon TetrachloridePerindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]16872305
D002251Carbon Tetrachloridepirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA]12445421
D002251Carbon TetrachlorideValsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]16872305
C007020chlorophyllin"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 mRNA]"22485181
C007020chlorophyllin"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 protein]"22485181
D004390ChlorpyrifosChlorpyrifos results in increased expression of SMAD7 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD7 mRNA22915297
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD7 mRNA]22915297
D003300CopperCopper results in decreased expression of SMAD7 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of SMAD7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SMAD7 mRNA27989131
C014347decitabinedecitabine results in increased expression of SMAD7 mRNA19194470
C014347decitabinedecitabine inhibits the reaction [TGFB1 protein results in decreased expression of SMAD7 mRNA]24211420
C014347decitabinedecitabine inhibits the reaction [TGFB1 protein results in decreased expression of SMAD7 protein]24211420
C014347decitabinedecitabine inhibits the reaction [TGFB1 protein results in increased methylation of SMAD7 promoter]24211420
D003907DexamethasoneDexamethasone results in decreased expression of SMAD7 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SMAD7 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SMAD7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SMAD7 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SMAD7 mRNA27594783
D002945CisplatinCisplatin results in decreased expression of SMAD7 mRNA22023808
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SMAD7 protein18971187
D002117CalcitriolCalcitriol results in increased expression of SMAD7 mRNA16002434|2358912
D002117CalcitriolFST protein inhibits the reaction [Calcitriol results in decreased expression of SMAD7 mRNA]23589129
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SMAD7 mRNA27638505
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of SMAD7 mRNA16507463
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 protein"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 mRNA]"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 protein]"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 mRNA]"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 protein]"22485181
D004237DiuronDiuron results in increased expression of SMAD7 mRNA25152437
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of SMAD7 protein23590892
D004317DoxorubicinDoxorubicin results in increased expression of SMAD7 protein18606404
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SMAD7 mRNA"23811387
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]"17163593
D004610Ellagic Acid"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 mRNA]"22485181
D004610Ellagic Acid"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of SMAD7 protein]"22485181
D004656EnalaprilEnalapril results in increased expression of SMAD7 mRNA19197123
D004656EnalaprilEnalapril results in increased expression of SMAD7 protein19197123|1934968
C118739entinostatentinostat results in increased expression of SMAD7 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SMAD7 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SMAD7 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of SMAD7 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SMAD7 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of SMAD7 mRNA23649840
D005688GalactosamineGalactosamine results in decreased expression of SMAD7 protein27876602
D005688GalactosamineGenistein inhibits the reaction [Galactosamine results in decreased expression of SMAD7 protein]27876602
C037032galangingalangin results in decreased expression of SMAD7 mRNA25268046
D019833GenisteinGenistein inhibits the reaction [Galactosamine results in decreased expression of SMAD7 protein]27876602
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of SMAD7 mRNA16206274
C010176halofuginonehalofuginone results in increased expression of SMAD7 mRNA17180598
D007213IndomethacinIndomethacin results in increased expression of SMAD7 mRNA16984733
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMAD7 mRNA25613284
D058085Iron CompoundsIron Compounds results in decreased expression of SMAD7 mRNA28483490
C018086isobutyl nitriteisobutyl nitrite results in increased expression of SMAD7 mRNA16288974
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SMAD7 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SMAD7 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD7 mRNA26378955
C025340manganese chloridemanganese chloride results in increased methylation of SMAD7 gene27913844
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD7 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD7 mRNA22915297
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD7 mRNA]22915297
D008727MethotrexateMethotrexate affects the expression of SMAD7 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SMAD7 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of SMAD7 mRNA25270620
C008493methylselenic acidmethylselenic acid results in increased expression of SMAD7 mRNA18548127
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of SMAD7 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of SMAD7 mRNA21195148
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SMAD7 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMAD7 mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of SMAD7 protein17337753
D009285NaphthoquinonesNaphthoquinones results in increased expression of SMAD7 mRNA23811387
D009532NickelNickel results in increased expression of SMAD7 mRNA23195993
C007350nitrofennitrofen results in decreased expression of SMAD7 mRNA12149686
D015282OctreotideOctreotide results in decreased expression of SMAD7 mRNA23137853
D010100OxygenOxygen deficiency results in increased expression of SMAD7 mRNA26516004
C037573oxymatrineoxymatrine results in increased expression of SMAD7 mRNA18395914
C016030pantogabpantogab results in decreased expression of SMAD7 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of SMAD7 mRNA23638009
C517782pasireotidepasireotide results in decreased expression of SMAD7 mRNA23137853
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SMAD7 mRNA19162173
D020913PerindoprilPerindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]16872305
D020913PerindoprilPerindopril results in increased expression of SMAD7 protein15619341
D010852PicrotoxinPicrotoxin results in decreased expression of SMAD7 mRNA15170462
C093844pirfenidonepirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA]12445421
C006253pirinixic acidpirinixic acid results in decreased expression of SMAD7 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SMAD7 mRNA]20059764
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMAD7 mRNA22714537
C045362prochlorazprochloraz results in increased expression of SMAD7 mRNA21470553
D011374ProgesteroneProgesterone results in increased expression of SMAD7 mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of SMAD7 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of SMAD7 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SMAD7 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD7 mRNA]22915297
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SMAD7 mRNA14699072
C031389resorcinolresorcinol results in decreased expression of SMAD7 mRNA22623647
C059514resveratrolresveratrol results in increased expression of SMAD7 mRNA18089832|2572186
C059514resveratrolresveratrol results in increased expression of SMAD7 protein20637737|2572186
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of SMAD7 mRNA"16251409
D012834SilverSilver results in increased expression of SMAD7 mRNA26014281|2895954
D012834SilverSilver results in decreased expression of SMAD7 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of SMAD7 mRNA16507463
C471405sorafenibsorafenib results in decreased expression of SMAD7 mRNA21360571
D013311StreptozocinStreptozocin affects the expression of SMAD7 mRNA17437042
D013311StreptozocinStreptozocin affects the expression of SMAD7 protein17437042
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD7 mRNA26378955
D016559TacrolimusTacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]16720724
D016559TacrolimusTacrolimus inhibits the reaction [SMAD7 protein binds to SMURF1 protein]16720724
D013629TamoxifenTamoxifen affects the expression of SMAD7 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of SMAD7 mRNA17555576
D013739TestosteroneTestosterone results in increased expression of SMAD7 mRNA22138414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMAD7 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD7 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMAD7 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD7 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMAD7 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of SMAD7 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of SMAD7 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SMAD7 mRNA28065790
C024746tobacco tartobacco tar results in decreased expression of SMAD7 mRNA19559774
D014212TretinoinTretinoin results in increased expression of SMAD724374174
D014212TretinoinTretinoin results in increased expression of SMAD7 mRNA21934132
D014212TretinoinTretinoin results in increased expression of SMAD7 protein16410076
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SMAD7 mRNA24935251|2627250
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SMAD7 mRNA19493473
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SMAD7 protein19493473
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SMAD7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SMAD7 mRNA24383497|2493525
D000068756ValsartanValsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]16872305
D000068756ValsartanValsartan results in increased expression of SMAD7 protein15619341
C111237vorinostatvorinostat results in decreased expression of SMAD7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0005515protein binding-IPI14993265  15231748  16601693  16720724  18593713  18762808  
20937913  21258410  22344298  22921829  25283809  
GO:0005518collagen binding-IEA-  
GO:0008013beta-catenin binding-IPI18593713  
GO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity-IDA9256479  
GO:0031625ubiquitin protein ligase binding-IPI12151385  
GO:0034713type I transforming growth factor beta receptor binding-IPI11278251  
GO:0044212transcription regulatory region DNA binding-IDA17438144  
GO:0046872metal ion binding-IEA-  
GO:0048185activin binding-IPI16720724  
GO:0070411I-SMAD binding-IPI9256479  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA17438144  
GO:0001657ureteric bud development-IEA-  
GO:0002725negative regulation of T cell cytokine production-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0010717regulation of epithelial to mesenchymal transition-IMP24887517  
GO:0010719negative regulation of epithelial to mesenchymal transition-IC18762808  
GO:0010719negative regulation of epithelial to mesenchymal transition-TAS19018011  
GO:0010801negative regulation of peptidyl-threonine phosphorylation-IDA18593713  
GO:0010944negative regulation of transcription by competitive promoter binding-IDA17438144  
GO:0016579protein deubiquitination-TAS-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IC18952608  
GO:0022409positive regulation of cell-cell adhesion-IDA18593713  
GO:0030336negative regulation of cell migration-TAS19018011  
GO:0030509BMP signaling pathway-TAS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IDA12151385  17438144  18762808  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0030514negative regulation of BMP signaling pathway-IDA17438144  
GO:0031397negative regulation of protein ubiquitination-IDA18593713  
GO:0031398positive regulation of protein ubiquitination-IDA16720724  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA11278251  
GO:0032925regulation of activin receptor signaling pathway-IDA16720724  
GO:0033137negative regulation of peptidyl-serine phosphorylation-IDA18593713  
GO:0034333adherens junction assembly-IMP18593713  
GO:0034616response to laminar fluid shear stress-IEP9256479  
GO:0034629cellular protein-containing complex localization-IDA18593713  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA17438144  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048844artery morphogenesis-ISS-  
GO:0050821protein stabilization-IDA18593713  
GO:0051444negative regulation of ubiquitin-protein transferase activity-IDA18593713  
GO:0055010ventricular cardiac muscle tissue morphogenesis-ISS-  
GO:0055117regulation of cardiac muscle contraction-ISS-  
GO:0060373regulation of ventricular cardiac muscle cell membrane depolarization-IC18952608  
GO:0060389pathway-restricted SMAD protein phosphorylation-ISS-  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IDA17438144  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-TAS19018011  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0071560cellular response to transforming growth factor beta stimulus-IMP18593713  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2000317negative regulation of T-helper 17 type immune response-ISS-  
GO:2000320negative regulation of T-helper 17 cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA11278251  12151385  17438144  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-IDA11278251  17438144  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA12151385  
GO:0005913cell-cell adherens junctioncolocalizes_withIDA18593713  
GO:0016342catenin complexcolocalizes_withIDA18593713  
GO:0032991protein-containing complex-IDA23610558  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173788Downregulation of TGF-beta receptor signalingIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsIEA
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerIEA
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionIEA
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesIEA
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006936Signaling by TGF-beta family membersIEA
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23275154Genetic variations in the TGFbeta signaling pathway, smoking and risk of colorectal cancer in a Chinese population. (2013 Apr)Zhong RCarcinogenesis
29089751Characteristics and potential role of M2 macrophages in COPD. (2017)He SInt J Chron Obstruct Pulmon Dis
19659652Simvastatin attenuates experimental small airway remodelling in rats. (2009 Jul)Ou XMRespirology
23560096Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. (2013)Jiang XPLoS One
19087346Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD. (2008 Dec 16)Zandvoort ARespir Res
22367214Characterization of gene-environment interactions for colorectal cancer susceptibility loci. (2012 Apr 15)Hutter CMCancer Res