Gene: SMAD9

4093
MADH6|MADH9|PPH2|SMAD8|SMAD8/9|SMAD8A|SMAD8B
SMAD family member 9
protein-coding
13q13.3
Ensembl:ENSG00000120693 MIM:603295 Vega:OTTHUMG00000016740 UniprotKB:O15198
NG_016963.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.094e-1 (AD)  1.365e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs576434chr13:36884002 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMAN10.761
POLK0.76
ELF20.756
ZBTB10.756
KIAA03550.755
TJP20.751
CEP440.75
PHF30.739
SGMS10.736
CTPS20.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.395
OR4F5-0.382
VGF-0.262
KCNG2-0.257
PTGDR2-0.243
CYP1A1-0.242
GGN-0.241
EGR4-0.239
LCN1-0.235
HES5-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SMAD9 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SMAD9 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
C0229095-methoxypsoralen5-methoxypsoralen results in increased phosphorylation of SMAD9 protein17980360
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD9 protein]"23936038
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SMAD9 mRNA26690555
D000082AcetaminophenAcetaminophen results in decreased phosphorylation of [SMAD1 protein binds to SMAD5 protein binds to SMAD9 protein]22610607
D020106AcrylamideAcrylamide results in decreased expression of SMAD9 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SMAD9 mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SMAD9 mRNA21298039
D0150812-Naphthylamine2-Naphthylamine results in increased expression of SMAD9 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMAD9 mRNA16483693
C000228aristolochic acid Iaristolochic acid I results in decreased expression of SMAD9 protein modified form22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD9 protein modified form]22525892
D001151ArsenicArsenic affects the expression of SMAD9 protein24675094
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased phosphorylation of SMAD9 protein"17975199
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMAD9 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMAD9 mRNA18247414
C006780bisphenol Abisphenol A affects the methylation of SMAD9 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SMAD9 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SMAD9 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased methylation of SMAD9 gene27509014
D016572CyclosporineCyclosporine results in decreased expression of SMAD9 mRNA25562108
C014347decitabinedecitabine results in decreased expression of SMAD9 mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SMAD9 mRNA]27941970
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SMAD9 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SMAD9 mRNA19467301
C118739entinostatentinostat results in decreased expression of SMAD9 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
C039281furanfuran results in decreased expression of SMAD9 mRNA24183702
C412815GW 4064GW 4064 results in decreased expression of SMAD9 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SMAD9 mRNA26846883
C031534imperatorinimperatorin results in increased phosphorylation of SMAD9 protein17980360
C554430LDN 193189LDN 193189 inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD9 protein]23936038
C008261lead acetatelead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD9 protein]17805416
C045463leflunomideleflunomide results in increased expression of SMAD9 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD9 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMAD9 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SMAD9 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMAD9 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SMAD9 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SMAD9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SMAD9 mRNA"25554681
D009538NicotineNicotine results in increased expression of SMAD9 mRNA18247414
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SMAD9 mRNA27935865
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMAD9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SMAD9 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SMAD9 mRNA27935865
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMAD9 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of SMAD9 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SMAD9 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of SMAD9 mRNA21540246
C059514resveratrolresveratrol results in increased phosphorylation of SMAD9 protein21745208
C009172rhodiolosiderhodioloside results in increased expression of SMAD9 mRNA24929042
C009172rhodiolosiderhodioloside results in increased phosphorylation of and results in increased expression of SMAD9 protein24929042
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of SMAD9 mRNA21127053
D019821SimvastatinSimvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]18310456
C439060sirtinolsirtinol results in decreased phosphorylation of SMAD9 protein21745208
C017947sodium arsenitesodium arsenite affects the methylation of SMAD9 gene28589171
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SMAD9 mRNA26378955
D013629TamoxifenTamoxifen results in increased expression of SMAD9 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMAD9 mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of SMAD9 mRNA28973375
D014212TretinoinTretinoin results in decreased expression of SMAD9 mRNA20530235
D014212TretinoinTretinoin results in increased expression of SMAD9 mRNA21934132|2372400
D014212TretinoinTretinoin results in increased expression of SMAD9 mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of SMAD9 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of SMAD9 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of SMAD9 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD9 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SMAD9 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of SMAD9 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SMAD9 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SMAD9 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI23455924  25755279  
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity-TAS19018011  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0030509BMP signaling pathway-ISS-  
GO:0030509BMP signaling pathway-TAS19018011  
GO:0030901midbrain development-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0051216cartilage development-IEA-  
GO:0060348bone development-IEA-  
GO:0060395SMAD protein signal transduction-ISS-  
GO:0060395SMAD protein signal transduction-NAS14687659  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0071773cellular response to BMP stimulus-NAS14687659  
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-TAS14687659  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS9256479  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-TAS19018011  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0071141SMAD protein complex-NAS14687659  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal