Gene info: ID 4094

Gene: MAF

GENE ID: 4094

Synonyms: AYGRP|CCA4|CTRCT21|c-MAF

Description: MAF bZIP transcription factor

Gene type: protein-coding

Location: 16q23.2

dbXrefs: Ensembl:ENSG00000178573 MIM:177075 Vega:OTTHUMG00000137621 UniprotKB:O75444

RefSeq: NG_016440.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 33

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.985e-1 (AD) 4.332e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
P2RY12	0.734
FOXN3	0.697
CYFIP1	0.686
MAFB	0.67
FOLR2	0.669
CREBL2	0.664
PLD4	0.662
P2RY13	0.657
SELPLG	0.654
ENTPD1	0.652

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.45
OR4F29	-0.386
TNFRSF13B	-0.317
SOX3	-0.292
TH	-0.26
FAM178B	-0.255
TMEM139	-0.253
BTBD16	-0.249
ZFP57	-0.247
KIF19	-0.247

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MAF mRNA	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MAF mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MAF mRNA"	27291303
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of MAF mRNA	19426978
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone promotes the reaction [[[NFE2L2 protein binds to MAF protein] which binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]	15832810
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MAF mRNA"	23196670
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of MAF mRNA"	24172598
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAF mRNA"	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of MAF mRNA	20829426
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAF mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of MAF mRNA	29067470
C109238	acyline	acyline results in decreased expression of MAF mRNA	17510436
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]	20146260
D012436	S-Adenosylmethionine	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]	20146260
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAF gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MAF mRNA	21641981
C430898	AGN 194204	AGN 194204 results in increased expression of MAF mRNA	11970994
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of MAF mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAF mRNA	16483693
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of MAF mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of MAF mRNA	23912714
D001151	Arsenic	Arsenic results in increased expression of MAF mRNA	27838757
D001280	Atrazine	Atrazine results in decreased expression of MAF mRNA	25929836
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAF mRNA	21295105
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAF mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAF mRNA	19770486
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of MAF mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of MAF mRNA	19484750
D004958	Estradiol	Estradiol results in decreased expression of MAF mRNA	20068009
C095105	bexarotene	bexarotene results in increased expression of MAF mRNA	17178900
D001663	Bilirubin	Bilirubin results in decreased expression of MAF mRNA	20196124
C006780	bisphenol A	bisphenol A results in decreased expression of MAF mRNA	25181051
C001371	boldenone undecylenate	[boldenone undecylenate co-treated with estradiol 3-benzoate] results in increased expression of MAF mRNA	16023321
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole promotes the reaction [[[NFE2L2 protein binds to MAF protein] which binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]	15832810
C018475	butyraldehyde	butyraldehyde results in increased expression of MAF mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of MAF mRNA	21694771
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAF mRNA	20061341
C054133	casticin	casticin results in decreased expression of MAF mRNA	28444820
D002509	Cephaloridine	Cephaloridine results in decreased expression of MAF mRNA	18500788
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of MAF mRNA	26272509
D002737	Chloroprene	Chloroprene results in decreased expression of MAF mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MAF mRNA	28472532
D002994	Clofibrate	Clofibrate affects the expression of MAF mRNA	16081524
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MAF mRNA	17602206
D005576	Colforsin	Colforsin results in decreased expression of MAF mRNA	16751804
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAF mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAF mRNA	19770486
D003622	Dapsone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA]	21440447
C014347	decitabine	decitabine affects the expression of MAF mRNA	17194187
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of MAF mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MAF mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MAF mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form] results in decreased expression of MAF mRNA	23625948
D004041	Dietary Fats	Dietary Fats results in increased expression of MAF mRNA	25016146
D004051	Diethylhexyl Phthalate	[OVAL protein co-treated with Diethylhexyl Phthalate] affects the expression of MAF mRNA	25093321
D004051	Diethylhexyl Phthalate	[OVAL protein co-treated with Diethylhexyl Phthalate] affects the expression of MAF protein	25093321
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAF mRNA	21295105
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MAF mRNA	17602206
D004237	Diuron	Diuron metabolite results in increased expression of MAF mRNA	24172598
D004237	Diuron	Diuron results in decreased expression of MAF mRNA	25152437
C118739	entinostat	entinostat results in decreased expression of MAF mRNA	26272509
C045651	epigallocatechin gallate	epigallocatechin gallate promotes the reaction [[[NFE2L2 protein binds to MAF protein] which binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]	15832810
C074283	estradiol 3-benzoate	[boldenone undecylenate co-treated with estradiol 3-benzoate] results in increased expression of MAF mRNA	16023321
C074283	estradiol 3-benzoate	[Testosterone co-treated with estradiol 3-benzoate] results in increased expression of MAF mRNA	16023321
D005419	Flavonoids	Flavonoids results in increased expression of MAF mRNA	18035473
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MAF mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of MAF mRNA	16557594
D004397	Fonofos	Fonofos results in increased methylation of MAF promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of MAF mRNA	18849615\|2766457
C056507	gemcitabine	gemcitabine results in increased expression of MAF mRNA	17039268
D019833	Genistein	Genistein results in decreased expression of MAF mRNA	15378649
D017313	Fenretinide	Fenretinide results in decreased expression of MAF mRNA	28973697
C051890	irinotecan	irinotecan affects the expression of MAF mRNA	20097248
D007529	Isoflavones	Isoflavones results in decreased expression of MAF mRNA	17374662
C544151	jinfukang	jinfukang results in increased expression of MAF mRNA	27392435
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of and results in increased activity of MAF protein	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]	20146260
D008095	Lithocholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]	20146260
D008345	Manganese	Manganese results in increased expression of MAF mRNA	23997110
D008713	Methimazole	Methimazole results in increased expression of MAF mRNA	22504374
D008731	Methoxychlor	Methoxychlor affects the expression of MAF mRNA	20829426
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MAF mRNA"	26251327
C008493	methylselenic acid	methylselenic acid results in increased expression of MAF mRNA	18548127
D015741	Metribolone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA]	21440447
D015741	Metribolone	Metribolone results in increased expression of MAF mRNA	16751804\|1701067
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of MAF mRNA	19812364
C029938	nickel sulfate	nickel sulfate results in decreased expression of MAF mRNA	16780908
C464660	obeticholic acid	obeticholic acid results in increased expression of MAF mRNA	27939613
D010076	Oxazepam	Oxazepam results in increased expression of MAF mRNA	12727805
D010278	Parathion	Parathion results in increased methylation of MAF promoter	22847954
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased expression of MAF mRNA	28973697
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MAF mRNA	19162173
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate promotes the reaction [[[NFE2L2 protein binds to MAF protein] which binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]	15832810
D010634	Phenobarbital	Phenobarbital results in decreased expression of MAF mRNA	23091169
D010695	Phlorhizin	Phlorhizin results in decreased expression of MAF mRNA	22538082
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAF mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of MAF mRNA	12727805
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of MAF mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of MAF mRNA	17404688
C045950	propiconazole	propiconazole results in decreased expression of MAF mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MAF mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MAF mRNA	22504374
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of MAF mRNA	19429434
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased expression of MAF mRNA	25800948
C059514	resveratrol	resveratrol results in decreased expression of MAF mRNA	18586690
C009271	sinomenine	sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF mRNA]	24066068
C009271	sinomenine	sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF protein]	24066068
C016104	sodium bichromate	sodium bichromate results in decreased expression of MAF mRNA	22155349
D012999	Soman	Soman results in increased expression of MAF mRNA	19281266
D053260	Soot	Soot results in increased expression of MAF mRNA	26551751
C016766	sulforafan	sulforafan promotes the reaction [[[NFE2L2 protein binds to MAF protein] which binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]	15832810
D013629	Tamoxifen	Tamoxifen affects the expression of MAF mRNA	14699072
C012568	terbufos	terbufos results in increased methylation of MAF promoter	22847954
D013739	Testosterone	[Testosterone co-treated with estradiol 3-benzoate] results in increased expression of MAF mRNA	16023321
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of MAF mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAF mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAF mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MAF gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAF mRNA	19465110\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAF mRNA	24058054\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAF mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAF mRNA	21215274
C402769	tipifarnib	tipifarnib results in increased expression of MAF mRNA	16403772
C009495	titanium dioxide	titanium dioxide results in increased expression of MAF mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MAF mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MAF mRNA	27865774
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MAF mRNA	20133372
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MAF mRNA"	19682533
D014192	Trapidil	Trapidil affects the reaction [PTH protein affects the expression of MAF mRNA]	18635661
D014212	Tretinoin	Tretinoin results in decreased expression of MAF mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of MAF mRNA	17118196
C012589	trichostatin A	trichostatin A results in increased expression of MAF mRNA	24935251
D014302	Trinitrobenzenesulfonic Acid	sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF mRNA]	24066068
D014302	Trinitrobenzenesulfonic Acid	sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF protein]	24066068
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of MAF mRNA	24066068
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of MAF protein	24066068
D014527	Uric Acid	MAF gene SNP affects the abundance of Uric Acid	23263486
D014580	Ursodeoxycholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]	20146260
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAF mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MAF mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MAF mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid results in increased expression of MAF mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of MAF mRNA	18849615
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MAF gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of MAF mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of MAF mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	20102225
GO:0043565	sequence-specific DNA binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001816	cytokine production	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	TAS	9616139
GO:0032330	regulation of chondrocyte differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048468	cell development	-	IEA	-
GO:0048839	inner ear development	-	IEA	-
GO:0070306	lens fiber cell differentiation	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000785	chromatin	-	TAS	9616139
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26762739	Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)	Liu Y	J Thorac Oncol
23019235	Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)	Zuo L	Alcohol Alcohol
14735840	[Impact of smoking in Italy in 1998: deaths and years of potential life lost]. (2003 Sep-Oct)	Gorini G	Epidemiol Prev
25569187	The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. (2015 Jan 8)	LaRusch J	Clin Transl Gastroenterol
21609526	[Genetic variations of bone morphogenetic protein 7 gene are associated with hypertriglyceridemia of Uygur Chinese in Xinjiang]. (2011 Mar)	Yan ZT	Zhonghua Xin Xue Guan Bing Za Zhi
22475777	Association between PPAR-gamma and RXR-alpha gene polymorphism and metabolic syndrome risk: a case-control study of a Chinese Han population. (2012 Apr)	Shi H	Arch Med Res
20592456	Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population. (2010)	Choi IG	Dis Markers
22488871	ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. (2012 Jun)	Hill SY	Am J Med Genet B Neuropsychiatr Genet
25225034	Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. (2014 Nov)	Blanke KL	Cancer Causes Control
23458267	Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study. (2013 Aug)	Choquet H	Alcohol Clin Exp Res
27473937	Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. (2016 Dec)	Zuo L	Am J Med Genet B Neuropsychiatr Genet
24829844	Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families. (2013 Dec)	Hill SY	Open J Genet
29182452	Exome Array Analysis of Nuclear Lens Opacity. (2018 Jun)	Loomis SJ	Ophthalmic Epidemiol
17079784	Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure. (2007 Apr)	Machiya J	Am J Respir Cell Mol Biol
24185078	Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese. (2014 Jan 25)	Li L	Gene
23512105	Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)	Beaty TH	Hum Genet
28413702	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American. (2017 Apr)	Zhang TX	Brain Behav
29523840	Collective effects of common SNPs and risk prediction in lung cancer. (2018 Mar 10)	Lei X	Heredity (Edinb)
22792237	Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population. (2012)	Curjuric I	PLoS One
19298322	Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. (2009 May)	Sherva R	Alcohol Clin Exp Res
23468174	Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)	Zuo L	Hum Genet
25010723	Are ALOX5AP gene SNPs a risk or protective factor for stroke? (2014 Sep 10)	Papapostolou A	Gene
26239294	Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. (2016 May)	Olfson E	Mol Psychiatry
23778322	Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (2013 Aug)	Zuo L	Pharmacogenet Genomics
25821040	ACN9 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. (2015 Apr)	Hill SY	Am J Med Genet B Neuropsychiatr Genet
24190612	Association of oxysterol binding protein-related protein 9 polymorphism with cerebral infarction in Hunan Han population. (2014 Sep)	Li L	Ir J Med Sci
19877503	[TRPV1 UTR-3 polymorphism and susceptibility of childhood asthma of the Han Nationality in Beijing]. (2009 Sep)	Wang Q	Wei Sheng Yan Jiu
27533483	Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population. (2017 Jan)	Postula M	Platelets
19899988	Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. (2009 Aug)	Pei XT	Curr Eye Res
16385453	Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. (2006 Jan)	Hinrichs AL	Am J Hum Genet
25683181	Common genetic variants associated with thyroid function may be risk alleles for Hashimoto's disease and Graves' disease. (2015 Feb 14)	Campbell P	Clin Endocrinol (Oxf)
19169232	Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. (2009 Dec)	Farwick A	Eye (Lond)
23462334	Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans. (2013 Sep 10)	Lv X	Gene