Gene info: ID 4097

Gene: MAFG

GENE ID: 4097

Synonyms: hMAF

Description: MAF bZIP transcription factor G

Gene type: protein-coding

Location: 17q25.3

dbXrefs: Ensembl:ENSG00000197063 MIM:602020 Vega:OTTHUMG00000177958 UniprotKB:O15525

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.778e-1 (AD) 9.407e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09489844	chr17:79880647	MAFG	Gene body	6.270e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HYOU1	0.91
USP22	0.909
ANKRD11	0.905
LASP1	0.899
TRAF3	0.898
DLGAP4	0.897
LARP1	0.896
RNF44	0.895
RAB35	0.894
GBA2	0.894

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.61
OR4F29	-0.576
IL18RAP	-0.445
FMO3	-0.421
CST7	-0.42
CCR2	-0.42
VNN2	-0.4
CD48	-0.4
TFPI2	-0.399
C1orf87	-0.394

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of MAFG mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of MAFG mRNA]"	27071940
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of MAFG mRNA	25596134
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MAFG mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MAFG mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MAFG mRNA"	19561079
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of MAFG mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of MAFG mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of MAFG mRNA"	19936915
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of MAFG mRNA"	26238291
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]	20146260
D012436	S-Adenosylmethionine	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]	20146260
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of MAFG mRNA	21757418
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of MAFG mRNA	21298039
D000638	Amiodarone	Amiodarone results in increased expression of MAFG mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAFG mRNA	16483693
C051597	Bandrowski's base	Bandrowski's base results in increased expression of MAFG mRNA	20566472
D019817	Benzoic Acid	Benzoic Acid results in increased expression of MAFG mRNA	20566472
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAFG mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAFG mRNA	21569818\|2171566
C006780	bisphenol A	bisphenol A results in increased expression of MAFG mRNA	29275510
C006780	bisphenol A	bisphenol A affects the methylation of MAFG promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of MAFG mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MAFG gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of MAFG mRNA	21601586
D000069286	Bortezomib	Bortezomib results in increased expression of MAFG mRNA	20977926
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of MAFG mRNA	12414654\|2750901
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased methylation of MAFG gene	27509014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAFG mRNA	11162468\|2559613
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAFG mRNA	19010381\|2129735
C037123	cadmium sulfate	cadmium sulfate results in increased expression of MAFG mRNA	12064557\|2178398
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of MAFG mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of MAFG mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of MAFG mRNA	23125180
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of MAFG mRNA	20566472
D004002	Clodronic Acid	Clodronic Acid results in increased expression of MAFG mRNA	25596134
D002994	Clofibrate	Clofibrate results in decreased expression of MAFG mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MAFG mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of MAFG mRNA	20971185
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of MAFG mRNA	25167922
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MAFG mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of MAFG mRNA	17211630
C030973	cupric oxide	cupric oxide results in increased expression of MAFG mRNA	22077320
D016572	Cyclosporine	Cyclosporine results in increased expression of MAFG mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAFG mRNA	25596134
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MAFG mRNA	21266533
C000944	dicrotophos	dicrotophos results in increased expression of MAFG mRNA	28302478
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of MAFG mRNA	20566472
D004221	Disulfiram	Disulfiram results in increased expression of MAFG mRNA	20566472
D004317	Doxorubicin	Doxorubicin results in decreased expression of MAFG mRNA	19277126
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MAFG mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MAFG mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAFG mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MAFG mRNA	29097150
D005054	Eugenol	Eugenol results in increased expression of MAFG mRNA	20566472
D011345	Fenofibrate	Fenofibrate results in increased expression of MAFG mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in decreased expression of MAFG mRNA	25596134
D005485	Flutamide	Flutamide results in increased expression of MAFG mRNA	24136188
C071834	glycidamide	glycidamide results in increased expression of MAFG mRNA	17822822
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of MAFG mRNA	20566472
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MAFG mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MAFG mRNA	12414654
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of MAFG mRNA	18156441
D007052	Ibuprofen	Ibuprofen results in decreased expression of MAFG mRNA	25596134
D007069	Ifosfamide	Ifosfamide results in increased expression of MAFG mRNA	25596134
C036643	isoeugenol	isoeugenol results in increased expression of MAFG mRNA	20566472
D019344	Lactic Acid	Lactic Acid results in increased expression of MAFG mRNA	20566472
D007854	Lead	Lead results in decreased expression of MAFG mRNA	19921347
C045463	leflunomide	leflunomide results in increased expression of MAFG mRNA	28988120
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of and results in increased activity of MAFG protein	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]	20146260
D008095	Lithocholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]	20146260
C042720	mercuric bromide	mercuric bromide results in increased expression of MAFG mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
D008687	Metformin	Metformin results in increased expression of MAFG mRNA	25596134
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MAFG mRNA	23179753\|2800136
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MAFG mRNA	20061341
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MAFG mRNA	23649840
C033069	methyl salicylate	methyl salicylate results in increased expression of MAFG mRNA	20566472
C026385	n-hexane	n-hexane results in increased expression of MAFG mRNA	20566472
C028007	nickel monoxide	nickel monoxide results in decreased expression of MAFG mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of MAFG mRNA	20566472
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of MAFG mRNA	20971185
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of MAFG mRNA	25167922
D010100	Oxygen	Oxygen deficiency results in increased expression of MAFG mRNA	25596134
D052638	Particulate Matter	Particulate Matter results in increased expression of MAFG mRNA	17450221
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of MAFG mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MAFG mRNA	23892564
D010634	Phenobarbital	Phenobarbital affects the expression of MAFG mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAFG mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MAFG mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of MAFG mRNA	22538082
C018637	phorone	phorone affects the expression of MAFG mRNA	18198479
D010938	Plant Oils	Plant Oils results in increased expression of MAFG mRNA	23370395
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MAFG mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of MAFG mRNA	22079256
D019840	2-Propanol	2-Propanol results in increased expression of MAFG mRNA	20566472
C045950	propiconazole	propiconazole results in decreased expression of MAFG mRNA	21278054
D011794	Quercetin	Quercetin results in increased expression of MAFG mRNA	21632981
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of MAFG mRNA	25800948
C089730	rosiglitazone	rosiglitazone results in decreased expression of MAFG mRNA	25596134
D012834	Silver	Silver results in increased expression of MAFG mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in increased activity of MAFG protein	12220541
C017947	sodium arsenite	sodium arsenite results in increased expression of MAFG mRNA	11162468\|2088654
C017947	sodium arsenite	sodium arsenite promotes the reaction [[NFE2L2 protein binds to MAFG protein] which binds to NQO1 promoter]	16785233
C017947	sodium arsenite	sodium arsenite results in decreased expression of MAFG mRNA	19822182
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of MAFG mRNA	20566472
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of MAFG mRNA	18175754
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAFG mRNA	26238291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAFG mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAFG mRNA	17942748
C009495	titanium dioxide	titanium dioxide results in increased expression of MAFG mRNA	23131501
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MAFG mRNA	22363418\|2740439
D014212	Tretinoin	Tretinoin results in increased expression of MAFG mRNA	23724009
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAFG mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of MAFG mRNA	25596134
D014520	Urethane	Urethane results in increased expression of MAFG mRNA	28818685
D014580	Ursodeoxycholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]	20146260
D014635	Valproic Acid	Valproic Acid affects the expression of MAFG mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MAFG mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of MAFG gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of MAFG mRNA	17292431
D024483	Vitamin K 3	Vitamin K 3 affects the expression of MAFG mRNA	20044591
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of MAFG mRNA	12414654
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of MAFG mRNA	18593933
C016837	zinc chloride	zinc chloride results in increased expression of MAFG mRNA	11162468

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	NAS	9286713
GO:0005515	protein binding	-	IPI	8932385 9421508 18692475 20102225 21988832 25416956 26496610
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001701	in utero embryonic development	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007596	blood coagulation	-	TAS	-
GO:0030534	adult behavior	-	IEA	-
GO:0030641	regulation of cellular pH	-	IEA	-
GO:0042127	regulation of cell proliferation	-	IEA	-
GO:0045604	regulation of epidermal cell differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-109582	Hemostasis	IEA
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	TAS
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19168627	MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. (2009 Feb 17)	Schembri F	Proc Natl Acad Sci U S A