Gene: MAG

4099
GMA|S-MAG|SIGLEC-4A|SIGLEC4A|SPG75
myelin associated glycoprotein
protein-coding
19q13.12
Ensembl:ENSG00000105695 MIM:159460 Vega:OTTHUMG00000183296 UniprotKB:P20916
NG_034078.1
PubMed
0   ANCO-SNPs
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.647e-1 (AD)  5.712e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11902728chr19:35786580MAG5.300e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOG0.967
TF0.966
MYRF0.954
GJB10.952
FA2H0.944
KLK60.944
ENPP20.939
CAPN30.934
CARNS10.931
CLDN110.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.356
PAX2-0.331
CUX2-0.329
CHRNA2-0.314
NEUROD1-0.313
GPR153-0.312
LTK-0.31
NPBWR1-0.304
OR4F29-0.304
NR2F2-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MAG mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MAG protein"21673325
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MAG mRNA"20206263
D000082AcetaminophenAcetaminophen affects the expression of MAG mRNA25064622
D000622Aminolevulinic AcidAminolevulinic Acid results in decreased expression of MAG protein18665889
D0157614-Aminopyridine4-Aminopyridine results in decreased expression of MAG mRNA24378259
D000638AmiodaroneAmiodarone affects the expression of MAG mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAG mRNA16483693
D001280AtrazineAtrazine results in increased expression of MAG mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAG mRNA22228805
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of MAG mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of MAG mRNA28641223
C006780bisphenol Abisphenol A affects the expression of MAG mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAG mRNA25084756|2518105
C006780bisphenol Abisphenol A results in decreased expression of MAG protein25084756
C006780bisphenol Abisphenol A results in increased methylation of MAG gene28505145
D019256Cadmium Chloride[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of MAG protein23680456
D002746ChlorpromazineChlorpromazine affects the expression of MAG mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MAG mRNA16675515
D003471CuprizoneCuprizone results in decreased expression of MAG mRNA26577399|2752363
D016572CyclosporineCyclosporine affects the expression of MAG mRNA25064622
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAG mRNA]27941970
D004041Dietary FatsDietary Fats results in increased expression of MAG mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MAG mRNA20387270
D004147DioxinsDioxins affects the expression of MAG mRNA20463971
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of MAG mRNA28542405
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of MAG mRNA12655031
D000431EthanolEthanol results in decreased expression of MAG mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MAG mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAG mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of MAG mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of MAG mRNA12679049
D006220HaloperidolHaloperidol results in decreased expression of MAG mRNA17177202
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAG mRNA25613284
C008261lead acetatelead acetate results in increased expression of MAG mRNA11578147
C008261lead acetate[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of MAG protein23680456
C045463leflunomideleflunomide results in increased expression of MAG mRNA28988120
C052901lemongrass oillemongrass oil results in increased expression of MAG mRNA25458622
D008731MethoxychlorMethoxychlor results in increased methylation of MAG gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAG mRNA23103053
C028007nickel monoxidenickel monoxide results in decreased expression of MAG mRNA19167457
D019787Linoleic AcidLinoleic Acid affects the expression of MAG mRNA28542405
D010100OxygenOxygen deficiency results in increased expression of MAG mRNA24205000
D019308Palmitic AcidPalmitic Acid affects the expression of MAG mRNA28542405
D000073878Palm OilPalm Oil results in increased expression of MAG mRNA18042831
D010269ParaquatParaquat affects the expression of MAG mRNA25064622
D010634PhenobarbitalPhenobarbital affects the expression of MAG mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of MAG mRNA19136022
D011280PregnanolonePregnanolone results in increased expression of MAG mRNA16787508
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAG mRNA24780913
C030984pyrenepyrene results in increased expression of MAG mRNA23656968
C059514resveratrolresveratrol results in decreased expression of MAG mRNA23419489
D012834SilverSilver results in increased expression of MAG mRNA27131904
D018030Silver CompoundsSilver Compounds results in decreased expression of MAG protein27427492
D018030Silver CompoundsSilver Compounds results in increased expression of MAG mRNA27427492
C017947sodium arsenite[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of MAG protein23680456
D013629TamoxifenTamoxifen results in decreased expression of MAG mRNA19457130
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAG mRNA17942748
D013752TetracyclineTetracycline affects the expression of MAG mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAG mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of MAG mRNA25064622
D014118Toxins, Biological"Toxins, Biological affects the expression of MAG mRNA"19682533
D014212TretinoinTretinoin results in increased expression of MAG mRNA23830798
D014241TrichloroethyleneTrichloroethylene affects the expression of MAG mRNA21135412
D014520UrethaneUrethane results in decreased expression of MAG mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MAG mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of MAG gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0030246carbohydrate binding-IEA-  
GO:0033691sialic acid binding-ISS-  
GO:0042803protein homodimerization activity-IEA-  
GO:1905576ganglioside GT1b binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0022010central nervous system myelination-IEA-  
GO:0030517negative regulation of axon extension-ISS-  
GO:0031643positive regulation of myelination-IEA-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0048711positive regulation of astrocyte differentiation-IEA-  
GO:0050771negative regulation of axonogenesis-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0098742cell-cell adhesion via plasma-membrane adhesion molecules-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA26179919  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0033270paranode region of axon-IEA-  
GO:0035749myelin sheath adaxonal region-IEA-  
GO:0043209myelin sheath-IDA6200494  
GO:0043218compact myelin-IDA6200494  
GO:0043220Schmidt-Lanterman incisure-IEA-  
GO:0045121membrane raft-IEA-  
GO:0097453mesaxon-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-193634Axonal growth inhibition (RHOA activation)TAS
R-HSA-193697p75NTR regulates axonogenesisTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210991Basigin interactionsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28360887Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle. (2017)Goncalves Mota MPFront Endocrinol (Lausanne)
25447590Clinical audit of patients hospitalized due to COPD exacerbation. MAG-1 Study. (2015 Oct)Escarrabill JArch Bronconeumol
18357522Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (2009 Jan)Kristiansen LVNeurochem Res
17291372Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? (2007 Aug)Sokolov BPInt J Neuropsychopharmacol