Gene: MAK

4117
RP62
male germ cell associated kinase
protein-coding
6p24.2
Ensembl:ENSG00000111837 MIM:154235 Vega:OTTHUMG00000014247 UniprotKB:P20794
NG_030040.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.075e-1 (AD)  1.554e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL2L140.788
IFNB10.767
C15orf480.67
HTRA40.668
HIST1H2BH0.659
OR9Q20.656
LAMP30.654
CYP19A10.652
HIST1H4D0.652
TAS2R300.651

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC1-0.291
FBXL22-0.287
CPLX3-0.281
KCNIP3-0.276
KCNN1-0.269
PARD6A-0.268
MYADML2-0.268
TTC9B-0.259
HBQ1-0.256
PAH-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MAK mRNA22230336
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [MAK protein binds to and results in increased activity of AR protein]16951154
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [[MAK protein binds to AR protein] which binds to KLK3 promoter]16951154
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of MAK protein16951154
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MAK mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of MAK mRNA21461292
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAK mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MAK promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAK mRNA22228805
C006780bisphenol Abisphenol A affects the expression of MAK mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MAK mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of MAK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAK gene28505145
D003471CuprizoneCuprizone results in increased expression of MAK mRNA26577399
D003622DapsoneDapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA]21440447
D003703DemecolcineDemecolcine results in increased expression of MAK mRNA23649840
D002945CisplatinCisplatin results in increased expression of MAK mRNA27392435
C118739entinostatentinostat results in decreased expression of MAK mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAK mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MAK mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of MAK mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of MAK mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of MAK mRNA22634610
D017313FenretinideFenretinide results in increased expression of MAK mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MAK mRNA26752646
C008261lead acetatelead acetate results in decreased expression of MAK mRNA22641619
D008727MethotrexateMethotrexate results in decreased expression of MAK mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAK mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MAK mRNA23649840
D015741MetriboloneDapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA]21440447
D015741MetriboloneMetribolone results in increased expression of MAK mRNA21440447
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of MAK mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of MAK mRNA21195148
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of MAK mRNA26272509
D010269ParaquatParaquat affects the expression of MAK mRNA16328009
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MAK mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of MAK mRNA24780913
C009277sodium arsenatesodium arsenate results in decreased expression of MAK mRNA23922661
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of MAK mRNA20189893
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAK mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MAK mRNA18087596
C012589trichostatin Atrichostatin A results in increased expression of MAK mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of MAK mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of MAK mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of MAK mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MAK mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAK mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MAK mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of MAK mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAK gene25560391
C111237vorinostatvorinostat results in increased expression of MAK mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA16951154  
GO:0004672protein kinase activity-NAS2183027  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI16951154  21986944  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IDA21986944  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-NAS2183027  
GO:0010468regulation of gene expression-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042073intraciliary transport-IBA21873635  
GO:0045494photoreceptor cell maintenance-ISS-  
GO:0046777protein autophosphorylation-IMP21986944  
GO:0060271cilium assembly-IBA21873635  
GO:1902856negative regulation of non-motile cilium assembly-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-ISS-  
GO:0001917photoreceptor inner segment-IDA21825139  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12084720  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IDA21986944  
GO:0005929cilium-IBA21873635  
GO:0005930axoneme-IEA-  
GO:0030496midbody-IDA21986944  
GO:0031514motile cilium-IEA-  
GO:0032391photoreceptor connecting cilium-IEA-  
GO:0072686mitotic spindle-IDA21986944  
GO:0097542ciliary tip-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7506117Collision of transitional cell carcinoma and renal cell carcinoma. An immunohistochemical study and review of the literature. (1994 Jan 1)Hart APCancer
10541915The exposure of healthy volunteers to 200 ppm 1,1,1-trichloroethane increases the concentration of proinflammatory cytokines in nasal secretions. (1999 Oct)Muttray AInt Arch Occup Environ Health
11954988Effects of an external exposure to 200 ppm methyl ethyl ketone on nasal mucosa in healthy volunteers. (2002 Mar)Muttray AInt Arch Occup Environ Health