Gene: STS

412
ARSC|ARSC1|ASC|ES|SSDD|XLI
steroid sulfatase
protein-coding
Xp22.31
Ensembl:ENSG00000101846 MIM:300747 Vega:OTTHUMG00000021102 UniprotKB:P08842
NG_021472.2
PubMed
CD|ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTNAP20.957
STXBP5L0.954
DLGAP10.948
PLCB10.948
FGF120.948
CREG20.947
OLFM30.947
GABRA10.946
FRMPD40.945
TRIM370.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.563
RAB13-0.559
CSAG1-0.556
HEY2-0.555
MYL3-0.541
YES1-0.536
RAI14-0.534
REST-0.532
AGTRAP-0.528
TGFB3-0.523

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02292IrosustatSmall Molecule288628-05-7InvestigationalTarget
DB027352-Amino-3-Oxo-4-Sulfo-Butyric AcidSmall MoleculeExperimentalTarget
DB06713NorelgestrominSmall Molecule53016-31-2Approved|InvestigationalEnzyme
DB09070TiboloneSmall Molecule5630-53-5Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of STS mRNA"19162173
C44552617-benzyl-5-androstane-3,17-diol"17-benzyl-5-androstane-3,17-diol results in decreased activity of STS protein"11600235
C4779311L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STS mRNA"21346803
C5003442-methoxyestradiol-3,17-bis-O,O-sulfamate"2-methoxyestradiol-3,17-bis-O,O-sulfamate analog results in decreased activity of STS protein"15862969
C5003442-methoxyestradiol-3,17-bis-O,O-sulfamate"2-methoxyestradiol-3,17-bis-O,O-sulfamate results in decreased activity of STS protein"12711022|1462354
C5264382-methoxyestradiol-3,17-O,O-bis(sulfamate)"2-methoxyestradiol-3,17-O,O-bis(sulfamate) results in decreased activity of STS protein"18450955
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
C0322784,17 beta-dihydroxy-4-androstene-3-one"4,17 beta-dihydroxy-4-androstene-3-one metabolite results in decreased activity of STS protein"11600235
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein"16178010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]"16178010
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]"16178010
C1216164-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]"16178010
C1216164-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [AGN 195183 results in increased activity of STS protein]"16178010
C1216164-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C0212284-nitrocatechol sulfate4-nitrocatechol sulfate results in decreased activity of STS protein6874424
C0233794-nitrophenyl sulfate4-nitrophenyl sulfate results in decreased activity of STS protein6874424
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
C0090335-pregnene-3,20-diol"5-pregnene-3,20-diol metabolite results in decreased activity of STS protein"11600235
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D000082AcetaminophenAcetaminophen results in decreased expression of STS mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of STS mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
C412373AG 1879AG 1879 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C090766AGN 190299AGN 190299 results in increased activity of STS protein16178010
C492393AGN 195183"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [AGN 195183 results in increased activity of STS protein]"16178010
C492393AGN 195183AGN 195183 results in increased activity of STS protein16178010
C492393AGN 195183wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]16178010
D000393Air PollutantsAir Pollutants results in decreased expression of STS mRNA23649983
C103303alitretinoinalitretinoin results in increased activity of STS protein16178010
C068073Am 580Am 580 results in increased activity of STS protein16178010
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STS mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
D015114AndrostenediolAndrostenediol metabolite results in decreased activity of STS protein11600235
D001280AtrazineAtrazine results in increased expression of STS mRNA22285353
D001379AzathioprineAzathioprine results in increased expression of STS mRNA19192274
D001562BenzimidazolesBenzimidazoles inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS protein]24055520
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of STS mRNA24055520
D004958EstradiolSTS protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Estradiol]26220752
D004958Estradiol[[STS protein results in increased hydrolysis of estrone sulfate] which results in increased abundance of Estrone] which results in increased abundance of Estradiol12413846
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of STS mRNA15912405
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of STS mRNA25607892
C006780bisphenol Abisphenol A results in increased expression of STS mRNA22285353|2518105
C059975bistratene A[Tretinoin co-treated with bistratene A] results in increased activity of STS protein16178010
D000069286BortezomibBortezomib inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
D000069286BortezomibBortezomib inhibits the reaction [IGF2 protein results in increased expression of STS protein]24055520
D000069286BortezomibBortezomib results in decreased expression of STS mRNA20977926
D0200011-Butanol1-Butanol inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of STS mRNA25607892
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of STS mRNA23741332
D002330CarmustineCarmustine results in increased expression of STS mRNA15980968
D000068579CelecoxibCelecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of STS mRNA26272509
D002746ChlorpromazineChlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D002922CiguatoxinsCiguatoxins affects the expression of STS mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of STS mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of STS mRNA19549813
D003474CurcuminCurcumin results in decreased expression of STS mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of STS mRNA20106945|2556210
D003613DanazolDanazol results in decreased activity of STS protein11600235
C107676deguelindeguelin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D003687DehydroepiandrosteroneSTS protein results in increased chemical synthesis of Dehydroepiandrosterone16054388
D019314Dehydroepiandrosterone SulfateSTS protein affects the metabolism of Dehydroepiandrosterone Sulfate16054388
D019314Dehydroepiandrosterone SulfateSTS protein results in increased metabolism of Dehydroepiandrosterone Sulfate11600235
D003703DemecolcineDemecolcine results in decreased expression of STS mRNA23649840
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of STS mRNA27392435
D002945CisplatinCisplatin results in decreased expression of STS mRNA27392435
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
D004008DiclofenacDiclofenac results in increased expression of STS mRNA19192274
C121718dicyclanildicyclanil results in decreased expression of STS mRNA15664270
D004041Dietary FatsSTS protein results in decreased susceptibility to Dietary Fats24497646
D004041Dietary FatsDietary Fats results in increased expression of STS mRNA24497646|2501614
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
D004054DiethylstilbestrolDiethylstilbestrol analog results in decreased activity of STS protein15597397
D0197942,3-Diphosphoglycerate"2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of STS mRNA12655031
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of STS mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
D004855EquileninSTS protein results in increased metabolism of Equilenin6874424
D004970EstroneSTS protein results in increased chemical synthesis of Estrone16054388
D004970Estrone[STS protein results in increased hydrolysis of estrone sulfate] which results in increased abundance of Estrone12413846
D004970Estrone[[STS protein results in increased hydrolysis of estrone sulfate] which results in increased abundance of Estrone] which results in increased abundance of Estradiol12413846
C088768estrone-3-O-sulfamateestrone-3-O-sulfamate results in decreased activity of STS protein11600235|1271102
C017296estrone sulfateSTS protein affects the metabolism of estrone sulfate16054388
C017296estrone sulfateSTS protein results in decreased sulfation of estrone sulfate15597397
C017296estrone sulfateSTS protein results in increased hydrolysis of estrone sulfate12413846
C017296estrone sulfate[STS protein results in increased hydrolysis of estrone sulfate] which results in increased abundance of Estrone12413846
C017296estrone sulfate[[STS protein results in increased hydrolysis of estrone sulfate] which results in increased abundance of Estrone] which results in increased abundance of Estradiol12413846
C017296estrone sulfateSTS protein results in increased metabolism of estrone sulfate11600235
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STS mRNA26865667
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of STS mRNA23649840
D005411Flame RetardantsFlame Retardants results in decreased expression of STS mRNA18534652
D005411Flame RetardantsFlame Retardants results in increased expression of STS mRNA18534652
D005485FlutamideFlutamide results in decreased expression of STS mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of STS mRNA23649840
C039281furanfuran results in decreased expression of STS mRNA24183702
C039281furanfuran results in decreased expression of STS mRNA25539665|2619464
D019833GenisteinGenistein results in decreased expression of STS mRNA26865667
C081021Go 6976Go 6976 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of STS mRNA19192274
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of STS mRNA18534652
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of STS mRNA18534652
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of STS mRNA16849584
C520511irosustatirosustat results in decreased activity of STS protein12711022|1462354
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of STS mRNA27392435
C544151jinfukangjinfukang results in decreased expression of STS mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of STS protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STS mRNA22904298|2675264
D048628KetolidesKetolides analog results in increased expression of STS mRNA24967691
C045463leflunomideleflunomide results in increased expression of STS mRNA24136188
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased activity of STS protein"26220752
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of STS mRNA"26220752
C440499lipopolysaccharide, Escherichia coli O111 B4"prolinedithiocarbamate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of STS protein]"26220752
C042720mercuric bromidemercuric bromide results in increased expression of STS mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of STS mRNA19192274
D008731MethoxychlorMethoxychlor results in decreased expression of STS mRNA22285353
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STS mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STS mRNA23649840
D008775MethylprednisoloneMethylprednisolone results in increased expression of STS mRNA19192274
C064769N-acetylsphingosineN-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D009281NaphthalenesNaphthalenes results in decreased expression of STS protein17337753
C029938nickel sulfatenickel sulfate results in decreased expression of STS mRNA22714537
C012655nimesulidenimesulide results in increased expression of STS mRNA24136188
D004962EstranesEstranes analog results in decreased activity of STS protein11600235
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of STS mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of STS mRNA25607892
C002669parthenolideparthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D010455PeptidesPeptides inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of STS mRNA26272509
D010710PhosphatesPhosphates results in decreased activity of STS protein6874424
D010712Phosphatidic AcidsPhosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein]16178010
C006253pirinixic acidpirinixic acid results in decreased expression of STS mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of STS mRNA]20059764
D010894PiroxicamPiroxicam results in increased expression of STS mRNA19192274
D011239PrednisolonePrednisolone results in increased expression of STS mRNA19192274
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
C066229prolinedithiocarbamate"prolinedithiocarbamate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of STS protein]"26220752
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STS protein]26220752
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of STS protein]26220752
D011433PropranololPropranolol inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C085746rottlerinrottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C093642SB 203580SB 203580 inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of STS mRNA25895662
D020123SirolimusSirolimus inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C118258SN50 peptideSN50 peptide inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C016104sodium bichromatesodium bichromate results in decreased expression of STS mRNA25993096
C010634sodium boratesodium borate results in decreased activity of STS protein6874424
D013267StilbenesStilbenes analog results in decreased activity of STS protein15597397
C515227STX 213STX 213 results in decreased activity of STS protein18450955
C005741sulfamic acidsulfamic acid analog results in decreased activity of STS protein15597397
C086827tazarotenetazarotene metabolite results in increased activity of STS protein16178010
C086827tazarotenetazarotene results in increased activity of STS protein16178010
C086827tazarotenewortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]16178010
D013755Tetradecanoylphorbol Acetateprolinedithiocarbamate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STS protein]26220752
D013755Tetradecanoylphorbol AcetateRELA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of STS protein]26220752
D013755Tetradecanoylphorbol AcetateSTS protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Estradiol]26220752
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of and results in increased activity of STS protein26220752
D013853ThioacetamideThioacetamide results in decreased expression of STS mRNA23411599
C483909torcetrapibtorcetrapib results in increased expression of STS mRNA23228038
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin1-Butanol inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin"2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
D014212Tretinoin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
D014212Tretinoin"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
D014212Tretinoin"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tretinoin results in increased activity of STS protein]"16178010
D014212Tretinoin7-hydroxystaurosporine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinAG 1879 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoinbisindolylmaleimide I inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinCelecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinChlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoindeguelin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinGo 6976 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinN-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoinparthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinPhosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinPRKCA protein affects the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinPRKCD protein affects the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinPropranolol inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinRARA protein promotes the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoinrottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinSirolimus inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinSN50 peptide inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoin[Tretinoin co-treated with bistratene A] results in increased activity of STS protein16178010
D014212TretinoinTretinoin results in increased activity of STS protein16178010
D014212TretinoinTretinoin results in increased expression of STS mRNA21934132
D014212TretinoinU 0126 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212Tretinoinwortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C012589trichostatin Atrichostatin A results in increased expression of STS mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of STS mRNA28973697
C080163trovafloxacintrovafloxacin results in increased expression of STS mRNA24136188
C113580U 0126U 0126 inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
C022884undecaneundecane results in decreased expression of STS protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STS mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of STS mRNA23179753|2438349
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA25607892
C025643vinclozolinvinclozolin results in decreased expression of STS mRNA22285353
D014750VincristineVincristine results in decreased expression of STS mRNA23649840
C009687wortmannin"wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]"16178010
C009687wortmanninwortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]16178010
C009687wortmanninwortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]24055520
C009687wortmanninwortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]16178010
C009687wortmanninwortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]16178010
D015032ZincZinc deficiency results in decreased expression of STS mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of STS mRNA]16140947
C071554ZK 119010ZK 119010 results in decreased activity of STS protein12413846
C403253ZK 164015ZK 164015 results in decreased activity of STS protein12413846

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004773steryl-sulfatase activity-TAS-  
GO:0008484sulfuric ester hydrolase activity-IDA15962010  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006687glycosphingolipid metabolic process-TAS-  
GO:0006706steroid catabolic process-TAS6957717  
GO:0007565female pregnancy-IEA-  
GO:0008544epidermis development-TAS9252398  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-TAS2668275  
GO:0005768endosome-TAS2668275  
GO:0005783endoplasmic reticulum-TAS2668275  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005794Golgi apparatus-TAS2668275  
GO:0005886plasma membrane-TAS2668275  
GO:0016020membrane-TAS2668275  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-TAS6957717  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-1663150The activation of arylsulfatasesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21682915'The smoking toolkit study': a national study of smoking and smoking cessation in England. (2011 Jun 18)Fidler JABMC Public Health
16116929Early postoperative complications after coronary artery bypass grafting at the San Juan Veterans Affairs Medical Center. (2005 Jun)Escabi-Mendoza JP R Health Sci J
26986948An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)Accordini SPLoS One
16862680Prevalence and an analysis of noise--induced hearing loss in army helicopter pilots and aircraft mechanics. (2005 Nov)Jaruchinda PJ Med Assoc Thai
267481051-Adamantylamine a simple urine marker for screening for third generation adamantyl-type synthetic cannabinoids by ultra-performance liquid chromatography tandem mass spectrometry. (2016 Nov)Ford LTAnn Clin Biochem
28040286Balloon dilatation and outcome among patients undergoing trans-femoral aortic valve replacement. (2017 Mar 1)Fink NInt J Cardiol
23723183Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: a snapshot of the German situation in the autumn of 2012. (2014 Jan-Feb)Langer NDrug Test Anal
29174391Prediction of Long-Term Survival After Lung Cancer Surgery for Elderly Patients in The Society of Thoracic Surgeons General Thoracic Surgery Database. (2018 Jan)Onaitis MWAnn Thorac Surg
21059812Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver. (2011 Mar)Tatematsu KMutagenesis
23919019The Evaluation of the Impact of Age, Skin Tags, Metabolic Syndrome, Body Mass Index, and Smoking on Homocysteine, Endothelin-1, High-sensitive C-reactive Protein, and on the Heart. (2013 Jul)El Safoury OSIndian J Dermatol
28149020Insulin Resistance in Young Obese Subjects and Its Relation to Smoking (A Pilot Study). (2017 Mar)Juneja AIndian J Clin Biochem
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
25428705Study on the phase I metabolism of novel synthetic cannabinoids, APICA and its fluorinated analogue. (2015 Feb)Sobolevsky TDrug Test Anal
29054831Web-Based Information on the Treatment of Tobacco Dependence for Oral Health Professionals: Analysis of English-Written Websites. (2017 Oct 20)Diniz-Freitas MJ Med Internet Res
16392767Higher small arterial elasticity in hypertensive patients treated with angiotensin II receptor blockers. (2005 Aug)Takeuchi KHypertens Res
11845863A decade of change--risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990-1999: a report from the STS National Database Committee and the Duke Clinical Research Institute. Society of Thoracic Surgeons. (2002 Feb)Ferguson TB JrAnn Thorac Surg
11565660Creative arterial bypass grafting can be performed on the beating heart. (2001 Sep)Quigley RLAnn Thorac Surg
16730924Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence. (2006 Dec 1)Elkashef ADrug Alcohol Depend
11972464Emphysema in heavy smokers with normal chest radiography. Detection and quantification by HCRT. (2002 Jan)Sashidhar KActa Radiol
23891405Pulmonary function tests overestimate chronic pulmonary disease in patients with severe aortic stenosis. (2013 Oct)Magee MJAnn Thorac Surg