Gene info: ID 4121

Gene: MAN1A1

GENE ID: 4121

Synonyms: HUMM3|HUMM9|MAN9

Description: mannosidase alpha class 1A member 1

Gene type: protein-coding

Location: 6q22.31

dbXrefs: Ensembl:ENSG00000111885 MIM:604344 Vega:OTTHUMG00000015472 UniprotKB:P33908

RefSeq: NC_000006.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.908e-1 (AD) 2.457e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17080911	chr6:119248936 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03051880	chr6:119662024	MAN1A1		6.800e-19	Smoking	27651444
cg02578070	chr6:119669305	MAN1A1		7.400e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAP2B	0.802
AKAP5	0.784
HECTD2	0.782
RPS6KA3	0.779
DIAPH2	0.778
PRKCD	0.773
GNAL	0.772
KCNG3	0.77
PTPRO	0.769
C16orf87	0.758

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BCAS1	-0.394
CTNNA3	-0.387
CDKN2C	-0.382
FXYD4	-0.378
RHBDL2	-0.373
KIAA1755	-0.372
ZFP57	-0.366
S100A1	-0.362
C19orf18	-0.358
S1PR5	-0.349

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of MAN1A1 mRNA"	20453058
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of MAN1A1 mRNA"	19414516
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MAN1A1 mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of MAN1A1 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MAN1A1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAN1A1 gene	27153756
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MAN1A1 mRNA	15761015
C547126	AZM551248	AZM551248 results in increased expression of MAN1A1 mRNA	22323515
D004958	Estradiol	Estradiol results in decreased expression of MAN1A1 mRNA	21185374
C053541	bicalutamide	bicalutamide results in increased expression of MAN1A1 mRNA	15638997
C006780	bisphenol A	bisphenol A affects the expression of MAN1A1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of MAN1A1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of MAN1A1 mRNA	28196854
C006780	bisphenol A	bisphenol A affects the expression of MAN1A1 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of MAN1A1 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MAN1A1 mRNA	22079614
C584509	C646 compound	C646 compound results in decreased expression of MAN1A1 mRNA	26191083
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of MAN1A1 mRNA	26272509
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MAN1A1 mRNA	24386269
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAN1A1 mRNA	25562108
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAN1A1 mRNA]	27941970
D002945	Cisplatin	Cisplatin results in decreased expression of MAN1A1 mRNA	27594783
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of MAN1A1 mRNA	23649840
D005472	Fluorouracil	Fluorouracil results in increased expression of MAN1A1 mRNA	16510598
D005485	Flutamide	Flutamide results in decreased expression of MAN1A1 mRNA	24136188
C492448	ICG 001	ICG 001 results in increased expression of MAN1A1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAN1A1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MAN1A1 mRNA	24796395
D007854	Lead	Lead affects the expression of MAN1A1 mRNA	28903495
C042720	mercuric bromide	mercuric bromide results in increased expression of MAN1A1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MAN1A1 mRNA	26011545
D015741	Metribolone	Metribolone results in decreased expression of MAN1A1 mRNA	17010675
C507134	ON 01910	ON 01910 results in increased expression of MAN1A1 mRNA	22351695
C030110	oxaliplatin	oxaliplatin results in increased expression of MAN1A1 mRNA	16510598
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAN1A1 mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of MAN1A1 mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MAN1A1 mRNA	26272509
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of MAN1A1 mRNA	22714537
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MAN1A1 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of MAN1A1 mRNA	21632981
D015474	Isotretinoin	Isotretinoin results in increased expression of MAN1A1 mRNA	20436886
D012906	Smoke	Smoke results in increased expression of MAN1A1 mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the expression of MAN1A1 mRNA	29319823
C017947	sodium arsenite	sodium arsenite results in increased expression of MAN1A1 mRNA	22714537
C016104	sodium bichromate	sodium bichromate affects the expression of MAN1A1 mRNA	22110744
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAN1A1 mRNA	17555868
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAN1A1 mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAN1A1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of MAN1A1 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MAN1A1 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of MAN1A1 mRNA	23179753\|2438349
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAN1A1 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of MAN1A1 mRNA	18769122
C111237	vorinostat	vorinostat results in increased expression of MAN1A1 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	-	IBA	21873635
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	-	TAS	-
GO:0005509	calcium ion binding	-	IEA	-
GO:0015923	mannosidase activity	-	TAS	8223597

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006486	protein glycosylation	-	IEA	-
GO:0006491	N-glycan processing	-	IBA	21873635
GO:1904381	Golgi apparatus mannose trimming	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IBA	21873635
GO:0000139	Golgi membrane	-	TAS	-
GO:0005783	endoplasmic reticulum	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	TAS	8223597
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	-	IDA	15308636
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00510	N-Glycan biosynthesis
hsa01100	Metabolic pathways
hsa04141	Protein processing in endoplasmic reticulum

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6811438	Intra-Golgi traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	TAS
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal